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Journal Articles

Abemaciclib Is Effective in Palbociclib-Resistant Hormone Receptor–Positive Metastatic Breast Cancers

Juliana Navarro-Yepes, Nicole M. Kettner, Xiayu Rao, Cassandra Santaella Bishop, Tuyen N. Bui, Hannah F. Wingate, Akshara Singareeka Raghavendra, Yan Wang, Jing Wang, Aysegul A. Sahin, Funda Meric-Bernstam, Kelly K. Hunt, Senthil Damodaran, Debu Tripathy, Khandan Keyomarsi
Journal: Cancer Research
Cancer Res OF1–OF20.
https://doi.org/10.1158/0008-5472.CAN-23-0705
Published: 11 September 2023
View article titled, Abemaciclib Is Effective in Palbociclib-Resistant Hormone Receptor–Positive Metastatic Breast Cancers
Open the PDF for Abemaciclib Is Effective in Palbociclib-Resistant Hormone Receptor–Positive Metastatic Breast Cancers in another window
Includes: Supplementary data
Journal Articles

DNA methylation-based testing in peripheral blood mononuclear cells enables accurate and early detection of colorectal cancer

Yan Xie, Peilong Li, Dong Sun, Qiuchen Qi, Suhong Ma, Yinghui Zhao, Shujun Zhang, Tiantian Wang, Jing Wang, Shijun Li, Tingting Gong, Huiting Xu, Mengqiu Xiong, Guanghua Li, Chongge You, Zhaofan Luo, Juan Li, Chuanxin Wang, Lutao Du
Journal: Cancer Research
Cancer Res CAN-22-3402.
https://doi.org/10.1158/0008-5472.CAN-22-3402
Published: 21 August 2023
View article titled, DNA methylation-based testing in peripheral blood mononuclear cells enables accurate and early detection of colorectal cancer
Open the PDF for DNA methylation-based testing in peripheral blood mononuclear cells enables accurate and early detection of colorectal cancer in another window
Includes: Supplementary data
Journal Articles

Abstract LB347: A lung-mimicking synthetic metastatic niche reveals N1 neutrophils drive breast cancer metastatic dormancy in the lungs

Jing Wang, Ramon Ocadiz-Ruiz, Matthew Hall, Grace Bushnell, Sophia Orbach, Joseph Decker, Ravi Raghani, Yining Zhang, Aaron Morris, Jacqueline Jeruss, Lonnie Shea
Journal: Cancer Research
Cancer Res (2023) 83 (8_Supplement): LB347.
https://doi.org/10.1158/1538-7445.AM2023-LB347
Published: 14 April 2023
View article titled, Abstract LB347: A lung-mimicking synthetic metastatic niche reveals N1 neutrophils drive breast cancer metastatic dormancy in the lungs
Journal Articles

Abstract CT134: Non-viral mesothelin-targeted CAR-T cells armored with IFNg-induced secretion of PD-1 nanobody in treatment of malignant mesothelioma in phase I clinical trial

Zhuqing Liu, Yong Xia, Linlin Li, Yan Sun, Zhicai Lin, Lijie Rong, Zhongzheng Zhu, Zongchang Song, Hui Xue, Jianchun Duan, Shujing Shen, Jing Wang, Linjie Lv, Yaping Yang, Xue Tan, Liping Han, Wei Zhao, Jie Wang, Wenfeng Xu, Weimin Zhu, Zhong Li, Xingya Li, Jinxing Lou, Qing Xu, Qijun Qian
Journal: Cancer Research
Cancer Res (2023) 83 (8_Supplement): CT134.
https://doi.org/10.1158/1538-7445.AM2023-CT134
Published: 14 April 2023
View article titled, Abstract CT134: Non-viral mesothelin-targeted CAR-T cells armored with IFNg-induced secretion of PD-1 nanobody in treatment of malignant mesothelioma in phase I clinical trial
Journal Articles

Abstract CT079: Efficacy and safety of sintilimab (anti-PD-1 mAb) for advanced cervical cancer: Results from a Phase II trial

Qinglei Gao, Jing Wang, Qin Xu, Ying Tang, Jieqing Zhang, Baoping Chang, Bairong Xia, Wei Duan, Danbo Wang, Lijing Zhu, Ruifang An, Guonan Zhang, Yaling Tang, Jianli Huang, Xiang Zhang, Hui Qiu, Wenting Ji, Li Li, Jianqing Zhu, Ding Ma
Journal: Cancer Research
Cancer Res (2023) 83 (8_Supplement): CT079.
https://doi.org/10.1158/1538-7445.AM2023-CT079
Published: 14 April 2023
View article titled, Abstract CT079: Efficacy and safety of sintilimab (anti-PD-1 mAb) for advanced cervical cancer: Results from a Phase II trial
Journal Articles

Abstract CT218: A phase II trial of niraparib plus dostarlimab in relapsed small cell lung cancer and other high-grade neuroendocrine carcinomas

Carl M. Gay, C. Allison Stewart, Michael Frumovitz, Junya Fujimoto, Yuann xi, Qi Wang, Runsheng Wang, Veronica Novegil, Mehmet Altan, Tina Cascone, Arvind Dasari, Yasir Y. Elamin, Frank V. Fossella, Bonnie S. Glisson, Charles S. Lu, Marcelo V. Negrao, Ferdinandos Skoulidis, Natalie Vokes, Robert J. Cardnell, Ignacio I. Wistuba, Jing Wang, John V. Heymach, Lauren A. Byers
Journal: Cancer Research
Cancer Res (2023) 83 (8_Supplement): CT218.
https://doi.org/10.1158/1538-7445.AM2023-CT218
Published: 14 April 2023
View article titled, Abstract CT218: A phase II trial of niraparib plus dostarlimab in relapsed small cell lung cancer and other high-grade neuroendocrine carcinomas
Journal Articles

Abstract LB098: Combination of a PD-1/CTLA-4 bispecific antibody with orally active PD-L1 inhibitor MAX-10181 effectively increased the percentage of tumors inhibited in animal model study

Yuguang Wang, Yuan Gao, Chenyu Mao, Nong Xu, Qiang Zhang, Jing Wang, Zhenhua Feng, Yonghong Zhu, Zhongmin Wang, Baiyong Li
Journal: Cancer Research
Cancer Res (2023) 83 (8_Supplement): LB098.
https://doi.org/10.1158/1538-7445.AM2023-LB098
Published: 14 April 2023
View article titled, Abstract LB098: Combination of a PD-1/CTLA-4 bispecific antibody with orally active PD-L1 inhibitor MAX-10181 effectively increased the percentage of tumors inhibited in animal model study
Journal Articles

Abstract LB302: Radiotherapy exposure and baseline gut microbiota predict clinical outcomes of fruquintinib plus sintilimab in microsatellite-stable metastatic colorectal cancer

Min Jin, Mingxia Cheng, Shengli Yang, Lei Zhao, Dandan Yu, Zhenyu Lin, Pindong Li, Jing Wang, Jun Xue, Hong Ma, Jianli Hu, Tao Zhang, Hongli Liu
Journal: Cancer Research
Cancer Res (2023) 83 (8_Supplement): LB302.
https://doi.org/10.1158/1538-7445.AM2023-LB302
Published: 14 April 2023
View article titled, Abstract LB302: Radiotherapy exposure and baseline gut microbiota predict clinical outcomes of fruquintinib plus sintilimab in microsatellite-stable metastatic colorectal cancer
Journal Articles

Abstract 3864: Targeting IL-6/STAT3 signaling in EGFR-mutant drug tolerant persister cells

Sonia A. Patel, Monique Nilsson, Yan Yang, Li Shen, Jing Wang, Alissa Poteete, Xiaoxing Yu, Xiaoyang Ren, Xiuning Le, John Heymach
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3864.
https://doi.org/10.1158/1538-7445.AM2023-3864
Published: 04 April 2023
View article titled, Abstract 3864: Targeting IL-6/STAT3 signaling in EGFR-mutant drug tolerant persister cells
Journal Articles

Abstract 3854: TNIK inhibition as a novel therapeutic in cMyc high/TTF1 low SCLC

Azusa Tanimoto, Robert J. Cardnell, Benjamin B. Morris, Kavya Ramkumar, Shen Li, Qi Wang, Allison C. Stewart, Carl Michael Gay, Jing Wang, Lauren Averett Byers
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3854.
https://doi.org/10.1158/1538-7445.AM2023-3854
Published: 04 April 2023
View article titled, Abstract 3854: TNIK inhibition as a novel therapeutic in cMyc high/TTF1 low SCLC
Journal Articles

Abstract 3196: Subtype-specific targeting of cell surfaceome with CAR T therapies in small cell lung cancer

Bingnan Zhang, Yan Yang, C.Allison Stewart, Kavya Ramkumar, Runsheng Wang, Robert Cardnell, Lixia Diao, Qi Wang, Jing Wang, Lauren Byers, Carl Gay, John Heymach
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3196.
https://doi.org/10.1158/1538-7445.AM2023-3196
Published: 04 April 2023
View article titled, Abstract 3196: Subtype-specific targeting of cell surfaceome with CAR T therapies in small cell lung cancer
Journal Articles

Abstract 2415: NBTXR3 radio-enhancing nanoparticle achieves a more robust antitumor immune response when combined with proton radiotherapy than photon radiotherapy

Yun Hu, Sébastien Paris, Narayan Sahoo, Qi Wang, Qianxia Wang, Hampartsoum B. Barsoumian, Jordan Da Silva, Célia Bienassis, Ailing Huang, Nahum Puebla-Osorio, Saumil Gandhi, Quynh-Nhu Nguyen, Jing Wang, Maria A. Cortez, James W. Welsh
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 2415.
https://doi.org/10.1158/1538-7445.AM2023-2415
Published: 04 April 2023
View article titled, Abstract 2415: NBTXR3 radio-enhancing nanoparticle achieves a more robust antitumor immune response when combined with proton radiotherapy than photon radiotherapy
Journal Articles

Abstract 1541: NextGen conditionally active biologic (CAB) anti-Nectin-4-ADC with improved stability and safety

Gerhard Frey, Jing Wang, Kyrie Johnson, Haizhen Liu, Christina Wheeler, Charles Xing, Ana Paula Cugnetti, Patricia McNeeley, Solmarie Joyner, Cathy Chang, William J. Boyle, Jay M. Short
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1541.
https://doi.org/10.1158/1538-7445.AM2023-1541
Published: 04 April 2023
View article titled, Abstract 1541: NextGen conditionally active biologic (CAB) anti-Nectin-4-ADC with improved stability and safety
Journal Articles

Abstract 474: Preclinical development of an oral selective estrogen receptor degrader (SERD) TFX06 for the treatment of ER+HER2− breast cancer

Jinping Wu, Ke An, Douglas D. Fang, Jianyu Lu, Lihong Hu, Jing Wang, Kaili Zhang, Yuanfeng Xia, Charles Ding, Shuhui Chen, Sha Wei
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 474.
https://doi.org/10.1158/1538-7445.AM2023-474
Published: 04 April 2023
View article titled, Abstract 474: Preclinical development of an oral selective estrogen receptor degrader (SERD) TFX06 for the treatment of ER<sup>+</sup>HER2<sup>−</sup> breast cancer
Journal Articles

Abstract 6115: Comprehensive DNA repair landscape analysis reveals novel small cell lung cancer biology

Benjamin B. Morris, Barzin Nabet, David Shames, Simon Heeke, Carl M. Gay, Jing Wang, Jianjun Zhang, John V. Heymach, Lauren A. Byers
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 6115.
https://doi.org/10.1158/1538-7445.AM2023-6115
Published: 04 April 2023
View article titled, Abstract 6115: Comprehensive DNA repair landscape analysis reveals novel small cell lung cancer biology
Journal Articles

Abstract 1799: BH3120, a bispecific antibody targeting 4-1BB and PD-L1 simultaneously, stimulates T cells in tumor tissue preferred manner

Jing Wang, Jun Wang, Yang Liu, Yan Pang, Aihong Zhang, Jie Feng, Aibo Sun, Xiao Ma, Jingmei Cai, Jiangcheng Xu, Jiawang Liu, Kyoungwoo Lee
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1799.
https://doi.org/10.1158/1538-7445.AM2023-1799
Published: 04 April 2023
View article titled, Abstract 1799: BH3120, a bispecific antibody targeting 4-1BB and PD-L1 simultaneously, stimulates T cells in tumor tissue preferred manner
Journal Articles

Abstract 6521: Subtype-specific molecular signatures of field cancerization in patients with sporadic breast cancer

Anjana Bhardwaj, Zhenlin Ju, Constance Albarracin, Celestine Trinidad, Preethi Gunaratne, Jing Wang, Randa El-Zein, Isabelle Bedrosian
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 6521.
https://doi.org/10.1158/1538-7445.AM2023-6521
Published: 04 April 2023
View article titled, Abstract 6521: Subtype-specific molecular signatures of field cancerization in patients with sporadic breast cancer
Journal Articles

Abstract 1879: A novel dual CAB nectin-4 x CD3 bispecific antibody targeting solid tumors

Matthew Lucas, Ana Paula Cugnetti, Haizhen Liu, Charles Xing, Jing Wang, Patricia McNeeley, Christina Wheeler, Solmarie Joyner, Kyrie Johnson, Kathryn Woodard, Wei Zhou, Cathy Chang, Gerhard Frey, William J. Boyle, Jay M. Short
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1879.
https://doi.org/10.1158/1538-7445.AM2023-1879
Published: 04 April 2023
View article titled, Abstract 1879: A novel dual CAB nectin-4 x CD3 bispecific antibody targeting solid tumors
Journal Articles

Abstract 1202: Targeting cell adhesion molecule 1 (CADM1) with an antibody drug conjugate for the treatment of osteosarcoma

Yifei Wang, Zhongting Zhang, Wendong Zhang, Xiangjun Tian, Rossana Lazcano, Michael Roth, Jonathan Gill, Douglas Harrison, Zhaohui Xu, Yizheng Tu, Sylvester Jusu, Giuseppe Longo, Xin Zhou, Jing Wang, Richard Gorlick
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1202.
https://doi.org/10.1158/1538-7445.AM2023-1202
Published: 04 April 2023
View article titled, Abstract 1202: Targeting cell adhesion molecule 1 (CADM1) with an antibody drug conjugate for the treatment of osteosarcoma
Journal Articles

Abstract 6206: Combined inhibition of AXL and ATR enhances replication stress, cell death and immune response in small cell lung cancer

Kavya Ramkumar, C. Allison Stewart, Azusa Tanimoto, Qi Wang, Yuanxin Xi, Benjamin B. Morris, Runsheng Wang, Li Shen, Robert J. Cardnell, Jing Wang, Carl M. Gay, Lauren A. Byers
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 6206.
https://doi.org/10.1158/1538-7445.AM2023-6206
Published: 04 April 2023
View article titled, Abstract 6206: Combined inhibition of AXL and ATR enhances replication stress, cell death and immune response in small cell lung cancer