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Joerg Heyer
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Journal Articles

Abstract 379: Genomic profiling of the tumors harboring activating epidermal growth factor receptor mutations

Jingrui Jiang, Meaghan Russell, Cheryl Eifert, Angeliki Pantazi, Ruobai Sun, Stephen Lyle, Joerg Heyer, Alexei Protopopov
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 379.
https://doi.org/10.1158/1538-7445.AM2017-379
Published: 01 July 2017
View articletitled, Abstract 379: Genomic profiling of the tumors harboring activating epidermal growth factor receptor mutations
Journal Articles

Abstract 2737: Spontaneous genomic alterations identified in a chimeric model of colorectal cancer guide effective combinatorial therapy.

Yinghui Zhou, William M. Rideout, Angela Bressel, Sireesha Yalavarthi, Tong Zi, Anthony Monti, Steve Bottega, Bin Feng, M. Isabel Chiu, Marcus Bosenberg, Joerg Heyer
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 2737.
https://doi.org/10.1158/1538-7445.AM2013-2737
Published: 15 April 2013
View articletitled, Abstract 2737: Spontaneous genomic alterations identified in a chimeric model of colorectal cancer guide effective combinatorial therapy.
Journal Articles

Abstract 642: Novel EGFR inhibitory antibodies directed against EGFR mutants with potentially reduced toxicity

Fang Wang, Donna McIntosh, Steve Bottega, Yinghui Zhou, Christina Fleet, Jinwei Jiang, Tin Chen, Solly Weiler, William Winston, Joerg Heyer, Steven Clark, Jeno Gyuris, Sylvie Vincent
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 642.
https://doi.org/10.1158/1538-7445.AM2011-642
Published: 15 April 2011
View articletitled, Abstract 642: Novel EGFR inhibitory antibodies directed against EGFR mutants with potentially reduced toxicity
Journal Articles

Abstract 5063: Preclinical evaluation of an EMT multi-gene biomarker index for predicting response to inhibitors of EGFR and IGF1R

Gretchen M. Argast, James Bean, Jian Wang, Matthew O'Connor, Bin Feng, Richard Nicoletti, Lorena Lerner, Joerg Heyer, Isabel Chiu, Murray Robinson, Elizabeth Buck, Stuart Thomson, Julie L.C. Kan, John D. Haley, David M. Epstein
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 5063.
https://doi.org/10.1158/1538-7445.AM2011-5063
Published: 15 April 2011
View articletitled, Abstract 5063: Preclinical evaluation of an EMT multi-gene biomarker index for predicting response to inhibitors of EGFR and IGF1R
Journal Articles

Abstract 1727: Preclinical evaluation of pan-VEGFR inhibitor tivozanib in combination with capecitabine, sirolimus or erlotinib in genetically engineered tumor models support combinations based on complementary mechanisms

Feng Jiang, Luhua Shen, Xiaojian Sun, Guangmu Li, Angela Bressel, William M. Rideout, Yinghui Zhou, Joerg Heyer, M. Isabel Chiu, Murray O. Robinson, Jie Lin
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 1727.
https://doi.org/10.1158/1538-7445.AM2011-1727
Published: 15 April 2011
View articletitled, Abstract 1727: Preclinical evaluation of pan-VEGFR inhibitor tivozanib in combination with capecitabine, sirolimus or erlotinib in genetically engineered tumor models support combinations based on complementary mechanisms
Journal Articles

Abstract 1378: Preclinical efficacy of the triple VEGFR inhibitor tivozanib (AV-951) in chimeric breast and lung tumor models

Yinghui Zhou, Tong Zi, Angela Bressel, Kristen Jesmer, Darren Potz, Anthony Monti, Joelle Brodeur, William Rideout, Maria Isabel Chiu, Murray O. Robinson, Joerg Heyer
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 1378.
https://doi.org/10.1158/1538-7445.AM10-1378
Published: 15 April 2010
View articletitled, Abstract 1378: Preclinical efficacy of the triple VEGFR inhibitor tivozanib (AV-951) in chimeric breast and lung tumor models
Journal Articles

Abstract 3267: Human population based engineered breast tumor model for in vivo biomarker discovery

Min Wu, Kimberly Clark, Nanhua Deng, Zuhua Cai, Megan E. Serpa, Tong Zi, Xiaojian Sun, Richard Nicoletti, Kathryn Sun, Bing Feng, Jie Lin, Joerg Heyer, M Isabel Chiu, Murray O. Robinson
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 3267.
https://doi.org/10.1158/1538-7445.AM10-3267
Published: 15 April 2010
View articletitled, Abstract 3267: Human population based engineered breast tumor model for in vivo biomarker discovery
Journal Articles

De novo Discovery of a γ-Secretase Inhibitor Response Signature Using a Novel In vivo Breast Tumor Model

James W. Watters, Chun Cheng, Pradip K. Majumder, Ruojie Wang, Sireesha Yalavarthi, Carol Meeske, Lingxin Kong, Wenping Sun, Jie Lin, Joerg Heyer, Chris Ware, Christopher Winter, John F. Reilly, Tim Demuth, Steve Clark, M. Isabel Chiu, Murray O. Robinson, Nancy Kohl, Karuppiah Kannan
Journal: Cancer Research
Cancer Res (2009) 69 (23): 8949–8957.
https://doi.org/10.1158/0008-5472.CAN-09-1544
Published: 30 November 2009
View articletitled, De novo Discovery of a γ-Secretase Inhibitor Response Signature Using a Novel In vivo Breast Tumor Model
Open the PDF for De novo Discovery of a γ-Secretase Inhibitor Response Signature Using a Novel In vivo Breast Tumor Model in another window
Includes: Supplementary data
Journal Articles

Abstract #1836: Generation of in vivo tumor models driven by PI3 kinase subunit p110\#945; and their use in the development of inhibitors to the pathway

Lorena Lerner, Qing Liu, John Yang, Nianjun Tao, Brian Krieger, Jodi Zarycki, Lu Huang, Joseph Growney, Sharon Barr, Lingxin Kong, Maryland Rosenfeld-Franklin, Karuppiah Kannnan, Yinghui Zhou, Joerg Heyer, Julie Kan, David Epstein, Maria Isabel Chiu, Murray Robinson
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 1836.
Published: 01 May 2009
View articletitled, Abstract #1836: Generation of in vivo tumor models driven by PI3 kinase subunit p110\#945; and their use in the development of inhibitors to the pathway
Journal Articles

Abstract #4979: Identification of a gene signature of epithelial to mesenchymal transition

Julie Kan, Gretchen Argast, Stuart Thomson, John Haley, Richard Nicoletti, James Abraham, Matthew O'Connor, Regina Sennello, G. David Young, Maryland Rosenfeld-Franklin, Karuppiah Kannan, Joerg Heyer, M. Isabel Chiu, David Epstein, Murray Robinson
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 4979.
Published: 01 May 2009
View articletitled, Abstract #4979: Identification of a gene signature of epithelial to mesenchymal transition
Journal Articles

Abstract #4064: Mouse models of hepatocellular carcinoma exhibit features of VEGF-driven angiogenesis

Yinghui Zhou, Samuel Farlow, Tong Zi, Kristen Jesmer, Angela Bressel, Darren Potz, Maria Isabel Chiu, Murray Robinson, Joerg Heyer
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 4064.
Published: 01 May 2009
View articletitled, Abstract #4064: Mouse models of hepatocellular carcinoma exhibit features of VEGF-driven angiogenesis
Journal Articles

Human cancer relevant genomic alterations in a population based genetically engineered murine model of human breast cancer

Karuppiah Kannan, Sireesha Yalavarthi, Jie Lin, Richard Nicoletti, Ruojie Wang, William Rideout, Yinghui Zhou, Joerg Heyer, James Watters, Robert Phillips, Isabel Chiu, Murray Robinson
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 1734.
Published: 01 May 2008
View articletitled, Human cancer relevant genomic alterations in a population based genetically engineered murine model of human breast cancer
Journal Articles

Predicting rapamycin response using pathway profile in a population of genetically engineered hHer2 driven breast tumor model

Karuppiah Kannan, Jie Lin, Sireesha Yalavarthi, Ruojie Wang, Lu Li, Yinghui Zhou, Joerg Heyer, Spring Cheng, James Watters, Robert Phillips, Isabel Chiu, Murray Robinson
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 3615.
Published: 01 May 2008
View articletitled, Predicting rapamycin response using pathway profile in a population of genetically engineered hHer2 driven breast tumor model
Journal Articles

Variation in response to VEGFR inhibitor AV-951 across a population of genetically engineered breast tumors reveals distinct phenotypic classes of resistance

Jie Lin, karrupiah Kannan, Joerg Heyer, Hongmei Yang, nan Liu, Gaoyuan Meng, Yinghui Zhou, William Rideout, Angela Bressel, Tong Zi, Sireesha Yalavarthi, Ruojie Wang, Murray Robinson
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 2499.
Published: 01 May 2008
View articletitled, Variation in response to VEGFR inhibitor AV-951 across a population of genetically engineered breast tumors reveals distinct phenotypic classes of resistance
Journal Articles

Oncogene and tissue specific pathway activation in an HER2 dependent mouse mammary tumor model

Joerg Heyer, Yinghui Zhou, Angela Bressel, Tong Zi, Qiurong Xiao, Adrian Cooper, Joelle Brodeur, Jodi Zarycki, John Yang, William Rideout, Lorena Lerner, Marcus Bosenberg, Isabel Chiu, Steven Clark, Murray Robinson
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 4573.
Published: 01 May 2008
View articletitled, Oncogene and tissue specific pathway activation in an HER2 dependent mouse mammary tumor model
Journal Articles

A novel chimeric approach to modeling cancer in mice reveals that EGFR dependency in lung tumors is mediated through non canonical RTK-MAPK signaling

Joerg Heyer, Yinghui Zhou, William Rideout, Shailaja Reddypalli, Angela Bressel, Tong Zi, Qiurong Xiao, Sriram Kollipara, Rebecca Rancourt, Steven Clark, Murray Robinson
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 5719.
Published: 01 May 2007
View articletitled, A novel chimeric approach to modeling cancer in mice reveals that EGFR dependency in lung tumors is mediated through non canonical RTK-MAPK signaling
Journal Articles

A chimeric mouse model of ovarian cancer driven by inducible expression of PI3K catalytic subunit (p110α)

Yinghui Zhou, Shailaja Reddypalli, Angela Bressel, Tong Zi, Qiurong Xiao, William Rideout, Adrian Cooper, Joelle Brodeur, Steve Clark, Murray Robinson, Joerg Heyer
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 3869.
Published: 01 May 2007
View articletitled, A chimeric mouse model of ovarian cancer driven by inducible expression of PI3K catalytic subunit (p110α)
Journal Articles

Comprehensive in vivo genetic screens for tumor maintenance pathways in solid tumor models by retroviral mutagenesis

Isabel Chiu, Lorena Lerner, Ti Cai, Jodi Zarycki, Omar Kabbarah, John Yang, Wei Hu, Sireesha Yalavarthi, Karuppiah Kannan, David Bailey, Kathryn Sun, Dmitri Bichko, Fanglei You, Jianhua Zhao, Sylvie Vincent, Steve Bottega, Ronan O'Hagan, Alisa Bell, Heidi Okamura, Yinghui Zhou, William Rideout, Min Wu, Joerg Heyer, Steve Clark, Murray Robinson
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 5686.
Published: 01 May 2007
View articletitled, Comprehensive in vivo genetic screens for tumor maintenance pathways in solid tumor models by retroviral mutagenesis
Journal Articles

A novel beta-Catenin dependent p53DN mouse model of colon cancer displays stage dependent expression of EGFR

Yinghui Zhou, Shailaja Reddypalli, Angela Bressel, Tong Zi, Qiurong Xiao, William Rideout, Adrian Cooper, Joelle Brodeur, Steve Clark, Murray Robinson, Joerg Heyer
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 3845.
Published: 01 May 2007
View articletitled, A novel beta-Catenin dependent p53DN mouse model of colon cancer displays stage dependent expression of EGFR
Journal Articles

Genetically engineered murine tumor models for drug response prediction: population based pathway profiles predict response to rapamycin in a HER2 driven breast model

Karuppiah Kannan, Jie Lin, Sireesha Yalavarthi, Nan Liu, Ruojie Wang, Angela Bressel, Tong Zi, Yinghui Zhou, Joerg Heyer, Spring Cheng, James Watters, Robert Phillips, Isabel Chiu, Murray Robinson
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 2230.
Published: 01 May 2007
View articletitled, Genetically engineered murine tumor models for drug response prediction: population based pathway profiles predict response to rapamycin in a HER2 driven breast model