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Abstract 5529: In vitro platforms representing tumor complexity for target validation and drug discovery.

John A. Hickman

Cancer Res (2013) 73 (8_Supplement): 5529.

DOI: https://doi.org/10.1158/1538-7445.AM2013-5529

Published: 15 April 2013

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Journal Articles

Abstract 2782: Bcl-2 selective antagonists show antitumor activity without dose limiting platelet toxicity

Olivier Geneste, James Murray, Thierry Le Diguarher, Jérome Starck, Patrick Casara, Guillaume De Nanteuil, James Davidson, Claire Nunns, Chris Graham, Natalia Matassova, Ijen Chen, Neil Whitehead, Pawel Dokurno, Alain Bruno, Alain Pierré, John. A. Hickman, Mike Wood, Francisco Cruzalegui, Stéphane Depil

Cancer Res (2012) 72 (8_Supplement): 2782.

DOI: https://doi.org/10.1158/1538-7445.AM2012-2782

Published: 15 April 2012

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Journal Articles

The Relationships between p53-dependent Apoptosis, Inhibition of Proliferation, and 5-Fluorouracil-induced Histopathology in Murine Intestinal Epithelia

D. Mark Pritchard, Christopher S. Potten, John A. Hickman

Cancer Res (1998) 58 (23): 5453–5465.

Published: 01 December 1998

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Journal Articles

Toxin-induced Increase in Survival Factor Receptors: Modulation of the Threshold for Apoptosis

Catherine C. Boyle, John A. Hickman

Cancer Res (1997) 57 (12): 2404–2409.

Published: 01 June 1997

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Journal Articles

Germinal Center-derived Signals Act with Bcl-2 to Decrease Apoptosis and Increase Clonogenicity of Drug-treated Human B Lymphoma Cells

Andrew Walker, Siân T. Taylor, John A. Hickman, Caroline Dive

Cancer Res (1997) 57 (10): 1939–1945.

Published: 01 May 1997

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Journal Articles

Hypersensitivity of Human Testicular Tumors to Etoposide-induced Apoptosis Is Associated with Functional p53 and a High Bax:Bcl-2 Ratio

Christine M. Chresta, John R. W. Masters, John A. Hickman

Cancer Res (1996) 56 (8): 1834–1841.

Published: 01 April 1996

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Journal Articles

The Role of p53 in Spontaneous and Radiation-induced Apoptosis in the Gastrointestinal Tract of Normal and p53-deficient Mice

Anita J. Merritt, Christopher S. Potten, Christopher J. Kemp, John A. Hickman, Allan Balmain, David P. Lane, Peter A. Hall

Cancer Res (1994) 54 (3): 614–617.

Published: 01 February 1994

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Journal Articles

bcl-2 Modulation of Apoptosis Induced by Anticancer Drugs: Resistance to Thymidylate Stress Is Independent of Classical Resistance Pathways

Thomas C. Fisher, Anne E. Milner, Christopher D. Gregory, Ann L. Jackman, G. Wynne Aherne, John A. Hartley, Caroline Dive, John A. Hickman

Cancer Res (1993) 53 (14): 3321–3326.

Published: 01 July 1993

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Journal Articles

Investigations of Mechanisms of Drug-induced Changes in Gene Expression: N-Methylformamide-induced Changes in Synthesis of the M_r 72,000 Constitutive Heat Shock Protein during Commitment of HL-60 Cells to Granulocyte Differentiation

Helen M. Beere, Richard I. Morimoto, John A. Hickman

Cancer Res (1993) 53 (13): 3034–3039.

Published: 01 July 1993

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Journal Articles

Elevation of Leukemic Cell Intracellular Calcium by the Ether Lipid SRI 62-834

Charles M. Lazenby, Michael G. Thompson, John A. Hickman

Cancer Res (1990) 50 (11): 3327–3330.

Published: 01 June 1990

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Journal Articles

Investigation of the Effects of Heat Shock and Agents Which Induce a Heat Shock Response on the Induction of Differentiation of HL-60 Cells

Frances M. Richards, Andrea Watson, John A. Hickman

Cancer Res (1988) 48 (23): 6715–6720.

Published: 01 December 1988

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Journal Articles

Effects of N-Methylformamide on the Growth, Cell Cycle, and Glutathione Status of Murine TLX5 Lymphoma Cells

Colin A. Bill, Andreas Gescher, John A. Hickman

Cancer Res (1988) 48 (12): 3389–3393.

Published: 01 June 1988

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Journal Articles

Antitumor Activity and Pharmacokinetics in Mice of 8-Carbamoyl-3-methyl-imidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one (CCRG 81045; M & B 39831), a Novel Drug with Potential as an Alternative to Dacarbazine

Malcolm F. G. Stevens, John A. Hickman, Simon P. Langdon, David Chubb, Lisa Vickers, Robert Stone, Ghousia Baig, Colin Goddard, Neil W. Gibson, John A. Slack, Christopher Newton, Edward Lunt, Christian Fizames, François Lavelle

Cancer Res (1987) 47 (22): 5846–5852.

Published: 01 November 1987

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Journal Articles

Inhibition of Human Erythrocyte Inositol Lipid Metabolism by Adriamycin

Michael G. Thompson, Suresh B. Chahwala, John A. Hickman

Cancer Res (1987) 47 (11): 2799–2803.

Published: 01 June 1987

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Journal Articles

Correlation between the Molecular Weight and Potency of Polar Compounds Which Induce the Differentiation of HL-60 Human Promyelocytic Leukemia Cells

Simon P. Langdon, John A. Hickman

Cancer Res (1987) 47 (1): 140–144.

Published: 01 January 1987

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Journal Articles

Effects of the Antitumor Drug Adriamycin on Human Red Blood Cell Discocyte-Echinocyte Transitions

Suresh B. Chahwala, John A. Hickman

Cancer Res (1985) 45 (10): 4986–4989.

Published: 01 October 1985

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Journal Articles

Experimental Antitumor Activity against Murine Tumor Model Systems of 8-Carbamoyl-3-(2-chloroethyl)imidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one (Mitozolomide), a Novel Broad-Spectrum Agent

John A. Hickman, Malcolm F. G. Stevens, Neil W. Gibson, Simon P. Langdon, Christian Fizames, François Lavelle, Ghanem Atassi, Edward Lunt, Robert M. Tilson

Cancer Res (1985) 45 (7): 3008–3013.

Published: 01 July 1985

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Journal Articles

DNA Cross-Linking and Cytotoxicity in Normal and Transformed Human Cells Treated in Vitro with 8-Carbamoyl-3-(2-chloroethyl)imidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one

Neil W. Gibson, John A. Hickman, Leonard C. Erickson

Cancer Res (1984) 44 (5): 1772–1775.

Published: 01 May 1984

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Journal Articles

Effects of the Antitumor Agent 8-Carbamoyl-3-(2-chloroethyl)imidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one on the DNA of Mouse L1210 Cells

Neil W. Gibson, Leonard C. Erickson, John A. Hickman

Cancer Res (1984) 44 (5): 1767–1771.

Published: 01 May 1984

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NARROW

Abstract 5529: In vitro platforms representing tumor complexity for target validation and drug discovery.

Abstract 2782: Bcl-2 selective antagonists show antitumor activity without dose limiting platelet toxicity

The Relationships between p53-dependent Apoptosis, Inhibition of Proliferation, and 5-Fluorouracil-induced Histopathology in Murine Intestinal Epithelia

Toxin-induced Increase in Survival Factor Receptors: Modulation of the Threshold for Apoptosis

Germinal Center-derived Signals Act with Bcl-2 to Decrease Apoptosis and Increase Clonogenicity of Drug-treated Human B Lymphoma Cells

Hypersensitivity of Human Testicular Tumors to Etoposide-induced Apoptosis Is Associated with Functional p53 and a High Bax:Bcl-2 Ratio

The Role of p53 in Spontaneous and Radiation-induced Apoptosis in the Gastrointestinal Tract of Normal and p53-deficient Mice

bcl-2 Modulation of Apoptosis Induced by Anticancer Drugs: Resistance to Thymidylate Stress Is Independent of Classical Resistance Pathways

Investigations of Mechanisms of Drug-induced Changes in Gene Expression: N-Methylformamide-induced Changes in Synthesis of the M_r 72,000 Constitutive Heat Shock Protein during Commitment of HL-60 Cells to Granulocyte Differentiation

Elevation of Leukemic Cell Intracellular Calcium by the Ether Lipid SRI 62-834

Investigation of the Effects of Heat Shock and Agents Which Induce a Heat Shock Response on the Induction of Differentiation of HL-60 Cells

Effects of N-Methylformamide on the Growth, Cell Cycle, and Glutathione Status of Murine TLX5 Lymphoma Cells

Antitumor Activity and Pharmacokinetics in Mice of 8-Carbamoyl-3-methyl-imidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one (CCRG 81045; M & B 39831), a Novel Drug with Potential as an Alternative to Dacarbazine

Inhibition of Human Erythrocyte Inositol Lipid Metabolism by Adriamycin

Correlation between the Molecular Weight and Potency of Polar Compounds Which Induce the Differentiation of HL-60 Human Promyelocytic Leukemia Cells

Effects of the Antitumor Drug Adriamycin on Human Red Blood Cell Discocyte-Echinocyte Transitions

Experimental Antitumor Activity against Murine Tumor Model Systems of 8-Carbamoyl-3-(2-chloroethyl)imidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one (Mitozolomide), a Novel Broad-Spectrum Agent

DNA Cross-Linking and Cytotoxicity in Normal and Transformed Human Cells Treated in Vitro with 8-Carbamoyl-3-(2-chloroethyl)imidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one

Effects of the Antitumor Agent 8-Carbamoyl-3-(2-chloroethyl)imidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one on the DNA of Mouse L1210 Cells

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