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Journal Articles

Abstract LB076: Spatial transcriptomics reveals differences in the tumor and immune microenvironment of high-grade serous ovarian cancers with differing responses to immune checkpoint inhibitors

Free
Jing Qian, Lynda D. Roman, Rania Bassiouni, Hanim I. Ozkizilkaya, Kathy Kwock, Yuxin Jin, Javier Arias-Stella, Joseph W. Carlson, John D. Carpten
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_2): LB076.
https://doi.org/10.1158/1538-7445.AM2025-LB076
Published: 25 April 2025
View articletitled, Abstract LB076: Spatial transcriptomics reveals differences in the tumor and immune microenvironment of high-grade serous ovarian cancers with differing responses to immune checkpoint inhibitors
Journal Articles

Abstract 646: Unravelling the mechanisms of resistance and hyperprogression of renal medullary carcinoma to immune checkpoint therapy

Free
Jing Qian, Melinda Soeung, Xinmiao Yan, Kai Yu, Ciro Zanca, Li Zhang, Ziheng Chen, Luigi Perelli, Jianfeng Chen, Rebecca Slack Tidwell, Hania Khan, Fei Duan, Menuka Karki, Rong He, Courtney N. Le, Truong N.A. Lam, Nirjar Bhattacharya, Mariah N. Williams, David H. Peng, Rutvi Shah, I-Lin Ho, Ningping Feng, Niki Millward Zacharias, Rahul Anil Sheth, Tharakeswara K. Bathala, Priya Rao, Najat C. Daw, Durga N. Tripathi, Cheryl L. Walker, Ruiping Wang, Minghao Dang, Enyu Dai, Fuduan Peng, Yunhe Liu, Akshaya S. Jadhav, Wenhua Lang, Claudio A. Arrechedera, Leticia Campos Clemente, Hsinyi Lu, Cara L. Haymaker, Ignacio I. Wistuba, Andrew Futreal, Andrea Viale, Timothy Heffernan, Giulio F. Draetta, Nazir M. Tannir, Jianjun Gao, Linghua Wang, Giannicola Genovese, Pavlos Msaouel
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 646.
https://doi.org/10.1158/1538-7445.AM2025-646
Published: 21 April 2025
View articletitled, Abstract 646: Unravelling the mechanisms of resistance and hyperprogression of renal medullary carcinoma to immune checkpoint therapy
Journal Articles

Abstract 5359: Multi-omics characterization of copy number variation in high-grade serous ovarian cancer

Free
Yuxin Jin, Jing Qian, Michelle G. Webb, David W. Craig, Lynda Roman, John D. Carpten, Rania Bassiouni
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 5359.
https://doi.org/10.1158/1538-7445.AM2025-5359
Published: 21 April 2025
View articletitled, Abstract 5359: Multi-omics characterization of copy number variation in high-grade serous ovarian cancer
Journal Articles

Abstract PO2-24-01: Kif11 Inhibition Preferentially Kills TP53-mutant Breast Cancer Cells

Free
Amanda Lanier, William Tahaney, Jing Qian, Cassandra Moyer, Yanxia Ma, Banu Arun, Abhijit Mazumdar, Powel Brown
Journal: Cancer Research
Cancer Res (2024) 84 (9_Supplement): PO2-24-01.
https://doi.org/10.1158/1538-7445.SABCS23-PO2-24-01
Published: 02 May 2024
View articletitled, Abstract PO2-24-01: Kif11 Inhibition Preferentially Kills TP53-mutant Breast Cancer Cells
Journal Articles

Abstract 522: TP53mutations promote death of breast cancer cells following Kif11 inhibition

Free
Amanda L. Lanier, William Tahaney, Jing Qian, Cassandra Moyer, Yanxia Ma, Banu Arun, Abhijit Mazumdar, Powel H. Brown
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 522.
https://doi.org/10.1158/1538-7445.AM2024-522
Published: 22 March 2024
View articletitled, Abstract 522: TP53mutations promote death of breast cancer cells following Kif11 inhibition
Journal Articles

Abstract 5479: Spatially resolved molecular features in the tumor-immune microenvironment of germline BRCA1/2 mutated versus BRCA wild type high grade serous ovarian cancers

Free
Jing Qian, Lynda D. Roman, Rania Bassiouni, Seeta Rajpara, Monica Neuman, Varun Khetan, David W. Craig, Joseph W. Carlson, John D. Carpten
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 5479.
https://doi.org/10.1158/1538-7445.AM2024-5479
Published: 22 March 2024
View articletitled, Abstract 5479: Spatially resolved molecular features in the tumor-immune microenvironment of germline BRCA1/2 mutated versus BRCA wild type high grade serous ovarian cancers
Journal Articles

Abstract 4343: Revealing ovarian cancer copy number variation in single cells

Free
Yuxin Jin, Rania Bassiouni, Lee D. Gibbs, Jing Qian, Solomon Rotimi, Michelle G. Webb, Seeta Rajpara, David W. Craig, Lynda D. Roman, John D. Carpten
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 4343.
https://doi.org/10.1158/1538-7445.AM2024-4343
Published: 22 March 2024
View articletitled, Abstract 4343: Revealing ovarian cancer copy number variation in single cells
Journal Articles

Abstract 6082: Assessing difference in the tumor and immune microenvironment of BRCA1/2 mutated versus BRCA wild type high grade serous ovarian cancers

Free
Jing Qian, Lynda D. Roman, Seeta Rajpara, Monica Neuman, Varun Khetan, David W. Craig, Joseph Carlson, John D. Carpten
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 6082.
https://doi.org/10.1158/1538-7445.AM2023-6082
Published: 04 April 2023
View articletitled, Abstract 6082: Assessing difference in the tumor and immune microenvironment of BRCA1/2 mutated versus BRCA wild type high grade serous ovarian cancers
Journal Articles

Abstract 1515: Tumor molecular profiling and spatial transcriptomics to assess colorectal cancer heterogeneity and microenvironment

Free
Enrique Velazquez Villarreal, Seeta Rajpara, Yuxin Jin, Jing Qian, Bohan Zhang, Brigette Waldrup, Donna Loza, Heinz-Josef Lenz, David W. Craig, John D. Carpten
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1515.
https://doi.org/10.1158/1538-7445.AM2023-1515
Published: 04 April 2023
View articletitled, Abstract 1515: Tumor molecular profiling and spatial transcriptomics to assess colorectal cancer heterogeneity and microenvironment
Journal Articles

Abstract 2180: The PD-L1 protein expression in Chinese patients with advanced esophageal cancers: a multi-center retrospective study

Free
Liyan Xue, Jiaqi Wang, Dong Kuang, Jingping Yun, Yuan Li, Lili Jiang, Daoyuan Wu, Pei Duan, Shixun Lu, Yan Jin, Du He, Jing Qian, Wenmin Tang, Yan Wang, Jielin Li, Jianming Ying
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 2180.
https://doi.org/10.1158/1538-7445.AM2023-2180
Published: 04 April 2023
View articletitled, Abstract 2180: The PD-L1 protein expression in Chinese patients with advanced esophageal cancers: a multi-center retrospective study
Journal Articles

Abstract 3966: Targeting S100A10, a SOX9 binding protein, for the treatment of triple negative breast cancer

Free
Yanxia Ma, Jing Qian, Cassandra Moyer, Amanda Lanier, Jamal Hill, Darian Coleman, David H. Hawke, Abhijit Mazumdar, Powel H. Brown
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3966.
https://doi.org/10.1158/1538-7445.AM2023-3966
Published: 04 April 2023
View articletitled, Abstract 3966: Targeting S100A10, a SOX9 binding protein, for the treatment of triple negative breast cancer
Journal Articles

Abstract P4-08-07: Inhibition of the NUDT5 phosphatase suppresses the growth of triple-negative breast cancers

Free
Jing Qian, Powel Brown
Journal: Cancer Research
Cancer Res (2023) 83 (5_Supplement): P4-08-07.
https://doi.org/10.1158/1538-7445.SABCS22-P4-08-07
Published: 01 March 2023
View articletitled, Abstract P4-08-07: Inhibition of the NUDT5 phosphatase suppresses the growth of triple-negative breast cancers
Journal Articles

Abstract GS1-09: Inhibition of GPX4 induces preferential death of p53-mutant triple-negative breast cancer cells

Free
William M Tahaney, Jing Qian, Reid Powell, Cassandra L Moyer, Yanxia Ma, Nghi Nguyen, Jamal Hill, Clifford Stephan, Abhijit Mazumdar, Peter JA Davies, Powel H Brown
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): GS1-09.
https://doi.org/10.1158/1538-7445.SABCS21-GS1-09
Published: 15 February 2022
View articletitled, Abstract GS1-09: Inhibition of GPX4 induces preferential death of p53-mutant triple-negative breast cancer cells
Journal Articles

Abstract P5-12-08: The role of a novel phosphatase NUDT5 in triple-negative breast cancer

Free
Jing Qian, William Tahaney, Yanxia Ma, Abhijit Mazumdar, Powel Brown
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P5-12-08.
https://doi.org/10.1158/1538-7445.SABCS21-P5-12-08
Published: 15 February 2022
View articletitled, Abstract P5-12-08: The role of a novel phosphatase NUDT5 in triple-negative breast cancer
Journal Articles

Abstract NG03: Spatial RNA-seq reveals intratumor heterogeneity and transcriptional substructure in high-grade ovarian cancers

Free
Lee D. Gibbs, Stephen R. Williams, Neil I. Weisenfeld, David W. Craig, Rania Bassiouni, Nigel F. Delaney, Diane Da Silva, Yifeng Yin, Solomon Rotimi, Jennifer Chew, Meghan Frey, Michelle Webb, Jing Qian, Heather Miller, Laila Murderspach, Troy McEachron, Lynda Roman, John D. Carpten
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): NG03.
https://doi.org/10.1158/1538-7445.AM2020-NG03
Published: 15 August 2020
View articletitled, Abstract NG03: Spatial RNA-seq reveals intratumor heterogeneity and transcriptional substructure in high-grade ovarian cancers
Journal Articles

Abstract 1303: PRTN3, RGCC and SLCO4C1 are critical SOX9-regulated genes that control TNBC growth

Free
Yanxia Ma, William M. Tahaney, Jing Qian, Jamal Hill, Yun Zhan, Abhijit Mazumdar, Powel H. Brown
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 1303.
https://doi.org/10.1158/1538-7445.AM2020-1303
Published: 15 August 2020
View articletitled, Abstract 1303: PRTN3, RGCC and SLCO4C1 are critical SOX9-regulated genes that control TNBC growth
Journal Articles

Abstract 1439: NUDT5 is a critical regulator of triple-negative breast cancer growth

Free
Jing Qian, William Tahaney, Yanxia Ma, Lakshmi Bollu, Abhijit Mazumdar, Jamal Hill, Yun Zhang, Powel Brown
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 1439.
https://doi.org/10.1158/1538-7445.AM2020-1439
Published: 15 August 2020
View articletitled, Abstract 1439: NUDT5 is a critical regulator of triple-negative breast cancer growth
Journal Articles

Abstract P3-03-08: Identification of drugs that induce the death or suppress the growth of p53-mutant breast cancer

Free
William Miska Tahaney, Reid Powell, Nghi Nguyen, Lakshmi Reddy Bollu, Jing Qian, Abhijit Mazumdar, Clifford Stephan, Peter JA Davies, Powel H Brown
Journal: Cancer Research
Cancer Res (2020) 80 (4_Supplement): P3-03-08.
https://doi.org/10.1158/1538-7445.SABCS19-P3-03-08
Published: 15 February 2020
View articletitled, Abstract P3-03-08: Identification of drugs that induce the death or suppress the growth of p53-mutant breast cancer
Journal Articles

Abstract 4703: Single Cell CNV End to End workflow to uncover tumor heterogeneity in a murine breast cancer model

Free
Lee D. Gibbs, Jing Qian, Michelle Webb, Sharon Chang, Zarko Manojlovic, Enrique I. Velazquez, Troy McEachron, David W. Craig, John D. Carpten
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4703.
https://doi.org/10.1158/1538-7445.AM2019-4703
Published: 01 July 2019
View articletitled, Abstract 4703: Single Cell CNV End to End workflow to uncover tumor heterogeneity in a murine breast cancer model
Journal Articles

Abstract 1648: Discovery and evolution of orally bioavailable selective estrogen receptor degraders for ER+ breast cancer: From GDC-0810 to GDC-0927

Free
Mehmet Kahraman, Steven P. Govek, Johnny Y. Nagasawa, Andiliy Lai, Celine Bonnefous, Karensa Douglas, John Sensintaffar, Nhin Lu, KyoungJin Lee, Anna Aparicio, Josh Kaufman, Jing Qian, Gang Shao, Rene Prudente, James D. Joseph, Beatrice Darimont, Daniel Brigham, Richard Heyman, Peter J. Rix, Jeffrey H. Hager, Nicholas D. Smith, Robert A. Blake, Jae Chang, Edna Choo, Anneleen Daemen, Lori S. Friedman, Jane Guan, Steven Hartman, Ellen Ingalla, James R. Kiefer, Tracy Kleinheinz, Sharada Labadie, Ciara Metcalfe, Vidhi Mody, Michelle Nannini, Deepak Sampath, Amy Young, Maia Vinogradova, Wei Zhou, Jun Liang, Xiaojing Wang
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1648.
https://doi.org/10.1158/1538-7445.AM2018-1648
Published: 01 July 2018
View articletitled, Abstract 1648: Discovery and evolution of orally bioavailable selective estrogen receptor degraders for ER+ breast cancer: From GDC-0810 to GDC-0927