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Jill P. Mesirov
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Journal Articles

MICAL2 Promotes Pancreatic Cancer Growth and Metastasis

Open Access
Bharti Garg, Sohini Khan, Asimina S. Courelli, Ponmathi Panneerpandian, Deepa Sheik Pran Babu, Evangeline S. Mose, Kevin Christian Montecillo Gulay, Shweta Sharma, Divya Sood, Alexander T. Wenzel, Alexei Martsinkovskiy, Nirakar Rajbhandari, Jay Patel, Dawn Jaquish, Edgar Esparza, Katelin Jaque, Neetu Aggarwal, Guillem Lambies, Anthony D’Ippolito, Kathryn Austgen, Brian Johnston, David A. Orlando, Gun Ho Jang, Steven Gallinger, Elliot Goodfellow, Pnina Brodt, Cosimo Commisso, Pablo Tamayo, Jill P. Mesirov, Hervé Tiriac, Andrew M. Lowy
Journal: Cancer Research
Cancer Res (2025) 85 (6): 1049–1063.
https://doi.org/10.1158/0008-5472.CAN-24-0744
Published: 14 March 2025
View articletitled, MICAL2 Promotes Pancreatic Cancer Growth and Metastasis
Open the PDF for MICAL2 Promotes Pancreatic Cancer Growth and Metastasis in another window
Includes: Supplementary data
Journal Articles

Abstract 7426: The GenePattern ecosystem for cancer bioinformatics

Free
Michael M. Reich, Thorin Tabor, John Liefeld, Edwin Huang, Forrest Kim, Jill P. Mesirov
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 7426.
https://doi.org/10.1158/1538-7445.AM2024-7426
Published: 22 March 2024
View articletitled, Abstract 7426: The GenePattern ecosystem for cancer bioinformatics
Journal Articles

Abstract 2343: Adapting gene set enrichment analysis to single cell data

Free
Alexander T. Wenzel, John Jun, Jill P. Mesirov
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 2343.
https://doi.org/10.1158/1538-7445.AM2024-2343
Published: 22 March 2024
View articletitled, Abstract 2343: Adapting gene set enrichment analysis to single cell data
Journal Articles

Abstract 2541: The landscape of circular extrachromosomal amplification in pediatric cancers

Free
Sunita Sridhar, Owen S. Chapman, Shanqing Wang, Aditi Dutta, Jill P. Mesirov, Lukas Chavez
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 2541.
https://doi.org/10.1158/1538-7445.AM2024-2541
Published: 22 March 2024
View articletitled, Abstract 2541: The landscape of circular extrachromosomal amplification in pediatric cancers
Journal Articles

Abstract 4281: Data driven refinement of gene signatures for enrichment analysis and cell state characterization

Free
Alexander T. Wenzel, Pablo Tamayo, Jill P. Mesirov
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4281.
https://doi.org/10.1158/1538-7445.AM2023-4281
Published: 04 April 2023
View articletitled, Abstract 4281: Data driven refinement of gene signatures for enrichment analysis and cell state characterization
Journal Articles

Abstract 2073: Genomics to Notebook (g2nb): Extending the electronic notebook to address the needs of cancer bioinformatics

Free
Michael M. Reich, Thorin Tabor, John Liefeld, Jayadev Joshi, Forrest Kim, Helga Thorvaldsdottir, Daniel Blankenberg, Jill P. Mesirov
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 2073.
https://doi.org/10.1158/1538-7445.AM2023-2073
Published: 04 April 2023
View articletitled, Abstract 2073: Genomics to Notebook (g2nb): Extending the electronic notebook to address the needs of cancer bioinformatics
Journal Articles

Abstract 6568: Extended support for model organisms: The next frontier for the molecular signatures database

Free
Anthony S. Castanza, Jill M. Recla, David Eby, Alexander T. Wenzel, Helga Thorvaldsdottir, Carol J. Bult, Jill P. Mesirov
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 6568.
https://doi.org/10.1158/1538-7445.AM2023-6568
Published: 04 April 2023
View articletitled, Abstract 6568: Extended support for model organisms: The next frontier for the molecular signatures database
Journal Articles

Abstract 2868: A chemogenetic approach reveals a GPCR-Gαs-PKA signaling axis promoting T cell dysfunction and cancer immunotherapy failure

Free
Bryan S. Yung, Victoria H. Wu, Farhoud Faraji, Robert Saddawi-Konefka, Zhiyong Wang, Alexander T. Wenzel, Miranda Song, Meghana S. Pagadala, Lauren M. Clubb, Joshua Chiou, Sanju Sinha, Marin Matic, Francesco Raimondi, Thomas Hoang, Rebecca Berdeaux, Dario A. Vignali, Ramiro Iglesias-Bartolome, Hannah Carter, Eytan Ruppin, Jill P. Mesirov, J. Silvio Gutkind
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 2868.
https://doi.org/10.1158/1538-7445.AM2023-2868
Published: 04 April 2023
View articletitled, Abstract 2868: A chemogenetic approach reveals a GPCR-Gαs-PKA signaling axis promoting T cell dysfunction and cancer immunotherapy failure
Journal Articles

Abstract 3825: Germline modifiers of the tumor immune microenvironment reveal drivers of immunotherapy response

Free
Meghana Pagadala, Victoria Wu, Eva Pérez-Guijarro, Hyo Kim, Andrea Castro, James Talwar, Cristian Gonzalez-Colin, Steven Cao, Benjamin J. Schmiedel, Timothy Sears, Shervin Goudarzi, Divya Kirani, Rany M. Salem, Gerald P. Morris, Olivier Harismendy, Sandip P. Patel, Jill P. Mesirov, Maurizio Zanetti, Chi-Ping Day, Chun C. Fan, Wesley K. Thompson, Glenn Merlino, J. Silvio Gutkind, Pandurangan Vijayanand, Hannah Carter
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3825.
https://doi.org/10.1158/1538-7445.AM2022-3825
Published: 15 June 2022
View articletitled, Abstract 3825: Germline modifiers of the tumor immune microenvironment reveal drivers of immunotherapy response
Journal Articles

Abstract 5032: Data driven refinement of gene signatures for enrichment analysis and cell state characterization

Free
Alexander T. Wenzel, Pablo Tamayo, Jill P. Mesirov
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5032.
https://doi.org/10.1158/1538-7445.AM2022-5032
Published: 15 June 2022
View articletitled, Abstract 5032: Data driven refinement of gene signatures for enrichment analysis and cell state characterization
Journal Articles

Abstract 1903: GenePattern Notebook: An integrative analytical environment for cancer research

Free
Michael M. Reich, Thorin Tabor, Edwin Juarez, Alexander Wenzel, Ted Liefeld, Barbara Hill, David Eby, Forrest Kim, Helga Thorvaldsdóttir, Pablo Tamayo, Jill P. Mesirov
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1903.
https://doi.org/10.1158/1538-7445.AM2022-1903
Published: 15 June 2022
View articletitled, Abstract 1903: GenePattern Notebook: An integrative analytical environment for cancer research
Journal Articles

Abstract 95: The landscape of extrachromosomal circular DNA in medulloblastoma subgroups

Free
Owen S. Chapman, Shanqing Wang, Jens Luebeck, Alexandra Garancher, Jon D. Larson, Joshua Lange, John Crawford, Scott L. Pomeroy, Paul Mischel, Ernest Fraenkel, Robert J. Wechsler-Reya, Vineet Bafna, Jill P. Mesirov, Lukas Chavez
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 95.
https://doi.org/10.1158/1538-7445.AM2021-95
Published: 01 July 2021
View articletitled, Abstract 95: The landscape of extrachromosomal circular DNA in medulloblastoma subgroups
Journal Articles

Functional Precision Medicine Identifies New Therapeutic Candidates for Medulloblastoma

Available to Purchase
Jessica M. Rusert, Edwin F. Juarez, Sebastian Brabetz, James Jensen, Alexandra Garancher, Lianne Q. Chau, Silvia K. Tacheva-Grigorova, Sameerah Wahab, Yoko T. Udaka, Darren Finlay, Huriye Seker-Cin, Brendan Reardon, Susanne Gröbner, Jonathan Serrano, Jonas Ecker, Lin Qi, Mari Kogiso, Yuchen Du, Patricia A. Baxter, Jacob J. Henderson, Michael E. Berens, Kristiina Vuori, Till Milde, Yoon-Jae Cho, Xiao-Nan Li, James M. Olson, Iris Reyes, Matija Snuderl, Terence C. Wong, David P. Dimmock, Shareef A. Nahas, Denise Malicki, John R. Crawford, Michael L. Levy, Eliezer M. Van Allen, Stefan M. Pfister, Pablo Tamayo, Marcel Kool, Jill P. Mesirov, Robert J. Wechsler-Reya
Journal: Cancer Research
Cancer Res (2020) 80 (23): 5393–5407.
https://doi.org/10.1158/0008-5472.CAN-20-1655
Published: 02 December 2020
View articletitled, Functional Precision Medicine Identifies New Therapeutic Candidates for Medulloblastoma
Open the PDF for Functional Precision Medicine Identifies New Therapeutic Candidates for Medulloblastoma in another window
Includes: Supplementary data
Journal Articles

Abstract 3207: GenePattern Notebook: An integrative analytical environment for cancer research

Free
Michael M. Reich, Thorin Tabor, Ted Liefeld, Edwin Juarez, Barbara Hill, Helga Thorvaldsdottir, Pablo Tamayo, Jill P. Mesirov
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 3207.
https://doi.org/10.1158/1538-7445.AM2020-3207
Published: 15 August 2020
View articletitled, Abstract 3207: GenePattern Notebook: An integrative analytical environment for cancer research
Journal Articles

Abstract 4411: A gene set enrichment analysis approach in single-cells along pseudotime trajectories reveals the dynamic activity of oncogenic pathways

Free
Alexander T. Wenzel, Devora Champa, Stephen B. Howell, Jill P. Mesirov, Olivier Harismendy
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 4411.
https://doi.org/10.1158/1538-7445.AM2020-4411
Published: 15 August 2020
View articletitled, Abstract 4411: A gene set enrichment analysis approach in single-cells along pseudotime trajectories reveals the dynamic activity of oncogenic pathways
Journal Articles

Abstract 447: Integrated omics modeling of transcriptional regulation in medulloblastoma subtypes

Free
Owen S. Chapman, Tobias Ehrenberger, Tenley C. Archer, Maxwell P. Gold, Filip Mundt, Miriam Adam, Clarence K. Mah, Karsten Krug, Sahaana Chandran, Jesse R. Dixon, Scot L. Pomeroy, Ernest Fraenkel, Jill P. Mesirov, Lukas Chavez
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 447.
https://doi.org/10.1158/1538-7445.AM2020-447
Published: 15 August 2020
View articletitled, Abstract 447: Integrated omics modeling of transcriptional regulation in medulloblastoma subtypes
Journal Articles

Abstract 5106: The GenePattern Notebook environment for reproducible cancer research

Free
Michael M. Reich, Thorin T. Tabor, Ted Liefeld, Barbara Hill, Helga Thorvaldsdottir, Jill P. Mesirov
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 5106.
https://doi.org/10.1158/1538-7445.AM2019-5106
Published: 01 July 2019
View articletitled, Abstract 5106: The GenePattern Notebook environment for reproducible cancer research
Journal Articles

Abstract 2279: The GenePattern Notebook environment for reproducible cancer research

Free
Michael M. Reich, Thorin T. Tabor, Ted Liefeld, Barbara Hill, Helga Thorvaldsdottir, Jill P. Mesirov
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 2279.
https://doi.org/10.1158/1538-7445.AM2018-2279
Published: 01 July 2018
View articletitled, Abstract 2279: The GenePattern Notebook environment for reproducible cancer research
Journal Articles

Variant Review with the Integrative Genomics Viewer

Free
James T. Robinson, Helga Thorvaldsdóttir, Aaron M. Wenger, Ahmet Zehir, Jill P. Mesirov
Journal: Cancer Research
Cancer Res (2017) 77 (21): e31–e34.
https://doi.org/10.1158/0008-5472.CAN-17-0337
Published: 31 October 2017
View articletitled, Variant Review with the Integrative Genomics Viewer
Open the PDF for Variant Review with the Integrative Genomics Viewer in another window
Includes: Multimedia, Supplementary data
Journal Articles

Abstract 2588: GenePattern Notebook: an environment for reproducible cancer research

Free
Michael M. Reich, Thorin T. Tabor, Ted Liefeld, Barbara Hill, Helga Thorvaldsdottir, Jill P. Mesirov
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 2588.
https://doi.org/10.1158/1538-7445.AM2017-2588
Published: 01 July 2017
View articletitled, Abstract 2588: GenePattern Notebook: an environment for reproducible cancer research