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John A. Hickman
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Journal Articles

Abstract 5529: In vitro platforms representing tumor complexity for target validation and drug discovery.

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John A. Hickman
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 5529.
https://doi.org/10.1158/1538-7445.AM2013-5529
Published: 15 April 2013
View articletitled, Abstract 5529: In vitro platforms representing tumor complexity for target validation and drug discovery.
Journal Articles

Abstract 2782: Bcl-2 selective antagonists show antitumor activity without dose limiting platelet toxicity

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Olivier Geneste, James Murray, Thierry Le Diguarher, Jérome Starck, Patrick Casara, Guillaume De Nanteuil, James Davidson, Claire Nunns, Chris Graham, Natalia Matassova, Ijen Chen, Neil Whitehead, Pawel Dokurno, Alain Bruno, Alain Pierré, John. A. Hickman, Mike Wood, Francisco Cruzalegui, Stéphane Depil
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 2782.
https://doi.org/10.1158/1538-7445.AM2012-2782
Published: 15 April 2012
View articletitled, Abstract 2782: Bcl-2 selective antagonists show antitumor activity without dose limiting platelet toxicity
Journal Articles

The Relationships between p53-dependent Apoptosis, Inhibition of Proliferation, and 5-Fluorouracil-induced Histopathology in Murine Intestinal Epithelia

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D. Mark Pritchard, Christopher S. Potten, John A. Hickman
Journal: Cancer Research
Cancer Res (1998) 58 (23): 5453–5465.
Published: 01 December 1998
View articletitled, The Relationships between p53-dependent Apoptosis, Inhibition of Proliferation, and 5-Fluorouracil-induced Histopathology in Murine Intestinal Epithelia
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Journal Articles

Toxin-induced Increase in Survival Factor Receptors: Modulation of the Threshold for Apoptosis

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Catherine C. Boyle, John A. Hickman
Journal: Cancer Research
Cancer Res (1997) 57 (12): 2404–2409.
Published: 01 June 1997
View articletitled, Toxin-induced Increase in Survival Factor Receptors: Modulation of the Threshold for Apoptosis
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Journal Articles

Germinal Center-derived Signals Act with Bcl-2 to Decrease Apoptosis and Increase Clonogenicity of Drug-treated Human B Lymphoma Cells

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Andrew Walker, Siân T. Taylor, John A. Hickman, Caroline Dive
Journal: Cancer Research
Cancer Res (1997) 57 (10): 1939–1945.
Published: 01 May 1997
View articletitled, Germinal Center-derived Signals Act with Bcl-2 to Decrease Apoptosis and Increase Clonogenicity of Drug-treated Human B Lymphoma Cells
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Journal Articles

Hypersensitivity of Human Testicular Tumors to Etoposide-induced Apoptosis Is Associated with Functional p53 and a High Bax:Bcl-2 Ratio

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Christine M. Chresta, John R. W. Masters, John A. Hickman
Journal: Cancer Research
Cancer Res (1996) 56 (8): 1834–1841.
Published: 01 April 1996
View articletitled, Hypersensitivity of Human Testicular Tumors to Etoposide-induced Apoptosis Is Associated with Functional p53 and a High Bax:Bcl-2 Ratio
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Journal Articles

The Role of p53 in Spontaneous and Radiation-induced Apoptosis in the Gastrointestinal Tract of Normal and p53-deficient Mice

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Anita J. Merritt, Christopher S. Potten, Christopher J. Kemp, John A. Hickman, Allan Balmain, David P. Lane, Peter A. Hall
Journal: Cancer Research
Cancer Res (1994) 54 (3): 614–617.
Published: 01 February 1994
View articletitled, The Role of p53 in Spontaneous and Radiation-induced Apoptosis in the Gastrointestinal Tract of Normal and p53-deficient Mice
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Journal Articles

Investigations of Mechanisms of Drug-induced Changes in Gene Expression: N-Methylformamide-induced Changes in Synthesis of the Mr 72,000 Constitutive Heat Shock Protein during Commitment of HL-60 Cells to Granulocyte Differentiation

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Helen M. Beere, Richard I. Morimoto, John A. Hickman
Journal: Cancer Research
Cancer Res (1993) 53 (13): 3034–3039.
Published: 01 July 1993
View articletitled, Investigations of Mechanisms of Drug-induced Changes in Gene Expression: N-Methylformamide-induced Changes in Synthesis of the Mr 72,000 Constitutive Heat Shock Protein during Commitment of HL-60 Cells to Granulocyte Differentiation
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Journal Articles

bcl-2 Modulation of Apoptosis Induced by Anticancer Drugs: Resistance to Thymidylate Stress Is Independent of Classical Resistance Pathways

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Thomas C. Fisher, Anne E. Milner, Christopher D. Gregory, Ann L. Jackman, G. Wynne Aherne, John A. Hartley, Caroline Dive, John A. Hickman
Journal: Cancer Research
Cancer Res (1993) 53 (14): 3321–3326.
Published: 01 July 1993
View articletitled, bcl-2 Modulation of Apoptosis Induced by Anticancer Drugs: Resistance to Thymidylate Stress Is Independent of Classical Resistance Pathways
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Journal Articles

Elevation of Leukemic Cell Intracellular Calcium by the Ether Lipid SRI 62-834

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Charles M. Lazenby, Michael G. Thompson, John A. Hickman
Journal: Cancer Research
Cancer Res (1990) 50 (11): 3327–3330.
Published: 01 June 1990
View articletitled, Elevation of Leukemic Cell Intracellular Calcium by the Ether Lipid SRI 62-834
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Journal Articles

Investigation of the Effects of Heat Shock and Agents Which Induce a Heat Shock Response on the Induction of Differentiation of HL-60 Cells

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Frances M. Richards, Andrea Watson, John A. Hickman
Journal: Cancer Research
Cancer Res (1988) 48 (23): 6715–6720.
Published: 01 December 1988
View articletitled, Investigation of the Effects of Heat Shock and Agents Which Induce a Heat Shock Response on the Induction of Differentiation of HL-60 Cells
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Journal Articles

Effects of N-Methylformamide on the Growth, Cell Cycle, and Glutathione Status of Murine TLX5 Lymphoma Cells

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Colin A. Bill, Andreas Gescher, John A. Hickman
Journal: Cancer Research
Cancer Res (1988) 48 (12): 3389–3393.
Published: 01 June 1988
View articletitled, Effects of N-Methylformamide on the Growth, Cell Cycle, and Glutathione Status of Murine TLX5 Lymphoma Cells
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Journal Articles

Antitumor Activity and Pharmacokinetics in Mice of 8-Carbamoyl-3-methyl-imidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one (CCRG 81045; M & B 39831), a Novel Drug with Potential as an Alternative to Dacarbazine

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Malcolm F. G. Stevens, John A. Hickman, Simon P. Langdon, David Chubb, Lisa Vickers, Robert Stone, Ghousia Baig, Colin Goddard, Neil W. Gibson, John A. Slack, Christopher Newton, Edward Lunt, Christian Fizames, François Lavelle
Journal: Cancer Research
Cancer Res (1987) 47 (22): 5846–5852.
Published: 01 November 1987
View articletitled, Antitumor Activity and Pharmacokinetics in Mice of 8-Carbamoyl-3-methyl-imidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one (CCRG 81045; M & B 39831), a Novel Drug with Potential as an Alternative to Dacarbazine
Open the PDF for Antitumor Activity and Pharmacokinetics in Mice of 8-Carbamoyl-3-methyl-imidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one (CCRG 81045; M & B 39831), a Novel Drug with Potential as an Alternative to Dacarbazine in another window
Journal Articles

Inhibition of Human Erythrocyte Inositol Lipid Metabolism by Adriamycin

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Michael G. Thompson, Suresh B. Chahwala, John A. Hickman
Journal: Cancer Research
Cancer Res (1987) 47 (11): 2799–2803.
Published: 01 June 1987
View articletitled, Inhibition of Human Erythrocyte Inositol Lipid Metabolism by Adriamycin
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Journal Articles

Correlation between the Molecular Weight and Potency of Polar Compounds Which Induce the Differentiation of HL-60 Human Promyelocytic Leukemia Cells

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Simon P. Langdon, John A. Hickman
Journal: Cancer Research
Cancer Res (1987) 47 (1): 140–144.
Published: 01 January 1987
View articletitled, Correlation between the Molecular Weight and Potency of Polar Compounds Which Induce the Differentiation of HL-60 Human Promyelocytic Leukemia Cells
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Journal Articles

Effects of the Antitumor Drug Adriamycin on Human Red Blood Cell Discocyte-Echinocyte Transitions

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Suresh B. Chahwala, John A. Hickman
Journal: Cancer Research
Cancer Res (1985) 45 (10): 4986–4989.
Published: 01 October 1985
View articletitled, Effects of the Antitumor Drug Adriamycin on Human Red Blood Cell Discocyte-Echinocyte Transitions
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Journal Articles

Experimental Antitumor Activity against Murine Tumor Model Systems of 8-Carbamoyl-3-(2-chloroethyl)imidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one (Mitozolomide), a Novel Broad-Spectrum Agent

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John A. Hickman, Malcolm F. G. Stevens, Neil W. Gibson, Simon P. Langdon, Christian Fizames, François Lavelle, Ghanem Atassi, Edward Lunt, Robert M. Tilson
Journal: Cancer Research
Cancer Res (1985) 45 (7): 3008–3013.
Published: 01 July 1985
View articletitled, Experimental Antitumor Activity against Murine Tumor Model Systems of 8-Carbamoyl-3-(2-chloroethyl)imidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one (Mitozolomide), a Novel Broad-Spectrum Agent
Open the PDF for Experimental Antitumor Activity against Murine Tumor Model Systems of 8-Carbamoyl-3-(2-chloroethyl)imidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one (Mitozolomide), a Novel Broad-Spectrum Agent in another window
Journal Articles

DNA Cross-Linking and Cytotoxicity in Normal and Transformed Human Cells Treated in Vitro with 8-Carbamoyl-3-(2-chloroethyl)imidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one

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Neil W. Gibson, John A. Hickman, Leonard C. Erickson
Journal: Cancer Research
Cancer Res (1984) 44 (5): 1772–1775.
Published: 01 May 1984
View articletitled, DNA Cross-Linking and Cytotoxicity in Normal and Transformed Human Cells Treated in Vitro with 8-Carbamoyl-3-(2-chloroethyl)imidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one
Open the PDF for DNA Cross-Linking and Cytotoxicity in Normal and Transformed Human Cells Treated in Vitro with 8-Carbamoyl-3-(2-chloroethyl)imidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one in another window
Journal Articles

Effects of the Antitumor Agent 8-Carbamoyl-3-(2-chloroethyl)imidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one on the DNA of Mouse L1210 Cells

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Neil W. Gibson, Leonard C. Erickson, John A. Hickman
Journal: Cancer Research
Cancer Res (1984) 44 (5): 1767–1771.
Published: 01 May 1984
View articletitled, Effects of the Antitumor Agent 8-Carbamoyl-3-(2-chloroethyl)imidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one on the DNA of Mouse L1210 Cells
Open the PDF for Effects of the Antitumor Agent 8-Carbamoyl-3-(2-chloroethyl)imidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one on the DNA of Mouse L1210 Cells in another window