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John B. Little
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Journal Articles

Abnormal Gene Expression Profiles in Unaffected Parents of Patients with Hereditary-Type Retinoblastoma

Eric Y. Chuang, Xi Chen, Mong-Hsun Tsai, Hailing Yan, Chuan-Yuan Li, James B. Mitchell, Hatsumi Nagasawa, Paul F. Wilson, Yuanlin Peng, Markus M. Fitzek, Joel S. Bedford, John B. Little
Journal: Cancer Research
Cancer Res (2006) 66 (7): 3428–3433.
https://doi.org/10.1158/0008-5472.CAN-05-2847
Published: 03 April 2006
View articletitled, Abnormal Gene Expression Profiles in Unaffected Parents of Patients with Hereditary-Type Retinoblastoma
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Journal Articles

Cellular Mechanisms for Low-Dose Ionizing Radiation–Induced Perturbation of the Breast Tissue Microenvironment

Kelvin K.C. Tsai, Eric Yao-Yu Chuang, John B. Little, Zhi-Min Yuan
Journal: Cancer Research
Cancer Res (2005) 65 (15): 6734–6744.
https://doi.org/10.1158/0008-5472.CAN-05-0703
Published: 01 August 2005
View articletitled, Cellular Mechanisms for Low-Dose Ionizing Radiation–Induced Perturbation of the Breast Tissue Microenvironment
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Includes: Supplementary data
Journal Articles

Expression of CONNEXIN43 Is Highly Sensitive to Ionizing Radiation and Other Environmental Stresses

Edouard I. Azzam, Sonia M. de Toledo, John B. Little
Journal: Cancer Research
Cancer Res (2003) 63 (21): 7128–7135.
Published: 11 November 2003
View articletitled, Expression of CONNEXIN43 Is Highly Sensitive to Ionizing Radiation and Other Environmental Stresses
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Journal Articles

Oxidative Metabolism Modulates Signal Transduction and Micronucleus Formation in Bystander Cells from α-Particle-irradiated Normal Human Fibroblast Cultures

Edouard I. Azzam, Sonia M. de Toledo, Douglas R. Spitz, John B. Little
Journal: Cancer Research
Cancer Res (2002) 62 (19): 5436–5442.
Published: 01 October 2002
View articletitled, Oxidative Metabolism Modulates Signal Transduction and Micronucleus Formation in Bystander Cells from α-Particle-irradiated Normal Human Fibroblast Cultures
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Journal Articles

Involvement of Membrane Signaling in the Bystander Effect in Irradiated Cells

Hatsumi Nagasawa, Aida Cremesti, Richard Kolesnick, Zvi Fuks, John B. Little
Journal: Cancer Research
Cancer Res (2002) 62 (9): 2531–2534.
Published: 01 May 2002
View articletitled, Involvement of Membrane Signaling in the Bystander Effect in Irradiated Cells
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Journal Articles

Persistent Genetic Instability in Cancer Cells Induced by Non-DNA-damaging Stress Exposures

Chuan-Yuan Li, John B. Little, Kang Hu, Wen Zhang, Li Zhang, Mark W. Dewhirst, Qian Huang
Journal: Cancer Research
Cancer Res (2001) 61 (2): 428–432.
Published: 01 January 2001
View articletitled, Persistent Genetic Instability in Cancer Cells Induced by Non-DNA-damaging Stress Exposures
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Journal Articles

Heat-induced Gene Expression as a Novel Targeted Cancer Gene Therapy Strategy

Qian Huang, Jim K. Hu, Frank Lohr, Li Zhang, Rod Braun, Jennifer Lanzen, John B. Little, Mark W. Dewhirst, Chuan-Yuan Li
Journal: Cancer Research
Cancer Res (2000) 60 (13): 3435–3439.
Published: 01 July 2000
View articletitled, Heat-induced Gene Expression as a Novel Targeted Cancer Gene Therapy Strategy
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Journal Articles

High and Low Fluences of α-Particles Induce a G1 Checkpoint in Human Diploid Fibroblasts

Edouard I. Azzam, Sonia M. de Toledo, Anthony J. Waker, John B. Little
Journal: Cancer Research
Cancer Res (2000) 60 (10): 2623–2631.
Published: 15 May 2000
View articletitled, High and Low Fluences of α-Particles Induce a G1 Checkpoint in Human Diploid Fibroblasts
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Journal Articles

Response of Human Tumor Cells of Varying Radiosensitivity and Radiocurability to Fractionated Irradiation

William K. Dahlberg, Edouard I. Azzam, Yongjia Yu, John B. Little
Journal: Cancer Research
Cancer Res (1999) 59 (20): 5365–5369.
Published: 01 October 1999
View articletitled, Response of Human Tumor Cells of Varying Radiosensitivity and Radiocurability to Fractionated Irradiation
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Journal Articles

Increased Ultraviolet Sensitivity and Chromosomal Instability Related to P53 Function in the Xeroderma Pigmentosum Variant

James E. Cleaver, Veena Afzal, Luzviminda Feeney, Mindy McDowell, Walt Sadinski, John P. G. Volpe, David B. Busch, Donna M. Coleman, Deborah W. Ziffer, Yongjia Yu, Hatsumi Nagasawa, John B. Little
Journal: Cancer Research
Cancer Res (1999) 59 (5): 1102–1108.
Published: 01 March 1999
View articletitled, Increased Ultraviolet Sensitivity and Chromosomal Instability Related to P53 Function in the Xeroderma Pigmentosum Variant
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Journal Articles

Loss of Normal G1 Checkpoint Control Is an Early Step in Carcinogenesis, Independent of p53 Status

Randi G. Syljuåsen, Bozena Krolewski, John B. Little
Journal: Cancer Research
Cancer Res (1999) 59 (5): 1008–1014.
Published: 01 March 1999
View articletitled, Loss of Normal G1 Checkpoint Control Is an Early Step in Carcinogenesis, Independent of p53 Status
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Journal Articles

p53 Is Involved in But Not Required for Ionizing Radiation-induced Caspase-3 Activation and Apoptosis in Human Lymphoblast Cell Lines

Yongjia Yu, John B. Little
Journal: Cancer Research
Cancer Res (1998) 58 (19): 4277–4281.
Published: 01 October 1998
View articletitled, p53 Is Involved in But Not Required for Ionizing Radiation-induced Caspase-3 Activation and Apoptosis in Human Lymphoblast Cell Lines
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Journal Articles

Absence of a Radiation-induced First-Cycle G1-S Arrest in p53+ Human Tumor Cells Synchronized by Mitotic Selection

Hatsumi Nagasawa, Peter Keng, Carl Maki, Yongjia Yu, John B. Little
Journal: Cancer Research
Cancer Res (1998) 58 (9): 2036–2041.
Published: 01 May 1998
View articletitled, Absence of a Radiation-induced First-Cycle G1-S Arrest in p53+ Human Tumor Cells Synchronized by Mitotic Selection
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Journal Articles

Relationship between Radiation-induced G1 Phase Arrest and p53 Function in Human Tumor Cells

Hatsumi Nagasawa, Chuan-Yuan Li, Carl G. Maki, Amy C. Imrich, John B. Little
Journal: Cancer Research
Cancer Res (1995) 55 (9): 1842–1846.
Published: 01 May 1995
View articletitled, Relationship between Radiation-induced G1 Phase Arrest and p53 Function in Human Tumor Cells
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Journal Articles

In Vivo Enhancement of Genomic Instability in Minisatellite Sequences of Mouse C3H/10T½ Cells Transformed in Vitro by X-Rays

Benoit Paquette, John B. Little
Journal: Cancer Research
Cancer Res (1994) 54 (12): 3173–3178.
Published: 01 June 1994
View articletitled, In Vivo Enhancement of Genomic Instability in Minisatellite Sequences of Mouse C3H/10T½ Cells Transformed in Vitro by X-Rays
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Journal Articles

Correspondence re: H. Nagasawa and J. B. Little, Induction of Sister Chromatid Exchanges by Extremely Low Doses of α-Particles. Cancer Res., 52: 6394–6396, 1992—Reply

Hatsumi Nagasawa, John B. Little
Journal: Cancer Research
Cancer Res (1993) 53 (9): 2188.
Published: 01 May 1993
View articletitled, Correspondence re: H. Nagasawa and J. B. Little, Induction of Sister Chromatid Exchanges by Extremely Low Doses of α-Particles. Cancer Res., 52: 6394–6396, 1992—Reply
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Journal Articles

Induction of Sister Chromatid Exchanges by Extremely Low Doses of α-Particles

Hatsumi Nagasawa, John B. Little
Journal: Cancer Research
Cancer Res (1992) 52 (22): 6394–6396.
Published: 01 November 1992
View articletitled, Induction of Sister Chromatid Exchanges by Extremely Low Doses of α-Particles
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Journal Articles

Mutation Spectrum of the p53 Gene in Bone and Soft Tissue Sarcomas

Junya Toguchida, Toshikazu Yamaguchi, Bruce Ritchie, Roberta L. Beauchamp, Siri H. Dayton, Guillermo E. Herrera, Takao Yamamuro, Yoshihiko Kotoura, Masao S. Sasaki, John B. Little, Ralph R. Weichselbaum, Kanji Ishizaki, David W. Yandell
Journal: Cancer Research
Cancer Res (1992) 52 (22): 6194–6199.
Published: 01 November 1992
View articletitled, Mutation Spectrum of the p53 Gene in Bone and Soft Tissue Sarcomas
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Journal Articles

Genomic Rearrangements in Mouse C3H/10T½ Cells Transformed by X-Rays, UV-C, and 3-Methylcholanthrene, Detected by a DNA Fingerprint Assay

Benoit Paquette, John B. Little
Journal: Cancer Research
Cancer Res (1992) 52 (20): 5788–5793.
Published: 01 October 1992
View articletitled, Genomic Rearrangements in Mouse C3H/10T½ Cells Transformed by X-Rays, UV-C, and 3-Methylcholanthrene, Detected by a DNA Fingerprint Assay
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Journal Articles

Radiation Sensitivity of Cell Strains from Families with Genetic Disorders Predisposing to Radiation-induced Cancer

John B. Little, Warren W. Nichols, Philip Troilo, Hatsumi Nagasawa, Louise C. Strong
Journal: Cancer Research
Cancer Res (1989) 49 (17): 4705–4714.
Published: 01 September 1989
View articletitled, Radiation Sensitivity of Cell Strains from Families with Genetic Disorders Predisposing to Radiation-induced Cancer
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