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Jie Luo
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Journal Articles

Abstract 4504: Discovery of CBPD-409 and CBPD-268 as highly potent and orally efficacious CBP/p300 PROTAC degraders for the treatment of castration-resistant prostate cancer

Zhixiang Chen, Mi Wang, Dimin Wu, Lijie Zhao, Tianfeng Xu, Hoda Metwally, Yu Wang, Donna McEachern, Wei Jiang, Longchuan Bai, Jie Luo, Meilin Wang, Ruiting Li, John Takyi-Williams, Lu Wang, Qiuxia Li, Bo Wen, Duxin Sun, Arul M. Chinnaiyan, Shaomeng Wang
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 4504.
https://doi.org/10.1158/1538-7445.AM2024-4504
Published: 22 March 2024
View article titled, Abstract 4504: Discovery of CBPD-409 and CBPD-268 as highly potent and orally efficacious CBP/p300 PROTAC degraders for the treatment of castration-resistant prostate cancer
Journal Articles

Abstract 6048: Targeting AR positive prostate cancer cells by the novel P300/CBP oral available PROTAC degrader

Jie luo, Abhijit Prolia, Yuanyuan Qiao, Jean Tian, Rahul Mannan, Somnath Mahapatra, Zhixiang Chen, Rithvik Seri, Shaomeng Wang, Arul Chinnaiyan
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6048.
https://doi.org/10.1158/1538-7445.AM2024-6048
Published: 22 March 2024
View article titled, Abstract 6048: Targeting AR positive prostate cancer cells by the novel P300/CBP oral available PROTAC degrader
Journal Articles

Abstract 1433: FOXA1 alterations distinctively drive prostate tumorigenesis or therapy resistance in mice

Sanjana Eyunni, Abhijit Parolia, Eleanor Young, James Matthew George, Rahul Mannan, Sandra E. Carson, Yuping Zhang, Jean Tien, Mustapha Jaber, Jie Luo, Matthew Pang, Rohit Mehra, Xuhong Cao, Fengyun Su, Rui Wang, Marcin Cieslik, Dong Kee Lee, Jianming Xu, Arul M. Chinnaiyan
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1433.
https://doi.org/10.1158/1538-7445.AM2024-1433
Published: 22 March 2024
View article titled, Abstract 1433: FOXA1 alterations distinctively drive prostate tumorigenesis or therapy resistance in mice
Journal Articles

FASN Inhibition Decreases MHC-I Degradation and Synergizes with PD-L1 Checkpoint Blockade in Hepatocellular Carcinoma

Jiao Huang, Wai Ying Tsang, Xiao-Na Fang, Yu Zhang, Jie Luo, Lan-Qi Gong, Bai-Feng Zhang, Ching Ngar Wong, Zhi-Hong Li, Bei-Lei Liu, Jin-Lin Huang, Yu-Ma Yang, Shan Liu, Liu-Xian Ban, Yiu Hong Chan, Xin-Yuan Guan
Journal: Cancer Research
Cancer Res (2024) 84 (6): 855–871.
https://doi.org/10.1158/0008-5472.CAN-23-0966
Published: 15 March 2024
View article titled, FASN Inhibition Decreases MHC-I Degradation and Synergizes with PD-L1 Checkpoint Blockade in Hepatocellular Carcinoma
Open the PDF for FASN Inhibition Decreases MHC-I Degradation and Synergizes with PD-L1 Checkpoint Blockade in Hepatocellular Carcinoma in another window
Includes: Supplementary data
Journal Articles

Abstract A055: NSD2 is a requisite and targetable subunit of the AR/FOXA1 neo-enhanceosome complex in prostate cancer cells

Abhijit Parolia, Brijesh K. Verma, Sanjana Eyunni, Sweta Aras, Sandra E. Carson, Eleanor Young, Chandan K. Das, James M. George, Reyaz ur Rasool, Prathibha Gajjala, Mohammed Alhusayan, Erick Mitchell-Velasquez, Lanbo Xiao, Jie Luo, Mustapha Jaber, Xuhong Cao, Fengyun Su, Rui Wang, Lianchao Liu, Zhen Wang, Ke Ding, Arul M. Chinnaiyan, Irfan Asangani
Journal: Cancer Research
Cancer Res (2023) 83 (11_Supplement): A055.
https://doi.org/10.1158/1538-7445.PRCA2023-A055
Published: 02 June 2023
View article titled, Abstract A055: NSD2 is a requisite and targetable subunit of the AR/FOXA1 <em>neo</em>-enhanceosome complex in prostate cancer cells
Journal Articles

Abstract A067: Cellular cartography reveals transcriptional specificity and spatial organization of diverse luminal epithelial cells in the murine prostate

Hanbyul Cho, Yuping Zhang, Jean Tien, Jie Luo, June E. Wilke, Saravana M. Dhanasekaran, Rahul Mannan, Lisha Wang, Fengyun Su, Rui Wang, Evan T. Keller, Xuhong Cao, Sethu Pitchaya, Arul M. Chinnaiyan
Journal: Cancer Research
Cancer Res (2023) 83 (11_Supplement): A067.
https://doi.org/10.1158/1538-7445.PRCA2023-A067
Published: 02 June 2023
View article titled, Abstract A067: Cellular cartography reveals transcriptional specificity and spatial organization of diverse luminal epithelial cells in the murine prostate
Journal Articles

Abstract 1489: Overexpression of ribosomal L22-like1 (RPL22L1) enhances cancer stem cell properties and promotes tumor progression in hepatocellular carcinoma (HCC)

JinLin Huang, Zhenyang Guo, Jie Luo, Beilei Liu, Lanqi Gong, Xiaona Fang, Dora Lai-wan Kwong, Xinyuan Guan
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1489.
https://doi.org/10.1158/1538-7445.AM2023-1489
Published: 04 April 2023
View article titled, Abstract 1489: Overexpression of ribosomal L22-like1 (RPL22L1) enhances cancer stem cell properties and promotes tumor progression in hepatocellular carcinoma (HCC)
Journal Articles

Abstract 4452: FASN inhibition overcomes immune evasion by upregulating MHC-I in hepatocellular carcinoma

Jiao Huang, Wai Ying Tsang, Xiaona Fang, Yu Zhang, Jie Luo, Lanqi Gong, Baifeng Zhang, Ching Ngar Wong, Beilei Liu, Jinlin Huang, Yuma Yang, Shan Liu, Zhihong Li, Xinyuan Guan
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4452.
https://doi.org/10.1158/1538-7445.AM2023-4452
Published: 04 April 2023
View article titled, Abstract 4452: FASN inhibition overcomes immune evasion by upregulating MHC-I in hepatocellular carcinoma
Journal Articles

Abstract 4450: SOX4 promotes tumor development and immune evasion via disruption of zinc homeostasis between nasopharyngeal carcinoma cells and T cells

Yuma Yang, Lanqi Gong, Jie Luo, Xiaona Fang, Jiao Huang, Lu Bai, Qin Liu, Beilei Liu, Shan Liu, Jinlin Huang, Ching Ngar Wong, Baifeng Zhang, Danyang Zheng, Yu Zhang, Wei Dai, Xinyuan Guan
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4450.
https://doi.org/10.1158/1538-7445.AM2023-4450
Published: 04 April 2023
View article titled, Abstract 4450: SOX4 promotes tumor development and immune evasion via disruption of zinc homeostasis between nasopharyngeal carcinoma cells and T cells
Journal Articles

Abstract 3212: OQL06x, a gut-restricted janus kinase inhibitor to control epidermal growth factor receptor inhibitor-induced diarrhea

Chengguang Wu, Kun Fang, Wenqin Zeng, Wenxi Li, Shilan Liu, Qing You, Robert Claude Tyler, Jie Luo, Shiyi Zhang, Hong Tang
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3212.
https://doi.org/10.1158/1538-7445.AM2023-3212
Published: 04 April 2023
View article titled, Abstract 3212: OQL06x, a gut-restricted janus kinase inhibitor to control epidermal growth factor receptor inhibitor-induced diarrhea
Journal Articles

Abstract 3211: OQL025, a topical cream for the prevention of epidermal growth factor receptor inhibitor-induced skin rash

Shilan Liu, Wenqin Zeng, Wenxi Li, Qing You, Robert Claude Tyler, Jie Luo, Hong Tang, Shiyi Zhang
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3211.
https://doi.org/10.1158/1538-7445.AM2023-3211
Published: 04 April 2023
View article titled, Abstract 3211: OQL025, a topical cream for the prevention of epidermal growth factor receptor inhibitor-induced skin rash
Journal Articles

Abstract 5502: Androgen blockade confers sensitivity to PIKfyve inhibition in prostate cancer

Yuanyuan Qiao, Sarah Nicole Yee, Caleb Cheng, Yang Zheng, Jie Luo, Yi Bao, Xia Jiang, Xuhong Cao, Yuping Zhang, Arul M. Chinnaiyan
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5502.
https://doi.org/10.1158/1538-7445.AM2023-5502
Published: 04 April 2023
View article titled, Abstract 5502: Androgen blockade confers sensitivity to PIKfyve inhibition in prostate cancer
Journal Articles

Abstract 2445: PPM1G enhances hepatocellular carcinoma stemness via interacting with YBX1

Shan Liu, Xiaona Fang, Jie Luo, Jiao Huang, Yuma Yang, Beilei Liu, Jinlin Huang, Ching Ngar Wong, Baifeng Zhang, Lanqi Gong, Liuxian Ban, Qian Yan, Xinyuan Guan
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 2445.
https://doi.org/10.1158/1538-7445.AM2023-2445
Published: 04 April 2023
View article titled, Abstract 2445: PPM1G enhances hepatocellular carcinoma stemness via interacting with YBX1
Journal Articles

Abstract 2441: Identification and characterization of the role of KRT17 in the stemness regulation of hepatocellular carcinoma

Xiaona Fang, Shan Liu, Liuxian Ban, Jiao Huang, Jie Luo, Lanqi Gong, Baifeng Zhang, Beilei Liu, Jinlin Huang, Yuma Yang, Ching Ngar Wong, Qian Yan, Xin-Yuan Guan
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 2441.
https://doi.org/10.1158/1538-7445.AM2023-2441
Published: 04 April 2023
View article titled, Abstract 2441: Identification and characterization of the role of KRT17 in the stemness regulation of hepatocellular carcinoma
Journal Articles

Abstract 629: Characterization of the molecular mechanism of APOC1 in anti-ferroptosis and lymph node microenvironment remodeling in ESCC metastasis process

Beilei Liu, Baifeng Zhang, Hongyu Zhou, Licheng Tan, Xiaona Fang, Lanqi Gong, Jie Luo, Jinlin Huang, Jiao Huang, Yuma Yang, Xinyuan Guan
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 629.
https://doi.org/10.1158/1538-7445.AM2023-629
Published: 04 April 2023
View article titled, Abstract 629: Characterization of the molecular mechanism of APOC1 in anti-ferroptosis and lymph node microenvironment remodeling in ESCC metastasis process
Journal Articles

Abstract 4145: Frizzled-4 expression enhances hepatocellular carcinoma progression, sorafenib resistance and suppresses anti-tumor CD8 T cell immunity

Jie Luo, Lanqi Gong, Yuma Yang, Qin Liu, Jiao Huang, Xiaona Fang, Xin-Yuan Guan
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4145.
https://doi.org/10.1158/1538-7445.AM2023-4145
Published: 04 April 2023
View article titled, Abstract 4145: Frizzled-4 expression enhances hepatocellular carcinoma progression, sorafenib resistance and suppresses anti-tumor CD8 T cell immunity
Journal Articles

Abstract 6064: ADAR1-dependent RNA editing of GLI1 drives hepatocellular carcinoma stem cell self-renewal by initiating mitophagy

Jie Luo, Lanqi Gong, Yuma Yang, Jiao Huang, Xiaona Fang, Baifeng Zhang, Ying Tang, Beilei Liu, Ming Liu, Lu Bai, Victor Ho-Fun Lee, Xin-Yuan Guan
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 6064.
https://doi.org/10.1158/1538-7445.AM2022-6064
Published: 15 June 2022
View article titled, Abstract 6064: ADAR1-dependent RNA editing of GLI1 drives hepatocellular carcinoma stem cell self-renewal by initiating mitophagy
Journal Articles

Abstract 6008: Effective depletion of tumor-infiltrating Tregs by a novel anti-CCR8 antibody (LM-108): Addressing resistance associated with immune checkpoint inhibitors

Jie Luo, Wentao Huang, Junwei Yang, Jin Li, Yifan Li, Da Fei, Xia Qin, Runsheng Li
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 6008.
https://doi.org/10.1158/1538-7445.AM2022-6008
Published: 15 June 2022
View article titled, Abstract 6008: Effective depletion of tumor-infiltrating Tregs by a novel anti-CCR8 antibody (LM-108): Addressing resistance associated with immune checkpoint inhibitors
Journal Articles

Abstract 6020: Preclinical activity of LM-305 targeting G-protein-coupled receptor class 5 member D (GPRC5D) antibody drug conjugate for the treatment of multiple myeloma

Wentao Huang, Jie Luo, Yifan Li, Da Fei, Xia Qin, Runsheng Li
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 6020.
https://doi.org/10.1158/1538-7445.AM2022-6020
Published: 15 June 2022
View article titled, Abstract 6020: Preclinical activity of LM-305 targeting G-protein-coupled receptor class 5 member D (GPRC5D) antibody drug conjugate for the treatment of multiple myeloma
Journal Articles

Abstract 6127: Single-cell spatial transcriptome sequencing characterizes CD70+ immune-resilient nasopharyngeal carcinoma cells as a vital mediator of Treg-induced suppression

Lanqi Gong, Jie Luo, Yuma Yang, Yu Zhang, Xin-Yuan Guan
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 6127.
https://doi.org/10.1158/1538-7445.AM2022-6127
Published: 15 June 2022
View article titled, Abstract 6127: Single-cell spatial transcriptome sequencing characterizes CD70+ immune-resilient nasopharyngeal carcinoma cells as a vital mediator of Treg-induced suppression