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Journal Articles

Comprehensive Target Engagement by the EZH2 Inhibitor Tulmimetostat Allows for Targeting of ARID1A Mutant Cancers

Patricia J. Keller, Elizabeth J. Adams, Rentian Wu, Alexandre Côté, Shilpi Arora, Nico Cantone, Rosana Meyer, Jennifer A. Mertz, Victor Gehling, Jike Cui, Jacob I. Stuckey, Avinash Khanna, Feng Zhao, Zehua Chen, Ziyang Yu, Richard T. Cummings, Mohammed Taimi, Nehal J. Lakhani, Drew Rasco, Martin Gutierrez, Linda Duska, Michael Devitt, Ronda Rippley, Julian Levell, Jennifer Truong, Jing Wang, Kaiming Sun, Patrick Trojer
Journal: Cancer Research
Cancer Res (2024) 84 (15): 2501–2517.
https://doi.org/10.1158/0008-5472.CAN-24-0398
Published: 01 August 2024
View article titled, Comprehensive Target Engagement by the EZH2 Inhibitor Tulmimetostat Allows for Targeting of <em>ARID1A</em> Mutant Cancers
Open the PDF for Comprehensive Target Engagement by the EZH2 Inhibitor Tulmimetostat Allows for Targeting of <em>ARID1A</em> Mutant Cancers in another window
Includes: Supplementary data
Journal Articles

DNA of Neutrophil Extracellular Traps Binds TMCO6 to Impair CD8+ T-cell Immunity in Hepatocellular Carcinoma

Mengjia Song, Chaoqi Zhang, Shaoyan Cheng, Dijun Ouyang, Yu Ping, Jieying Yang, YaoJun Zhang, Yan Tang, Hao Chen, Qi-jing Wang, Yong-qiang Li, Jia He, Tong Xiang, Yizhuo Zhang, Jian-Chuan Xia
Journal: Cancer Research
Cancer Res (2024) 84 (10): 1613–1629.
https://doi.org/10.1158/0008-5472.CAN-23-2986
Published: 15 May 2024
View article titled, DNA of Neutrophil Extracellular Traps Binds TMCO6 to Impair CD8<sup>+</sup> T-cell Immunity in Hepatocellular Carcinoma
Open the PDF for DNA of Neutrophil Extracellular Traps Binds TMCO6 to Impair CD8<sup>+</sup> T-cell Immunity in Hepatocellular Carcinoma in another window
Includes: Supplementary data
Journal Articles

Abstract PO2-18-12: Updated Results of a Phase II Study: Neoadjuvant Inetetamab Combined with Pertuzumab, Paclitaxel and Carboplatin for Locally Advanced HER2-Positive Breast Cancer

Yue Chai, Jiaxuan Liu, Mingxia Jiang, Maiyue He, Xin Wang, Yipeng Wang, Xue Yang, Jing Wang, Binghe Xu, Qiao Li
Journal: Cancer Research
Cancer Res (2024) 84 (9_Supplement): PO2-18-12.
https://doi.org/10.1158/1538-7445.SABCS23-PO2-18-12
Published: 02 May 2024
View article titled, Abstract PO2-18-12: Updated Results of a Phase II Study: Neoadjuvant Inetetamab Combined with Pertuzumab, Paclitaxel and Carboplatin for Locally Advanced HER2-Positive Breast Cancer
Journal Articles

Abstract PO3-15-03: Abemaciclib is effective in palbociclib resistant estrogen receptor positive breast cancers

Juliana Navarro-Yepes, Nicole Kettner, Xiayu Rao, Tuyen Bui, Cassandra Bishop, Hannah Wingate, Akshara Singareeka Raghavendra, Yan Wang, Jing Wang, Aysegul Sahin, Funda Meric-Bernstam, Kelly Hunt, Senthil Damodaran, Debu Tripathy, Khandan Keyomarsi
Journal: Cancer Research
Cancer Res (2024) 84 (9_Supplement): PO3-15-03.
https://doi.org/10.1158/1538-7445.SABCS23-PO3-15-03
Published: 02 May 2024
View article titled, Abstract PO3-15-03: Abemaciclib is effective in palbociclib resistant estrogen receptor positive breast cancers
Journal Articles

Abstract PO1-06-05: Heterogeneity and prognostic characteristics of HER2-low breast cancer: A retrospective analysis of patients with HER2-negative metastatic breast cancer

Huimin Lv, Min Yan, Mengwei Zhang, Limin Niu, Huiai Zeng, Huihui Sun, Shengnan Zhao, Jing Wang
Journal: Cancer Research
Cancer Res (2024) 84 (9_Supplement): PO1-06-05.
https://doi.org/10.1158/1538-7445.SABCS23-PO1-06-05
Published: 02 May 2024
View article titled, Abstract PO1-06-05: Heterogeneity and prognostic characteristics of HER2-low breast cancer: A retrospective analysis of patients with HER2-negative metastatic breast cancer
Journal Articles

Abstract PO2-09-05: Building genomic and transcriptomic data among African American and Black patients with triple-negative inflammatory breast cancer

Wencai Ma, Li Zhao, Gayathri Devi, Savitri Krishnamurthy, Larry Coffer, Angela Alexander, Megumi Kai, Xiaoping Wang, Huong Le-Petross, Miral Patel, Bisrat Debeb, Chandra Bartholomeusz, Jianhua Zhang, Xingzhi Song, Andrew Futreal, Naoto Ueno, Rachel Layman, Anthony Lucci, Jing Wang, Wendy Woodward
Journal: Cancer Research
Cancer Res (2024) 84 (9_Supplement): PO2-09-05.
https://doi.org/10.1158/1538-7445.SABCS23-PO2-09-05
Published: 02 May 2024
View article titled, Abstract PO2-09-05: Building genomic and transcriptomic data among African American and Black patients with triple-negative inflammatory breast cancer
Journal Articles

Abstract PO2-05-01: Famitinib, a multi-targeted receptor tyrosine kinase inhibitor, combined with dalpicilib and fulvestrant in advanced HR-positive and HER2-negative breast cancer

Min Yan, Mengwei Zhang, Limin Niu, Huimin Lv, Zhenzhen Liu, Huiai Zeng, Shengnan Zhao, Huihui Sun, Jing Wang, Yajing Feng, Huajun Li
Journal: Cancer Research
Cancer Res (2024) 84 (9_Supplement): PO2-05-01.
https://doi.org/10.1158/1538-7445.SABCS23-PO2-05-01
Published: 02 May 2024
View article titled, Abstract PO2-05-01: Famitinib, a multi-targeted receptor tyrosine kinase inhibitor, combined with dalpicilib and fulvestrant in advanced HR-positive and HER2-negative breast cancer
Journal Articles

Abstract CT246: Open-label, single-arm, multicenter, phase 2 trial of garsorasib in KRAS G12C-mutated non-small-cell lung cancer

Ziming Li, Xiaomin Dang, Dingzhi Huang, Shi Jin, Weiwei Li, Jianhua Shi, Xicheng Wang, Yiping Zhang, Zhengbo Song, Junping Zhang, Wu Zhuang, Xuewen Liu, Liyan Jiang, Xiangjiao Meng, Mingfang Zhao, Jianying Zhou, Liangming Zhang, Pingli Wang, Hui Luo, Junquan Yang, Shundong Cang, Xiang Wang, Jing Wang, Jiuwei Cui, Yan Yu, Zhihong Zhang, Junguo Lu, Weihua Yang, Gaofeng Li, Jifeng Feng, Dongqing Lv, Lin Wu, Yong Fang, Yan Wang, Yanqiu Zhao, Baoshan Cao, Wei Zhu, Zhixiang Zhuang, Qingshan Li, Mingxi Wang, Huan Zhou, Xiaorong Dong, Sheng Hu, Jian Fang, Yihong Zhang, Wenjia Wang, Ziyong Xiang, Zhe Shi, Ling Zhang, Shun Lu
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): CT246.
https://doi.org/10.1158/1538-7445.AM2024-CT246
Published: 05 April 2024
View article titled, Abstract CT246: Open-label, single-arm, multicenter, phase 2 trial of garsorasib in KRAS G12C-mutated non-small-cell lung cancer
Journal Articles

Abstract 6646: Investigating the combination of radiation and subsequent immune checkpoint inhibitor treatment in head and neck squamous cell carcinoma models

Hanne Lind, Alexander Strait, Spencer Hall, Jack B. Goon, John D. Aleman, Samantha Chen, Philip Owens, Jing H. Wang, Christian Young, Xiao-Jing Wang
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6646.
https://doi.org/10.1158/1538-7445.AM2024-6646
Published: 22 March 2024
View article titled, Abstract 6646: Investigating the combination of radiation and subsequent immune checkpoint inhibitor treatment in head and neck squamous cell carcinoma models
Journal Articles

Abstract 5864: YAP1 defines a highly plastic, persister cell population in small cell lung cancer (SCLC) following relapse

C. Allison Stewart, Sarah M. Groves, Runsheng Wang, Kavya Ramkumar, Yuanxin Xi, Lixia Diao, Alejandra G. Serrano, Azusa Tanimoto, Ashley M. Victorian, Sayantan Bhattacharyya, Alexa J. Halliday, Neda Kalhor, Luisa Maren Soto, Pedro Filipe Da Rocha, Natalie Vokes, Loukia G. Karacosta, Jing Wang, John V. Heymach, Vito Quaranta, Bonnie Glisson, Lauren Averett Byers, Carl M. Gay
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 5864.
https://doi.org/10.1158/1538-7445.AM2024-5864
Published: 22 March 2024
View article titled, Abstract 5864: YAP1 defines a highly plastic, persister cell population in small cell lung cancer (SCLC) following relapse
Journal Articles

Abstract 1962: PH009-1, a highly potent, selective and brain-penetrable fourth-generation EGFR-TKI that overcome classic and resistant EGFR mutations in NSCLC

Feng Gao, Jing Wang, Bin Liu, Yongyong Wu, Liandong Jing, Pengzhi Zhang, Yu Gao, Zhizhong Li, Yongqi Guo
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1962.
https://doi.org/10.1158/1538-7445.AM2024-1962
Published: 22 March 2024
View article titled, Abstract 1962: PH009-1, a highly potent, selective and brain-penetrable fourth-generation EGFR-TKI that overcome classic and resistant EGFR mutations in NSCLC
Journal Articles

Abstract 743: Using a novel NextGen linker system to generate a conditionally active biologic (CAB) anti-nectin4-ADC demonstrates improved efficacy in pancreatic PDX cancer models and improved tolerability and toxicity profile in non-human primates

Jing Wang, Jian Chen, Gerhard Frey, Haizhen Liu, Charles Xing, Kathryn Woodard, Hwai Chang, William J. Boyle, Jay M. Short
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 743.
https://doi.org/10.1158/1538-7445.AM2024-743
Published: 22 March 2024
View article titled, Abstract 743: Using a novel NextGen linker system to generate a conditionally active biologic (CAB) anti-nectin4-ADC demonstrates improved efficacy in pancreatic PDX cancer models and improved tolerability and toxicity profile in non-human primates
Journal Articles

Abstract 1084: Preclinical testing of a cell adhesion molecule 1 (CADM1) targeting antibody-drug conjugate in osteosarcoma and other pediatric solid tumor models

Zhongting Zhang, Yifei Wang, Wendong Zhang, Xiangjun Tian, Qi Wang, Rossana N Lazcano Segura, Michael Roth, Jonathan Gill, Douglas Harrison, Zhaohui Xu, Yianhua Yi, Sylvester Jusu, Giuseppe Longo, Xin Zhou, Jing Wang, Richard Gorlick
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1084.
https://doi.org/10.1158/1538-7445.AM2024-1084
Published: 22 March 2024
View article titled, Abstract 1084: Preclinical testing of a cell adhesion molecule 1 (CADM1) targeting antibody-drug conjugate in osteosarcoma and other pediatric solid tumor models
Journal Articles

Abstract 5061: Improved survival and unique mutational signatures in small cell lung cancer arising in patients with limited tobacco use

Kyle Concannon, Moushumi Sahu, Whitney Lewis, Hai Tran, Lixia Diao, Yuanxin Xi, Benjamin Morris, Simon Heeke, Ximing Tang, John Stewart, Ivan Valiev, Gabriela Raso, Jing Wang, Koji Sasaki, Carl Gay, John Heymach, Lauren Byers
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 5061.
https://doi.org/10.1158/1538-7445.AM2024-5061
Published: 22 March 2024
View article titled, Abstract 5061: Improved survival and unique mutational signatures in small cell lung cancer arising in patients with limited tobacco use
Journal Articles

Abstract 1148: Multimodal spatial transcriptomics and proteomics analysis of the resectable NSCLC ecosystem following neoadjuvant chemoimmunotherapy

Zahraa Rahal, Tieling Zhou, Sujuan Yang, Alejandra Serrano, Jiping Feng, Ansam Sinjab, John T. Le, Xin Sun, Michael Wang, Wei Hu, Jianjun Zang, Tullia Bruno, Hai T. Tran, Stephen G. Swisher, Cheuk Hong Leung, Heather Y. Lin, J. Jack Lee, Jing Wang, John Victor Heymach, Don Lynn Gibbons, Ignacio Ivan Wistuba, Annikka Weissferdt, Jared K. Burks, Luisa Maren Solis Soto, Humam Kadara, Tina Cascone
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1148.
https://doi.org/10.1158/1538-7445.AM2024-1148
Published: 22 March 2024
View article titled, Abstract 1148: Multimodal spatial transcriptomics and proteomics analysis of the resectable NSCLC ecosystem following neoadjuvant chemoimmunotherapy
Journal Articles

Abstract 1929: Acquired resistance to sotorasib in KRASG12C mutant NSCLC is vulnerable to PI3K-mTOR pathway inhibition and regulated by 4E-BP1

Ismail M. Meraz, Shuhong Wu, Mourad Majidi, Chenghui Ren, Yi Xu, Feng Meng, Lihui Gao, Renduo Song, Ran Zhang, Bingliang Fang, Qi Wang, Yuanxin Xi, Jing Wang, Sung Yun Jung, Jack A. Roth
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1929.
https://doi.org/10.1158/1538-7445.AM2024-1929
Published: 22 March 2024
View article titled, Abstract 1929: Acquired resistance to sotorasib in KRAS<sup>G12C</sup> mutant NSCLC is vulnerable to PI3K-mTOR pathway inhibition and regulated by 4E-BP1
Journal Articles

Abstract 1424: Epigenetic activation of tumoral IFNγresponse and pyroptosis overcomes immunotherapy resistance in hepatocellular carcinoma

Yalin Tu, Haoran Wu, Chengpeng Zhong, Zhewen Xiong, Jing Wang, Patrick Pak-Chun Wong, Weiqin Yang, Jiahuan Lu, Zhixian Liang, Shufen Chen, Lingyun Zhang, Siyun Chen, Jingying Zhou, Ka-Fai To, Joseph Jao-Yiu Sung, Stephen Lam Chan, David Kerr, Nick La Thangue, Alfred Sze-Lok Cheng
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1424.
https://doi.org/10.1158/1538-7445.AM2024-1424
Published: 22 March 2024
View article titled, Abstract 1424: Epigenetic activation of tumoral IFNγresponse and pyroptosis overcomes immunotherapy resistance in hepatocellular carcinoma
Journal Articles

Abstract 1420: Mechanism of NPRL2 gene therapy induced antitumor immunity in KRAS/STK11mt aPD1 resistant metastatic NSCLC

Ismail M. Meraz, Mourad Majidi, Renduo Song, Feng Meng, Lihui Gao, Qi Wang, Jing Wang, Elizabeth Shpall, Jack A. Roth
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1420.
https://doi.org/10.1158/1538-7445.AM2024-1420
Published: 22 March 2024
View article titled, Abstract 1420: Mechanism of NPRL2 gene therapy induced antitumor immunity in KRAS/STK11<sup>mt</sup> aPD1 resistant metastatic NSCLC
Journal Articles

Abstract 4591: PH020-2: an MTA-cooperative PRMT5 inhibitor with excellent selectivity and brain-penetration capability that targets MTAP-deleted tumors

Feng Gao, Bin Liu, Jing Wang, Liandong Jing, Yongyong Wu, Pengzhi Zhang, Yu Gao, Zhizhong Li, Yongqi Guo
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 4591.
https://doi.org/10.1158/1538-7445.AM2024-4591
Published: 22 March 2024
View article titled, Abstract 4591: PH020-2: an MTA-cooperative PRMT5 inhibitor with excellent selectivity and brain-penetration capability that targets MTAP-deleted tumors
Journal Articles

Abstract 4206: Regional transcriptomic profiling of the head and neck squamous cell carcinoma tumor microenvironment paired with murine models identify extracellular matrix components that mediate tumor progression and immune suppression

John D. Aleman, Khoa A. Nguyen, Erica Wong, Yao Ke, Hanne T. Lind, Clifford G. Tepper, Andrew C. Birkeland, Christian D. Young, Sana D. Karam, Xiao-Jing Wang
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 4206.
https://doi.org/10.1158/1538-7445.AM2024-4206
Published: 22 March 2024
View article titled, Abstract 4206: Regional transcriptomic profiling of the head and neck squamous cell carcinoma tumor microenvironment paired with murine models identify extracellular matrix components that mediate tumor progression and immune suppression