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Joan M. Carboni
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Journal Articles

Dual IGF-1R/InsR Inhibitor BMS-754807 Synergizes with Hormonal Agents in Treatment of Estrogen-Dependent Breast Cancer

Xiaonan Hou, Fei Huang, Luciana F. Macedo, Sean C. Harrington, Karen A. Reeves, Ann Greer, Friedrich Graf Finckenstein, Angela Brodie, Marco M. Gottardis, Joan M. Carboni, Paul Haluska
Journal: Cancer Research
Cancer Res (2011) 71 (24): 7597–7607.
https://doi.org/10.1158/0008-5472.CAN-11-1080
Published: 15 December 2011
View article titled, Dual IGF-1R/InsR Inhibitor BMS-754807 Synergizes with Hormonal Agents in Treatment of Estrogen-Dependent Breast Cancer
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Includes: Supplementary data
Journal Articles

Abstract 2300: Insulin receptor kinase inhibition is better tolerated than hypoinsulinemia and more effective than metformin in treating breast cancer

Carly Dool, Haider Mashhedi, Mahvash Zakikhani, Stephanie David, Yunhua Zhao, Elena Birman, Joan M. Carboni, Marco Gottardis, Marie-Jose Blouin, Michael N. Pollak
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 2300.
https://doi.org/10.1158/1538-7445.AM2011-2300
Published: 15 April 2011
View article titled, Abstract 2300: Insulin receptor kinase inhibition is better tolerated than hypoinsulinemia and more effective than metformin in treating breast cancer
Journal Articles

ETV6-NTRK3–Mediated Breast Epithelial Cell Transformation Is Blocked by Targeting the IGF1R Signaling Pathway

Cristina E. Tognon, Aruna M. Somasiri, Valentina E. Evdokimova, Genny Trigo, Evett E. Uy, Nataliya Melnyk, Joan M. Carboni, Marco M. Gottardis, Calvin D. Roskelley, Michael Pollak, Poul H.B. Sorensen
Journal: Cancer Research
Cancer Res (2011) 71 (3): 1060–1070.
https://doi.org/10.1158/0008-5472.CAN-10-3096
Published: 01 February 2011
View article titled, ETV6-NTRK3–Mediated Breast Epithelial Cell Transformation Is Blocked by Targeting the IGF1R Signaling Pathway
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Includes: Supplementary data
Journal Articles

Synthetic Lethality Screens Reveal RPS6 and MST1R as Modifiers of Insulin-like Growth Factor-1 Receptor Inhibitor Activity in Childhood Sarcomas

Jenny C. Potratz, Darren N. Saunders, Daniel H. Wai, Tony L. Ng, Steven E. McKinney, Joan M. Carboni, Marco M. Gottardis, Timothy J. Triche, Heribert Jürgens, Michael N. Pollak, Samuel A. Aparicio, Poul H.B. Sorensen
Journal: Cancer Research
Cancer Res (2010) 70 (21): 8770–8781.
https://doi.org/10.1158/0008-5472.CAN-10-1093
Published: 31 October 2010
View article titled, Synthetic Lethality Screens Reveal RPS6 and MST1R as Modifiers of Insulin-like Growth Factor-1 Receptor Inhibitor Activity in Childhood Sarcomas
Open the PDF for Synthetic Lethality Screens Reveal RPS6 and MST1R as Modifiers of Insulin-like Growth Factor-1 Receptor Inhibitor Activity in Childhood Sarcomas in another window
Includes: Supplementary data
Journal Articles

Differential Mechanisms of Acquired Resistance to Insulin-like Growth Factor-I Receptor Antibody Therapy or to a Small-Molecule Inhibitor, BMS-754807, in a Human Rhabdomyosarcoma Model

Fei Huang, Warren Hurlburt, Ann Greer, Karen A. Reeves, Stephen Hillerman, Han Chang, Joseph Fargnoli, Friedrich Graf Finckenstein, Marco M. Gottardis, Joan M. Carboni
Journal: Cancer Research
Cancer Res (2010) 70 (18): 7221–7231.
https://doi.org/10.1158/0008-5472.CAN-10-0391
Published: 14 September 2010
View article titled, Differential Mechanisms of Acquired Resistance to Insulin-like Growth Factor-I Receptor Antibody Therapy or to a Small-Molecule Inhibitor, BMS-754807, in a Human Rhabdomyosarcoma Model
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Includes: Supplementary data
Journal Articles

Abstract 363: Therapeutic targeting of insulin receptor-A with a dual IGF-1R/IR inhibitor: Overcoming a potential escape mechanism from IGF-1R-specific signaling inhibition in insulin receptor-A transfected cancer cells

Stephen M. Hillerman, Ann F. Greer, Warren Hurlburt, Fei Huang, Karen Reeves, Rolf Ryseck, Friedrich Graf Finckenstein, Arindam Dhar, Robert A. Kramer, Marco M. Gottardis, Joan M. Carboni
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 363.
https://doi.org/10.1158/1538-7445.AM10-363
Published: 15 April 2010
View article titled, Abstract 363: Therapeutic targeting of insulin receptor-A with a dual IGF-1R/IR inhibitor: Overcoming a potential escape mechanism from IGF-1R-specific signaling inhibition in insulin receptor-A transfected cancer cells
Journal Articles

Insulin-Mediated Acceleration of Breast Cancer Development and Progression in a Nonobese Model of Type 2 Diabetes

Ruslan Novosyadlyy, Danielle E. Lann, Archana Vijayakumar, Anne Rowzee, Deborah A. Lazzarino, Yvonne Fierz, Joan M. Carboni, Marco M. Gottardis, Patricia A. Pennisi, Alfredo A. Molinolo, Naamit Kurshan, Wilson Mejia, Stefania Santopietro, Shoshana Yakar, Teresa L. Wood, Derek LeRoith
Journal: Cancer Research
Cancer Res (2010) 70 (2): 741–751.
https://doi.org/10.1158/0008-5472.CAN-09-2141
Published: 13 January 2010
View article titled, Insulin-Mediated Acceleration of Breast Cancer Development and Progression in a Nonobese Model of Type 2 Diabetes
Open the PDF for Insulin-Mediated Acceleration of Breast Cancer Development and Progression in a Nonobese Model of Type 2 Diabetes in another window
Includes: Supplementary data
Journal Articles

Expression of Insulin Receptor Isoform A and Insulin-like Growth Factor-1 Receptor in Human Acute Myelogenous Leukemia: Effect of the Dual-Receptor Inhibitor BMS-536924 In vitro

Andrea E. Wahner Hendrickson, Paul Haluska, Paula A. Schneider, David A. Loegering, Kevin L. Peterson, Ricardo Attar, B. Douglas Smith, Charles Erlichman, Marco Gottardis, Judith E. Karp, Joan M. Carboni, Scott H. Kaufmann
Journal: Cancer Research
Cancer Res (2009) 69 (19): 7635–7643.
https://doi.org/10.1158/0008-5472.CAN-09-0511
Published: 01 October 2009
View article titled, Expression of Insulin Receptor Isoform A and Insulin-like Growth Factor-1 Receptor in Human Acute Myelogenous Leukemia: Effect of the Dual-Receptor Inhibitor BMS-536924 <em>In vitro</em>
Open the PDF for Expression of Insulin Receptor Isoform A and Insulin-like Growth Factor-1 Receptor in Human Acute Myelogenous Leukemia: Effect of the Dual-Receptor Inhibitor BMS-536924 <em>In vitro</em> in another window
Includes: Supplementary data
Journal Articles

Abstract #1743: Combined estrogen signaling inhibition and IGF-1R/InsR inhibition with BMS-754807 in estrogen-dependent breast cancer model has synergistic antitumor activity in vitro and in vivo

Xiaonan hou, Joan M. Carboni, Luciana F Macedo, Sean C Harrington, Friedrich Finckenstein, Angela Brodie, Marco Gottardis, Paul Haluska
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 1743.
Published: 01 May 2009
View article titled, Abstract #1743: Combined estrogen signaling inhibition and IGF-1R/InsR inhibition with BMS-754807 in estrogen-dependent breast cancer model has synergistic antitumor activity in vitro and in vivo
Journal Articles

Insulin Receptor Isoform A and Insulin-like Growth Factor II as Additional Treatment Targets in Human Osteosarcoma

Sofia Avnet, Laura Sciacca, Manuela Salerno, Giovanni Gancitano, Maria Francesca Cassarino, Alessandra Longhi, Mahvash Zakikhani, Joan M. Carboni, Marco Gottardis, Armando Giunti, Michael Pollak, Riccardo Vigneri, Nicola Baldini
Journal: Cancer Research
Cancer Res (2009) 69 (6): 2443–2452.
https://doi.org/10.1158/0008-5472.CAN-08-2645
Published: 17 March 2009
View article titled, Insulin Receptor Isoform A and Insulin-like Growth Factor II as Additional Treatment Targets in Human Osteosarcoma
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Journal Articles

The Mechanisms of Differential Sensitivity to an Insulin-like Growth Factor-1 Receptor Inhibitor (BMS-536924) and Rationale for Combining with EGFR/HER2 Inhibitors

Fei Huang, Ann Greer, Warren Hurlburt, Xia Han, Rameh Hafezi, Gayle M. Wittenberg, Karen Reeves, Jiwen Chen, Douglas Robinson, Aixin Li, Francis Y. Lee, Marco M. Gottardis, Edwin Clark, Lee Helman, Ricardo M. Attar, Ashok Dongre, Joan M. Carboni
Journal: Cancer Research
Cancer Res (2009) 69 (1): 161–170.
https://doi.org/10.1158/0008-5472.CAN-08-0835
Published: 31 December 2008
View article titled, The Mechanisms of Differential Sensitivity to an Insulin-like Growth Factor-1 Receptor Inhibitor (BMS-536924) and Rationale for Combining with EGFR/HER2 Inhibitors
Open the PDF for The Mechanisms of Differential Sensitivity to an Insulin-like Growth Factor-1 Receptor Inhibitor (BMS-536924) and Rationale for Combining with EGFR/HER2 Inhibitors in another window
Includes: Supplementary data
Journal Articles

Mammary tumor models for the study of IGF1R -dependent tumor growth

Joseph E. Dinchuk, Joan M. Carboni, Ching-Ping Ho, Janet Dell John, Ann F. Greer, Aixin Li, Anne Lewin, Richard Westhouse, Fanny Myers, Ricardo Attar, Marco Gottardis
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 416–417.
Published: 15 April 2006
View article titled, Mammary tumor models for the study of IGF1R -dependent tumor growth
Journal Articles

In vitro and In vivo Antitumor Effects of the Dual Insulin-Like Growth Factor-I/Insulin Receptor Inhibitor, BMS-554417

Paul Haluska, Joan M. Carboni, David A. Loegering, Francis Y. Lee, Mark Wittman, Mark G. Saulnier, David B. Frennesson, Kimberly R. Kalli, Cheryl A. Conover, Ricardo M. Attar, Scott H. Kaufmann, Marco Gottardis, Charles Erlichman
Journal: Cancer Research
Cancer Res (2006) 66 (1): 362–371.
https://doi.org/10.1158/0008-5472.CAN-05-1107
Published: 05 January 2006
View article titled, <em>In vitro</em> and <em>In vivo</em> Antitumor Effects of the Dual Insulin-Like Growth Factor-I/Insulin Receptor Inhibitor, BMS-554417
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Journal Articles

Tumor Development by Transgenic Expression of a Constitutively Active Insulin-Like Growth Factor I Receptor

Joan M. Carboni, Adrian V. Lee, Darryl L. Hadsell, Bruce R. Rowley, Francis Y. Lee, David K. Bol, Amy E. Camuso, Marco Gottardis, Ann F. Greer, Ching Ping Ho, Warren Hurlburt, Aixin Li, Mark Saulnier, Upender Velaparthi, Cindy Wang, Mei-Li Wen, Richard A. Westhouse, Mark Wittman, Kurt Zimmermann, Brent A. Rupnow, Tai W. Wong
Journal: Cancer Research
Cancer Res (2005) 65 (9): 3781–3787.
https://doi.org/10.1158/0008-5472.CAN-04-4602
Published: 02 May 2005
View article titled, Tumor Development by Transgenic Expression of a Constitutively Active Insulin-Like Growth Factor I Receptor
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Journal Articles

BMS-536924, a potent, small molecule inhibitor of the IGF-1 receptor in vitro and in vivo

Joan M. Carboni, Mark Wittman, Ricardo Attar, Praveen Balimane, Stephen Castaneda, Janet Dell, Marco Gottardis, Ann Greer, Ching-Ping Ho, Chen-Yi Hung, Warren Hurlburt, Ivan Inigo, David Kan, Francis Y. Lee, Aixin Li, Tai-An Lin, Becky Penhallow, Mark Saulnier, Upender Velaparthi, Zheng Yang, Kurt Zimmermann
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 1406.
Published: 01 May 2005
View article titled, BMS-536924, a potent, small molecule inhibitor of the IGF-1 receptor <em>in vitro</em> and <em>in vivo</em>
Journal Articles

BMS-554417, an inhibitor of the insulin-like growth factor I receptor and insulin receptor, inhibits proliferation and induces mitochondrial pathway-mediated apoptosis in cancer cell lines

Paul Haluska, Joan M. Carboni, David A. Loegering, Francis Y. Lee, Mark Saulnier, David Frennesson, Ricardo M. Attar, Kimberly R. Kalli, Cheryl A. Conover, Sumithra J. Mandrekar, Scott H. Kaufmann, Marco Gottardis, Charles Erlichman
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 1191.
Published: 01 May 2005
View article titled, BMS-554417, an inhibitor of the insulin-like growth factor I receptor and insulin receptor, inhibits proliferation and induces mitochondrial pathway-mediated apoptosis in cancer cell lines
Journal Articles

Induction of Ornithine Decarboxylase Activity Is a Necessary Step for Mitogen-Activated Protein Kinase Kinase–Induced Skin Tumorigenesis

David J. Feith, David K. Bol, Joan M. Carboni, Mark J. Lynch, Suzanne Sass-Kuhn, Paula L. Shoop, Lisa M. Shantz
Journal: Cancer Research
Cancer Res (2005) 65 (2): 572–578.
https://doi.org/10.1158/0008-5472.572.65.2
Published: 03 February 2005
View article titled, Induction of Ornithine Decarboxylase Activity Is a Necessary Step for Mitogen-Activated Protein Kinase Kinase–Induced Skin Tumorigenesis
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Journal Articles

Eleutherobin, a Novel Cytotoxic Agent That Induces Tubulin Polymerization, Is Similar to Paclitaxel (Taxol®)

Byron H. Long, Joan M. Carboni, Arthur J. Wasserman, Laurie A. Cornell, Anna Maria Casazza, Paul R. Jensen, Thomas Lindel, William Fenical, Craig R. Fairchild
Journal: Cancer Research
Cancer Res (1998) 58 (6): 1111–1115.
Published: 01 March 1998
View article titled, Eleutherobin, a Novel Cytotoxic Agent That Induces Tubulin Polymerization, Is Similar to Paclitaxel (Taxol®)
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Journal Articles

Transforming Growth Factor-β1 Induces Transforming Growth Factor-α Promoter Activity and Transforming Growth Factor-α Secretion in the Human Colon Adenocarcinoma Cell Line FET

Mark J. Lynch, Lenore Pelosi, Joan M. Carboni, June Merwin, Kevin Coleman, Richard R. C. Wang, Pin-Fang M. Lin, Diane L. Henry, Michael G. Brattain
Journal: Cancer Research
Cancer Res (1993) 53 (17): 4041–4047.
Published: 01 September 1993
View article titled, Transforming Growth Factor-β1 Induces Transforming Growth Factor-α Promoter Activity and Transforming Growth Factor-α Secretion in the Human Colon Adenocarcinoma Cell Line FET
Open the PDF for Transforming Growth Factor-β1 Induces Transforming Growth Factor-α Promoter Activity and Transforming Growth Factor-α Secretion in the Human Colon Adenocarcinoma Cell Line FET in another window