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Journal Articles

Abstract 2563: FAK inhibitor APG-2449 and CDK4/6 inhibitor palbociclib synergistically suppress mesothelioma tumor growth via autophagy induction

Ran Tao, Douglas D. Fang, Yuanbao Li, Guoqin Zhai, Feng Zhou, Qixin Wang, Jing Deng, Dajun Yang, Yifan Zhai

Cancer Res (2022) 82 (12_Supplement): 2563.

https://doi.org/10.1158/1538-7445.AM2022-2563

Published: 15 June 2022

View article titled, Abstract 2563: FAK inhibitor APG-2449 and CDK4/6 inhibitor palbociclib synergistically suppress mesothelioma tumor growth via autophagy induction

Journal Articles

Abstract 3964: Co-targeting MDM2-p53 and BCL-2 apoptosis pathways overcomes resistance conferred by acquired BCL-2 gene mutations in preclinical models

Jing Deng, Kaixiang Zhang, Qiuqiong Tang, Xiaojing Huang, Qixin Wang, Na Li, Douglas D. Fang, Dajun Yang, Yifan Zhai

Cancer Res (2022) 82 (12_Supplement): 3964.

https://doi.org/10.1158/1538-7445.AM2022-3964

Published: 15 June 2022

View article titled, Abstract 3964: Co-targeting MDM2-p53 and BCL-2 apoptosis pathways overcomes resistance conferred by acquired <em>BCL-2</em> gene mutations in preclinical models

Journal Articles

Abstract 984: Targeting BCL-xL addiction with APG-1252 (pelcitoclax) to overcome apoptotic blockade in neuroendocrine neoplasm (NEN)

Yu Guo, Jing Deng, Lin Zhang, Xiaojing Huang, Kaixiang Zhang, Feng Zhou, Yuanbao Li, Fan Luo, Douglas D. Fang, Dajun Yang, Jie Chen, Yifan Zhai

Cancer Res (2021) 81 (13_Supplement): 984.

https://doi.org/10.1158/1538-7445.AM2021-984

Published: 01 July 2021

View article titled, Abstract 984: Targeting BCL-xL addiction with APG-1252 (pelcitoclax) to overcome apoptotic blockade in neuroendocrine neoplasm (NEN)

Journal Articles

Abstract 981: BCL-2 inhibitor APG-2575 and homoharringtonine (HHT) synergistically induces apoptosis and inhibits tumor growth in preclinical models of acute myeloid leukemia and myelodysplastic syndromes (AML/MDS)

Douglas D. Fang, Qiuqiong Tang, Yanhui Kong, Tao Rong, Qixin Wang, Jing Deng, Dajun Yang, Yifan Zhai

Cancer Res (2021) 81 (13_Supplement): 981.

https://doi.org/10.1158/1538-7445.AM2021-981

Published: 01 July 2021

View article titled, Abstract 981: BCL-2 inhibitor APG-2575 and homoharringtonine (HHT) synergistically induces apoptosis and inhibits tumor growth in preclinical models of acute myeloid leukemia and myelodysplastic syndromes (AML/MDS)

Journal Articles

Abstract 976: Inhibition of BCL-2 (by APG-2575) and CDK4/6 synergistically induces cell cycle arrest and apoptosis in ER⁺ breast cancer

Jing Deng, Ran Tao, Douglas D. Fang, Qiuqiong Tang, Yan Yin, Kaixiang Zhang, Yuanbao Li, Guoqin Zhai, Qixin Wang, Dajun Yang, Yifan Zhai

Cancer Res (2021) 81 (13_Supplement): 976.

https://doi.org/10.1158/1538-7445.AM2021-976

Published: 01 July 2021

View article titled, Abstract 976: Inhibition of BCL-2 (by APG-2575) and CDK4/6 synergistically induces cell cycle arrest and apoptosis in ER<sup>+</sup> breast cancer

Journal Articles

Abstract 74: Co-targeting BCL-xL and HER2 high expression to overcome apoptosis blockade in gastric cancer

Jing Deng, Xiaojing Huang, Guoqin Zhai, Kaixiang Zhang, Jiaxing Gu, Tingting Mao, Yan Yin, Ran Tao, Douglas D. Fang, Dajun Yang, Yifan Zhai

Cancer Res (2020) 80 (16_Supplement): 74.

https://doi.org/10.1158/1538-7445.AM2020-74

Published: 15 August 2020

View article titled, Abstract 74: Co-targeting BCL-xL and HER2 high expression to overcome apoptosis blockade in gastric cancer

Journal Articles

Abstract 73: Development of APG-3526 as a novel and highly efficacious MCL-1 inhibitor

Jianyong Chen, Chengzhe Wu, Lingling Jiao, Leilei Zhao, Yunlong Zhou, Dongbo Li, Guozhi Tang, Shoulai Gu, Jing Deng, Guangfeng Wang, Douglas D. Fang, Shaomeng Wang, Dajun Yang, Yifan Zhai

Cancer Res (2020) 80 (16_Supplement): 73.

https://doi.org/10.1158/1538-7445.AM2020-73

Published: 15 August 2020

View article titled, Abstract 73: Development of APG-3526 as a novel and highly efficacious MCL-1 inhibitor

Journal Articles

Abstract 2503: Predicting drug sensitivity to a novel BCL-2 and BCL-xL dual inhibitor in solid tumor PDX trials

Jing Deng, Xiaojing Huang, Guoqin Zhai, Tingting Mao, Yan Yin, Douglas D. Fang, Dajun Yang, Yifan Zhai

Cancer Res (2019) 79 (13_Supplement): 2503.

https://doi.org/10.1158/1538-7445.AM2019-2503

Published: 01 July 2019

View article titled, Abstract 2503: Predicting drug sensitivity to a novel BCL-2 and BCL-xL dual inhibitor in solid tumor PDX trials

Journal Articles

Abstract 3125: SOX2 controls the tumor initiation and development and acts as a prognostic predictor of oral squamous cell carcinoma

ZIHAO WEI, FENGYING YIN, PENG DENG, XUEFENG ZHANG, JING DENG, JING LI, LIANG XIE, QIANMING CHEN

Cancer Res (2019) 79 (13_Supplement): 3125.

https://doi.org/10.1158/1538-7445.AM2019-3125

Published: 01 July 2019

View article titled, Abstract 3125: SOX2 controls the tumor initiation and development and acts as a prognostic predictor of oral squamous cell carcinoma

Journal Articles

Abstract 307: Targeting BCL-2 and BCL-xL with a novel dual inhibitor APG-1252 triggers cell death and inhibits tumor growth in small cell lung cancer models

GuangFeng Wang, Ping Min, MiaoYi Wu, Shuo Dang, ChuanYan Tang, Fei Zhang, Ming Guo, Shaomeng Wang, Jing Deng, Douglas D. Fang, DaJun Yang, YiFan Zhai

Cancer Res (2018) 78 (13_Supplement): 307.

https://doi.org/10.1158/1538-7445.AM2018-307

Published: 01 July 2018

View article titled, Abstract 307: Targeting BCL-2 and BCL-xL with a novel dual inhibitor APG-1252 triggers cell death and inhibits tumor growth in small cell lung cancer models

Journal Articles

Abstract 4728: Apoptotic priming is regulated by a developmental program and predisposes children to therapy-induced toxicity

Kristopher A. Sarosiek, Michael Ziller, Cameron Fraser, Patrick Bhola, Jeremy Ryan, Jing Deng, Brian Jian, Marti Goldenberg, Joseph Madsen, Ruben Carrasco, Shenandoah Robinson, Javid Moslehi, Anthony Letai

Cancer Res (2015) 75 (15_Supplement): 4728.

https://doi.org/10.1158/1538-7445.AM2015-4728

Published: 01 August 2015

View article titled, Abstract 4728: Apoptotic priming is regulated by a developmental program and predisposes children to therapy-induced toxicity

Journal Articles

Proapoptotic BH3-Only BCL-2 Family Protein BIM Connects Death Signaling from Epidermal Growth Factor Receptor Inhibition to the Mitochondrion

Jing Deng, Takeshi Shimamura, Samanthi Perera, Nicole E. Carlson, Dongpo Cai, Geoffrey I. Shapiro, Kwok-Kin Wong, Anthony Letai

Cancer Res (2007) 67 (24): 11867–11875.

https://doi.org/10.1158/0008-5472.CAN-07-1961

Published: 18 December 2007

View article titled, Proapoptotic BH3-Only BCL-2 Family Protein BIM Connects Death Signaling from Epidermal Growth Factor Receptor Inhibition to the Mitochondrion

NARROW

Abstract 2563: FAK inhibitor APG-2449 and CDK4/6 inhibitor palbociclib synergistically suppress mesothelioma tumor growth via autophagy induction

Abstract 3964: Co-targeting MDM2-p53 and BCL-2 apoptosis pathways overcomes resistance conferred by acquired BCL-2 gene mutations in preclinical models

Abstract 984: Targeting BCL-xL addiction with APG-1252 (pelcitoclax) to overcome apoptotic blockade in neuroendocrine neoplasm (NEN)

Abstract 981: BCL-2 inhibitor APG-2575 and homoharringtonine (HHT) synergistically induces apoptosis and inhibits tumor growth in preclinical models of acute myeloid leukemia and myelodysplastic syndromes (AML/MDS)

Abstract 976: Inhibition of BCL-2 (by APG-2575) and CDK4/6 synergistically induces cell cycle arrest and apoptosis in ER⁺ breast cancer

Abstract 74: Co-targeting BCL-xL and HER2 high expression to overcome apoptosis blockade in gastric cancer

Abstract 73: Development of APG-3526 as a novel and highly efficacious MCL-1 inhibitor

Abstract 2503: Predicting drug sensitivity to a novel BCL-2 and BCL-xL dual inhibitor in solid tumor PDX trials

Abstract 3125: SOX2 controls the tumor initiation and development and acts as a prognostic predictor of oral squamous cell carcinoma

Abstract 307: Targeting BCL-2 and BCL-xL with a novel dual inhibitor APG-1252 triggers cell death and inhibits tumor growth in small cell lung cancer models

Abstract 4728: Apoptotic priming is regulated by a developmental program and predisposes children to therapy-induced toxicity

Proapoptotic BH3-Only BCL-2 Family Protein BIM Connects Death Signaling from Epidermal Growth Factor Receptor Inhibition to the Mitochondrion

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