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Jiehui Deng
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Journal Articles

Abstract 3916: TNG260, a small molecule CoREST inhibitor, sensitizes STK11-mutant NSCLC to anti-PD1 immunotherapy

Ayushi Patel, Soumyadip Sahu, Ke Geng, Salman Punekar, Janaye Stephens, Jiehui Deng, Ting Chen, Leanne Ahronian, Minjie Zhang, Jannik Andersen, Brian Haines, Kwok-Kin Wong
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3916.
https://doi.org/10.1158/1538-7445.AM2024-3916
Published: 22 March 2024
View article titled, Abstract 3916: TNG260, a small molecule CoREST inhibitor, sensitizes STK11-mutant NSCLC to anti-PD1 immunotherapy
Journal Articles

Abstract 1356: In vivo epigenetic CRISPR screen identifies PRMT5 as an immune suppressor in pancreatic cancer

Hai Hu, Jiehui Deng, Fei Li, wei wang, Alireza Khodadadi-Jamayran
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1356.
https://doi.org/10.1158/1538-7445.AM2022-1356
Published: 15 June 2022
View article titled, Abstract 1356: In vivo epigenetic CRISPR screen identifies PRMT5 as an immune suppressor in pancreatic cancer
Journal Articles

Targeting HER2 Exon 20 Insertion–Mutant Lung Adenocarcinoma with a Novel Tyrosine Kinase Inhibitor Mobocertinib

Han Han, Shuai Li, Ting Chen, Michael Fitzgerald, Shengwu Liu, Chengwei Peng, Kwan Ho Tang, Shougen Cao, Johara Chouitar, Jiansheng Wu, David Peng, Jiehui Deng, Zhendong Gao, Theresa E. Baker, Fei Li, Hua Zhang, Yuanwang Pan, Hailin Ding, Hai Hu, Val Pyon, Cassandra Thakurdin, Eleni Papadopoulos, Sittinon Tang, Francois Gonzalvez, Haiquan Chen, Victor M. Rivera, Rachael Brake, Sylvie Vincent, Kwok-Kin Wong
Journal: Cancer Research
Cancer Res (2021) 81 (20): 5311–5324.
https://doi.org/10.1158/0008-5472.CAN-21-1526
Published: 15 October 2021
View article titled, Targeting <em>HER2</em> Exon 20 Insertion–Mutant Lung Adenocarcinoma with a Novel Tyrosine Kinase Inhibitor Mobocertinib
Open the PDF for Targeting <em>HER2</em> Exon 20 Insertion–Mutant Lung Adenocarcinoma with a Novel Tyrosine Kinase Inhibitor Mobocertinib in another window
Includes: Supplementary data
Journal Articles

Epigenetic CRISPR Screens Identify Npm1 as a Therapeutic Vulnerability in Non–Small Cell Lung Cancer

Fei Li, Wai-Lung Ng, Troy A. Luster, Hai Hu, Vladislav O. Sviderskiy, Catríona M. Dowling, Kate E.R. Hollinshead, Paula Zouitine, Hua Zhang, Qingyuan Huang, Michela Ranieri, Wei Wang, Zhaoyuan Fang, Ting Chen, Jiehui Deng, Kai Zhao, Hon-Cheong So, Alireza Khodadadi-Jamayran, Mousheng Xu, Angeliki Karatza, Val Pyon, Shuai Li, Yuanwang Pan, Kristen Labbe, Christina Almonte, John T. Poirier, George Miller, Richard Possemato, Jun Qi, Kwok-Kin Wong
Journal: Cancer Research
Cancer Res (2020) 80 (17): 3556–3567.
https://doi.org/10.1158/0008-5472.CAN-19-3782
Published: 02 September 2020
View article titled, Epigenetic CRISPR Screens Identify <em>Npm1</em> as a Therapeutic Vulnerability in Non–Small Cell Lung Cancer
Open the PDF for Epigenetic CRISPR Screens Identify <em>Npm1</em> as a Therapeutic Vulnerability in Non–Small Cell Lung Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 923: Pulsatile MEK inhibition improves anti-tumor immunity and T cell function in Kras mutant lung cancer

Hyejin Choi, Jiehui Deng, Shuai Li, Tarik Silk, Lauren Dong, Elliott J. Brea, Sean Houghton, David Redmond, Hong Zhong, Jonathan Boiarsky, Esra A. Akbay, Paul D. Smith, Taha Merghoub, Kwok-Kin Wong, Jedd D. Wolchok
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 923.
https://doi.org/10.1158/1538-7445.AM2020-923
Published: 15 August 2020
View article titled, Abstract 923: Pulsatile MEK inhibition improves anti-tumor immunity and T cell function in Kras mutant lung cancer
Journal Articles

Abstract 4563: Profiling the tumor immune microenvironment of adenocarcinoma and squamous cell NSCLC

Kayla Harmeyer, Jiehui Deng, Suhagi Shah, Ece Bagdatlioglu, Aarif Ahsan, Christopher Reid, Aatish Thennavan, Charles Perou, Kwok-Kin Wong, Harvey Pass
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4563.
https://doi.org/10.1158/1538-7445.AM2019-4563
Published: 01 July 2019
View article titled, Abstract 4563: Profiling the tumor immune microenvironment of adenocarcinoma and squamous cell NSCLC
Journal Articles

Abstract 4044: The immune phenotype in serial biopsies from metastatic TNBC undergoing chemo-immunotherapy

Jiehui Deng, Suhagi Shah, Aatish Thennavan, Michelle Krogsgaard, Charles M. Perou, Kwok-Kin Wong, Sylvia Adams
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4044.
https://doi.org/10.1158/1538-7445.AM2019-4044
Published: 01 July 2019
View article titled, Abstract 4044: The immune phenotype in serial biopsies from metastatic TNBC undergoing chemo-immunotherapy
Journal Articles

Abstract 3223: Overcome LKB1 mutated cancer resistance to anti-PD1 treatment

Jiehui Deng, Aatish Thennavan, Yuanwang Pan, Igor Dolgalev, Ting Chen, Heather Silver, Matthew Harris, Val Pyon, Fei Li, Chelsea Lee, Aristotelis Tsirigos, Eli Rothenberg, Charles M. Perou, Kwok-Kin Wong
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3223.
https://doi.org/10.1158/1538-7445.AM2019-3223
Published: 01 July 2019
View article titled, Abstract 3223: Overcome LKB1 mutated cancer resistance to anti-PD1 treatment
Journal Articles

Abstract 4778: Assessing efficacy of neratinib in HER2-driven lung cancer

Shuai Li, Shengwu Liu, Ting Chen, Jiehui Deng, Min Wu, Mari Kuraguchi, Cam Anh Tran, Paul T. Kirschmeier, Francesca Avogadri-Connors, Richard E. Cutler, Alshad S. Lalani, Kwok-Kin Wong
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 4778.
https://doi.org/10.1158/1538-7445.AM2018-4778
Published: 01 July 2018
View article titled, Abstract 4778: Assessing efficacy of neratinib in HER2-driven lung cancer
Journal Articles

Abstract 4184: Pre-clinical study using KRAS mutant mouse models for lung cancer immunotherapy together with MEK inhibition

Jiehui Deng, Shuai Li, Grit Herter-Sprie, Paul D. Smith, Gordon J. Freeman, Jeffrey A. Engelman, Peter Hammerman, Kwok-Kin Wong
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 4184.
https://doi.org/10.1158/1538-7445.AM2016-4184
Published: 15 July 2016
View article titled, Abstract 4184: Pre-clinical study using KRAS mutant mouse models for lung cancer immunotherapy together with MEK inhibition
Journal Articles

A Requirement of STAT3 DNA Binding Precludes Th-1 Immunostimulatory Gene Expression by NF-κB in Tumors

Heehyoung Lee, Jiehui Deng, Hong Xin, Yong Liu, Drew Pardoll, Hua Yu
Journal: Cancer Research
Cancer Res (2011) 71 (11): 3772–3780.
https://doi.org/10.1158/0008-5472.CAN-10-3304
Published: 31 May 2011
View article titled, A Requirement of STAT3 DNA Binding Precludes Th-1 Immunostimulatory Gene Expression by NF-κB in Tumors
Open the PDF for A Requirement of STAT3 DNA Binding Precludes Th-1 Immunostimulatory Gene Expression by NF-κB in Tumors in another window
Includes: Supplementary data
Journal Articles

Abstract 405: The role of Stat3 in pre-metastatic niche formation: Examination in murine models and benign lymph nodes from prostate cancer patients

Jiehui Deng, Yong Liu, Wang Zhang, Heehyoung Lee, Andreas Herrmann, Robert A. Figlin, Hua Yu, Sumanta K. Pal
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 405.
https://doi.org/10.1158/1538-7445.AM2011-405
Published: 15 April 2011
View article titled, Abstract 405: The role of Stat3 in pre-metastatic niche formation: Examination in murine models and benign lymph nodes from prostate cancer patients
Journal Articles

Targeting STAT3 in Adoptively Transferred T Cells Promotes Their In Vivo Expansion and Antitumor Effects

Maciej Kujawski, Chunyan Zhang, Andreas Herrmann, Karen Reckamp, Anna Scuto, Michael Jensen, Jiehui Deng, Stephen Forman, Robert Figlin, Hua Yu
Journal: Cancer Research
Cancer Res (2010) 70 (23): 9599–9610.
https://doi.org/10.1158/0008-5472.CAN-10-1293
Published: 06 December 2010
View article titled, Targeting STAT3 in Adoptively Transferred T Cells Promotes Their <em>In Vivo</em> Expansion and Antitumor Effects
Open the PDF for Targeting STAT3 in Adoptively Transferred T Cells Promotes Their <em>In Vivo</em> Expansion and Antitumor Effects in another window
Includes: Supplementary data
Journal Articles

Targeting Stat3 in the Myeloid Compartment Drastically Improves the In vivo Antitumor Functions of Adoptively Transferred T Cells

Andreas Herrmann, Marcin Kortylewski, Maciej Kujawski, Chunyan Zhang, Karen Reckamp, Brian Armstrong, Lin Wang, Claudia Kowolik, Jiehui Deng, Robert Figlin, Hua Yu
Journal: Cancer Research
Cancer Res (2010) 70 (19): 7455–7464.
https://doi.org/10.1158/0008-5472.CAN-10-0736
Published: 29 September 2010
View article titled, Targeting Stat3 in the Myeloid Compartment Drastically Improves the <em>In vivo</em> Antitumor Functions of Adoptively Transferred T Cells
Open the PDF for Targeting Stat3 in the Myeloid Compartment Drastically Improves the <em>In vivo</em> Antitumor Functions of Adoptively Transferred T Cells in another window
Includes: Supplementary data