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Jiexin Zhang
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Journal Articles

Abstract 223: Chronic exposure to waterpipe smoke elicits immunomodulatory and carcinogenic effects in the lung

Zahraa Rahal, Maya Hassane, Nareg Karaoghlanian, Jiexin Zhang, Ansam Sinjab, J. Jack Lee, Maria Gabriela Raso, Junya Fujimoto, Hassan Chami, Alan Shihadeh, Humam Kadara
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 223.
https://doi.org/10.1158/1538-7445.AM2022-223
Published: 15 June 2022
View article titled, Abstract 223: Chronic exposure to waterpipe smoke elicits immunomodulatory and carcinogenic effects in the lung
Journal Articles

Abstract 1974: Immune gene expression signatures associated clinical benefit from nivolumab and ipilimumab for previously treated patients with stage IV squamous cell lung cancer: An immune biomarker analysis of phase III SWOG LungMAP S1400I trial

Dzifa Y. Duose, Jiexin Zhang, Mary Redman, Baili Zhang, Ethan Cerami, James Lindsay, Joyce Yu, Roshni Biswas, Stephen Van Nostrand, Radim Moravec, Rajyalakshmi Luthra, Gheath Al-Atrash, Karen Kelly, Roy Herbst, Ignacio Wistuba, Scott Gettinger, Lyudmila Bazhenova, J. Jack Lee, Jianjun Zhang, Cara Haymaker
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1974.
https://doi.org/10.1158/1538-7445.AM2022-1974
Published: 15 June 2022
View article titled, Abstract 1974: Immune gene expression signatures associated clinical benefit from nivolumab and ipilimumab for previously treated patients with stage IV squamous cell lung cancer: An immune biomarker analysis of phase III SWOG LungMAP S1400I trial
Journal Articles

Abstract 2580: Infiltration and spatial distribution of immune cells are associated clinical benefit from Nivolumab and Ipilimumab for previously treated patients with stage IV squamous cell lung cancer: an immune biomarker analysis of Phase III SWOG LungMAP S1400I trial

Edwin Roger Parra, Jiexin Zhang, Mary Redman, Rossana Lazcano, Piubelli Mario, Caddie Laberiano Fernandez, Renganayaki K. Krishna, Shanyu Zhang, Hong Chen, Ganiraju Manyam, Radim Moravec, Ethan Cerami, James Lindsay, Joyce Yu, Roshni Biswas, Stephen Van Nostrand, Dzifa Y. Duose, Jianjun Zhang, Roy Herbst, Gheath Al-Atrash, Kasthuri Kannan, Ignacio I. Wistuba, Scott Gettinger, Lyudmila Bazhenova, Jack Lee, Jianhua Zhang, Cara Haymaker
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2580.
https://doi.org/10.1158/1538-7445.AM2022-2580
Published: 15 June 2022
View article titled, Abstract 2580: Infiltration and spatial distribution of immune cells are associated clinical benefit from Nivolumab and Ipilimumab for previously treated patients with stage IV squamous cell lung cancer: an immune biomarker analysis of Phase III SWOG LungMAP S1400I trial
Journal Articles

Abstract 6152: Distinct immune gene programs associated with host tumor immunity, neoadjuvant chemotherapy and chemoimmunotherapy in resectable NSCLC

Pedro Rocha, Jiexin Zhang, Raquel Laza-Briviesca, Alberto Cruz-Bermúdez, Katsuhiro Yoshimura, Carmen Behrens, Apar Pataer, Edwin Parra-Cuentas, Cara Haymaker, Junya Fujimoto, Stephen Swisher, John Heymach, Don L. Gibbons, J Jack Lee, Boris Sepesi, Tina Cascone, Luisa M. Solis, Mariano Provencio, Ignacio I. Wistuba, Humam Kadara
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 6152.
https://doi.org/10.1158/1538-7445.AM2022-6152
Published: 15 June 2022
View article titled, Abstract 6152: Distinct immune gene programs associated with host tumor immunity, neoadjuvant chemotherapy and chemoimmunotherapy in resectable NSCLC
Journal Articles

Abstract 130: Resolving the spatial and cellular architecture of lung adenocarcinoma by multi-region single-cell sequencing

Ansam Sinjab, Guangchun Han, Warapen Treekitkarnmongkol, Kieko Hara, Patrick Brennan, Minghao Dang, Dapeng Hao, Ruiping Wang, Enyu Dai, Hitoshi Dejima, Jiexin Zhang, Elena Bogatenkova, Beatriz Sanchez-Espiridion, Kyle Chang, Danielle R. Little, Samer Bazzi, Linh Tran, Kostyantyn Krysan, Carmen Behrens, Dzifa Duose, Edwin R. Parra, Maria Gabriela Raso, Luisa M. Solis, Junya Fukuoka, Jianjun Zhang, Boris Sepesi, Tina Cascone, Lauren A. Byers, Don L. Gibbons, Jichao Chen, Seyed Javad Moghaddam, Edwin J. Ostrin, Daniel G. Rosen, John V. Heymach, Paul Scheet, Steven Dubinett, Ignacio I. Wistuba, Junya Fujimoto, Christopher S. Stevenson, Avrum E. Spira, Linghua Wang, Humam Kadara
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 130.
https://doi.org/10.1158/1538-7445.AM2021-130
Published: 01 July 2021
View article titled, Abstract 130: Resolving the spatial and cellular architecture of lung adenocarcinoma by multi-region single-cell sequencing
Journal Articles

Abstract 3162: Prognostic value of tumor mutational burden using a 409 gene NGS panel in cancer patients with advanced stage recurrent or treatment refractory disease

Richard K. Yang, Peng Wang, Fatima Z. Jelloul, Mark J. Routbort, Scott Kopetz, Kenna R. Shaw, Jack J. Lee, Jiexin Zhang, Hui Chen, Keyur P. Patel, Raja Luthra, Russell R. Broaddus
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3162.
https://doi.org/10.1158/1538-7445.AM2019-3162
Published: 01 July 2019
View article titled, Abstract 3162: Prognostic value of tumor mutational burden using a 409 gene NGS panel in cancer patients with advanced stage recurrent or treatment refractory disease
Journal Articles

Abstract 2790: Characterization of the immune microenvironment in brain metastasis from non-small cell lung cancer

Yujin Kudo, Cara Haymaker, Jiexin Zhang, Alexandre Reuben, Dzifa Yawa Duose, Junya Fujimoto, Sinchita Roy-Chowdhuri, Luisa Maren Solis, Hitoshi Dejima, Edwin Roger Cuentas, Barbara Mino, Ronald Abraham, Norihiko Ikeda, Rajyalakshmi Luthra, Jack J. Lee, Humam Kadara, Jason T. Huse, Ignacio I. Wistuba
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2790.
https://doi.org/10.1158/1538-7445.AM2019-2790
Published: 01 July 2019
View article titled, Abstract 2790: Characterization of the immune microenvironment in brain metastasis from non-small cell lung cancer
Journal Articles

Abstract 4054: Gene expression difference (GED) revealed immune function gene down-regulation as tumor-associated inflammatory cell (TAIC) infiltration in microenvironment in non-small cell lung cancer (NSCLC)

Ximing Tang, Wei Lu, Jiexin Zhang, Carmen Berhens, Edwin R. Parra, John Wineman, Jianjun Zhang, Don Lynn Gibbons, Mark Koeppel, BJ Kerns, Mark Stern, Boris Sepesi, Jack J. Lee, Ignacio I. Wistuba
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 4054.
https://doi.org/10.1158/1538-7445.AM2018-4054
Published: 01 July 2018
View article titled, Abstract 4054: Gene expression difference (GED) revealed immune function gene down-regulation as tumor-associated inflammatory cell (TAIC) infiltration in microenvironment in non-small cell lung cancer (NSCLC)
Journal Articles

Abstract 5506: NOTCH1 activation in head and neck squamous cell carcinoma leads to growth inhibition, changes in gene expression associated with early differentiation, and acquisition of stem cell-like properties

Chenfei Huang, Shhyam Moorthy, Qiuli Li, Rami Saade, Jiping Wang, Xiayu Rao, Noriaki Tanaka, Jiexin Zhang, Lin Tang, Curtis R. Pickering, Patrick A. Zweidler-McKay, Abdullah A. Osman, Tong-Xin Xie, Eve Shinbrot, Liu Xi, David Wheeler, Adel K. El-Naggar, Jing Wang, Jeffrey N. Myers, Mitchell J. Frederick
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5506.
https://doi.org/10.1158/1538-7445.AM2018-5506
Published: 01 July 2018
View article titled, Abstract 5506: NOTCH1 activation in head and neck squamous cell carcinoma leads to growth inhibition, changes in gene expression associated with early differentiation, and acquisition of stem cell-like properties
Journal Articles

Abstract 3633: Immunofluorescence profiling of co-expression of multiple immune checkpoints in malignant and tumor infiltrated lymphocytes in non-small cell lung carcinomas using image analysis system

Edwin Roger Parra, Mei Jiang, Jiexin Zhang, Carmen Behrens, Jack Lee, John Victor Heymach, Marie-Andrée Forget, Cara Haymaker, Chantale Bernatchez, Cesar Moran, Jianjun Zhang, Don Gibbons, Ignacio Wistuba
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 3633.
https://doi.org/10.1158/1538-7445.AM2018-3633
Published: 01 July 2018
View article titled, Abstract 3633: Immunofluorescence profiling of co-expression of multiple immune checkpoints in malignant and tumor infiltrated lymphocytes in non-small cell lung carcinomas using image analysis system
Journal Articles

Abstract 3413: A pan-cancer atlas of genomic, epigenomic and transcriptomic alterations in the TGF-β pathway

Anil Korkut, Sobia Zaidi, Rupa Kanchi, Ashton C. Berger, Gordon Robertson, Lawrence N. Kwong, Mike Datto, Jason Roszik, Shiyun Ling, Andre Schultz, Visweswaran Ravikumar, Ganiraju Manyam, Arvind Rao, Simon Shelley, Yuexin Liu, Zhenlin Ju, Donna Hansel, Guillermo de Velasco, Arjun Pennathur, Jesper B. Andersen, Colm J. O'Rourke, Kazufumi Ohshiro, Wilma Jogunoori, Nancy Gough, Shulin Li, Hatice Osmanbeyoglu, Andres Houseman, Shuyun Rao, Maciej Wiznerowicz, Jian Chen, Shoujun Gu, Wencai Ma, Jiexin Zhang, Pan Tong, Andrew D. Cherniack, Chuxia Deng, Linda Resar-Smith, Jaffer Ajani, The Cancer Genome Atlas Research Network, John N. Weinstein, Lopa Mishra, Rehan Akbani
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 3413.
https://doi.org/10.1158/1538-7445.AM2018-3413
Published: 01 July 2018
View article titled, Abstract 3413: A pan-cancer atlas of genomic, epigenomic and transcriptomic alterations in the TGF-β pathway
Journal Articles

CDKN2A/p16 Deletion in Head and Neck Cancer Cells Is Associated with CDK2 Activation, Replication Stress, and Vulnerability to CHK1 Inhibition

Mayur A. Gadhikar, Jiexin Zhang, Li Shen, Xiayu Rao, Jing Wang, Mei Zhao, Nene N. Kalu, Faye M. Johnson, Lauren A. Byers, John Heymach, Walter N. Hittelman, Durga Udayakumar, Raj K. Pandita, Tej K. Pandita, Curtis R. Pickering, Abena B. Redwood, Helen Piwnica-Worms, Katharina Schlacher, Mitchell J. Frederick, Jeffrey N. Myers
Journal: Cancer Research
Series: Author Choice
Cancer Res (2018) 78 (3): 781–797.
https://doi.org/10.1158/0008-5472.CAN-17-2802
Published: 31 January 2018
View article titled, <em>CDKN2A/p16</em> Deletion in Head and Neck Cancer Cells Is Associated with CDK2 Activation, Replication Stress, and Vulnerability to CHK1 Inhibition
Open the PDF for <em>CDKN2A/p16</em> Deletion in Head and Neck Cancer Cells Is Associated with CDK2 Activation, Replication Stress, and Vulnerability to CHK1 Inhibition in another window
Includes: Supplementary data
Journal Articles

Abstract 2934: Neoadjuvant chemotherapy influence changes of the immune response in non-small cell lung carcinomas immune response in non-small cell lung carcinomas

Edwin Roger Cuentas, Carmen Behrens, Jaime Rodriguez-Canales, Mei Jiang, Apar Pataer, Arelene Correa, Stephen Swisher, Boris Sepesi, Annikka Weissferdt, Neda Kalhor, Jiexin Zhang, Jack Lee, John Heymach, Cesar Moran, Jianjun Zhang, Don Gibbons, Ignacio Wistuba
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 2934.
https://doi.org/10.1158/1538-7445.AM2017-2934
Published: 01 July 2017
View article titled, Abstract 2934: Neoadjuvant chemotherapy influence changes of the immune response in non-small cell lung carcinomas immune response in non-small cell lung carcinomas
Journal Articles

Abstract 89: Whole-exome sequencing and immune profiling of early-stage lung adenocarcinoma

Humam Kadara, Murim Choi, Jiexin Zhang, Edwin Parra Cuentas, Jaime Rodriguez Canales, Stephen Gaffney, Zi-Ming Zhao, Carmen Behrens, Junya Fujimoto, Chi-Wan Chow, Neda Kalhor, Cesar Moran, David Rimm, Stephen G. Swisher, Don L. Gibbons, John V. Heymach, Edward Kaftan, Jeffrey Townsend, Thomas J. Lynch, Joseph Schlessinger, J. Jack Lee, Richard Lifton, Ignacio I. Wistuba, Roy S. Herbst
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 89.
https://doi.org/10.1158/1538-7445.AM2016-89
Published: 15 July 2016
View article titled, Abstract 89: Whole-exome sequencing and immune profiling of early-stage lung adenocarcinoma
Journal Articles

Abstract 142: Mutation and immune profiles in early-stage lung squamous cell carcinoma

Murim Choi, Humam Kadara, Jiexin Zhang, Edwin Parra Cuentas, Jaime Rodriguez Canales, Stephen G. Gaffney, Zi-Ming Zhao, Carmen Behrens, Junya Fujimoto, Chi-Wan Chow, Neda Kalhor, Cesar Moran, David Rimm, Stephen Swisher, Don L. Gibbons, John V. Heymach, Edward Kaftan, Jeffrey Townsend, Thomas J. Lynch, Joseph Schlessinger, J. Jack Lee, Richard Lifton, Roy S. Herbst, Ignacio I. Wistuba
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 142.
https://doi.org/10.1158/1538-7445.AM2016-142
Published: 15 July 2016
View article titled, Abstract 142: Mutation and immune profiles in early-stage lung squamous cell carcinoma
Journal Articles

Abstract 2982: Genome sequencing reveals the multicentric nature of multiple synchronous lung adenocarcinomas

Jianjun Zhang, Yu Liu, Lin Li, Jianhua Zhang, Guangliang Yin, Dongmei Lin, Xiangyang Liu, Hannah Cheung, Sahil Seth, Xingzhi Song, Xizeng Mao, Jiexin Zhang, Shujun Cheng, Andrew Futreal, Yanning Gao
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 2982.
https://doi.org/10.1158/1538-7445.AM2015-2982
Published: 01 August 2015
View article titled, Abstract 2982: Genome sequencing reveals the multicentric nature of multiple synchronous lung adenocarcinomas
Journal Articles

Inhibition of mTORC1/2 Overcomes Resistance to MAPK Pathway Inhibitors Mediated by PGC1α and Oxidative Phosphorylation in Melanoma

Y.N. Vashisht Gopal, Helen Rizos, Guo Chen, Wanleng Deng, Dennie T. Frederick, Zachary A. Cooper, Richard A. Scolyer, Gulietta Pupo, Kakajan Komurov, Vasudha Sehgal, Jiexin Zhang, Lalit Patel, Cristiano G. Pereira, Bradley M. Broom, Gordon B. Mills, Prahlad Ram, Paul D. Smith, Jennifer A. Wargo, Georgina V. Long, Michael A. Davies
Journal: Cancer Research
Cancer Res (2014) 74 (23): 7037–7047.
https://doi.org/10.1158/0008-5472.CAN-14-1392
Published: 30 November 2014
View article titled, Inhibition of mTORC1/2 Overcomes Resistance to MAPK Pathway Inhibitors Mediated by PGC1α and Oxidative Phosphorylation in Melanoma
Open the PDF for Inhibition of mTORC1/2 Overcomes Resistance to MAPK Pathway Inhibitors Mediated by PGC1α and Oxidative Phosphorylation in Melanoma in another window
Includes: Supplementary data
Journal Articles

Abstract 991: The DNA methylome of castration-resistant prostate cancer

Brittney N. Kleb, Marcos Estecio, Jiexin Zhang, Vasso Tzelepi, Woonbok Chung, Sankar Maity, Christopher Logothetis, Patricia Troncoso, Nora Navone, Jaroslav Jelinek, Shoudan Liang, Jean-Pierre Issa, Ana Aparicio
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 991.
https://doi.org/10.1158/1538-7445.AM2012-991
Published: 15 April 2012
View article titled, Abstract 991: The DNA methylome of castration-resistant prostate cancer
Journal Articles

Abstract 36: Molecular profiling of prostate cancer xenografts and human specimens reveals overexpression of UBE2C/UBCH10 and activation of aurora kinases in poorly differentiated neuroendocrine carcinoma of the prostate

Vassiliki Tzelepi, Sankar Maity, Jiexin Zhang, Shoudan Liang, Jing-Fang Lu, Anh Hoang, Brittany Kleb, Eleni Efstathiou, Nora Navone, Patricia Troncoso, Christopher Logothetis, Ana Aparicio
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 36.
https://doi.org/10.1158/1538-7445.AM2011-36
Published: 15 April 2011
View article titled, Abstract 36: Molecular profiling of prostate cancer xenografts and human specimens reveals overexpression of UBE2C/UBCH10 and activation of aurora kinases in poorly differentiated neuroendocrine carcinoma of the prostate
Journal Articles

Abstract 947: Effect of estrogen on gene expression profiling in endometrium of obese, insulin resistant animals

Qian Zhang, Joseph Celestino, Jiexin Zhang, David Loose, Karen H. Lu
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 947.
https://doi.org/10.1158/1538-7445.AM10-947
Published: 15 April 2010
View article titled, Abstract 947: Effect of estrogen on gene expression profiling in endometrium of obese, insulin resistant animals