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John C. Dawson
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Journal Articles

Targeting the PREX2/RAC1/PI3Kβ Signaling Axis Confers Sensitivity to Clinically Relevant Therapeutic Approaches in Melanoma

Catriona A. Ford, Dana Koludrovic, Patricia P. Centeno, Mona Foth, Elpida Tsonou, Nikola Vlahov, Nathalie Sphyris, Kathryn Gilroy, Courtney Bull, Colin Nixon, Bryan Serrels, Alison F. Munro, John C. Dawson, Neil O. Carragher, Valeria Pavet, David C. Hornigold, Philip D. Dunne, Julian Downward, Heidi C.E. Welch, Simon T. Barry, Owen J. Sansom, Andrew D. Campbell
Journal: Cancer Research
Cancer Res (2025) 85 (4): 808–824.
https://doi.org/10.1158/0008-5472.CAN-23-2814
Published: 17 February 2025
View article titled, Targeting the PREX2/RAC1/PI3Kβ Signaling Axis Confers Sensitivity to Clinically Relevant Therapeutic Approaches in Melanoma
Open the PDF for Targeting the PREX2/RAC1/PI3Kβ Signaling Axis Confers Sensitivity to Clinically Relevant Therapeutic Approaches in Melanoma in another window
Includes: Supplementary data
Journal Articles

Abstract 615: NXP900, a novel YES1/SRC kinase inhibitor in phase 1, demonstrates potent inhibition of proliferation in cell lines resistant to ALK and EGFR inhibitors

Neil O. Carragher, Enrique Poradosu, Ben King, Alison F. Munro, John C. Dawson, Asier Unciti-Broceta
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 615.
https://doi.org/10.1158/1538-7445.AM2024-615
Published: 22 March 2024
View article titled, Abstract 615: NXP900, a novel YES1/SRC kinase inhibitor in phase 1, demonstrates potent inhibition of proliferation in cell lines resistant to ALK and EGFR inhibitors
Journal Articles

Abstract 4031: In vivo studies demonstrate differences in target inhibition and anticancer efficacy between NXP900 and dasatinib in ovarian clear cell carcinoma model

Saúl Navarro-Marchal, Carolin Temps, Iñigo Lanzagorta-Calvillo, John C. Dawson, Enrique Poradosu, Neil O. Carragher, Valerie G. Brunton, Asier Unciti-Broceta
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4031.
https://doi.org/10.1158/1538-7445.AM2023-4031
Published: 04 April 2023
View article titled, Abstract 4031: <em>In vivo</em> studies demonstrate differences in target inhibition and anticancer efficacy between NXP900 and dasatinib in ovarian clear cell carcinoma model
Journal Articles

A Conformation Selective Mode of Inhibiting SRC Improves Drug Efficacy and Tolerability

Carolin Temps, Daniel Lietha, Emily R. Webb, Xue-Feng Li, John C. Dawson, Morwenna Muir, Kenneth G. Macleod, Teresa Valero, Alison F. Munro, Rafael Contreras-Montoya, Juan R. Luque-Ortega, Craig Fraser, Henry Beetham, Christina Schoenherr, Maria Lopalco, Mark J. Arends, Margaret C. Frame, Bin-Zhi Qian, Valerie G. Brunton, Neil O. Carragher, Asier Unciti-Broceta
Journal: Cancer Research
Cancer Res (2021) 81 (21): 5438–5450.
https://doi.org/10.1158/0008-5472.CAN-21-0613
Published: 01 November 2021
View article titled, A Conformation Selective Mode of Inhibiting SRC Improves Drug Efficacy and Tolerability
Open the PDF for A Conformation Selective Mode of Inhibiting SRC Improves Drug Efficacy and Tolerability in another window
Includes: Supplementary data
Journal Articles

Kindlin-1 Promotes Pulmonary Breast Cancer Metastasis

Sana Sarvi, Hitesh Patel, Jun Li, Georgia L. Dodd, Helen Creedon, Morwenna Muir, Jocelyn Ward, John C. Dawson, Martin Lee, Jayne Culley, Donald M. Salter, Andrew H. Sims, Adam Byron, Valerie G. Brunton
Journal: Cancer Research
Cancer Res (2018) 78 (6): 1484–1496.
https://doi.org/10.1158/0008-5472.CAN-17-1518
Published: 14 March 2018
View article titled, Kindlin-1 Promotes Pulmonary Breast Cancer Metastasis
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Includes: Supplementary data
Journal Articles

Abstract 4303: A high-throughput cell invasion assay combined with reverse phase protein microarrays for rational development of drug combination strategies targeting tumor invasion

John C. Dawson, Neil O. Carragher, Jennifer Fronczak, Keren Hulkower
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 4303.
https://doi.org/10.1158/1538-7445.AM2012-4303
Published: 15 April 2012
View article titled, Abstract 4303: A high-throughput cell invasion assay combined with reverse phase protein microarrays for rational development of drug combination strategies targeting tumor invasion