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Journal Articles

Combining Apatinib and Oxaliplatin Remodels the Immunosuppressive Tumor Microenvironment and Sensitizes Desert-Type Gastric Cancer to Immunotherapy

Open Access
Guang-Tan Lin, Cheng Yan, Lu-Jie Li, Xiao-Wen Qiu, Yu-Xuan Zhao, Ju-Li Lin, Yu-Jing Chen, Chuan Feng, Shao-Qiong Chen, Jian-Wei Xie, Chao-Hui Zheng, Sachiyo Nomura, Chang-Ming Huang, Ping Li, Long-Long Cao
Journal: Cancer Research
Cancer Res (2025) 85 (11): 2117–2133.
https://doi.org/10.1158/0008-5472.CAN-24-2697
Published: 02 June 2025
View articletitled, Combining Apatinib and Oxaliplatin Remodels the Immunosuppressive Tumor Microenvironment and Sensitizes Desert-Type Gastric Cancer to Immunotherapy
Open the PDF for Combining Apatinib and Oxaliplatin Remodels the Immunosuppressive Tumor Microenvironment and Sensitizes Desert-Type Gastric Cancer to Immunotherapy in another window
Includes: Supplementary data
Journal Articles

Abstract 6325: Zeaxanthin augments CD8+ effector T cell function by enhancing TCR stimulation

Free
Freya Q. Zhang, Jiacheng Li, Rukang Zhang, Jiayi Tu, Zhicheng Xie, Takemasa Tsuji, Hardik Shah, Matthew O. Ross, Ruitu Lyu, Junko Matsuzaki, Kelly Xue, Fatima Choudhry, Chunzhao Yin, Hamed R. Youshanlouei, Syed Shah, Michael W. Drazer, Marc Bissonnette, Yuancheng Li, Hui Mao, Jun Huang, Lei Dong, Rui Su, Chuan He, Kunle Odunsi, Jing Chen, Hao Fan
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 6325.
https://doi.org/10.1158/1538-7445.AM2025-6325
Published: 21 April 2025
View articletitled, Abstract 6325: Zeaxanthin augments CD8+ effector T cell function by enhancing TCR stimulation
Journal Articles

Abstract 2575: Tumor microenvironmental metabolites regulate cancer-associated fibroblast heterogeneity

Free
Chufan Cai, Marta Storl-Desmond, Kristof Turan, Axel R. Concepcion, Jing Chen, Simon Schwoerer
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 2575.
https://doi.org/10.1158/1538-7445.AM2025-2575
Published: 21 April 2025
View articletitled, Abstract 2575: Tumor microenvironmental metabolites regulate cancer-associated fibroblast heterogeneity
Journal Articles

Abstract 345: Trop2 and B7H4 bi-specific ADC with improved efficacy and safety for gynecologic cancers

Free
Jing Chen, Chenjuan Zhu, Chenchen Zhu, Zhongmin Liu, Min Wu, Weiwei Wu, Junjie Deng, Yi Wang, Xiguang Zhang, Yiming Li
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 345.
https://doi.org/10.1158/1538-7445.AM2025-345
Published: 21 April 2025
View articletitled, Abstract 345: Trop2 and B7H4 bi-specific ADC with improved efficacy and safety for gynecologic cancers
Journal Articles

Abstract 6067: Preclinical evaluation of XB628: A novel PD-L1 x NKG2A bispecific antibody

Free
Bee-Cheng Sim, Bonnie Hammer, Dileep Pulukkunat, Jing Chen, Annika Lee, Mark Bercher, Hanying Li, Jeffrey Higaki, Anna Ritter, Seema Kantak
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 6067.
https://doi.org/10.1158/1538-7445.AM2025-6067
Published: 21 April 2025
View articletitled, Abstract 6067: Preclinical evaluation of XB628: A novel PD-L1 x NKG2A bispecific antibody
Journal Articles

Abstract CT118: Phase I dose escalation of ASKC202, a novel cMET tyrosine kinase inhibitor, in patients with advanced solid tumors

Free
Tingting Song, Caicun Zhou, Wei Li, Xingya Li, Lin Wu, Shan Zeng, Liyun Miao, Baogang Liu, Xuyu Wei, Jing Chen, Luwei Han
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): CT118.
https://doi.org/10.1158/1538-7445.AM2024-CT118
Published: 05 April 2024
View articletitled, Abstract CT118: Phase I dose escalation of ASKC202, a novel cMET tyrosine kinase inhibitor, in patients with advanced solid tumors
Journal Articles

Abstract 3275: PHGDH-mediated serine-glycine-one-carbon metabolism drives ferroptosis- and chemotherapy-resistance in colorectal cancer

Free
Guanzhan Liang, Jing Chen, Xiaofeng Wen, Zongjin Zhang, Zexian Chen, Yongle Chen, Zhenyu Xian, Xiaowen He, Xianrui Wu, Ping Lan, Tuo Hu
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3275.
https://doi.org/10.1158/1538-7445.AM2024-3275
Published: 22 March 2024
View articletitled, Abstract 3275: PHGDH-mediated serine-glycine-one-carbon metabolism drives ferroptosis- and chemotherapy-resistance in colorectal cancer
Journal Articles

Abstract CT208: Tebotelimab, a PD-1/LAG-3 bispecific antibody, in patients with untreated, unresectable, recurrent or metastatic, mucosal melanoma: An open-label, single-arm, Phase 1 study

Free
Si Lu, Yu Chen, Meiyu Fang, Zhengyun Zou, Di Wu, Zhiguo Luo, Jian Zhang, Jing Chen, Gang Huang, Hongming Pan, Xiubao Ren, Ying Cheng, Haichuan Su, Yuan Xin, Qiong Hua, Jianmei Hou, Jun Guo
Journal: Cancer Research
Cancer Res (2023) 83 (8_Supplement): CT208.
https://doi.org/10.1158/1538-7445.AM2023-CT208
Published: 14 April 2023
View articletitled, Abstract CT208: Tebotelimab, a PD-1/LAG-3 bispecific antibody, in patients with untreated, unresectable, recurrent or metastatic, mucosal melanoma: An open-label, single-arm, Phase 1 study
Journal Articles

Abstract 6604: Analytical development and validation of a personalized hybrid capture based assay for high sensitivity monitoring minimal residual disease (MRD)

Free
Xiaoqiang Wang, Lei Ye, Chao Zhang, Wanglong Deng, Yongjie Wei, Jing Chen, Xuan Tang, Xiaoxuan Wang, Chao Song, Qing Xu, Yong Ren
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 6604.
https://doi.org/10.1158/1538-7445.AM2023-6604
Published: 04 April 2023
View articletitled, Abstract 6604: Analytical development and validation of a personalized hybrid capture based assay for high sensitivity monitoring minimal residual disease (MRD)
Journal Articles

Abstract 283: AHCYL1 is crucial for NRAS mutant-expressing melanoma tumor growth by governing ER calcium homeostasis

Free
Chufan Cai, Jiayi Tu, Jeronimo Najarro, Rukang Zhang, Xue Gao, Hao Fan, Freya Zhang, Jiacheng Li, Michele Ciboddo, Shannon Elf, Rong Wu, Jing Chen
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 283.
https://doi.org/10.1158/1538-7445.AM2023-283
Published: 04 April 2023
View articletitled, Abstract 283: AHCYL1 is crucial for NRAS mutant-expressing melanoma tumor growth by governing ER calcium homeostasis
Journal Articles

Androgen Signaling Contributes to Sex Differences in Cancer by Inhibiting NF-κB Activation in T Cells and Suppressing Antitumor Immunity

Free
Xiaomin Zhang, Limin Cheng, Chengqi Gao, Jing Chen, Shuangye Liao, Yongqiang Zheng, Liping Xu, Jingjing He, Danyang Wang, Ziqian Fang, Jianeng Zhang, Min Yan, Yi Luan, Siyu Chen, Likun Chen, Xiaojun Xia, Chunhao Deng, Guokai Chen, Wende Li, Zexian Liu, Penghui Zhou
Journal: Cancer Research
Cancer Res (2023) 83 (6): 906–921.
https://doi.org/10.1158/0008-5472.CAN-22-2405
Published: 15 March 2023
View articletitled, Androgen Signaling Contributes to Sex Differences in Cancer by Inhibiting NF-κB Activation in T Cells and Suppressing Antitumor Immunity
Open the PDF for Androgen Signaling Contributes to Sex Differences in Cancer by Inhibiting NF-κB Activation in T Cells and Suppressing Antitumor Immunity in another window
Includes: Supplementary data
Journal Articles

Abstract 5764: Genomic profiling of cutaneous, acral and mucosal melanomas in Chinese populations

Free
Jing Chen, Ting Ye, Li Fan, Jieying Zhang, Rubo Cao, Yanshen Liu
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5764.
https://doi.org/10.1158/1538-7445.AM2022-5764
Published: 15 June 2022
View articletitled, Abstract 5764: Genomic profiling of cutaneous, acral and mucosal melanomas in Chinese populations
Journal Articles

Abstract 5774: Investigating the characteristics of BRAF Mutations and its potential relationship with therapy in a large Chinese Lung Cancer cohort

Free
Jianqing Zhang, Jiagang Feng, Ling Liu, Man Jia, Tong Liu, Jiaqiang Zhang, Zehua Liao, Jianmei Zhao, Yu Fang, Jing Chen, Xiaoyan Zhang, Tonghui Ma
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5774.
https://doi.org/10.1158/1538-7445.AM2022-5774
Published: 15 June 2022
View articletitled, Abstract 5774: Investigating the characteristics of BRAF Mutations and its potential relationship with therapy in a large Chinese Lung Cancer cohort
Journal Articles

Abstract 2294: NEK1 phosphorylation of YAP promotes its stabilization and transcriptional output

Free
Md Imtiaz Khalil, Ishita Ghosh, Vibha Singh, Jing Chen, Haining Zhu, Arrigo De Benedetti
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 2294.
https://doi.org/10.1158/1538-7445.AM2021-2294
Published: 01 July 2021
View articletitled, Abstract 2294: NEK1 phosphorylation of YAP promotes its stabilization and transcriptional output
Journal Articles

Abstract 2063: TLK1 phosphorylates RAD54 to promote homology driven DSB repair

Free
Ishita Ghosh, Youngho Kwon, Jing Chen, Platon Selemenakis, Claudia Wiese, Patrick Sung, Arrigo DeBenedetti
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 2063.
https://doi.org/10.1158/1538-7445.AM2021-2063
Published: 01 July 2021
View articletitled, Abstract 2063: TLK1 phosphorylates RAD54 to promote homology driven DSB repair
Journal Articles

Abstract 3206: IQuery: A tool aggregating multiple gene set analysis methods, based on networks and pathways in a community-driven public data repository

Free
Dexter R. Pratt, Keiichiro Ono, Sophie Liu, Jing Chen, Christopher Churas
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 3206.
https://doi.org/10.1158/1538-7445.AM2020-3206
Published: 15 August 2020
View articletitled, Abstract 3206: IQuery: A tool aggregating multiple gene set analysis methods, based on networks and pathways in a community-driven public data repository
Journal Articles

Abstract 1837: Tyr phosphorylation activates and inhibits upstream acetyltransferases and deacetylase of 6PGD, respectively, to promote cancer metabolism and tumor growth

Free
Siyuan Xia, Changliang Shan, Jun Fan, Jing Chen
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 1837.
https://doi.org/10.1158/1538-7445.AM2019-1837
Published: 01 July 2019
View articletitled, Abstract 1837: Tyr phosphorylation activates and inhibits upstream acetyltransferases and deacetylase of 6PGD, respectively, to promote cancer metabolism and tumor growth
Journal Articles

Oncogenic Kinase–Induced PKM2 Tyrosine 105 Phosphorylation Converts Nononcogenic PKM2 to a Tumor Promoter and Induces Cancer Stem–like Cells

Free
Zhifen Zhou, Min Li, Lin Zhang, Hong Zhao, Özgür Şahin, Jing Chen, Jean J. Zhao, Zhou Songyang, Dihua Yu
Journal: Cancer Research
Cancer Res (2018) 78 (9): 2248–2261.
https://doi.org/10.1158/0008-5472.CAN-17-2726
Published: 30 April 2018
View articletitled, Oncogenic Kinase–Induced PKM2 Tyrosine 105 Phosphorylation Converts Nononcogenic PKM2 to a Tumor Promoter and Induces Cancer Stem–like Cells
Open the PDF for Oncogenic Kinase–Induced PKM2 Tyrosine 105 Phosphorylation Converts Nononcogenic PKM2 to a Tumor Promoter and Induces Cancer Stem–like Cells in another window
Includes: Supplementary data
Journal Articles

NDEx 2.0: A Clearinghouse for Research on Cancer Pathways

Free
Dexter Pratt, Jing Chen, Rudolf Pillich, Vladimir Rynkov, Aaron Gary, Barry Demchak, Trey Ideker
Journal: Cancer Research
Cancer Res (2017) 77 (21): e58–e61.
https://doi.org/10.1158/0008-5472.CAN-17-0606
Published: 01 November 2017
View articletitled, NDEx 2.0: A Clearinghouse for Research on Cancer Pathways
Open the PDF for NDEx 2.0: A Clearinghouse for Research on Cancer Pathways in another window
Includes: Multimedia, Supplementary data
Journal Articles

Abstract 5251: Amentoflavone regulate Hh-Gli1 signaling pathway and inhibits tumorsphere formation in U251 glioblastoma cells

Free
Jing Chen, Cheng Bao, Hong Jin Lee
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 5251.
https://doi.org/10.1158/1538-7445.AM2017-5251
Published: 01 July 2017
View articletitled, Abstract 5251: Amentoflavone regulate Hh-Gli1 signaling pathway and inhibits tumorsphere formation in U251 glioblastoma cells