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Journal Articles

Abstract 9: AFNT-212: A TRAC-knocked-in KRASG12D-specific TCR-T cell product enhanced with CD8αβ and a chimeric cytokine receptor for treatment of solid cancers

Allison Drain, Nicholas Rouillard, Nathaniel Swanson, Martina Canestraro, Santosh Narayan, Tyler Warner, Nicole Danek, Ken Gareau, Jinsheng Liang, Luhua Shen, Tanya Tetrault, Iqraa Priyata, Sarah Vidyasagar, Taylor Riggins-Walker, Hui-Wen Liu, Klaus Pechhold, Lauren Brown, Joshua Francis, Xingyue He, Patrick Browne, Rebecca Lamothe, Meghan Storlie, Gregory Cost, Thomas M. Schmitt, Philip D. Greenberg, Smita S. Chandran, Christopher A. Klebanoff, Hubert Lam, Ankit Gupta, Damien Hallet, Gary Shapiro, Kim Nguyen, Loïc Vincent
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 9.
https://doi.org/10.1158/1538-7445.AM2024-9
Published: 22 March 2024
View article titled, Abstract 9: AFNT-212: A <em>TRAC</em>-knocked-in KRAS<sup>G12D</sup>-specific TCR-T cell product enhanced with CD8αβ and a chimeric cytokine receptor for treatment of solid cancers
Journal Articles

Abstract 10: Non-viral engineered T cell therapy specific for the hotspot mutation p53 R175H that integrates signal 1 (TCR), signal 2 (co-stimulation) and signal 3 (cytokine) and co-opts FasL-dependent apoptosis to achieve a coordinated antitumor CD4/8 T cell response

Santosh Narayan, Ken Gareau, Ankit Gupta, Josh Ferrell, Nicholas Rouillard, Tyler Warner, Jinsheng Liang, Luhua Shen, Tanya Tetrault, Joshua Francis, Xingyue He, Patrick J. Browne, Rebecca Lamothe, Meghan D. Storlie, Gregory J. Cost, Thomas M. Schmitt, Philip D. Greenberg, Smita S. Chandran, Damien Hallet, Michael Gormally, Chistopher A. Klebanoff, Gary Shapiro, Kim Nguyen, Loïc Vincent
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 10.
https://doi.org/10.1158/1538-7445.AM2024-10
Published: 22 March 2024
View article titled, Abstract 10: Non-viral engineered T cell therapy specific for the hotspot mutation p53 R175H that integrates signal 1 (TCR), signal 2 (co-stimulation) and signal 3 (cytokine) and co-opts FasL-dependent apoptosis to achieve a coordinated antitumor CD4/8 T cell response
Journal Articles

Inhibition of MDM2 Promotes Antitumor Responses in p53 Wild-Type Cancer Cells through Their Interaction with the Immune and Stromal Microenvironment

Hui Qin Wang, Iain J. Mulford, Fiona Sharp, Jinsheng Liang, Sema Kurtulus, Gina Trabucco, David S. Quinn, Tyler A. Longmire, Nidhi Patel, Roshani Patil, Matthew D. Shirley, Yan Chen, Hao Wang, David A. Ruddy, Claire Fabre, Juliet A. Williams, Peter S. Hammerman, Jennifer Mataraza, Barbara Platzer, Ensar Halilovic
Journal: Cancer Research
Cancer Res (2021) 81 (11): 3079–3091.
https://doi.org/10.1158/0008-5472.CAN-20-0189
Published: 01 June 2021
View article titled, Inhibition of MDM2 Promotes Antitumor Responses in p53 Wild-Type Cancer Cells through Their Interaction with the Immune and Stromal Microenvironment
Open the PDF for Inhibition of MDM2 Promotes Antitumor Responses in p53 Wild-Type Cancer Cells through Their Interaction with the Immune and Stromal Microenvironment in another window
Includes: Supplementary data
Journal Articles

Abstract 5560: PD-1/PD-L1 blockade enhances MDM2 inhibitor activity in p53 wild-type cancers

Hui Qin Wang, Jinsheng Liang, Iain Mulford, Fiona Sharp, Swann Gaulis, Yan Chen, Gina Trabucco, David Quinn, Joseph D. Growney, Matthew J. Meyer, Juliet Williams, Peter Hammerman, Francesco Hofmann, Glenn Dranoff, Jeffrey Engelman, Jennifer Mataraza, Ensar Halilovic
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5560.
https://doi.org/10.1158/1538-7445.AM2018-5560
Published: 01 July 2018
View article titled, Abstract 5560: PD-1/PD-L1 blockade enhances MDM2 inhibitor activity in p53 wild-type cancers
Journal Articles

Abstract 1007: SHP2 inhibition restores sensitivity to ALK inhibition in resistant ALK-rearranged non-small cell lung cancer (NSCLC)

Leila Dardaei, Hui Qin Wang, Paul Fordjour, Manrose Singh, Grainne Kerr, Satoshi Yoda, Jinsheng Liang, Yichen Cao, Yan Chen, Justin F. Gainor, Luc Friboulet, Ibiayi Dagogo-Jack, David T. Myers, Emma Labrot, David Ruddy, Melissa Parks, Dana Lee, Richard H. DiCecca, Susan Moody, Huaixiang Hao, Morvarid Mohseni, Matthew LaMarche, Juliet Williams, Keith Hoffmaster, Giordano Caponigro, Cyril H. Benes, Alice T. Shaw, Aaron N. Hata, Fang Li, Jeffrey A. Engelman
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1007.
https://doi.org/10.1158/1538-7445.AM2017-1007
Published: 01 July 2017
View article titled, Abstract 1007: SHP2 inhibition restores sensitivity to ALK inhibition in resistant ALK-rearranged non-small cell lung cancer (NSCLC)
Journal Articles

Abstract 782: Modulation of receptor tyrosine kinase signaling by cMET inhibitor, INC280, in cMETmut/amp gastric carcinoma cell line Hs746.T

Maria C. Pinzon-Ortiz, Xianhui Rong, Jinsheng Liang, Hui Qin Wang, Alan Huang, Robert Schlegel, Z. Alexander Cao
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 782.
https://doi.org/10.1158/1538-7445.AM2015-782
Published: 01 August 2015
View article titled, Abstract 782: Modulation of receptor tyrosine kinase signaling by cMET inhibitor, INC280, in cMET<sup>mut/amp g</sup>astric carcinoma cell line Hs746.T
Journal Articles

Abstract 2929: The Mdm2 inhibitor NVP-CGM097 enhances the anti-tumor activity of NVP-LDK378 in ALK mutant neuroblastoma models

Hui Qin Wang, Linda Battalagine, Jinsheng Liang, Ensar Halilovic, Robert Schlegel, Alan Huang, Z. Alexander Cao, John Monahan, Fang Li
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 2929.
https://doi.org/10.1158/1538-7445.AM2014-2929
Published: 01 October 2014
View article titled, Abstract 2929: The Mdm2 inhibitor NVP-CGM097 enhances the anti-tumor activity of NVP-LDK378 in ALK mutant neuroblastoma models
Journal Articles

Abstract 2612: ljm716, an anti her3 antibody that inhibits her3 dimerization, displays anti-tumor activity in esophageal squamous cell cancer

Qing Sheng, Hui-Qin Wang, rita das, yan chen, jinsheng liang, Fiona Xu, zongyao Wang, Z. Alexander Cao, youzhen Wang, alan huang
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 2612.
https://doi.org/10.1158/1538-7445.AM2014-2612
Published: 01 October 2014
View article titled, Abstract 2612: ljm716, an anti her3 antibody that inhibits her3 dimerization, displays anti-tumor activity in esophageal squamous cell cancer
Journal Articles

An Antibody That Locks HER3 in the Inactive Conformation Inhibits Tumor Growth Driven by HER2 or Neuregulin

Andrew P. Garner, Carl U. Bialucha, Elizabeth R. Sprague, Joan T. Garrett, Qing Sheng, Sharon Li, Olga Sineshchekova, Parmita Saxena, Cammie R. Sutton, Dongshu Chen, Yan Chen, Huiqin Wang, Jinsheng Liang, Rita Das, Rebecca Mosher, Jian Gu, Alan Huang, Nicole Haubst, Carolin Zehetmeier, Manuela Haberl, Winfried Elis, Christian Kunz, Analeah B. Heidt, Kara Herlihy, Joshua Murtie, Alwin Schuller, Carlos L. Arteaga, William R. Sellers, Seth A. Ettenberg
Journal: Cancer Research
Cancer Res (2013) 73 (19): 6024–6035.
https://doi.org/10.1158/0008-5472.CAN-13-1198
Published: 01 October 2013
View article titled, An Antibody That Locks HER3 in the Inactive Conformation Inhibits Tumor Growth Driven by HER2 or Neuregulin
Open the PDF for An Antibody That Locks HER3 in the Inactive Conformation Inhibits Tumor Growth Driven by HER2 or Neuregulin in another window
Includes: Supplementary data
Journal Articles

Abstract 4261: Targeting HER3 and PI3K in head and neck squamous cancer cells.

Qing Sheng, HuiQin Wang, Rita Das, Yan Chen, Jinsheng Liang, Alex Cao, Carl Uli Bialucha, Seth Ettenberg, Alan Huang
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 4261.
https://doi.org/10.1158/1538-7445.AM2013-4261
Published: 15 April 2013
View article titled, Abstract 4261: Targeting HER3 and PI3K in head and neck squamous cancer cells.
Journal Articles

Abstract 2733: LJM716: an anti-HER3 antibody that inhibits both HER2 and NRG driven tumor growth by trapping HER3 in the inactive conformation.

Andrew Garner, Qing Sheng, Uli Bialucha, Dongshu Chen, Yan Chen, Rita Das, Winfried Elis, Analeah Heidt, Christian Kunz, Sharon Li, Jinsheng Liang, Joshua Murtie, Parmita Saxena, Alwin Schuller, Olga Sineshchekova, Elizabeth Sprague, Hui Qin Wang, Alan Huang, Seth Ettenberg
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 2733.
https://doi.org/10.1158/1538-7445.AM2012-2733
Published: 15 April 2012
View article titled, Abstract 2733: LJM716: an anti-HER3 antibody that inhibits both HER2 and NRG driven tumor growth by trapping HER3 in the inactive conformation.