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Joaquín Arribas
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Journal Articles

Abstract 6118: Engineering p95HER2 CAR T cells for the treatment of HER2-positive tumors

Ariadna Grinyo-Escuer, Marta Bort-Brusca, Pablo Ovejero, Julia Fernandez Torrente, Judit Gago, Marta Escorihuela, Macarena Roman, Joaquin Arribas
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 6118.
https://doi.org/10.1158/1538-7445.AM2025-6118
Published: 21 April 2025
View articletitled, Abstract 6118: Engineering p95HER2 CAR T cells for the treatment of HER2-positive tumors
Journal Articles

Abstract C060: Characterization of a collection of patient-derived xenograft models for pancreatic ductal adenocarcinoma translational research

Mariana Yáñez, Enrique Javier Arenas, Teresa Macarulla, Tian Tian, Joaquín Arribas, Sofía Llorente, Carles Fabregat, Marta Escorihuela, Florian Castet, Jessica Querol, Maria Teresa Salcedo
Journal: Cancer Research
Cancer Res (2024) 84 (2_Supplement): C060.
https://doi.org/10.1158/1538-7445.PANCA2023-C060
Published: 16 January 2024
View articletitled, Abstract C060: Characterization of a collection of patient-derived xenograft models for pancreatic ductal adenocarcinoma translational research
Journal Articles

Abstract P1-05-14: ctDNA IN BREAST MILK FOR EARLY DETECTION OF PREGNANCY ASSOCIATED BREAST CANCER

Cristina Saura, Carolina Ortiz, Enrique Javier Arenas, Judit Matito, Anna Suñol-Camas, Octavi Cordoba, Alex Martinez-Sabadell, Itziar Garcia-Ruiz, Ignacio Miranda, Clara Morales-Comas, Estela Carrasco Lopez, Cristina Viaplana, Vicente Peg, Paolo Nuciforo, Neus Bayo, Josep Maria Miquel, Marina Gomez-Rey, Guillermo Villacampa, Silvia Arevalo, Javier Carmona, Martín Espinosa-Bravo, Judith Balmaña, Rodrigo Dienstmann, Joaquin Arribas, Josep Tabernero, miriam sanso, Ana Vivancos
Journal: Cancer Research
Cancer Res (2023) 83 (5_Supplement): P1-05-14.
https://doi.org/10.1158/1538-7445.SABCS22-P1-05-14
Published: 01 March 2023
View articletitled, Abstract P1-05-14: ctDNA IN BREAST MILK FOR EARLY DETECTION OF PREGNANCY ASSOCIATED BREAST CANCER
Journal Articles

Therapy-Induced Senescence Enhances the Efficacy of HER2-Targeted Antibody–Drug Conjugates in Breast Cancer

Santiago Duro-Sánchez, Mercedes Nadal-Serrano, Marta Lalinde-Gutiérrez, Enrique Javier Arenas, Cristina Bernadó Morales, Beatriz Morancho, Marta Escorihuela, Sandra Pérez-Ramos, Santiago Escrivá-de-Romaní, Lucía Gandullo-Sánchez, Atanasio Pandiella, Anna Esteve-Codina, Verónica Rodilla, Fred A. Dijcks, Wim H.A. Dokter, Javier Cortés, Cristina Saura, Joaquín Arribas
Journal: Cancer Research
Cancer Res (2022) 82 (24): 4670–4679.
https://doi.org/10.1158/0008-5472.CAN-22-0787
Published: 16 December 2022
View articletitled, Therapy-Induced Senescence Enhances the Efficacy of HER2-Targeted Antibody–Drug Conjugates in Breast Cancer
Open the PDF for Therapy-Induced Senescence Enhances the Efficacy of HER2-Targeted Antibody–Drug Conjugates in Breast Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 2044: The target antigen determines the mechanism of acquired resistance to T cell based therapies

Alex Martínez-Sabadell, Beatriz Morancho, Irene Rius, Marta Escorihuela, Antonio Luque, Irene Chicote, Hector García Palmer, Marina Bacac, Joaquin Arribas, Enrique Javier Arenas Lahuerta
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2044.
https://doi.org/10.1158/1538-7445.AM2022-2044
Published: 15 June 2022
View articletitled, Abstract 2044: The target antigen determines the mechanism of acquired resistance to T cell based therapies
Journal Articles

Abstract 3970: Acquired cancer cell resistance to T cell bispecific antibodies and CAR T targeting HER2 through JAK2 down-modulation

Alex Martínez-Sabadell, Enrique J. Arenas, Irene Rius Ruiz, Macarena Román Alonso, Marta Escorihuela, Antonio Luque, Carlos Alberto Fajardo, Alena Gros, Christian Klein, Joaquin Arribas
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3970.
https://doi.org/10.1158/1538-7445.AM2022-3970
Published: 15 June 2022
View articletitled, Abstract 3970: Acquired cancer cell resistance to T cell bispecific antibodies and CAR T targeting HER2 through JAK2 down-modulation
Journal Articles

Preclinical In Vivo Validation of the RAD51 Test for Identification of Homologous Recombination-Deficient Tumors and Patient Stratification

Benedetta Pellegrino, Andrea Herencia-Ropero, Alba Llop-Guevara, Flaminia Pedretti, Alejandro Moles-Fernández, Cristina Viaplana, Guillermo Villacampa, Marta Guzmán, Olga Rodríguez, Judit Grueso, Jose Jiménez, Enrique J. Arenas, Andrea Degasperi, João M.L. Dias, Josep V. Forment, Mark J. O'Connor, Olivier Déas, Stefano Cairo, Yinghui Zhou, Antonino Musolino, Carlos Caldas, Serena Nik-Zainal, Robert B. Clarke, Paolo Nuciforo, Orland Díez, Xavier Serres-Créixams, Vicente Peg, Martín Espinosa-Bravo, Teresa Macarulla, Ana Oaknin, Joaquin Mateo, Joaquín Arribas, Rodrigo Dienstmann, Meritxell Bellet, Mafalda Oliveira, Cristina Saura, Sara Gutiérrez-Enríquez, Judith Balmaña, Violeta Serra
Journal: Cancer Research
Cancer Res (2022) 82 (8): 1646–1657.
https://doi.org/10.1158/0008-5472.CAN-21-2409
Published: 15 April 2022
View articletitled, Preclinical In Vivo Validation of the RAD51 Test for Identification of Homologous Recombination-Deficient Tumors and Patient Stratification
Open the PDF for Preclinical In Vivo Validation of the RAD51 Test for Identification of Homologous Recombination-Deficient Tumors and Patient Stratification in another window
Includes: Supplementary data
Journal Articles

Abstract GS3-03: Genomic analysis of 733 HER2+ breast cancers identifies recurrent pathways alterations associated with anti-HER2 resistance and new therapeutic vulnerabilities

Emanuela Ferraro, Alison Smith, Anton Safonov, Paulino Tallon De Lara, Cristina Bernado', Enrique J. Arenas Lahuerta, Joaquín Arribas, David Solit, Jorge S. Reis-Filho, Neal Rosen, Larry Norton, Shanu Modi, Mark E. Robson, Chau T. Dang, Giuseppe Curigliano, Sarat Chandarlapaty, Pedram Razavi
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): GS3-03.
https://doi.org/10.1158/1538-7445.SABCS21-GS3-03
Published: 15 February 2022
View articletitled, Abstract GS3-03: Genomic analysis of 733 HER2+ breast cancers identifies recurrent pathways alterations associated with anti-HER2 resistance and new therapeutic vulnerabilities
Journal Articles

The Transcription Factor SLUG Uncouples Pancreatic Cancer Progression from the RAF–MEK1/2–ERK1/2 Pathway

Faiz Bilal, Enrique J. Arenas, Kim Pedersen, Alex Martínez-Sabadell, Behnam Nabet, Elizabeth Guruceaga, Silvestre Vicent, Josep Tabernero, Teresa Macarulla, Joaquín Arribas
Journal: Cancer Research
Series: Author Choice
Cancer Res (2021) 81 (14): 3849–3861.
https://doi.org/10.1158/0008-5472.CAN-20-4263
Published: 15 July 2021
View articletitled, The Transcription Factor SLUG Uncouples Pancreatic Cancer Progression from the RAF–MEK1/2–ERK1/2 Pathway
Open the PDF for The Transcription Factor SLUG Uncouples Pancreatic Cancer Progression from the RAF–MEK1/2–ERK1/2 Pathway in another window
Includes: Supplementary data
Journal Articles

Abstract 1075: AXL is a potential druggable target in trastuzumab resistance in HER2+ breast cancer patients

Anna Adam-Artigues, Raimundo Cervera, Enrique Javier Arenas, Fara Brasó-Maristany, Alex Martinez-Sabadell, Eduardo Tormo, Cristina Hernando, Maria Teresa Martinez, Soraya Simon, Jesús Poveda, Octavio Burgués, Ana Rovira, Federico Rojo, Joan Albanell, Begoña Bermejo, Ana Lluch, Pilar Eroles, Aleix Prat, Joaquin Arribas, Juan Miguel Cejalvo
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1075.
https://doi.org/10.1158/1538-7445.AM2021-1075
Published: 01 July 2021
View articletitled, Abstract 1075: AXL is a potential druggable target in trastuzumab resistance in HER2+ breast cancer patients
Journal Articles

Abstract 1859: The antigen target is critical in the mechanism of resistance to T-cell based therapies

Alex Martínez-Sabadell, Enrique J. Arenas, Beatriz Morancho, Irene Rius, Marta Escorihuela, Antonio Luque, Joaquín Arribas
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1859.
https://doi.org/10.1158/1538-7445.AM2021-1859
Published: 01 July 2021
View articletitled, Abstract 1859: The antigen target is critical in the mechanism of resistance to T-cell based therapies
Journal Articles

Abstract 1690: JAK2 downmodulation leads to interferon gamma deficient response and resistance to immunotherapy in breast cancer

Enrique Javier Arenas Lahuerta, Alex Martínez-Sabadell, Irene Rius Ruiz, Macarena Román Alonso, Marta Escorihuela, Antonio Luque, Carlos A. Fajardo, Alena Gros, Christian Klein, Joaquín Arribas
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1690.
https://doi.org/10.1158/1538-7445.AM2021-1690
Published: 01 July 2021
View articletitled, Abstract 1690: JAK2 downmodulation leads to interferon gamma deficient response and resistance to immunotherapy in breast cancer
Journal Articles

Abstract PS18-13: Men1611 is a pi3k α/β selective and δ sparing inhibitor with long-lasting antitumor activity in different genetic backgrounds of pik3ca mutant breast cancer models

Alessio Fiascarelli, Corrado Carrisi, Giuseppe Merlino, Stefania Capano, Diego Bisignano, Simone Talucci, Alessandro Bressan, Daniele Bellarosa, Mario Bigioni, Maurizio Scaltriti, Joaquin Arribas, Andrea Pellacani, Massimiliano Salerno, Monica Binaschi
Journal: Cancer Research
Cancer Res (2021) 81 (4_Supplement): PS18-13.
https://doi.org/10.1158/1538-7445.SABCS20-PS18-13
Published: 15 February 2021
View articletitled, Abstract PS18-13: Men1611 is a pi3k α/β selective and δ sparing inhibitor with long-lasting antitumor activity in different genetic backgrounds of pik3ca mutant breast cancer models
Journal Articles

Abstract 1282: Overcoming resistance to inhibitors of CDK4/6 and BET in estrogen receptor-positive breast cancer

Marc Cosín, Tian Tian, Winona Oliveros, Olesya A. Kharenko, Edward H. van der Horst, Reena G. Patel, Cyrus Calosing, Eric Campeau, Ravi Jahagirdar, Sanjay Lakhotia, Marta Melé, Marta Palafox, Joaquín Arribas, Mafalda Oliveira, Cristina Saura, Violeta Serra, Sandra Peiro
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 1282.
https://doi.org/10.1158/1538-7445.AM2020-1282
Published: 15 August 2020
View articletitled, Abstract 1282: Overcoming resistance to inhibitors of CDK4/6 and BET in estrogen receptor-positive breast cancer
Journal Articles

Abstract 3767: FBXO32 ubiquitin ligase mediates apoptosis evasion and adaptation to KIT inhibition in gastrointestinal stromal tumor - GIST

Alfonso García Valverde, Jordi Rosell, Daniel Pilco Janeta, Sergi Sayols, Claudia Valverde, Anna Esteve, Marta Gut, Jordi Barretina, George D. Demetri, Jonathan A. Fletcher, Joan Carles, Joaquín Arribas, César Serrano
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 3767.
https://doi.org/10.1158/1538-7445.AM2020-3767
Published: 15 August 2020
View articletitled, Abstract 3767: FBXO32 ubiquitin ligase mediates apoptosis evasion and adaptation to KIT inhibition in gastrointestinal stromal tumor - GIST
Journal Articles

Abstract 1685: The EurOPDX Research Infrastructure: Supporting European and worldwide cancer research with patient-derived xenografts

Emilie Vinolo, Joaquin Arribas, Andrea Bertotti, Alejandra Bruna, Annette T. Byrne, Robert B. Clarke, Nathalie Conte, Steven de Jong, Didier Decaudin, Zdenka Dudova, Jos Jonkers, Daniela Krasser, Ales Krenek, Luisa Lanfrancone, Eleonora Leucci, Elisabetta Marangoni, Gunhild Mari Maelandsmo, Michaela Th. Mayrhofer, Terrence F. Meehan, Jens Henrik Norum, Hector G. Palmer, Alejandro Piris Gimenez, Leo Price, Sergio Roman-Roman, Francesca Sarno, Violeta Serra, Laura Soucek, Livio Trusolino, Marieke van de Ven, Luca Vezzadini, Alberto Villanueva, Andrea Wutte, Enzo Medico, on behalf of the EurOPDX Research Infrastructure
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 1685.
https://doi.org/10.1158/1538-7445.AM2020-1685
Published: 15 August 2020
View articletitled, Abstract 1685: The EurOPDX Research Infrastructure: Supporting European and worldwide cancer research with patient-derived xenografts
Journal Articles

Abstract 1823: Translating Myc inhibition to the clinic in metastatic breast cancer

Daniel Massó-Vallés, Marie-Eve Beaulieu, Toni Jauset, Erika Serrano, Sandra Martínez-Martín, Laia Foradada, Virginia Castillo, Francisco Castillo, Génesis Martín, Sílvia Casacuberta-Serra, Mariano F. Zacarias-Fluck, Antonio Luque-García, Marta Escorihuela, Jonathan R. Whitfield, Joaquín Arribas, Laura Soucek
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 1823.
https://doi.org/10.1158/1538-7445.AM2020-1823
Published: 15 August 2020
View articletitled, Abstract 1823: Translating Myc inhibition to the clinic in metastatic breast cancer
Journal Articles

Abstract 5570: Identification of novel mechanisms of resistance against the redirection of T-cell effector function for cancer therapy

Enrique Javier Arenas Lahuerta, Alex Martínez-Sabadell, Irene Rius Ruiz, Beatriz Morancho, Macarena Román, Cristina Bernadó, Joaquín Arribas
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 5570.
https://doi.org/10.1158/1538-7445.AM2020-5570
Published: 15 August 2020
View articletitled, Abstract 5570: Identification of novel mechanisms of resistance against the redirection of T-cell effector function for cancer therapy
Journal Articles

Abstract 5573: Mechanism of resistance against T cell bispecific antibodies depends on targeted antigen

Alex Martínez-Sabadell, Enrique J. Arenas, Irene Rius, Macarena Román, Beatriz Morancho, Cristina Bernado, Joaquin Arribas
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 5573.
https://doi.org/10.1158/1538-7445.AM2020-5573
Published: 15 August 2020
View articletitled, Abstract 5573: Mechanism of resistance against T cell bispecific antibodies depends on targeted antigen
Journal Articles

Chromosome 12p Amplification in Triple-Negative/BRCA1-Mutated Breast Cancer Associates with Emergence of Docetaxel Resistance and Carboplatin Sensitivity

Jorge Gómez-Miragaya, Ander Díaz-Navarro, Raul Tonda, Sergi Beltran, Luis Palomero, Marta Palafox, Lacey E. Dobrolecki, Chen Huang, Suhas Vasaikar, Bing Zhang, Gerburg M. Wulf, Alejandro Collado-Sole, Eva M. Trinidad, Purificación Muñoz, Laia Paré, Aleix Prat, Alejandra Bruna, Carlos Caldas, Joaquín Arribas, María Teresa Soler-Monso, Anna Petit, Judith Balmaña, Cristina Cruz, Violeta Serra, Miguel Angel Pujana, Michael T. Lewis, Xose S. Puente, Eva González-Suárez
Journal: Cancer Research
Cancer Res (2019) 79 (16): 4258–4270.
https://doi.org/10.1158/0008-5472.CAN-18-3835
Published: 15 August 2019
View articletitled, Chromosome 12p Amplification in Triple-Negative/BRCA1-Mutated Breast Cancer Associates with Emergence of Docetaxel Resistance and Carboplatin Sensitivity
Open the PDF for Chromosome 12p Amplification in Triple-Negative/BRCA1-Mutated Breast Cancer Associates with Emergence of Docetaxel Resistance and Carboplatin Sensitivity in another window
Includes: Supplementary data