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Johannes V. Swinnen
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Journal Articles

Abstract 4152: Disrupting lipid elongation impairs prostate cancer progression in c-MYC driven mouse models

Silvia D. Rodrigues, Isadora F. Teixeira, Giuseppe N. Fanelli, Caroline F. Ribeiro, Fabio Socciarelli, Jeanne Jiang, Debora C. Bastos, Hubert Pakula, Filippo Pederzoli, Pier V. Nuzzo, Alessandro Barberis, Lisa M. Butler, Johannes V. Swinnen, Massimo Loda
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 4152.
https://doi.org/10.1158/1538-7445.AM2025-4152
Published: 21 April 2025
View articletitled, Abstract 4152: Disrupting lipid elongation impairs prostate cancer progression in c-MYC driven mouse models
Journal Articles

Abstract 3110: A clinically actionable lipid metabolic approach in potentiating the response to anti-androgen therapy in a castration resistant prostate cancer model

Cynthia Sprenger, Silvia Rodrigues, Ali Talebi, Kathryn Soriano Epilepsia, Shihua Sun, Caroline Fidalgo Ribeiro, Fabio Socciarelli, Jonas Dehairs, Lisa Butler, Johannes V. Swinnen, Massimo Loda, Stephen Plymate
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 3110.
https://doi.org/10.1158/1538-7445.AM2025-3110
Published: 21 April 2025
View articletitled, Abstract 3110: A clinically actionable lipid metabolic approach in potentiating the response to anti-androgen therapy in a castration resistant prostate cancer model
Journal Articles

ACSM1 and ACSM3 Regulate Fatty Acid Metabolism to Support Prostate Cancer Growth and Constrain Ferroptosis

Raj K. Shrestha, Zeyad D. Nassar, Adrienne R. Hanson, Richard Iggo, Scott L. Townley, Jonas Dehairs, Chui Y. Mah, Madison Helm, Mohammadreza Alizadeh-Ghodsi, Marie Pickering, Bart Ghesquière, Matthew J. Watt, Lake-Ee Quek, Andrew J. Hoy, Wayne D. Tilley, Johannes V. Swinnen, Lisa M. Butler, Luke A. Selth
Journal: Cancer Research
Cancer Res (2024) 84 (14): 2313–2332.
https://doi.org/10.1158/0008-5472.CAN-23-1489
Published: 15 July 2024
View articletitled, ACSM1 and ACSM3 Regulate Fatty Acid Metabolism to Support Prostate Cancer Growth and Constrain Ferroptosis
Open the PDF for ACSM1 and ACSM3 Regulate Fatty Acid Metabolism to Support Prostate Cancer Growth and Constrain Ferroptosis in another window
Includes: Supplementary data
Journal Articles

Abstract A031: A fat lot of good: A novel monounsaturated fatty acid promotes prostate cancer growth and survival

Julia S. Scott, Reuben Young, Swati Irani, Jonas Dehairs, Stephen Blanksby, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Journal: Cancer Research
Cancer Res (2023) 83 (11_Supplement): A031.
https://doi.org/10.1158/1538-7445.PRCA2023-A031
Published: 02 June 2023
View articletitled, Abstract A031: A fat lot of good: A novel monounsaturated fatty acid promotes prostate cancer growth and survival
Journal Articles

Abstract 1157: Uncovering a novel role of peroxisomal β-oxidation in advanced, treatment-resistant prostate cancer

Chui Yan Mah, An D. Nguyen, Takuto Niijima, Madison Helm, Jonas Dehairs, Feargal J. Ryan, Natalie Ryan, Ian G. Mills, Johannes V. Swinnen, David J. Lynn, Zeyad D. Nassar, Lisa M. Butler
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1157.
https://doi.org/10.1158/1538-7445.AM2023-1157
Published: 04 April 2023
View articletitled, Abstract 1157: Uncovering a novel role of peroxisomal β-oxidation in advanced, treatment-resistant prostate cancer
Journal Articles

Lipidomic Profiling of Clinical Prostate Cancer Reveals Targetable Alterations in Membrane Lipid Composition

Lisa M. Butler, Chui Yan Mah, Jelle Machiels, Andrew D. Vincent, Swati Irani, Shadrack M. Mutuku, Xander Spotbeen, Muralidhararao Bagadi, David Waltregny, Max Moldovan, Jonas Dehairs, Frank Vanderhoydonc, Katarzyna Bloch, Rajdeep Das, Jurgen Stahl, James G. Kench, Thomas Gevaert, Rita Derua, Etienne Waelkens, Zeyad D. Nassar, Luke A. Selth, Paul J. Trim, Marten F. Snel, David J. Lynn, Wayne D. Tilley, Lisa G. Horvath, Margaret M. Centenera, Johannes V. Swinnen
Journal: Cancer Research
Cancer Res (2021) 81 (19): 4981–4993.
https://doi.org/10.1158/0008-5472.CAN-20-3863
Published: 01 October 2021
View articletitled, Lipidomic Profiling of Clinical Prostate Cancer Reveals Targetable Alterations in Membrane Lipid Composition
Open the PDF for Lipidomic Profiling of Clinical Prostate Cancer Reveals Targetable Alterations in Membrane Lipid Composition in another window
Includes: Supplementary data
Journal Articles

Fat Induces Glucose Metabolism in Nontransformed Liver Cells and Promotes Liver Tumorigenesis

Lindsay A. Broadfield, João André Gonçalves Duarte, Roberta Schmieder, Dorien Broekaert, Koen Veys, Mélanie Planque, Kim Vriens, Yasuaki Karasawa, Francesco Napolitano, Suguru Fujita, Masashi Fujii, Miki Eto, Bryan Holvoet, Roman Vangoitsenhoven, Juan Fernandez-Garcia, Joke Van Elsen, Jonas Dehairs, Jia Zeng, James Dooley, Rebeca Alba Rubio, Jos van Pelt, Thomas G.P. Grünewald, Adrian Liston, Chantal Mathieu, Christophe M. Deroose, Johannes V. Swinnen, Diether Lambrechts, Diego di Bernardo, Shinya Kuroda, Katrien De Bock, Sarah-Maria Fendt
Journal: Cancer Research
Cancer Res (2021) 81 (8): 1988–2001.
https://doi.org/10.1158/0008-5472.CAN-20-1954
Published: 15 April 2021
View articletitled, Fat Induces Glucose Metabolism in Nontransformed Liver Cells and Promotes Liver Tumorigenesis
Open the PDF for Fat Induces Glucose Metabolism in Nontransformed Liver Cells and Promotes Liver Tumorigenesis in another window
Includes: Supplementary data
Journal Articles

ELOVL5 Is a Critical and Targetable Fatty Acid Elongase in Prostate Cancer

Margaret M. Centenera, Julia S. Scott, Jelle Machiels, Zeyad D. Nassar, Deanna C. Miller, Irene Zinonos, Jonas Dehairs, Ingrid J.G. Burvenich, Giorgia Zadra, Paolo M. Chetta, Clyde Bango, Emma Evergren, Natalie K. Ryan, Joanna L. Gillis, Chui Yan Mah, Terence Tieu, Adrienne R. Hanson, Ryan Carelli, Katarzyna Bloch, Vasilios Panagopoulos, Etienne Waelkens, Rita Derua, Elizabeth D. Williams, Andreas Evdokiou, Anna Cifuentes-Rius, Nicolas H. Voelcker, Ian G. Mills, Wayne D. Tilley, Andrew M. Scott, Massimo Loda, Luke A. Selth, Johannes V. Swinnen, Lisa M. Butler
Journal: Cancer Research
Cancer Res (2021) 81 (7): 1704–1718.
https://doi.org/10.1158/0008-5472.CAN-20-2511
Published: 01 April 2021
View articletitled, ELOVL5 Is a Critical and Targetable Fatty Acid Elongase in Prostate Cancer
Open the PDF for ELOVL5 Is a Critical and Targetable Fatty Acid Elongase in Prostate Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 237: DECR1: The rate limiting enzyme of polyunsaturated fatty acid metabolism and a novel therapeutic target in prostate cancer

Chui Yan Mah, Zeyad D. Nassar, Ingrid J. Burvenich, Swati Irani, Margaret M. Centenera, Max Moldovan, David J. Lynn, Andrew J. Hoy, Johannes V. Swinnen, Lisa M. Butler
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 237.
https://doi.org/10.1158/1538-7445.AM2020-237
Published: 15 August 2020
View articletitled, Abstract 237: DECR1: The rate limiting enzyme of polyunsaturated fatty acid metabolism and a novel therapeutic target in prostate cancer
Journal Articles

Abstract 1152: Lipid elongation: an unexplored therapeutic target in prostate cancer

Zeyad D. Nassar, Margaret M. Centenera, Jelle Machiels, Samuel J. Polacek, Katarzyna Bloch, Wayne D. Tilley, Luke A. Selth, Johannes V. Swinnen, Lisa Butler
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1152.
https://doi.org/10.1158/1538-7445.AM2017-1152
Published: 01 July 2017
View articletitled, Abstract 1152: Lipid elongation: an unexplored therapeutic target in prostate cancer
Journal Articles

ATP-Citrate Lyase: A Key Player in Cancer Metabolism

Nousheen Zaidi, Johannes V. Swinnen, Karine Smans
Journal: Cancer Research
Cancer Res (2012) 72 (15): 3709–3714.
https://doi.org/10.1158/0008-5472.CAN-11-4112
Published: 31 July 2012
View articletitled, ATP-Citrate Lyase: A Key Player in Cancer Metabolism
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Journal Articles

Abstract 1256: A role for lipoprotein lipase in fatty acid acquisition by breast, prostate and liposarcoma tumors

Nancy B. Kuemmerle, Evelien Rysman, Portia S. Lombardo, Alison J. Flanagan, Brea C. Lipe, Catherine Fricano, Wendy A. Wells, Jason R. Pettus, Heather Froehlich, Peter M. Morganelli, Vincent A. Memoli, Johannes V. Swinnen, Liuika A. Timmerman, Leila Chaychi, Burton L. Eisenberg, William B. Coleman, William B. Kinlaw
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 1256.
https://doi.org/10.1158/1538-7445.AM2011-1256
Published: 15 April 2011
View articletitled, Abstract 1256: A role for lipoprotein lipase in fatty acid acquisition by breast, prostate and liposarcoma tumors
Journal Articles

Aberrant Activation of Fatty Acid Synthesis Suppresses Primary Cilium Formation and Distorts Tissue Development

Nicolas Willemarck, Evelien Rysman, Koen Brusselmans, Griet Van Imschoot, Frank Vanderhoydonc, Katrien Moerloose, Evelyne Lerut, Guido Verhoeven, Frans van Roy, Kris Vleminckx, Johannes V. Swinnen
Journal: Cancer Research
Cancer Res (2010) 70 (22): 9453–9462.
https://doi.org/10.1158/0008-5472.CAN-10-2324
Published: 14 November 2010
View articletitled, Aberrant Activation of Fatty Acid Synthesis Suppresses Primary Cilium Formation and Distorts Tissue Development
Open the PDF for Aberrant Activation of Fatty Acid Synthesis Suppresses Primary Cilium Formation and Distorts Tissue Development in another window
Includes: Multimedia, Supplementary data
Journal Articles

De novo Lipogenesis Protects Cancer Cells from Free Radicals and Chemotherapeutics by Promoting Membrane Lipid Saturation

Evelien Rysman, Koen Brusselmans, Katryn Scheys, Leen Timmermans, Rita Derua, Sebastian Munck, Paul P. Van Veldhoven, David Waltregny, Veerle W. Daniëls, Jelle Machiels, Frank Vanderhoydonc, Karine Smans, Etienne Waelkens, Guido Verhoeven, Johannes V. Swinnen
Journal: Cancer Research
Cancer Res (2010) 70 (20): 8117–8126.
https://doi.org/10.1158/0008-5472.CAN-09-3871
Published: 13 October 2010
View articletitled, De novo Lipogenesis Protects Cancer Cells from Free Radicals and Chemotherapeutics by Promoting Membrane Lipid Saturation
Open the PDF for De novo Lipogenesis Protects Cancer Cells from Free Radicals and Chemotherapeutics by Promoting Membrane Lipid Saturation in another window
Includes: Supplementary data
Journal Articles

Chemical Inhibition of Acetyl-CoA Carboxylase Induces Growth Arrest and Cytotoxicity Selectively in Cancer Cells

Annelies Beckers, Sophie Organe, Leen Timmermans, Katryn Scheys, Annelies Peeters, Koen Brusselmans, Guido Verhoeven, Johannes V. Swinnen
Journal: Cancer Research
Cancer Res (2007) 67 (17): 8180–8187.
https://doi.org/10.1158/0008-5472.CAN-07-0389
Published: 05 September 2007
View articletitled, Chemical Inhibition of Acetyl-CoA Carboxylase Induces Growth Arrest and Cytotoxicity Selectively in Cancer Cells
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Journal Articles

RNA Interference–Mediated Silencing of the Acetyl-CoA-Carboxylase-α Gene Induces Growth Inhibition and Apoptosis of Prostate Cancer Cells

Koen Brusselmans, Ellen De Schrijver, Guido Verhoeven, Johannes V. Swinnen
Journal: Cancer Research
Cancer Res (2005) 65 (15): 6719–6725.
https://doi.org/10.1158/0008-5472.CAN-05-0571
Published: 01 August 2005
View articletitled, RNA Interference–Mediated Silencing of the Acetyl-CoA-Carboxylase-α Gene Induces Growth Inhibition and Apoptosis of Prostate Cancer Cells
Open the PDF for RNA Interference–Mediated Silencing of the Acetyl-CoA-Carboxylase-α Gene Induces Growth Inhibition and Apoptosis of Prostate Cancer Cells in another window
Journal Articles

Mimicry of a cellular low energy status blocks tumor cell anabolism and suppresses the malignant phenotype: synergism between AICA riboside and methotrexate

Johannes V. Swinnen, Annelies Beckers, Koen Brusselmans, Leen Timmermans, Guido Verhoeven
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 353–354.
Published: 01 May 2005
View articletitled, Mimicry of a cellular low energy status blocks tumor cell anabolism and suppresses the malignant phenotype: synergism between AICA riboside and methotrexate
Journal Articles

Mimicry of a Cellular Low Energy Status Blocks Tumor Cell Anabolism and Suppresses the Malignant Phenotype

Johannes V. Swinnen, Annelies Beckers, Koen Brusselmans, Sophie Organe, Joanna Segers, Leen Timmermans, Frank Vanderhoydonc, Ludo Deboel, Rita Derua, Etienne Waelkens, Ellen De Schrijver, Tine Van de Sande, Agnès Noël, Fabienne Foufelle, Guido Verhoeven
Journal: Cancer Research
Cancer Res (2005) 65 (6): 2441–2448.
https://doi.org/10.1158/0008-5472.CAN-04-3025
Published: 21 March 2005
View articletitled, Mimicry of a Cellular Low Energy Status Blocks Tumor Cell Anabolism and Suppresses the Malignant Phenotype
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Journal Articles

RNA Interference-mediated Silencing of the Fatty Acid Synthase Gene Attenuates Growth and Induces Morphological Changes and Apoptosis of LNCaP Prostate Cancer Cells

Ellen De Schrijver, Koen Brusselmans, Walter Heyns, Guido Verhoeven, Johannes V. Swinnen
Journal: Cancer Research
Cancer Res (2003) 63 (13): 3799–3804.
Published: 01 July 2003
View articletitled, RNA Interference-mediated Silencing of the Fatty Acid Synthase Gene Attenuates Growth and Induces Morphological Changes and Apoptosis of LNCaP Prostate Cancer Cells
Open the PDF for RNA Interference-mediated Silencing of the Fatty Acid Synthase Gene Attenuates Growth and Induces Morphological Changes and Apoptosis of LNCaP Prostate Cancer Cells in another window
Journal Articles

Role of the Phosphatidylinositol 3′-Kinase/PTEN/Akt Kinase Pathway in the Overexpression of Fatty Acid Synthase in LNCaP Prostate Cancer Cells

Tine Van de Sande, Ellen De Schrijver, Walter Heyns, Guido Verhoeven, Johannes V. Swinnen
Journal: Cancer Research
Cancer Res (2002) 62 (3): 642–646.
Published: 01 February 2002
View articletitled, Role of the Phosphatidylinositol 3′-Kinase/PTEN/Akt Kinase Pathway in the Overexpression of Fatty Acid Synthase in LNCaP Prostate Cancer Cells
Open the PDF for Role of the Phosphatidylinositol 3′-Kinase/PTEN/Akt Kinase Pathway in the Overexpression of Fatty Acid Synthase in LNCaP Prostate Cancer Cells in another window