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Journal Articles

Finally, An Apoptosis-Targeting Therapeutic for Cancer

Carlo M. Croce, John C. Reed

Cancer Res (2016) 76 (20): 5914–5920.

https://doi.org/10.1158/0008-5472.CAN-16-1248

Published: 13 October 2016

View article titled, Finally, An Apoptosis-Targeting Therapeutic for Cancer

Journal Articles

PCTAIRE1 Phosphorylates p27 and Regulates Mitosis in Cancer Cells

Teruki Yanagi, Maryla Krajewska, Shu-ichi Matsuzawa, John C. Reed

Cancer Res (2014) 74 (20): 5795–5807.

https://doi.org/10.1158/0008-5472.CAN-14-0872

Published: 14 October 2014

View article titled, PCTAIRE1 Phosphorylates p27 and Regulates Mitosis in Cancer Cells

Includes: Supplementary data

Journal Articles

Abstract LB-74: The NLR-related protein NWD1 is associated with prostate cancer and modulates androgen receptor signaling

Ricardo G. Correa, Maryla Krajewska, Carl F. Ware, Motti Gerlic, John C. Reed

Cancer Res (2014) 74 (19_Supplement): LB-74.

https://doi.org/10.1158/1538-7445.AM2014-LB-74

Published: 01 October 2014

View article titled, Abstract LB-74: The NLR-related protein NWD1 is associated with prostate cancer and modulates androgen receptor signaling

Journal Articles

Abstract 2928: Interleukin-1 receptor-associated kinase-2 (IRAK2) is a critical mediator of endoplasmic reticulum (ER) stress.

Ravanan Palaniyandi, Samir Benosman, Ying-Chen Hou, Ricardo G. Correa, Minjia Yu, Muhammet Fatih Gulen, Xiaoxia Li, James Thomas, Yasuko Matsuzawa, Shu-Ichi Matsuzawa, John C. Reed

Cancer Res (2013) 73 (8_Supplement): 2928.

https://doi.org/10.1158/1538-7445.AM2013-2928

Published: 15 April 2013

View article titled, Abstract 2928: Interleukin-1 receptor-associated kinase-2 (IRAK2) is a critical mediator of endoplasmic reticulum (ER) stress.

Journal Articles

Abstract 217: BCR-ABL tyrosine kinase inhibition combined with a novel pan BCL2 family inhibitor abrogates leukemia stem cell survival in a niche-dependent manner.

Wenxue Ma, Janine Low-Marchelli, Heather S. Leu, Angela Court Recart, Jun Wei, Xianshu Huang, Maryla Krajewska, Maurizio Pellecchia, John C. Reed, Catriona H.M. Jamieson

Cancer Res (2013) 73 (8_Supplement): 217.

https://doi.org/10.1158/1538-7445.AM2013-217

Published: 15 April 2013

View article titled, Abstract 217: BCR-ABL tyrosine kinase inhibition combined with a novel pan BCL2 family inhibitor abrogates leukemia stem cell survival in a niche-dependent manner.

Journal Articles

Abstract 4609: Novel phosphorylation and ubiquitination sites regulate ROS-dependent degradation of c-FLIP and sensitization of cancer cells to TRAIL.

Rachel P. Wilkie-Grantham, Shu-Ichi Matsuzawa, John C. Reed

Cancer Res (2013) 73 (8_Supplement): 4609.

https://doi.org/10.1158/1538-7445.AM2013-4609

Published: 15 April 2013

View article titled, Abstract 4609: Novel phosphorylation and ubiquitination sites regulate ROS-dependent degradation of c-FLIP and sensitization of cancer cells to TRAIL.

Journal Articles

Abstract 4540: Development of a biochemical High Throughput Screening (HTS) assay for chemical inhibitors of MALT1, a target for lymphoma therapeutics.

Dayong Zhai, Chih-Wen Shu, Paul Diaz, John C. Reed

Cancer Res (2013) 73 (8_Supplement): 4540.

https://doi.org/10.1158/1538-7445.AM2013-4540

Published: 15 April 2013

View article titled, Abstract 4540: Development of a biochemical High Throughput Screening (HTS) assay for chemical inhibitors of MALT1, a target for lymphoma therapeutics.

Journal Articles

Abstract 605: Apogossypolone derivative -BI97D6 effectively targets MCL1 overexpressing Acute Myeloid Leukemia cells.

Rongqing Pan, Vivian Ruvolo, Maurizio Pellecchia, Jun Wei, Marina Konopleva, John C. Reed, Peter Ruvolo, Michael Andreeff

Cancer Res (2013) 73 (8_Supplement): 605.

https://doi.org/10.1158/1538-7445.AM2013-605

Published: 15 April 2013

View article titled, Abstract 605: Apogossypolone derivative -BI97D6 effectively targets MCL1 overexpressing Acute Myeloid Leukemia cells.

Journal Articles

Abstract 4318: Development of a novel SurrobodyTM that simultaneously activates both death receptors DR4 and DR5 and induces cancer cell death with high potency.

Snezana Milutinovic, Sihong Zhou, Carina Wimer, Paul W. Diaz, Arun K. Kashyap, Ramesh R. Bhatt, John C. Reed

Cancer Res (2013) 73 (8_Supplement): 4318.

https://doi.org/10.1158/1538-7445.AM2013-4318

Published: 15 April 2013

View article titled, Abstract 4318: Development of a novel SurrobodyTM that simultaneously activates both death receptors DR4 and DR5 and induces cancer cell death with high potency.

Journal Articles

Abstract LB-128: High throughput screening kinase activators of Atg4B for cancer therapy.

Chih-Wen Shu, Pei-Feng Liu, John C. Reed

Cancer Res (2013) 73 (8_Supplement): LB-128.

https://doi.org/10.1158/1538-7445.AM2013-LB-128

Published: 15 April 2013

View article titled, Abstract LB-128: High throughput screening kinase activators of Atg4B for cancer therapy.

Journal Articles

Abstract 2008: Broad spectrum BH3 mimetic BI-97D6 induces apoptosis of acute myeloid leukemia cells even when co-cultured with supporting stromal cells

Rongqing Pan, Peter P. Ruvolo, Maurizio Pellecchia, Jun Wei, Yuexi Shi, Marina Konopleva, John C. Reed, Michael Andreeff

Cancer Res (2012) 72 (8_Supplement): 2008.

https://doi.org/10.1158/1538-7445.AM2012-2008

Published: 15 April 2012

View article titled, Abstract 2008: Broad spectrum BH3 mimetic BI-97D6 induces apoptosis of acute myeloid leukemia cells even when co-cultured with supporting stromal cells

Journal Articles

Abstract 5: Synthesis and biological evaluation of 5, 5’ substituted apogossypol and apogossypolone derivatives as pan-active inhibitors of anti-apoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins

Jun Wei, William J. Placzek, John L. Stebbins, John C. Reed, Maurizio Pellecchia, Paul B. Fisher, Rupesh Dash, Catriona Jamieson, Shinichi Kitada

Cancer Res (2011) 71 (8_Supplement): 5.

https://doi.org/10.1158/1538-7445.AM2011-5

Published: 15 April 2011

View article titled, Abstract 5: Synthesis and biological evaluation of 5, 5’ substituted apogossypol and apogossypolone derivatives as pan-active inhibitors of anti-apoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins

Journal Articles

Mechanism by Which Mcl-1 Regulates Cancer-Specific Apoptosis Triggered by mda-7/IL-24, an IL-10–Related Cytokine

Rupesh Dash, Joanna E. Richards, Zhao-zhong Su, Sujit K. Bhutia, Belal Azab, Mohamed Rahmani, Girija Dasmahapatra, Adly Yacoub, Paul Dent, Igor P. Dmitriev, David T. Curiel, Steven Grant, Maurizio Pellecchia, John C. Reed, Devanand Sarkar, Paul B. Fisher

Cancer Res (2010) 70 (12): 5034–5045.

https://doi.org/10.1158/0008-5472.CAN-10-0563

Published: 14 June 2010

View article titled, Mechanism by Which Mcl-1 Regulates Cancer-Specific Apoptosis Triggered by mda-7/IL-24, an IL-10–Related Cytokine

Includes: Supplementary data

Journal Articles

Apoptotic Activity and Mechanism of 2-Cyano-3,12-Dioxoolean-1,9-Dien-28-Oic-Acid and Related Synthetic Triterpenoids in Prostate Cancer

Marc L. Hyer, Ranxin Shi, Maryla Krajewska, Colin Meyer, Irina V. Lebedeva, Paul B. Fisher, John C. Reed

Cancer Res (2008) 68 (8): 2927–2933.

https://doi.org/10.1158/0008-5472.CAN-07-5759

Published: 15 April 2008

View article titled, Apoptotic Activity and Mechanism of 2-Cyano-3,12-Dioxoolean-1,9-Dien-28-Oic-Acid and Related Synthetic Triterpenoids in Prostate Cancer

Includes: Supplementary data

Journal Articles

BAG3 Regulates Motility and Adhesion of Epithelial Cancer Cells

Masahiro Iwasaki, Sachiko Homma, Akinori Hishiya, Samuel J. Dolezal, John C. Reed, Shinichi Takayama

Cancer Res (2007) 67 (21): 10252–10259.

https://doi.org/10.1158/0008-5472.CAN-07-0618

Published: 01 November 2007

View article titled, BAG3 Regulates Motility and Adhesion of Epithelial Cancer Cells

Includes: Supplementary data

Journal Articles

Mice Lacking bi-1 Gene Show Accelerated Liver Regeneration

Béatrice Bailly-Maitre, Emilie Bard-Chapeau, Fréderic Luciano, Nathalie Droin, Jean-Marie Bruey, Benjamin Faustin, Christina Kress, Juan M. Zapata, John C. Reed

Cancer Res (2007) 67 (4): 1442–1450.

https://doi.org/10.1158/0008-5472.CAN-06-0850

Published: 16 February 2007

View article titled, Mice Lacking <em>bi-1</em> Gene Show Accelerated Liver Regeneration

Includes: Supplementary data

Journal Articles

Daxx Represses Expression of a Subset of Antiapoptotic Genes Regulated by Nuclear Factor-κB

Rhonda Croxton, Lorena A. Puto, Ian de Belle, Michael Thomas, Seiji Torii, Farid Hanaii, Michael Cuddy, John C. Reed

Cancer Res (2006) 66 (18): 9026–9035.

https://doi.org/10.1158/0008-5472.CAN-06-1047

Published: 18 September 2006

View article titled, Daxx Represses Expression of a Subset of Antiapoptotic Genes Regulated by Nuclear Factor-κB

Journal Articles

HBXIP, Cellular Target of Hepatitis B Virus Oncoprotein, Is a Regulator of Centrosome Dynamics and Cytokinesis

Ryoji Fujii, Changjun Zhu, Yunfei Wen, Hiroyuki Marusawa, Beatrice Bailly-Maitre, Shu-ichi Matsuzawa, Hong Zhang, Youngsoo Kim, C. Frank Bennett, Wei Jiang, John C. Reed

Cancer Res (2006) 66 (18): 9099–9107.

https://doi.org/10.1158/0008-5472.CAN-06-1886

Published: 18 September 2006

View article titled, HBXIP, Cellular Target of Hepatitis B Virus Oncoprotein, Is a Regulator of Centrosome Dynamics and Cytokinesis

Journal Articles

Roadblocks to caspase-dependent cell death in cancer: Therapeutic strategies.

John C. Reed

Cancer Res (2006) 66 (8_Supplement): 1361–1362.

Published: 15 April 2006

View article titled, Roadblocks to caspase-dependent cell death in cancer: Therapeutic strategies.

Journal Articles

Structure activity relation study of small-molecule antagonists of apoptosis suppressor XIAP

Kate Welsh, Clemencia Pinilla, Adel Nefzi, John M. Ostresh, Maurizio Pellecchia, Richard A. Houghten, John C. Reed

Cancer Res (2006) 66 (8_Supplement): 187.

Published: 15 April 2006

View article titled, Structure activity relation study of small-molecule antagonists of apoptosis suppressor XIAP

NARROW

Finally, An Apoptosis-Targeting Therapeutic for Cancer

PCTAIRE1 Phosphorylates p27 and Regulates Mitosis in Cancer Cells

Abstract LB-74: The NLR-related protein NWD1 is associated with prostate cancer and modulates androgen receptor signaling

Abstract 2928: Interleukin-1 receptor-associated kinase-2 (IRAK2) is a critical mediator of endoplasmic reticulum (ER) stress.

Abstract 217: BCR-ABL tyrosine kinase inhibition combined with a novel pan BCL2 family inhibitor abrogates leukemia stem cell survival in a niche-dependent manner.

Abstract 4609: Novel phosphorylation and ubiquitination sites regulate ROS-dependent degradation of c-FLIP and sensitization of cancer cells to TRAIL.

Abstract 4540: Development of a biochemical High Throughput Screening (HTS) assay for chemical inhibitors of MALT1, a target for lymphoma therapeutics.

Abstract 605: Apogossypolone derivative -BI97D6 effectively targets MCL1 overexpressing Acute Myeloid Leukemia cells.

Abstract 4318: Development of a novel SurrobodyTM that simultaneously activates both death receptors DR4 and DR5 and induces cancer cell death with high potency.

Abstract LB-128: High throughput screening kinase activators of Atg4B for cancer therapy.

Abstract 2008: Broad spectrum BH3 mimetic BI-97D6 induces apoptosis of acute myeloid leukemia cells even when co-cultured with supporting stromal cells

Abstract 5: Synthesis and biological evaluation of 5, 5’ substituted apogossypol and apogossypolone derivatives as pan-active inhibitors of anti-apoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins

Mechanism by Which Mcl-1 Regulates Cancer-Specific Apoptosis Triggered by mda-7/IL-24, an IL-10–Related Cytokine

Apoptotic Activity and Mechanism of 2-Cyano-3,12-Dioxoolean-1,9-Dien-28-Oic-Acid and Related Synthetic Triterpenoids in Prostate Cancer

BAG3 Regulates Motility and Adhesion of Epithelial Cancer Cells

Mice Lacking bi-1 Gene Show Accelerated Liver Regeneration

Daxx Represses Expression of a Subset of Antiapoptotic Genes Regulated by Nuclear Factor-κB

HBXIP, Cellular Target of Hepatitis B Virus Oncoprotein, Is a Regulator of Centrosome Dynamics and Cytokinesis

Roadblocks to caspase-dependent cell death in cancer: Therapeutic strategies.

Structure activity relation study of small-molecule antagonists of apoptosis suppressor XIAP

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