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Journal Articles

PICH Activates Cyclin A1 Transcription to Drive S-Phase Progression and Chemoresistance in Gastric Cancer

Huili Ye, Wengui Shi, Jing Yang, Long Wang, Xiangyan Jiang, Huiming Zhao, Long Qin, Junjie Qin, Lianshun Li, Weiwen Cai, Junhong Guan, Hanteng Yang, Huinian Zhou, Zeyuan Yu, Hui Sun, Zuoyi Jiao
Journal: Cancer Research
Cancer Res (2023) 83 (22): 3767–3782.
https://doi.org/10.1158/0008-5472.CAN-23-1331
Published: 15 November 2023
View article titled, PICH Activates Cyclin A1 Transcription to Drive S-Phase Progression and Chemoresistance in Gastric Cancer
Open the PDF for PICH Activates Cyclin A1 Transcription to Drive S-Phase Progression and Chemoresistance in Gastric Cancer in another window
Includes: Supplementary data
Journal Articles

ANO1 Reprograms Cholesterol Metabolism and the Tumor Microenvironment to Promote Cancer Metastasis

Chun-Miao Deng, Guo-Geng Zhang, Qin-Wen Liu, Jiao-Jiao Xu, Zhi-Chao Liu, Jing Yang, Tao-Yang Xu, Zhi-Gang Li, Fan Zhang, Bin Li
Journal: Cancer Research
Cancer Res (2023) 83 (11): 1851–1865.
https://doi.org/10.1158/0008-5472.CAN-22-3490
Published: 02 June 2023
View article titled, ANO1 Reprograms Cholesterol Metabolism and the Tumor Microenvironment to Promote Cancer Metastasis
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Includes: Supplementary data
Journal Articles

Abstract 6140: Caspase-3 mediated cleavage of GSDME enhances the antitumor efficacy of HER2-targeted therapy in HER2-positive gastric cancer

Qiuyun Luo, Zengfei Xia, Jing Yang, Wentao Pan, Fan Luo, Jiaxin Cao, Yuting Sun, Liqiong Yang, Lin Zhang, Miaozhen Qiu, Dajun Yang
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 6140.
https://doi.org/10.1158/1538-7445.AM2023-6140
Published: 04 April 2023
View article titled, Abstract 6140: Caspase-3 mediated cleavage of GSDME enhances the antitumor efficacy of HER2-targeted therapy in HER2-positive gastric cancer
Journal Articles

Abstract 1863: Evaluation of BDB101, a first-in-class TLR7/8 dual agonist conjugated to an anti-PD-L1 mAb, in cancer treatment

Jing Yang, Robert H. Andtbacka, Walter Lau, Lixin Li
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1863.
https://doi.org/10.1158/1538-7445.AM2023-1863
Published: 04 April 2023
View article titled, Abstract 1863: Evaluation of BDB101, a first-in-class TLR7/8 dual agonist conjugated to an anti-PD-L1 mAb, in cancer treatment
Journal Articles

KDM6A Loss Recruits Tumor-Associated Neutrophils and Promotes Neutrophil Extracellular Trap Formation in Pancreatic Cancer

Jing Yang, Lin Jin, Hong Sun Kim, Feng Tian, Zhujun Yi, Karan Bedi, Mats Ljungman, Marina Pasca di Magliano, Howard Crawford, Jiaqi Shi
Journal: Cancer Research
Cancer Res (2022) 82 (22): 4247–4260.
https://doi.org/10.1158/0008-5472.CAN-22-0968
Published: 15 November 2022
View article titled, KDM6A Loss Recruits Tumor-Associated Neutrophils and Promotes Neutrophil Extracellular Trap Formation in Pancreatic Cancer
Open the PDF for KDM6A Loss Recruits Tumor-Associated Neutrophils and Promotes Neutrophil Extracellular Trap Formation in Pancreatic Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract C037: KMT2D loss in pancreatic cancer cells leads to an immunosuppressive tumor microenvironment by upregulating the interferon and inflammatory response pathways

Hong S. Kim, Jing Yang, Shuang Lu, Marina Pasca di Magliano, Kai Ge, Jiaqi Shi
Journal: Cancer Research
Cancer Res (2022) 82 (22_Supplement): C037.
https://doi.org/10.1158/1538-7445.PANCA22-C037
Published: 15 November 2022
View article titled, Abstract C037: KMT2D loss in pancreatic cancer cells leads to an immunosuppressive tumor microenvironment by upregulating the interferon and inflammatory response pathways
Journal Articles

CYP4F2-Catalyzed Metabolism of Arachidonic Acid Promotes Stromal Cell-Mediated Immunosuppression in Non–Small Cell Lung Cancer

Xuehan Chen, Yanzhuo Liu, Yang Wang, Chenlong Wang, Xuewei Chen, Yu Xiong, Lilong Liu, Xi Yuan, Honglin Tang, Chong Shu, Jing Zhang, Austin M. Guo, Honglei Chen, Jing Yang
Journal: Cancer Research
Cancer Res (2022) 82 (21): 4016–4030.
https://doi.org/10.1158/0008-5472.CAN-21-4029
Published: 02 November 2022
View article titled, CYP4F2-Catalyzed Metabolism of Arachidonic Acid Promotes Stromal Cell-Mediated Immunosuppression in Non–Small Cell Lung Cancer
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Includes: Supplementary data
Journal Articles

Anti-HIV Drug Elvitegravir Suppresses Cancer Metastasis via Increased Proteasomal Degradation of m6A Methyltransferase METTL3

Long Liao, Yan He, Shu-Jun Li, Guo-Geng Zhang, Wei Yu, Jing Yang, Zi-Jia Huang, Can-Can Zheng, Qing-Yu He, Yan Li, Bin Li
Journal: Cancer Research
Cancer Res (2022) 82 (13): 2444–2457.
https://doi.org/10.1158/0008-5472.CAN-21-4124
Published: 05 July 2022
View article titled, Anti-HIV Drug Elvitegravir Suppresses Cancer Metastasis via Increased Proteasomal Degradation of m<sup>6</sup>A Methyltransferase METTL3
Open the PDF for Anti-HIV Drug Elvitegravir Suppresses Cancer Metastasis via Increased Proteasomal Degradation of m<sup>6</sup>A Methyltransferase METTL3 in another window
Includes: Supplementary data
Journal Articles

Abstract 5018: A comprehensive analysis of genomic determinants of response to immune checkpoint inhibitor-based immunotherapy

Jing Yang, Qi Liu, Yu Shyr
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5018.
https://doi.org/10.1158/1538-7445.AM2022-5018
Published: 15 June 2022
View article titled, Abstract 5018: A comprehensive analysis of genomic determinants of response to immune checkpoint inhibitor-based immunotherapy
Journal Articles

Abstract 3641: Age-related changes in microenvironmental collagen affect ovarian cancer metastasis

Elizabeth Harper, Elizabeth Agadi, Emma Sheedy, Preston Carey, Paul Wilkinson, Michael Siroky, Tyvette Hilliard, Ethan Low, Annemarie Leonard, Yueying Liu, Jing Yang, M. Sharon Stack
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3641.
https://doi.org/10.1158/1538-7445.AM2022-3641
Published: 15 June 2022
View article titled, Abstract 3641: Age-related changes in microenvironmental collagen affect ovarian cancer metastasis
Journal Articles

Abstract 2189: The role of generational obesity on the ovarian metastatic niche

Tyvette Hilliard, Phillip Petrasko, Yueying Liu, Jing Yang, Marwa Asem, Jeff Johnson, Gifty Marfowaa, Brooke Kowalski, Elinor Schnautz, Morgan McCabe, M. Sharon Stack
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2189.
https://doi.org/10.1158/1538-7445.AM2022-2189
Published: 15 June 2022
View article titled, Abstract 2189: The role of generational obesity on the ovarian metastatic niche
Journal Articles

Abstract P2-13-10: First-in-human HER2-targeted bispecific antibody KN026 for the treatment of patients with HER2-positive metastatic breast cancer: Results from a phase I study

Jian Zhang, Dongmei Ji, Li Cai, Herui Yao, Min Yan, Xiaojia Wang, Weina Shen, Yiqun Du, Hui Pang, Xiuping Lai, Huiai Zeng, Jian Huang, Yan Sun, Xinxin Peng, Junfang Xu, Jing Yang, Fei Yang, Ting Xu, Xichun Hu
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P2-13-10.
https://doi.org/10.1158/1538-7445.SABCS21-P2-13-10
Published: 15 February 2022
View article titled, Abstract P2-13-10: First-in-human HER2-targeted bispecific antibody KN026 for the treatment of patients with HER2-positive metastatic breast cancer: Results from a phase I study
Journal Articles

A Pan-Cancer Immunogenomic Atlas for Immune Checkpoint Blockade Immunotherapy

Jing Yang, Shilin Zhao, Jing Wang, Quanhu Sheng, Qi Liu, Yu Shyr
Journal: Cancer Research
Cancer Res (2022) 82 (4): 539–542.
https://doi.org/10.1158/0008-5472.CAN-21-2335
Published: 15 February 2022
View article titled, A Pan-Cancer Immunogenomic Atlas for Immune Checkpoint Blockade Immunotherapy
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Includes: Supplementary data
Journal Articles

Abstract PO-125: The role of KDM6A in pancreatic cancer immune microenvironment

Lin Jin, Jing Yang, Zhujun Yi, Hong S. Kim, Feng Tian, Jiaqi Shi
Journal: Cancer Research
Cancer Res (2021) 81 (22_Supplement): PO-125.
https://doi.org/10.1158/1538-7445.PANCA21-PO-125
Published: 15 November 2021
View article titled, Abstract PO-125: The role of KDM6A in pancreatic cancer immune microenvironment
Journal Articles

Abstract CT213: NEON-1: a first-in-human phase I open-label study of ALPN-202, a conditional CD28 costimulator and dual checkpoint inhibitor, in advanced malignancies

Mark Voskoboynik, Justin C. Moser, Nehal Lakhani, Michael Millward, Diwakar Davar, Wael A. Harb, Jing Yang, Gary Means, Kristi Manjarrez, Almudena Tercero, Hany Zayed, Jan Hillson, Christine Dela Cruz, Graciela Perez, Stanford L. Peng
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): CT213.
https://doi.org/10.1158/1538-7445.AM2021-CT213
Published: 01 July 2021
View article titled, Abstract CT213: NEON-1: a first-in-human phase I open-label study of ALPN-202, a conditional CD28 costimulator and dual checkpoint inhibitor, in advanced malignancies
Journal Articles

Abstract 1660: Preliminary safety tolerability & efficacy results of KN046 (an anti-PD-L1/CTLA-4 bispecific antibody) in combination with Nab-paclitaxel in patients with metastatic triple-negative breast cancer (mTNBC)

Binghe Xu, Qiao Li, Qingyuan Zhang, Yue Zhang, Quchang Ouyang, Yang Zhang, Qiang Liu, Tao Sun, June Xu, Jing Yang, Yue Yang, Xin Luo, Paul Kong, Ting Xu
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1660.
https://doi.org/10.1158/1538-7445.AM2021-1660
Published: 01 July 2021
View article titled, Abstract 1660: Preliminary safety tolerability &amp; efficacy results of KN046 (an anti-PD-L1/CTLA-4 bispecific antibody) in combination with Nab-paclitaxel in patients with metastatic triple-negative breast cancer (mTNBC)
Journal Articles

Abstract 1740: Engineered variant domain fusion proteins provide checkpoint inhibition and tumor antigen dependent CD28 costimulation resulting in potent anti-tumor immunity

Steven D. Levin, Mark F. Maurer, Chelsea Gudgeon, Siddarth Chandrasekaran, Daniel Ardourel, Daniel Demonte, Joseph Kuijper, Martin Wolfson, Logan Garrett, Kayla N. Kleist, Sherri Mudri, Hieu Nguyen, Michelle Seaberg, Rachel Wang, Jing Yang, Katherine E. Lewis, Stacey R. Dillon, Mark Rixon, Stanford L. Peng
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1740.
https://doi.org/10.1158/1538-7445.AM2021-1740
Published: 01 July 2021
View article titled, Abstract 1740: Engineered variant domain fusion proteins provide checkpoint inhibition and tumor antigen dependent CD28 costimulation resulting in potent anti-tumor immunity
Journal Articles

MDMX Recruits UbcH5c to Facilitate MDM2 E3 Ligase Activity and Subsequent p53 Degradation In Vivo

Jing Yang, Aiwen Jin, Jing Han, Xin Chen, Junnian Zheng, Yanping Zhang
Journal: Cancer Research
Cancer Res (2021) 81 (4): 898–909.
https://doi.org/10.1158/0008-5472.CAN-20-0790
Published: 15 February 2021
View article titled, MDMX Recruits UbcH5c to Facilitate MDM2 E3 Ligase Activity and Subsequent p53 Degradation <em>In Vivo</em>
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Journal Articles

Abstract 3022: Using translational tumor growth inhibition modeling approach and population PK analysis to predict efficacious doses for KN026, a HER2 bispecific antibody

Dongmei Ji, Yuan Xiong, Jing Yang, Pilin Wang, Jiarong Wang, Fei Yang, Junfang Xu
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 3022.
https://doi.org/10.1158/1538-7445.AM2020-3022
Published: 15 August 2020
View article titled, Abstract 3022: Using translational tumor growth inhibition modeling approach and population PK analysis to predict efficacious doses for KN026, a HER2 bispecific antibody
Journal Articles

Abstract CT406: Patients with cancer appear more vulnerable to SARS-COV-2: A multi-center study during the COVID-19 outbreak

Meng-Yuan Dai, Dian-bo Liu, Miao Liu, Fu-Xiang Zhou, Gui-Ling Li, Zhen Chen, Zhi-An Zhang, Hua-You Md, Meng Wu, Qi-Chao Zheng, Yong Xiong, Hui-Hua Xiong, Chun Wang, Chang-Chun Chen, Fei Xiong, Yan Zhang, Ya-Qin Peng, Si-Ping Ge, Bo Zhen, Ting-Ting Yu, Ling Wang, Hua Wang, Yu Liu, Ye-Shan Chen, Jun-Hua Mei, Xiao-Jia Gao, Zhu-Yan Li, Li-Juan Gan, Can He, Zhen Li, Yu-Ying Shi, Yu-Wen Qi, Jing Yang, Daniel G. Tenen, Li Chai, Lorelei Ann Mucci, Mauricio Santillana, Hongbing Cai
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): CT406.
https://doi.org/10.1158/1538-7445.AM2020-CT406
Published: 15 August 2020
View article titled, Abstract CT406: Patients with cancer appear more vulnerable to SARS-COV-2: A multi-center study during the COVID-19 outbreak