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Journal Articles

Abstract CT208: Tebotelimab, a PD-1/LAG-3 bispecific antibody, in patients with untreated, unresectable, recurrent or metastatic, mucosal melanoma: An open-label, single-arm, Phase 1 study

Si Lu, Yu Chen, Meiyu Fang, Zhengyun Zou, Di Wu, Zhiguo Luo, Jian Zhang, Jing Chen, Gang Huang, Hongming Pan, Xiubao Ren, Ying Cheng, Haichuan Su, Yuan Xin, Qiong Hua, Jianmei Hou, Jun Guo
Journal: Cancer Research
Cancer Res (2023) 83 (8_Supplement): CT208.
https://doi.org/10.1158/1538-7445.AM2023-CT208
Published: 14 April 2023
View article titled, Abstract CT208: Tebotelimab, a PD-1/LAG-3 bispecific antibody, in patients with untreated, unresectable, recurrent or metastatic, mucosal melanoma: An open-label, single-arm, Phase 1 study
Journal Articles

Abstract 283: AHCYL1 is crucial for NRAS mutant-expressing melanoma tumor growth by governing ER calcium homeostasis

Chufan Cai, Jiayi Tu, Jeronimo Najarro, Rukang Zhang, Xue Gao, Hao Fan, Freya Zhang, Jiacheng Li, Michele Ciboddo, Shannon Elf, Rong Wu, Jing Chen
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 283.
https://doi.org/10.1158/1538-7445.AM2023-283
Published: 04 April 2023
View article titled, Abstract 283: AHCYL1 is crucial for NRAS mutant-expressing melanoma tumor growth by governing ER calcium homeostasis
Journal Articles

Abstract 6604: Analytical development and validation of a personalized hybrid capture based assay for high sensitivity monitoring minimal residual disease (MRD)

Xiaoqiang Wang, Lei Ye, Chao Zhang, Wanglong Deng, Yongjie Wei, Jing Chen, Xuan Tang, Xiaoxuan Wang, Chao Song, Qing Xu, Yong Ren
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 6604.
https://doi.org/10.1158/1538-7445.AM2023-6604
Published: 04 April 2023
View article titled, Abstract 6604: Analytical development and validation of a personalized hybrid capture based assay for high sensitivity monitoring minimal residual disease (MRD)
Journal Articles

Androgen Signaling Contributes to Sex Differences in Cancer by Inhibiting NF-κB Activation in T Cells and Suppressing Antitumor Immunity

Xiaomin Zhang, Limin Cheng, Chengqi Gao, Jing Chen, Shuangye Liao, Yongqiang Zheng, Liping Xu, Jingjing He, Danyang Wang, Ziqian Fang, Jianeng Zhang, Min Yan, Yi Luan, Siyu Chen, Likun Chen, Xiaojun Xia, Chunhao Deng, Guokai Chen, Wende Li, Zexian Liu, Penghui Zhou
Journal: Cancer Research
Cancer Res (2023) 83 (6): 906–921.
https://doi.org/10.1158/0008-5472.CAN-22-2405
Published: 15 March 2023
View article titled, Androgen Signaling Contributes to Sex Differences in Cancer by Inhibiting NF-κB Activation in T Cells and Suppressing Antitumor Immunity
Open the PDF for Androgen Signaling Contributes to Sex Differences in Cancer by Inhibiting NF-κB Activation in T Cells and Suppressing Antitumor Immunity in another window
Includes: Supplementary data
Journal Articles

Abstract 5774: Investigating the characteristics of BRAF Mutations and its potential relationship with therapy in a large Chinese Lung Cancer cohort

Jianqing Zhang, Jiagang Feng, Ling Liu, Man Jia, Tong Liu, Jiaqiang Zhang, Zehua Liao, Jianmei Zhao, Yu Fang, Jing Chen, Xiaoyan Zhang, Tonghui Ma
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5774.
https://doi.org/10.1158/1538-7445.AM2022-5774
Published: 15 June 2022
View article titled, Abstract 5774: Investigating the characteristics of BRAF Mutations and its potential relationship with therapy in a large Chinese Lung Cancer cohort
Journal Articles

Abstract 5764: Genomic profiling of cutaneous, acral and mucosal melanomas in Chinese populations

Jing Chen, Ting Ye, Li Fan, Jieying Zhang, Rubo Cao, Yanshen Liu
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5764.
https://doi.org/10.1158/1538-7445.AM2022-5764
Published: 15 June 2022
View article titled, Abstract 5764: Genomic profiling of cutaneous, acral and mucosal melanomas in Chinese populations
Journal Articles

Abstract 2294: NEK1 phosphorylation of YAP promotes its stabilization and transcriptional output

Md Imtiaz Khalil, Ishita Ghosh, Vibha Singh, Jing Chen, Haining Zhu, Arrigo De Benedetti
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 2294.
https://doi.org/10.1158/1538-7445.AM2021-2294
Published: 01 July 2021
View article titled, Abstract 2294: NEK1 phosphorylation of YAP promotes its stabilization and transcriptional output
Journal Articles

Abstract 2063: TLK1 phosphorylates RAD54 to promote homology driven DSB repair

Ishita Ghosh, Youngho Kwon, Jing Chen, Platon Selemenakis, Claudia Wiese, Patrick Sung, Arrigo DeBenedetti
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 2063.
https://doi.org/10.1158/1538-7445.AM2021-2063
Published: 01 July 2021
View article titled, Abstract 2063: TLK1 phosphorylates RAD54 to promote homology driven DSB repair
Journal Articles

Abstract 3206: IQuery: A tool aggregating multiple gene set analysis methods, based on networks and pathways in a community-driven public data repository

Dexter R. Pratt, Keiichiro Ono, Sophie Liu, Jing Chen, Christopher Churas
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 3206.
https://doi.org/10.1158/1538-7445.AM2020-3206
Published: 15 August 2020
View article titled, Abstract 3206: IQuery: A tool aggregating multiple gene set analysis methods, based on networks and pathways in a community-driven public data repository
Journal Articles

Abstract 1837: Tyr phosphorylation activates and inhibits upstream acetyltransferases and deacetylase of 6PGD, respectively, to promote cancer metabolism and tumor growth

Siyuan Xia, Changliang Shan, Jun Fan, Jing Chen
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 1837.
https://doi.org/10.1158/1538-7445.AM2019-1837
Published: 01 July 2019
View article titled, Abstract 1837: Tyr phosphorylation activates and inhibits upstream acetyltransferases and deacetylase of 6PGD, respectively, to promote cancer metabolism and tumor growth
Journal Articles

Oncogenic Kinase–Induced PKM2 Tyrosine 105 Phosphorylation Converts Nononcogenic PKM2 to a Tumor Promoter and Induces Cancer Stem–like Cells

Zhifen Zhou, Min Li, Lin Zhang, Hong Zhao, Özgür Şahin, Jing Chen, Jean J. Zhao, Zhou Songyang, Dihua Yu
Journal: Cancer Research
Cancer Res (2018) 78 (9): 2248–2261.
https://doi.org/10.1158/0008-5472.CAN-17-2726
Published: 30 April 2018
View article titled, Oncogenic Kinase–Induced PKM2 Tyrosine 105 Phosphorylation Converts Nononcogenic PKM2 to a Tumor Promoter and Induces Cancer Stem–like Cells
Open the PDF for Oncogenic Kinase–Induced PKM2 Tyrosine 105 Phosphorylation Converts Nononcogenic PKM2 to a Tumor Promoter and Induces Cancer Stem–like Cells in another window
Includes: Supplementary data
Journal Articles

NDEx 2.0: A Clearinghouse for Research on Cancer Pathways

Dexter Pratt, Jing Chen, Rudolf Pillich, Vladimir Rynkov, Aaron Gary, Barry Demchak, Trey Ideker
Journal: Cancer Research
Cancer Res (2017) 77 (21): e58–e61.
https://doi.org/10.1158/0008-5472.CAN-17-0606
Published: 31 October 2017
View article titled, NDEx 2.0: A Clearinghouse for Research on Cancer Pathways
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Journal Articles

Abstract 5251: Amentoflavone regulate Hh-Gli1 signaling pathway and inhibits tumorsphere formation in U251 glioblastoma cells

Jing Chen, Cheng Bao, Hong Jin Lee
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 5251.
https://doi.org/10.1158/1538-7445.AM2017-5251
Published: 01 July 2017
View article titled, Abstract 5251: Amentoflavone regulate Hh-Gli1 signaling pathway and inhibits tumorsphere formation in U251 glioblastoma cells
Journal Articles

Abstract 2904: Induction of autophagy reveals a cytoprotective mechanism by which DNA polymerase gamma (pol-γ) prevents UVB-induced skin cancer

Sanjit K. Dhar, Vasu Bakthavachalu, Tadahide Izumi, Jing Chen, Haining Zhu, Daret K. St. Clair
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 2904.
https://doi.org/10.1158/1538-7445.AM2015-2904
Published: 01 August 2015
View article titled, Abstract 2904: Induction of autophagy reveals a cytoprotective mechanism by which DNA polymerase gamma (pol-γ) prevents UVB-induced skin cancer
Journal Articles

LASP1 Is a HIF1α Target Gene Critical for Metastasis of Pancreatic Cancer

Tiansuo Zhao, He Ren, Jing Li, Jing Chen, Huan Zhang, Wen Xin, Yan Sun, Lei Sun, Yongwei Yang, Junwei Sun, Xiuchao Wang, Song Gao, Chongbiao Huang, Huafeng Zhang, Shengyu Yang, Jihui Hao
Journal: Cancer Research
Cancer Res (2015) 75 (1): 111–119.
https://doi.org/10.1158/0008-5472.CAN-14-2040
Published: 04 January 2015
View article titled, LASP1 Is a HIF1α Target Gene Critical for Metastasis of Pancreatic Cancer
Open the PDF for LASP1 Is a HIF1α Target Gene Critical for Metastasis of Pancreatic Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 961: 6-phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumor growth by inhibiting LKB1-AMPK signaling

Changliang Shan, Shannon E. Elf, Ting-Lei Gu, Hanna J. Khoury, Titus Boggon, Sumin Kang, Jing Chen
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 961.
https://doi.org/10.1158/1538-7445.AM2014-961
Published: 01 October 2014
View article titled, Abstract 961: 6-phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumor growth by inhibiting LKB1-AMPK signaling
Journal Articles

Abstract 1382: Developmental exposure to BPA increases the prostate cancer susceptibility via reprogramming of androgen-responsive genes via increased H3K4me3 methylation

Quan Wang, Rebecca Lee Yean Wong, Donna F. Kusewitt, Maarten C. Bosland, Jing Chen, Mario Medvedovic, Gail S. Prins, Kurunthachalam Kannan, Shuk-Mei Ho, Cheryl Lyn Walker
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 1382.
https://doi.org/10.1158/1538-7445.AM2014-1382
Published: 01 October 2014
View article titled, Abstract 1382: Developmental exposure to BPA increases the prostate cancer susceptibility via reprogramming of androgen-responsive genes via increased H3K4me3 methylation
Journal Articles

Abstract 3162: Differential mechanisms utilized by pancreatic tumor cells and associated fibroblasts to remodel stroma during metastatic invasion

Hong Cao, Robbin Eppinga, Eugene Krueger, Jing Chen, Gina Razidlo, Mark A. McNiven
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 3162.
https://doi.org/10.1158/1538-7445.AM2014-3162
Published: 01 October 2014
View article titled, Abstract 3162: Differential mechanisms utilized by pancreatic tumor cells and associated fibroblasts to remodel stroma during metastatic invasion
Journal Articles

Abstract 3362: Tyr-phosphorylation of PDP1 toggles recruitment between ACAT1 and SIRT3 to regulate pyruvate dehydrogenase complex and promote the Warburg effect

Jun Fan, Ting-Lei Gu, Titus Boggon, Sumin Kang, Jing Chen
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 3362.
https://doi.org/10.1158/1538-7445.AM2014-3362
Published: 01 October 2014
View article titled, Abstract 3362: Tyr-phosphorylation of PDP1 toggles recruitment between ACAT1 and SIRT3 to regulate pyruvate dehydrogenase complex and promote the Warburg effect
Journal Articles

YAP/TEAD–Mediated Transcription Controls Cellular Senescence

Qi Xie, Jing Chen, Han Feng, Shengyi Peng, Ursula Adams, Yujie Bai, Li Huang, Ji Li, Junjian Huang, Songshu Meng, Zengqiang Yuan
Journal: Cancer Research
Cancer Res (2013) 73 (12): 3615–3624.
https://doi.org/10.1158/0008-5472.CAN-12-3793
Published: 13 June 2013
View article titled, YAP/TEAD–Mediated Transcription Controls Cellular Senescence
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Includes: Supplementary data