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Journal Articles

Chromatin Helicase CHD6 Establishes Proinflammatory Enhancers and Is a Synthetic Lethal Target in FH-Deficient Renal Cell Carcinoma

Juan Jin, Jun Luo, Xiaodong Jin, Kiat Shenq Lim, Yang He, Jiawei Ding, Yan Shen, Yuchen Hou, Hanqing Liu, Xiaoyu Zhu, Jing Zhao, Wenjie Zhou, Hai Huang, Yi Gao, Jun Xiao, Hongchao He, Qunyi Li, Lianxin Liu, Li Chen, Qiang He, Chuanjie Zhang
Journal: Cancer Research
Cancer Res (2025) 85 (4): 675–691.
https://doi.org/10.1158/0008-5472.CAN-24-0787
Published: 17 February 2025
View article titled, Chromatin Helicase CHD6 Establishes Proinflammatory Enhancers and Is a Synthetic Lethal Target in FH-Deficient Renal Cell Carcinoma
Open the PDF for Chromatin Helicase CHD6 Establishes Proinflammatory Enhancers and Is a Synthetic Lethal Target in FH-Deficient Renal Cell Carcinoma in another window
Includes: Supplementary data
Journal Articles

Abstract 5333: NeoMab: A novel platform for fully human therapeutic antibody development

Mingkun Zhang, Cunxiang Ju, Song Li, Junchao Peng, Jing Zhao, Xiang Gao
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 5333.
https://doi.org/10.1158/1538-7445.AM2024-5333
Published: 22 March 2024
View article titled, Abstract 5333: NeoMab: A novel platform for fully human therapeutic antibody development
Journal Articles

Abstract 6652: Advanced glioblastoma immunotherapy: Attenuated herpes oncolytic virus armed with anti-PD-1 antibody and IL-12

Lei Wang, Xusha Zhou, Xiaoqing Chen, Yuanyuan Liu, Yanxin Zheng, Runbin Yan, Yonghong Liu, Jing Zhao, Grace Guoying Zhou
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6652.
https://doi.org/10.1158/1538-7445.AM2024-6652
Published: 22 March 2024
View article titled, Abstract 6652: Advanced glioblastoma immunotherapy: Attenuated herpes oncolytic virus armed with anti-PD-1 antibody and IL-12
Journal Articles

Abstract 4189: BALB/c-hIL12RB1/hIL12RB2: A robust model for preclinical research in human IL-12 therapy

Yuan Fang, Huiyi Wang, Jun Xing, Lu Yang, Jing Zhao, Xiang Gao, Cunxiang Ju
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 4189.
https://doi.org/10.1158/1538-7445.AM2024-4189
Published: 22 March 2024
View article titled, Abstract 4189: BALB/c-hIL12RB1/hIL12RB2: A robust model for preclinical research in human IL-12 therapy
Journal Articles

Abstract 537: Preclinical PD-1 resistance models: Crucial tools for unveiling PD-1 resistance mechanisms and advancing novel treatment strategies

Yini Zhu, Yuan Fang, Huiyi Wang, Jun Xing, Lu Yang, Jing Zhao, Xiang Gao, Cunxiang Ju
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 537.
https://doi.org/10.1158/1538-7445.AM2024-537
Published: 22 March 2024
View article titled, Abstract 537: Preclinical PD-1 resistance models: Crucial tools for unveiling PD-1 resistance mechanisms and advancing novel treatment strategies
Journal Articles

Abstract 2831: Development and application of the NCG-hIL2 mouse model: A humanized platform for enhanced NK cell evaluation in ADCC efficacy testing

Yuan Fang, Hongyan Sun, Huiyi Wang, Jun Xing, Jialu Fan, Jing Zhao, Xiang Gao, Cunxiang Ju
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 2831.
https://doi.org/10.1158/1538-7445.AM2024-2831
Published: 22 March 2024
View article titled, Abstract 2831: Development and application of the NCG-hIL2 mouse model: A humanized platform for enhanced NK cell evaluation in ADCC efficacy testing
Journal Articles

Abstract 4190: Patient-derived xenograft (PDX) models with differential HER2 expression for preclinical evaluation of HER2-targeted therapies

Xiaoliu Yang, Shiying Guo, Huiyi Wang, Xu Su, Jing Zhao, Xiang Gao, Cunxiang Ju
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 4190.
https://doi.org/10.1158/1538-7445.AM2024-4190
Published: 22 March 2024
View article titled, Abstract 4190: Patient-derived xenograft (PDX) models with differential HER2 expression for preclinical evaluation of HER2-targeted therapies
Journal Articles

Abstract 118: Development of a novel murine model, NCG-M/hIL15, for enhanced post-HSC transplantation immunoreconstruction

Huiyi Wang, Jun Xing, Jialu Fan, Yuan Fan, Jing Zhao, Xiang Gao, Cunxiang Ju
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 118.
https://doi.org/10.1158/1538-7445.AM2024-118
Published: 22 March 2024
View article titled, Abstract 118: Development of a novel murine model, NCG-M/hIL15, for enhanced post-HSC transplantation immunoreconstruction
Journal Articles

Abstract 536: Breaking through ADCs resistance: Constructing preclinical enhertu-induced resistant model

Yuan Fang, Huiyi Wang, Jun Xing, Lu Yang, Jing Zhao, Xiang Gao, Cunxiang Ju
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 536.
https://doi.org/10.1158/1538-7445.AM2024-536
Published: 22 March 2024
View article titled, Abstract 536: Breaking through ADCs resistance: Constructing preclinical enhertu-induced resistant model
Journal Articles

Abstract 3970: NCG-hIL15 humanized mice: an ideal model for human immune reconstitution of NK cells

Xing Liu, Meirong Wu, Huiyi Wang, Weiwei Yu, Jianming Xu, Hongyan Sun, Cunxiang Ju, Hongyu Wang, Santi Suryani Chen, Zhiying Li, Mark Wade Moore, Jing Zhao, Xiang Gao
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3970.
https://doi.org/10.1158/1538-7445.AM2023-3970
Published: 04 April 2023
View article titled, Abstract 3970: NCG-hIL15 humanized mice: an ideal model for human immune reconstitution of NK cells
Journal Articles

Abstract 5205: B6-KrasLSL-G12C mouse model for assessing the occurrence and development of lung and pancreatic cancer tumors

Xiaoliu Yang, Yunlong Jiang, Xue Wu, Mingkun Zhang, Jing Zhao, Santi Suryani Chen, Zhiying Li, Erica Trujillo, Mark Wade Moore, Xiang Gao, Cunxiang Ju
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5205.
https://doi.org/10.1158/1538-7445.AM2023-5205
Published: 04 April 2023
View article titled, Abstract 5205: B6-<em>KrasLSL-G12C</em> mouse model for assessing the occurrence and development of lung and pancreatic cancer tumors
Journal Articles

Abstract 5072: “Armed” oncolytic herpes simplex virus enables CD19 CAR-T for solid tumor cell treatment as a combination therapy

Yanxin Zheng, Yuanyuan Liu, Tianyi Deng, Yue Huang, Ziwen Liu, Borui Zhan, Xusha Zhou, Runbin Yan, Jiangtao Ren, Yun Xing, Guixing Wu, Yonghong Liu, Jing Zhao, Xiaoqing Chen, Grace Zhou
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5072.
https://doi.org/10.1158/1538-7445.AM2023-5072
Published: 04 April 2023
View article titled, Abstract 5072: “Armed” oncolytic herpes simplex virus enables CD19 CAR-T for solid tumor cell treatment as a combination therapy
Journal Articles

Abstract 3242: Efficacy evaluation by novel humanized mouse models for preclinical study of ADCs combined with immunotherapy

Fang Zhu, Hongyan Sun, Qian Lu, Yuan Fang, Jianming Xu, Cunxiang Ju, Hongyu Wang, Santi Suryani Chen, Zhiying Li, Mark Wade Moore, Jing Zhao, Xiang Gao
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3242.
https://doi.org/10.1158/1538-7445.AM2023-3242
Published: 04 April 2023
View article titled, Abstract 3242: Efficacy evaluation by novel humanized mouse models for preclinical study of ADCs combined with immunotherapy
Journal Articles

Abstract 5202: NCG-M humanized mice: an excellent model for human immune reconstitution of myeloid lineages

Huiyi Wang, Jialu Fan, Shiying Guo, Mingkun Zhang, Shuai Li, Santi Suryani Chen, Zhiying Li, Mark Wade Moore, Jing Zhao, Xiang Gao, Cunxiang Ju
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5202.
https://doi.org/10.1158/1538-7445.AM2023-5202
Published: 04 April 2023
View article titled, Abstract 5202: NCG-M humanized mice: an excellent model for human immune reconstitution of myeloid lineages
Journal Articles

Abstract 5201: TNFR2 humanized mice: an ideal model for studying anti-TNFR2 antibodies

Huiyi Wang, Ying Li, Mingkun Zhang, Xu Su, Santi Suryani Chen, Zhiying Li, Mark Wade Moore, Jing Zhao, Xiang Gao, Cunxiang Ju
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5201.
https://doi.org/10.1158/1538-7445.AM2023-5201
Published: 04 April 2023
View article titled, Abstract 5201: TNFR2 humanized mice: an ideal model for studying anti-TNFR2 antibodies
Journal Articles

Abstract 5199: B7-H3 & PD-L1 double-humanized BALB/c mouse: a novel animal model for preclinical studies of human B7-H3 antibodies or bispecific antibodies

Shiying Guo, Lingyu Song, Xin Qin, Jianming Xu, Hongyan Sun, Cunxiang Ju, Hongyu Wang, Santi Suryani Chen, Zhiying Li, Mark Wade Moore, Jing Zhao, Xiang Gao
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5199.
https://doi.org/10.1158/1538-7445.AM2023-5199
Published: 04 April 2023
View article titled, Abstract 5199: B7-H3 &amp; PD-L1 double-humanized BALB/c mouse: a novel animal model for preclinical studies of human B7-H3 antibodies or bispecific antibodies
Journal Articles

Abstract 5198: Humanized mice for preclinical efficacy evaluation of drugs targeting GARP

Xing Liu, Meirong Wu, Huiyi Wang, Weiwei Yu, Jianming Xu, Hongyan Sun, Cunxiang Ju, Hongyu Wang, Santi Suryani Chen, Zhiying Li, Mark Wade Moore, Jing Zhao, Xiang Gao
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5198.
https://doi.org/10.1158/1538-7445.AM2023-5198
Published: 04 April 2023
View article titled, Abstract 5198: Humanized mice for preclinical efficacy evaluation of drugs targeting GARP
Journal Articles

Abstract 5197: NCG-hIL2 mice: a novel model to support the development of T regulatory and NK cells

Xinxin Zhang, Meirong Wu, Huiyi Wang, Weiwei Yu, Fang Zhu, Jianming Xu, Hongyan Sun, Hongyu Wang, Cunxiang Ju, Santi Suryani Chen, Zhiying Li, Mark Wade Moore, Jing Zhao, Xiang Gao
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5197.
https://doi.org/10.1158/1538-7445.AM2023-5197
Published: 04 April 2023
View article titled, Abstract 5197: NCG-hIL2 mice: a novel model to support the development of T regulatory and NK cells
Journal Articles

Abstract 5192: NCG-MHC-dKO mice: an excellent model for PBMC reconstitution and pharmacodynamic evaluation in the absence of GvHD

Huiyi Wang, Jun Xing, Jialu Fan, Huanhuan Hou, Santi Suryani Chen, Zhiying Li, Mark Wade Moore, Jing Zhao, Xiang Gao, Cunxiang Ju
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5192.
https://doi.org/10.1158/1538-7445.AM2023-5192
Published: 04 April 2023
View article titled, Abstract 5192: NCG-MHC-dKO mice: an excellent model for PBMC reconstitution and pharmacodynamic evaluation in the absence of GvHD
Journal Articles

Abstract 4472: A mouse model for GvHD: an excellent tool for evaluating the efficacy of anti-GvHD drugs and testing mechanisms of immunoregulation

Meirong Wu, Shiru Zhang, Fang Zhu, Hongyan Sun, Jianming Xu, Cunxiang Ju, Hongyu Wang, Santi Suryani Chen, Zhiying Li, Mark Wade Moore, Jing Zhao, Xiang Gao
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4472.
https://doi.org/10.1158/1538-7445.AM2023-4472
Published: 04 April 2023
View article titled, Abstract 4472: A mouse model for GvHD: an excellent tool for evaluating the efficacy of anti-GvHD drugs and testing mechanisms of immunoregulation