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Joan S. Brugge
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Journal Articles

Abstract 7152: High-dimensional, single-cell analysis and transcriptional profiling reveal novel correlatives of response to PARP inhibition plus PD-1 blockade in triple-negative breast cancer

Free
Alexander P. Gottlieb, Gregory J. Baker, Jia-Ren Lin, Ricardo Pastorello, Yu-An Chen, Tuulia Vallius, Janae Davis, Clarence Yapp, Sarah E. Church, Eric Miller, Anniina Farkkila, Shaveta Vinayak, Melinda L. Telli, Sara M. Tolaney, Filipa Lynce, Joan S. Brugge, Alan D'Andrea, Geoffrey Shapiro, Sandro Santagata, Peter K. Sorger, Elizabeth A. Mittendorf, Jennifer L. Guerriero
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 7152.
https://doi.org/10.1158/1538-7445.AM2025-7152
Published: 21 April 2025
View articletitled, Abstract 7152: High-dimensional, single-cell analysis and transcriptional profiling reveal novel correlatives of response to PARP inhibition plus PD-1 blockade in triple-negative breast cancer
Journal Articles

Abstract 1249: Chemotherapy enriches one of two pre-existing coordinated cellular programs characterized by inflammatory and stress pathways in high grade serous ovarian cancer

Free
Nomeda Girnius, Muyi Liu, Laura M. Selfors, Jaeyoung Kang, Linna Lahmadi, Mayura Thomas, Aylin Z. Henstridge, Morgan Gruner, Jordan Mattson, Dennis J. Slamon, Gottfried E. Koneckny, Andrew C. Nelson, Timothy K. Starr, Ronny Drapkin, Boris J. Winterhoff, Joan S. Brugge
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 1249.
https://doi.org/10.1158/1538-7445.AM2025-1249
Published: 21 April 2025
View articletitled, Abstract 1249: Chemotherapy enriches one of two pre-existing coordinated cellular programs characterized by inflammatory and stress pathways in high grade serous ovarian cancer
Journal Articles

Abstract 3821: Epigenetic mechanisms in early-onset hereditary cancer: Insights from a new Brca1 mouse model

Free
Carman Li, Alyssa Cordes, Michael U. Oliphant, S. Aidan Quinn, Mayura Thomas, Laura M. Selfors, Francesca Silvestri, Nomeda Girnius, Gianmarco Rinaldi, Jason Zoeller, Hana Shapiro, Christina Tsiobikas, Kushali P. Gupta, Shailja Pathania, Aviv Regev, Cigall Kadoch, Senthil K. Muthuswamy, Joan S. Brugge
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 3821.
https://doi.org/10.1158/1538-7445.AM2025-3821
Published: 21 April 2025
View articletitled, Abstract 3821: Epigenetic mechanisms in early-onset hereditary cancer: Insights from a new Brca1 mouse model
Journal Articles

Abstract B055: Identifying compounds to promote apoptotic cell death in clear cell ovarian cancer

Free
Brendan Shay, Abram Handly-Santana, Xingping Qin, Jonathan Choniere, Kristopher Sarosiek, Joan S. Brugge, Elizabeth H. Stover
Journal: Cancer Research
Cancer Res (2024) 84 (5_Supplement_2): B055.
https://doi.org/10.1158/1538-7445.OVARIAN23-B055
Published: 04 March 2024
View articletitled, Abstract B055: Identifying compounds to promote apoptotic cell death in clear cell ovarian cancer
Journal Articles

Abstract A035: An analysis of the contribution of the glutathione and thioredoxin antioxidant pathways to triple negative breast cancer development

Free
Nomeda Girnius, Aylin Z Henstridge, Francesca Silvestri, Carman Man Chung Li, Joan S Brugge
Journal: Cancer Research
Cancer Res (2024) 84 (3_Supplement_1): A035.
https://doi.org/10.1158/1538-7445.ADVBC23-A035
Published: 01 February 2024
View articletitled, Abstract A035: An analysis of the contribution of the glutathione and thioredoxin antioxidant pathways to triple negative breast cancer development
Journal Articles

Abstract CT142: TALAVE: Induction talazoparib (tala) followed by combined tala and avelumab in patients (pts) with advanced breast cancer (ABC)

Free
Filipa Lynce, Kenichi Shimada, Xue Geng, Edward T. Richardson, Candace Mainor, Mei Wei, Julie M. Collins, Paula P. Pohlmann, Arielle L. Heeke, Kelly F. Zheng, Madeline Townsend, Jane Staunton, Stuart J. Schnitt, Joan S. Brugge, Hongkun Wang, Claudine Isaacs, Geoffrey I. Shapiro, Jennifer L. Guerriero
Journal: Cancer Research
Cancer Res (2023) 83 (8_Supplement): CT142.
https://doi.org/10.1158/1538-7445.AM2023-CT142
Published: 14 April 2023
View articletitled, Abstract CT142: TALAVE: Induction talazoparib (tala) followed by combined tala and avelumab in patients (pts) with advanced breast cancer (ABC)
Journal Articles

Abstract 3459: Drug persistence pathways in ovarian cancer identified by single-cell analysis of patient samples and cell line models

Free
Elizaveta Leshchiner, Richard Panayiotou, Anay Gupta, Thomas Zhang, Kayli Neil, Nomeda Girnius, Aylin Henstridge, Brian P. Danysh, Ignaty Leshchiner, Sarah J. Hill, Laxmi Parida, Ursula A. Matulonis, Joan S. Brugge, Gad Getz
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3459.
https://doi.org/10.1158/1538-7445.AM2023-3459
Published: 04 April 2023
View articletitled, Abstract 3459: Drug persistence pathways in ovarian cancer identified by single-cell analysis of patient samples and cell line models
Journal Articles

Abstract 11: Prophylactic use of tamoxifen could reduce the risk of breast cancer in women who do not breast feed postpartum

Free
Bhuvaneswari Ramaswamy, Neelam Shinde, Gary K. Gray, Resham Mawalkar, Allen Zhang, Mustafa Basree, Xiaoli Zhang, Ramesh Ganju, Gina M. Sizemore, Joan S. Brugge, Sarmila Majumder
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 11.
https://doi.org/10.1158/1538-7445.AM2022-11
Published: 15 June 2022
View articletitled, Abstract 11: Prophylactic use of tamoxifen could reduce the risk of breast cancer in women who do not breast feed postpartum
Journal Articles

Abstract 342: Development and characterization of a novel anti-CLDN6 antibody drug conjugate for the treatment of CLDN6 positive cancers

Free
Martina S. McDermott, Ke Wei Gong, Neil A. O'Brien, Dylan Conklin, Benjamin Hoffstrom, Ming Lu, Jun Zhang, Tong Luo, Weiping Jia, Jenny J. Hong, Kevin Chau, Simon Davenport, Michael F. Press, Abram Handly-Santana, Joan S. Brugge, Ronny Drapkin, John A. Glaspy, Leonard Presta, Dennis J. Slamon
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 342.
https://doi.org/10.1158/1538-7445.AM2022-342
Published: 15 June 2022
View articletitled, Abstract 342: Development and characterization of a novel anti-CLDN6 antibody drug conjugate for the treatment of CLDN6 positive cancers
Journal Articles

Abstract PD7-03: A living biobank of normal mammary organoids derived from patients at low and increased risk of developing breast cancer

Free
Jennifer M Rosenbluth, Carman Man-Chung Li, Kenneth G Gray, Walter Gao, Ron CJ Schackmann, Jason J Zoeller, Laura M Selfors, Kaitlin Moore, Deborah Dillon, Judy Garber, Joan S Brugge
Journal: Cancer Research
Cancer Res (2021) 81 (4_Supplement): PD7-03.
https://doi.org/10.1158/1538-7445.SABCS20-PD7-03
Published: 15 February 2021
View articletitled, Abstract PD7-03: A living biobank of normal mammary organoids derived from patients at low and increased risk of developing breast cancer
Journal Articles

Abstract P3-11-06: Pre-clinical assessment of combined ABT-263/Navitoclax and ABT-414 or ABBV-321 treatment for EGFR-expressing TNBC

Free
Jason J Zoeller, Aleksandr Vagodny, Veerle W. Daniels, Krishan Taneja, Benjamin Y. Tan, Yoko S. DeRose, Maihi Fujita, Alana L. Welm, Anthony Letai, Joel D. Leverson, Vincent Blot, Roderick T. Bronson, Deborah A. Dillon, Joan S. Brugge
Journal: Cancer Research
Cancer Res (2020) 80 (4_Supplement): P3-11-06.
https://doi.org/10.1158/1538-7445.SABCS19-P3-11-06
Published: 15 February 2020
View articletitled, Abstract P3-11-06: Pre-clinical assessment of combined ABT-263/Navitoclax and ABT-414 or ABBV-321 treatment for EGFR-expressing TNBC
Journal Articles

Abstract P4-07-01: Tumor expression and microenvironment in HER2-positive breast cancer before and on HER2-targeted therapy: Analysis of microarray expression data from the TRIO-US B07 trial

Free
Jennifer L. Caswell-Jin, Katherine L. McNamara, Judy Dering, Hsiao-Wang Chen, Robert Dichmann, Alejandra Perez, Ravindranath Patel, Eran Kotler, Jason J. Zoeller, Joan S. Brugge, Michael F. Press, Dennis J. Slamon, Christina Curtis, Sara A. Hurvitz
Journal: Cancer Research
Cancer Res (2020) 80 (4_Supplement): P4-07-01.
https://doi.org/10.1158/1538-7445.SABCS19-P4-07-01
Published: 15 February 2020
View articletitled, Abstract P4-07-01: Tumor expression and microenvironment in HER2-positive breast cancer before and on HER2-targeted therapy: Analysis of microarray expression data from the TRIO-US B07 trial
Journal Articles

Abstract 3775: Characterization of intratumoral heterogeneity in drug sensitivity and modeling of drug combination effects using subclonal cell populations derived from a single breast cancer cell line

Free
Hendrik J. Kuiken, Chandler M. Friend, Steven M. Corsello, Christopher C. Mader, Joan S. Brugge
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3775.
https://doi.org/10.1158/1538-7445.AM2019-3775
Published: 01 July 2019
View articletitled, Abstract 3775: Characterization of intratumoral heterogeneity in drug sensitivity and modeling of drug combination effects using subclonal cell populations derived from a single breast cancer cell line
Journal Articles

Abstract 969: Characterization of murine mammary epithelial populations throughout development and in premalignant tissue via mass cytometry

Free
Gary K. Gray, Joan S. Brugge
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 969.
https://doi.org/10.1158/1538-7445.AM2019-969
Published: 01 July 2019
View articletitled, Abstract 969: Characterization of murine mammary epithelial populations throughout development and in premalignant tissue via mass cytometry
Journal Articles

Abstract 884: Interplay between NRF2 and GPX4 is critical for cancer cell survival in 3D spheroids

Free
Patricia Cho, Nobuaki Takahashi, Laura M. Selfors, Hendrik J. Kuiken, Joan S. Brugge
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 884.
https://doi.org/10.1158/1538-7445.AM2019-884
Published: 01 July 2019
View articletitled, Abstract 884: Interplay between NRF2 and GPX4 is critical for cancer cell survival in 3D spheroids
Journal Articles

Abstract 2978: Clinical evaluation of lapatinib induced BCL-2 adaptive responses

Free
Jason J. Zoeller, Sara A. Hurvitz, Michael F. Press, Laura M. Selfors, Judy Dering, Dennis J. Slamon, Joan S. Brugge
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2978.
https://doi.org/10.1158/1538-7445.AM2019-2978
Published: 01 July 2019
View articletitled, Abstract 2978: Clinical evaluation of lapatinib induced BCL-2 adaptive responses
Journal Articles

Abstract 2101: Targeting the root of cancer persister cells using an expressed barcode library

Free
Yaara Oren, Pratiksha Thakore, Mike S. Cuoco, Heidie Frisco Cabanos, Aaron Hata, Joan S. Brugge, Aviv Regev
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2101.
https://doi.org/10.1158/1538-7445.AM2019-2101
Published: 01 July 2019
View articletitled, Abstract 2101: Targeting the root of cancer persister cells using an expressed barcode library
Journal Articles

Abstract 1851: Combined inhibition of PARP and the unfolded protein response synergistically reduces viability in BRCA1-mutant breast cancer cells

Free
Jennifer E. Endress, Isaac S. Harris, Jacob Stewart-Ornstein, Galit Lahav, Joan S. Brugge
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1851.
https://doi.org/10.1158/1538-7445.AM2018-1851
Published: 01 July 2018
View articletitled, Abstract 1851: Combined inhibition of PARP and the unfolded protein response synergistically reduces viability in BRCA1-mutant breast cancer cells
Journal Articles

Abstract 2140: Mesenchymal stromal cells expressing a PEAK1/Cripto axis sustain pro-survival NF-κB signaling in adjacent tumor cells to promote disease progression and therapy resistance

Free
Sarkis Hamalian, Robert Güth, Ioannis Zervantonakis, Erika Duell, Jia-Ren Lin, Preston Shisgal, Justin Molnar, Cameron Geller, Megan Agajanian, Julia Tchou, Peter K. Sorger, Joan S. Brugge, Jonathan A. Kelber
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 2140.
https://doi.org/10.1158/1538-7445.AM2018-2140
Published: 01 July 2018
View articletitled, Abstract 2140: Mesenchymal stromal cells expressing a PEAK1/Cripto axis sustain pro-survival NF-κB signaling in adjacent tumor cells to promote disease progression and therapy resistance
Journal Articles

Abstract 3155: Loss of YAP1 dysregulates RhoA signaling and promotes cell invasion

Free
Natalie M. Hendrick, Marcin P. Iwanicki, Carman Man-Chung Li, Duyen Amy Bui, Laura M. Selfors, Joan S. Brugge
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 3155.
https://doi.org/10.1158/1538-7445.AM2018-3155
Published: 01 July 2018
View articletitled, Abstract 3155: Loss of YAP1 dysregulates RhoA signaling and promotes cell invasion