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Journal Articles

Abstract CT117: A phase 1 study of D3S-001, a second-generation GDP-bound KRAS G12C inhibitor, as monotherapy in patients with KRAS G12C-mutated solid tumors

Byoung Chul Cho, Shun Lu, Myung Ah Lee, Zhengbo Song, John Park, Sun Min Lim, Ziming Li, Jun Zhao, Gary Richardson, Yanqiao Zhang, Jun Zhang, Anwen Liu, Cheng Chen, Jia Wang, Jingtao Lu, Haopeng Rui, Qian Chen, Hui Wang, Jing Zhang, Zhi Jian Chen, Tony Mok
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): CT117.
https://doi.org/10.1158/1538-7445.AM2024-CT117
Published: 05 April 2024
View article titled, Abstract CT117: A phase 1 study of D3S-001, a second-generation GDP-bound KRAS G12C inhibitor, as monotherapy in patients with KRAS G12C-mutated solid tumors
Journal Articles

Abstract 5802: An orally available small molecule JMBI-001 elicits MYC-synthetic lethality and anti-tumor immunity by disabling MKLP2-mediated cellular processes

Ting Zhang, Qiong Shi, Julia Kalashova, Xumei Liu, Xiaohu Zhou, Chenglu Yang, Yan Long, Hongmei Li, Jinhua Li, Gang Lv, Duo Yu, Xuejiao Jiang, Shenqiu Zhang, Jing Zhang, Hong Liu, Dun Yang
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 5802.
https://doi.org/10.1158/1538-7445.AM2024-5802
Published: 22 March 2024
View article titled, Abstract 5802: An orally available small molecule JMBI-001 elicits MYC-synthetic lethality and anti-tumor immunity by disabling MKLP2-mediated cellular processes
Journal Articles

Abstract 386: BACH1 is a key regulator of the tumor hypoxia response

Long Chi Nguyen, Christopher Dann, Dongbo Yang, Madeline Henn, Emily Shi, Thomas Li, Letícia Stock, Wenchao Liu, Margarite Matossian, Andrea Valdespino, Yoo Jane Han, Jing Zhang, Geetha Priyanka Yerradoddi, Yan Li, Mitsuyo Matsumoto, Olufunmilayo I. Olopade, Kazuhiko Igarashi, Marsha R. Rosner
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 386.
https://doi.org/10.1158/1538-7445.AM2024-386
Published: 22 March 2024
View article titled, Abstract 386: BACH1 is a key regulator of the tumor hypoxia response
Journal Articles

Abstract 5024: Analytical performance of a genome-wide methylome enrichment platform to detect minimal residual disease from plasma-derived cell-free DNA

Shu Yi Shen, Iulia Cirlan, Felicia Vincelli, Ben Brown, Jun Min, Justin Burgener, Junjun Zhang, Yulia Newton, Margaret Gruca, Abel Licon, Jing Zhang, Anne-Renee Hartman, Alan Williams, Hestia Mellert, Daniel D. De Carvalho
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 5024.
https://doi.org/10.1158/1538-7445.AM2024-5024
Published: 22 March 2024
View article titled, Abstract 5024: Analytical performance of a genome-wide methylome enrichment platform to detect minimal residual disease from plasma-derived cell-free DNA
Journal Articles

Abstract 2427: The development of a tissue-agnostic genome-wide methylome enrichment MRD assay for applications across the cancer care continuum for head and neck malignancies

Geoffrey Liu, Jun Min, Yarong Wang, Justin Burgener, Ben Brown, Karen Budhraja, Junjun Zhang, Owen Hall, Shu Yi Shen, Martha Pienkowski, Shao Hui Huang, Laurie Ailles, Katrina Rey-McIntyre, Jeremy B. Provance, Eduardo Sosa, Cynthia Frye, Scott Bratman, Brian Allen, Joshua T. Jones, Abel Licon, Jing Zhang, Anne-Renee Hartman, Daniel D. De Carvalho
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 2427.
https://doi.org/10.1158/1538-7445.AM2024-2427
Published: 22 March 2024
View article titled, Abstract 2427: The development of a tissue-agnostic genome-wide methylome enrichment MRD assay for applications across the cancer care continuum for head and neck malignancies
Journal Articles

Abstract 115: Developing uPAR CAR T Cells for High-Grade Serous Ovarian Cancer

Zeda Zhang, Xin Fang, Yu-jui Ho, Sascha Haubner, Friederike Kogel, Clemens Hinterleitner, Stella Paffenholz, Kevin Chen, Wei Luan, Amanda Kulick, Gertrude Gunset, Andreina Garcia Angus, Jing Zhang, Zijian Xu, Adam Wang, Qingwen Jiang, Elisa de Stanchina, Britta Weigelt, Dmitriy Zamarin, Aveline Filliol, Judith Feucht, Jorge Mansilla-Soto, Corina Amor, Michel Sadelain, Scott Lowe
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 115.
https://doi.org/10.1158/1538-7445.AM2024-115
Published: 22 March 2024
View article titled, Abstract 115: Developing uPAR CAR T Cells for High-Grade Serous Ovarian Cancer
Journal Articles

Abstract 6503: D3S-001, a second-generation GDP-bound KRAS G12C inhibitor, overcomes nucleotide cycling and demonstrates robust preclinical and clinical activities

Jing Zhang, Sun Min Lim, Mi Ra Yu, Cheng Chen, Jia Wang, Wenqian Wang, Haopeng Rui, Jingtao Lu, Shun Lu, Tony Mok, Zhi Jian Chen, Byoung Chul Cho
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6503.
https://doi.org/10.1158/1538-7445.AM2024-6503
Published: 22 March 2024
View article titled, Abstract 6503: D3S-001, a second-generation GDP-bound KRAS G12C inhibitor, overcomes nucleotide cycling and demonstrates robust preclinical and clinical activities
Journal Articles

Abstract 1030: Development of a genome-wide methylome enrichment platform for multi-cancer early detection (MCED)

Ben H. Park, Shu Yi Shen, Jun Min, Neil Fleshner, Jennifer Knox, Taymaa May, Laurie Ailles, Yulia Newton, Junjun Zhang, Rajat Singhania, Morgan Weichert, Justin Burgener, Iulia Cirlan, Jing Zhang, Yarong Wang, Eduardo Sosa, Angelica Polio, Owen Hall, Sarah Goldberg, Peter Mazzone, Brian Rini, Scott Bratman, Brian Allen, Krystal Brown, Abel Licon, Anne-Renee Hartman, Daniel D. De Carvalho, Geoffrey Liu
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1030.
https://doi.org/10.1158/1538-7445.AM2023-1030
Published: 29 May 2023
View article titled, Abstract 1030: Development of a genome-wide methylome enrichment platform for multi-cancer early detection (MCED)
Journal Articles

ASS1-Mediated Reductive Carboxylation of Cytosolic Glutamine Confers Ferroptosis Resistance in Cancer Cells

Qiangsheng Hu, Jie Dai, Zheng Zhang, Huansha Yu, Jing Zhang, Xinsheng Zhu, Yi Qin, Lele Zhang, Peng Zhang
Journal: Cancer Research
Cancer Res (2023) 83 (10): 1646–1665.
https://doi.org/10.1158/0008-5472.CAN-22-1999
Published: 15 May 2023
View article titled, ASS1-Mediated Reductive Carboxylation of Cytosolic Glutamine Confers Ferroptosis Resistance in Cancer Cells
Open the PDF for ASS1-Mediated Reductive Carboxylation of Cytosolic Glutamine Confers Ferroptosis Resistance in Cancer Cells in another window
Includes: Supplementary data
Journal Articles

Abstract 3286: B-hCD94/hNKG2A mice provide a preclinical tool for evaluating therapeutic antibodies targeting human NKG2A

Chengzhang Shang, Fang He, Mari Kuraguchi, Jing Zhang, Qingcong Lin
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3286.
https://doi.org/10.1158/1538-7445.AM2023-3286
Published: 04 April 2023
View article titled, Abstract 3286: B-hCD94/hNKG2A mice provide a preclinical tool for evaluating therapeutic antibodies targeting human NKG2A
Journal Articles

Abstract 5320: The RenMice™ HiTS (Hyperimmune target specific) Platform facilitates identification of novel therapeutic antibodies for challenging targets

Xiaoqian Zhang, Shufang Fu, Shujin Zhang, Xin Ji, Li Hui, James Jin, Jing Zhang
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5320.
https://doi.org/10.1158/1538-7445.AM2023-5320
Published: 04 April 2023
View article titled, Abstract 5320: The RenMice™ HiTS (Hyperimmune target specific) Platform facilitates identification of novel therapeutic antibodies for challenging targets
Journal Articles

Abstract 5208: Development of immunodeficient mice expressing human IL3, GM-CSF, CSF1 and THPO for improved human myeloid and lymphoid cell reconstitution

Ruili Lv, Yanhui Nie, Jing Zhang, Jenna Frame, Qiang Liu, James Jin
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5208.
https://doi.org/10.1158/1538-7445.AM2023-5208
Published: 04 April 2023
View article titled, Abstract 5208: Development of immunodeficient mice expressing human IL3, GM-CSF, CSF1 and THPO for improved human myeloid and lymphoid cell reconstitution
Journal Articles

Abstract 3099: Hnd-01: a potent inhibitor of wild type mutant BTK

Jing Zhang, Ahmed A. Samatar, Yue Tan, Shiqing Pi, Zhigang Zhou, Yan Xu, Daihong Yang
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3099.
https://doi.org/10.1158/1538-7445.AM2023-3099
Published: 04 April 2023
View article titled, Abstract 3099: Hnd-01: a potent inhibitor of wild type mutant BTK
Journal Articles

Abstract 5501: Vertical inhibition of the MAPK pathway with D3S-002, a potent and selective ERK1/2 inhibitor, to improve anti-tumor activity of and overcome resistance to KRAS G12C inhibitors

Jing Zhang, Jingtao Lu, Zhiqiang Zheng, Jiang Lu, Allison Wang, Jia Wang, Janet Chen, Haopeng Rui, Cheng Chen, Zhi Jian Chen
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5501.
https://doi.org/10.1158/1538-7445.AM2023-5501
Published: 04 April 2023
View article titled, Abstract 5501: Vertical inhibition of the MAPK pathway with D3S-002, a potent and selective ERK1/2 inhibitor, to improve anti-tumor activity of and overcome resistance to KRAS G12C inhibitors
Journal Articles

Abstract 6436: 1C3, a novel non-blocking anti-human TNFR2 antibody, promotes effector T cell responses and demonstrates potent anti-tumor activity

Yongfei Yang, Shuzhen Cao, Wenjiao Zhang, Jing Zhang, Zhe Shao, Xueyuan Jiang, Qingya Duan, Maopeng Tian, Sen Mei, Zhaoxue Yu
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 6436.
https://doi.org/10.1158/1538-7445.AM2023-6436
Published: 04 April 2023
View article titled, Abstract 6436: 1C3, a novel non-blocking anti-human TNFR2 antibody, promotes effector T cell responses and demonstrates potent anti-tumor activity
Journal Articles

Abstract OT2-16-04: KN026 in combination with docetaxel as neoadjuvant treatment for HER2-positive early or locally advanced breast cancer: A single arm, multicenter, phase 2 study

Jiong Wu, Benlong Yang, Linxiaoxi Ma, Mingliang Zhang, Kun Wang, Yiding Chen, Zhimin Fan, Jing Zhang, Summer Xia
Journal: Cancer Research
Cancer Res (2023) 83 (5_Supplement): OT2-16-04.
https://doi.org/10.1158/1538-7445.SABCS22-OT2-16-04
Published: 01 March 2023
View article titled, Abstract OT2-16-04: KN026 in combination with docetaxel as neoadjuvant treatment for HER2-positive early or locally advanced breast cancer: A single arm, multicenter, phase 2 study
Journal Articles

CYP4F2-Catalyzed Metabolism of Arachidonic Acid Promotes Stromal Cell-Mediated Immunosuppression in Non–Small Cell Lung Cancer

Xuehan Chen, Yanzhuo Liu, Yang Wang, Chenlong Wang, Xuewei Chen, Yu Xiong, Lilong Liu, Xi Yuan, Honglin Tang, Chong Shu, Jing Zhang, Austin M. Guo, Honglei Chen, Jing Yang
Journal: Cancer Research
Cancer Res (2022) 82 (21): 4016–4030.
https://doi.org/10.1158/0008-5472.CAN-21-4029
Published: 02 November 2022
View article titled, CYP4F2-Catalyzed Metabolism of Arachidonic Acid Promotes Stromal Cell-Mediated Immunosuppression in Non–Small Cell Lung Cancer
Open the PDF for CYP4F2-Catalyzed Metabolism of Arachidonic Acid Promotes Stromal Cell-Mediated Immunosuppression in Non–Small Cell Lung Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract CT544: Multi-omics analysis uncovers prognostic biomarkers and tumor ecosystem dynamics during toripalimab combined with nab-paclitaxel and s-1 as neoadjuvant therapy for esophageal squamous carcinoma: A single-center, open-label, single-arm phase 2 trial

Guoqing Zhang, Jing Yuan, Chaohu Pan, Qing Xu, Xiaoli Cui, Jing Zhang, Minglu Liu, Zhigang Song, Liangliang Wu, Dongfang Wu, Bo Yang, Haitao Luo, Yi Hu, Shunchang Jiao
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): CT544.
https://doi.org/10.1158/1538-7445.AM2022-CT544
Published: 15 June 2022
View article titled, Abstract CT544: Multi-omics analysis uncovers prognostic biomarkers and tumor ecosystem dynamics during toripalimab combined with nab-paclitaxel and s-1 as neoadjuvant therapy for esophageal squamous carcinoma: A single-center, open-label, single-arm phase 2 trial
Journal Articles

Abstract 2907: 1C3, a Novel non-blocking anti-human TNFR2 antibody generated from RenMice, exhibits promising anti-tumor activity and safety in syngeneic tumor models in humanized TNFR2 mice

Yongfei Yang, Shuzhen Cao, Jing Zhang, Zhe Shao, Xueyuan Jiang, Qingya Duan, Maopeng Tian, Sen Mei, Luke (Zhaoxue) Yu
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2907.
https://doi.org/10.1158/1538-7445.AM2022-2907
Published: 15 June 2022
View article titled, Abstract 2907: 1C3, a Novel non-blocking anti-human TNFR2 antibody generated from RenMice, exhibits promising anti-tumor activity and safety in syngeneic tumor models in humanized TNFR2 mice
Journal Articles

Abstract LB538: Characterization of GB263T, a tri-specific antibody against EGFR/cMET/cMET for NSCLC

Qinglin Du, Wengang Zeng, Xueyan Yang, Liwen Liang, Xueqin Li, Yan Li, Yiqi Cao, Zongjun Xia, Jing Zhang, Qian Ding, Shuhua Han
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): LB538.
https://doi.org/10.1158/1538-7445.AM2022-LB538
Published: 15 June 2022
View article titled, Abstract LB538: Characterization of GB263T, a tri-specific antibody against EGFR/cMET/cMET for NSCLC