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Johannes V. Swinnen
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Journal Articles

Abstract A031: A fat lot of good: A novel monounsaturated fatty acid promotes prostate cancer growth and survival

Julia S. Scott, Reuben Young, Swati Irani, Jonas Dehairs, Stephen Blanksby, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Journal: Cancer Research
Cancer Res (2023) 83 (11_Supplement): A031.
https://doi.org/10.1158/1538-7445.PRCA2023-A031
Published: 02 June 2023
View article titled, Abstract A031: A fat lot of good: A novel monounsaturated fatty acid promotes prostate cancer growth and survival
Journal Articles

Abstract 1157: Uncovering a novel role of peroxisomal β-oxidation in advanced, treatment-resistant prostate cancer

Chui Yan Mah, An D. Nguyen, Takuto Niijima, Madison Helm, Jonas Dehairs, Feargal J. Ryan, Natalie Ryan, Ian G. Mills, Johannes V. Swinnen, David J. Lynn, Zeyad D. Nassar, Lisa M. Butler
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1157.
https://doi.org/10.1158/1538-7445.AM2023-1157
Published: 04 April 2023
View article titled, Abstract 1157: Uncovering a novel role of peroxisomal β-oxidation in advanced, treatment-resistant prostate cancer
Journal Articles

Lipidomic Profiling of Clinical Prostate Cancer Reveals Targetable Alterations in Membrane Lipid Composition

Lisa M. Butler, Chui Yan Mah, Jelle Machiels, Andrew D. Vincent, Swati Irani, Shadrack M. Mutuku, Xander Spotbeen, Muralidhararao Bagadi, David Waltregny, Max Moldovan, Jonas Dehairs, Frank Vanderhoydonc, Katarzyna Bloch, Rajdeep Das, Jurgen Stahl, James G. Kench, Thomas Gevaert, Rita Derua, Etienne Waelkens, Zeyad D. Nassar, Luke A. Selth, Paul J. Trim, Marten F. Snel, David J. Lynn, Wayne D. Tilley, Lisa G. Horvath, Margaret M. Centenera, Johannes V. Swinnen
Journal: Cancer Research
Cancer Res (2021) 81 (19): 4981–4993.
https://doi.org/10.1158/0008-5472.CAN-20-3863
Published: 01 October 2021
View article titled, Lipidomic Profiling of Clinical Prostate Cancer Reveals Targetable Alterations in Membrane Lipid Composition
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Includes: Supplementary data
Journal Articles

Fat Induces Glucose Metabolism in Nontransformed Liver Cells and Promotes Liver Tumorigenesis

Lindsay A. Broadfield, João André Gonçalves Duarte, Roberta Schmieder, Dorien Broekaert, Koen Veys, Mélanie Planque, Kim Vriens, Yasuaki Karasawa, Francesco Napolitano, Suguru Fujita, Masashi Fujii, Miki Eto, Bryan Holvoet, Roman Vangoitsenhoven, Juan Fernandez-Garcia, Joke Van Elsen, Jonas Dehairs, Jia Zeng, James Dooley, Rebeca Alba Rubio, Jos van Pelt, Thomas G.P. Grünewald, Adrian Liston, Chantal Mathieu, Christophe M. Deroose, Johannes V. Swinnen, Diether Lambrechts, Diego di Bernardo, Shinya Kuroda, Katrien De Bock, Sarah-Maria Fendt
Journal: Cancer Research
Cancer Res (2021) 81 (8): 1988–2001.
https://doi.org/10.1158/0008-5472.CAN-20-1954
Published: 15 April 2021
View article titled, Fat Induces Glucose Metabolism in Nontransformed Liver Cells and Promotes Liver Tumorigenesis
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Includes: Supplementary data
Journal Articles

ELOVL5 Is a Critical and Targetable Fatty Acid Elongase in Prostate Cancer

Margaret M. Centenera, Julia S. Scott, Jelle Machiels, Zeyad D. Nassar, Deanna C. Miller, Irene Zinonos, Jonas Dehairs, Ingrid J.G. Burvenich, Giorgia Zadra, Paolo M. Chetta, Clyde Bango, Emma Evergren, Natalie K. Ryan, Joanna L. Gillis, Chui Yan Mah, Terence Tieu, Adrienne R. Hanson, Ryan Carelli, Katarzyna Bloch, Vasilios Panagopoulos, Etienne Waelkens, Rita Derua, Elizabeth D. Williams, Andreas Evdokiou, Anna Cifuentes-Rius, Nicolas H. Voelcker, Ian G. Mills, Wayne D. Tilley, Andrew M. Scott, Massimo Loda, Luke A. Selth, Johannes V. Swinnen, Lisa M. Butler
Journal: Cancer Research
Cancer Res (2021) 81 (7): 1704–1718.
https://doi.org/10.1158/0008-5472.CAN-20-2511
Published: 01 April 2021
View article titled, ELOVL5 Is a Critical and Targetable Fatty Acid Elongase in Prostate Cancer
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Includes: Supplementary data
Journal Articles

Abstract 237: DECR1: The rate limiting enzyme of polyunsaturated fatty acid metabolism and a novel therapeutic target in prostate cancer

Chui Yan Mah, Zeyad D. Nassar, Ingrid J. Burvenich, Swati Irani, Margaret M. Centenera, Max Moldovan, David J. Lynn, Andrew J. Hoy, Johannes V. Swinnen, Lisa M. Butler
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 237.
https://doi.org/10.1158/1538-7445.AM2020-237
Published: 15 August 2020
View article titled, Abstract 237: DECR1: The rate limiting enzyme of polyunsaturated fatty acid metabolism and a novel therapeutic target in prostate cancer
Journal Articles

Abstract 1152: Lipid elongation: an unexplored therapeutic target in prostate cancer

Zeyad D. Nassar, Margaret M. Centenera, Jelle Machiels, Samuel J. Polacek, Katarzyna Bloch, Wayne D. Tilley, Luke A. Selth, Johannes V. Swinnen, Lisa Butler
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1152.
https://doi.org/10.1158/1538-7445.AM2017-1152
Published: 01 July 2017
View article titled, Abstract 1152: Lipid elongation: an unexplored therapeutic target in prostate cancer
Journal Articles

ATP-Citrate Lyase: A Key Player in Cancer Metabolism

Nousheen Zaidi, Johannes V. Swinnen, Karine Smans
Journal: Cancer Research
Cancer Res (2012) 72 (15): 3709–3714.
https://doi.org/10.1158/0008-5472.CAN-11-4112
Published: 31 July 2012
View article titled, ATP-Citrate Lyase: A Key Player in Cancer Metabolism
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Journal Articles

Abstract 1256: A role for lipoprotein lipase in fatty acid acquisition by breast, prostate and liposarcoma tumors

Nancy B. Kuemmerle, Evelien Rysman, Portia S. Lombardo, Alison J. Flanagan, Brea C. Lipe, Catherine Fricano, Wendy A. Wells, Jason R. Pettus, Heather Froehlich, Peter M. Morganelli, Vincent A. Memoli, Johannes V. Swinnen, Liuika A. Timmerman, Leila Chaychi, Burton L. Eisenberg, William B. Coleman, William B. Kinlaw
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 1256.
https://doi.org/10.1158/1538-7445.AM2011-1256
Published: 15 April 2011
View article titled, Abstract 1256: A role for lipoprotein lipase in fatty acid acquisition by breast, prostate and liposarcoma tumors
Journal Articles

Aberrant Activation of Fatty Acid Synthesis Suppresses Primary Cilium Formation and Distorts Tissue Development

Nicolas Willemarck, Evelien Rysman, Koen Brusselmans, Griet Van Imschoot, Frank Vanderhoydonc, Katrien Moerloose, Evelyne Lerut, Guido Verhoeven, Frans van Roy, Kris Vleminckx, Johannes V. Swinnen
Journal: Cancer Research
Cancer Res (2010) 70 (22): 9453–9462.
https://doi.org/10.1158/0008-5472.CAN-10-2324
Published: 14 November 2010
View article titled, Aberrant Activation of Fatty Acid Synthesis Suppresses Primary Cilium Formation and Distorts Tissue Development
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Includes: Multimedia, Supplementary data
Journal Articles

De novo Lipogenesis Protects Cancer Cells from Free Radicals and Chemotherapeutics by Promoting Membrane Lipid Saturation

Evelien Rysman, Koen Brusselmans, Katryn Scheys, Leen Timmermans, Rita Derua, Sebastian Munck, Paul P. Van Veldhoven, David Waltregny, Veerle W. Daniëls, Jelle Machiels, Frank Vanderhoydonc, Karine Smans, Etienne Waelkens, Guido Verhoeven, Johannes V. Swinnen
Journal: Cancer Research
Cancer Res (2010) 70 (20): 8117–8126.
https://doi.org/10.1158/0008-5472.CAN-09-3871
Published: 13 October 2010
View article titled, <em>De novo</em> Lipogenesis Protects Cancer Cells from Free Radicals and Chemotherapeutics by Promoting Membrane Lipid Saturation
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Includes: Supplementary data
Journal Articles

Chemical Inhibition of Acetyl-CoA Carboxylase Induces Growth Arrest and Cytotoxicity Selectively in Cancer Cells

Annelies Beckers, Sophie Organe, Leen Timmermans, Katryn Scheys, Annelies Peeters, Koen Brusselmans, Guido Verhoeven, Johannes V. Swinnen
Journal: Cancer Research
Cancer Res (2007) 67 (17): 8180–8187.
https://doi.org/10.1158/0008-5472.CAN-07-0389
Published: 05 September 2007
View article titled, Chemical Inhibition of Acetyl-CoA Carboxylase Induces Growth Arrest and Cytotoxicity Selectively in Cancer Cells
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Journal Articles

RNA Interference–Mediated Silencing of the Acetyl-CoA-Carboxylase-α Gene Induces Growth Inhibition and Apoptosis of Prostate Cancer Cells

Koen Brusselmans, Ellen De Schrijver, Guido Verhoeven, Johannes V. Swinnen
Journal: Cancer Research
Cancer Res (2005) 65 (15): 6719–6725.
https://doi.org/10.1158/0008-5472.CAN-05-0571
Published: 01 August 2005
View article titled, RNA Interference–Mediated Silencing of the <em>Acetyl-CoA-Carboxylase-α</em> Gene Induces Growth Inhibition and Apoptosis of Prostate Cancer Cells
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Journal Articles

Mimicry of a cellular low energy status blocks tumor cell anabolism and suppresses the malignant phenotype: synergism between AICA riboside and methotrexate

Johannes V. Swinnen, Annelies Beckers, Koen Brusselmans, Leen Timmermans, Guido Verhoeven
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 353–354.
Published: 01 May 2005
View article titled, Mimicry of a cellular low energy status blocks tumor cell anabolism and suppresses the malignant phenotype: synergism between AICA riboside and methotrexate
Journal Articles

Mimicry of a Cellular Low Energy Status Blocks Tumor Cell Anabolism and Suppresses the Malignant Phenotype

Johannes V. Swinnen, Annelies Beckers, Koen Brusselmans, Sophie Organe, Joanna Segers, Leen Timmermans, Frank Vanderhoydonc, Ludo Deboel, Rita Derua, Etienne Waelkens, Ellen De Schrijver, Tine Van de Sande, Agnès Noël, Fabienne Foufelle, Guido Verhoeven
Journal: Cancer Research
Cancer Res (2005) 65 (6): 2441–2448.
https://doi.org/10.1158/0008-5472.CAN-04-3025
Published: 21 March 2005
View article titled, Mimicry of a Cellular Low Energy Status Blocks Tumor Cell Anabolism and Suppresses the Malignant Phenotype
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Journal Articles

RNA Interference-mediated Silencing of the Fatty Acid Synthase Gene Attenuates Growth and Induces Morphological Changes and Apoptosis of LNCaP Prostate Cancer Cells

Ellen De Schrijver, Koen Brusselmans, Walter Heyns, Guido Verhoeven, Johannes V. Swinnen
Journal: Cancer Research
Cancer Res (2003) 63 (13): 3799–3804.
Published: 01 July 2003
View article titled, RNA Interference-mediated Silencing of the Fatty Acid Synthase Gene Attenuates Growth and Induces Morphological Changes and Apoptosis of LNCaP Prostate Cancer Cells
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Journal Articles

Role of the Phosphatidylinositol 3′-Kinase/PTEN/Akt Kinase Pathway in the Overexpression of Fatty Acid Synthase in LNCaP Prostate Cancer Cells

Tine Van de Sande, Ellen De Schrijver, Walter Heyns, Guido Verhoeven, Johannes V. Swinnen
Journal: Cancer Research
Cancer Res (2002) 62 (3): 642–646.
Published: 01 February 2002
View article titled, Role of the Phosphatidylinositol 3′-Kinase/PTEN/Akt Kinase Pathway in the Overexpression of Fatty Acid Synthase in LNCaP Prostate Cancer Cells
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Journal Articles

Androgens Stimulate Fatty Acid Synthease in the Human Prostate Cancer Cell Line LNCaP

Johannes V. Swinnen, Murielle Esquenet, Karine Goossens, Walter Heyns, Guido Verhoeven
Journal: Cancer Research
Cancer Res (1997) 57 (6): 1086–1090.
Published: 01 March 1997
View article titled, Androgens Stimulate Fatty Acid Synthease in the Human Prostate Cancer Cell Line LNCaP
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