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Journal Articles

Abstract LB242: Discovery and characterization of BRSD-143, an orally bioavailable panKRAS inhibitor

Charles Y. Cho, Qian Liu, Jun Liu, Deborah A. Knee, David P. Kodack, Dean P. Phillips, Phillip B. Alper, Hong Jin, Wendy Richmond, Sarah E. Kochanek, Hong Yin, Yu Chen, Jie Li, Cyrus Virata, David H. Jones, Jose C. Juarez, Michael DiDonato, Brandon L. Taylor, Dmitry Borkin, Dong Han, Xianzhong Liu, Vicki W. Zhou, Lilin Li, Rita Das, Varunika Vivekanandan, Flavio Somanji, David A. Ruddy, Michelle Piquet, Miriam Coor, Eiru Kim, Yelena Sarkisova, Min Lu, Guoxun Liu, Danielle Roman, William P. Gordon, Todd Groessl, Michael Shapiro, Yvonne Wang, Darbi Witmer, Agnes Vidal-Biggart, Yong Jia, Jacob R. Haling
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_2): LB242.
https://doi.org/10.1158/1538-7445.AM2025-LB242
Published: 25 April 2025
View articletitled, Abstract LB242: Discovery and characterization of BRSD-143, an orally bioavailable panKRAS inhibitor
Journal Articles

Abstract 1789: Preclinical characterization of BGB-B3227, a MUC1 x CD16A bispecific engager, for the treatment of MUC1-expressing solid tumors

Hengrui Zhu, Hui Li, Zhuo Li, Qi Liu, Liu Xue, Liang Qu, Ming Jiang, Jie Li, Xin Chen, Wenjie Wang, Yun Chen, Jie Pan, Yuanyuan Xie, Ting Shao, Peiqi Li, Renke Li, Caizhi Liu, Xiaoliang Chen, Lei Jiang, jingyuan Sun, Lingmin Zheng, Xiangli Ma, Juan Yang, Haoxuan Song, Fuyun Sun, Jiyuan Zhang, Xi Wu, Xianyan Tang, Qiansheng Ren, Chichi Huang, Mingchao Kang, Xiaomin Song, Zhirong Shen, Lai Wang
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 1789.
https://doi.org/10.1158/1538-7445.AM2025-1789
Published: 21 April 2025
View articletitled, Abstract 1789: Preclinical characterization of BGB-B3227, a MUC1 x CD16A bispecific engager, for the treatment of MUC1-expressing solid tumors
Journal Articles

Abstract 6009: BGB-B2033, a novel 4-1BB/GPC3 bispecific antibody, exhibits potent in vitro and vivo antitumor activity in preclinical models

Jie Li, Xi Yuan, Ruyue Ji, Chang Song, Yanwen Ma, Yuan Zhao, Yue Cao, Xinyi Liang, Yilu Zhang, Jingjuan Sun, Xiangli Ma, Lingmin Zheng, Beibei Jiang, Xiaomin Song, Yu Shen, Lai Wang
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 6009.
https://doi.org/10.1158/1538-7445.AM2025-6009
Published: 21 April 2025
View articletitled, Abstract 6009: BGB-B2033, a novel 4-1BB/GPC3 bispecific antibody, exhibits potent in vitro and vivo antitumor activity in preclinical models
Journal Articles

Abstract 5461: BG-C477, a novel topoisomerase 1 inhibitor-based ADC, exhibits antitumor activity in carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5)-expressing preclinical models

Daochuan He, Yiren Xiao, Zhuo Li, Jie Li, Hongyu Chen, Weijie Li, Huang Yan, Kunji Liu, Yang Lyu, Qingsong Hu, Mengjia Wang, Lai Xu, Zhitao Wan, Xiaomin Song, Yu Shen, Lai Wang
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 5461.
https://doi.org/10.1158/1538-7445.AM2025-5461
Published: 21 April 2025
View articletitled, Abstract 5461: BG-C477, a novel topoisomerase 1 inhibitor-based ADC, exhibits antitumor activity in carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5)-expressing preclinical models
Journal Articles

Combining Apatinib and Oxaliplatin Remodels the Immunosuppressive Tumor Microenvironment and Sensitizes Desert-Type Gastric Cancer to Immunotherapy

Guang-Tan Lin, Cheng Yan, Lu-Jie Li, Xiao-Wen Qiu, Yu-Xuan Zhao, Ju-Li Lin, Yu-Jing Chen, Chuan Feng, Shao-Qiong Chen, Jian-Wei Xie, Chao-Hui Zheng, Sachiyo Nomura, Chang-Ming Huang, Ping Li, Long-Long Cao
Journal: Cancer Research
Cancer Res (2025)
https://doi.org/10.1158/0008-5472.CAN-24-2697
Published: 07 March 2025
View articletitled, Combining Apatinib and Oxaliplatin Remodels the Immunosuppressive Tumor Microenvironment and Sensitizes Desert-Type Gastric Cancer to Immunotherapy
Open the PDF for Combining Apatinib and Oxaliplatin Remodels the Immunosuppressive Tumor Microenvironment and Sensitizes Desert-Type Gastric Cancer to Immunotherapy in another window
Includes: Supplementary data
Journal Articles

Macrophage-Derived Itaconate Suppresses Dendritic Cell Function to Promote Acquired Resistance to Anti-PD-1 Immunotherapy

Xiao Yang, Yue Deng, Ying Ye, Jingshu Meng, Mengyao Su, Wenwen Wei, You Qin, Haibo Zhang, Yu Tian, Suke Deng, Zhiyun Liao, Zhiyuan Zhou, Jie Li, Yan Hu, Bin Zhang, Yajie Sun, Lu Wen, Zhanjie Zhang, Fang Huang, Chao Wan, Kunyu Yang
Journal: Cancer Research
Cancer Res (2025)
https://doi.org/10.1158/0008-5472.CAN-24-2982
Published: 04 March 2025
View articletitled, Macrophage-Derived Itaconate Suppresses Dendritic Cell Function to Promote Acquired Resistance to Anti-PD-1 Immunotherapy
Open the PDF for Macrophage-Derived Itaconate Suppresses Dendritic Cell Function to Promote Acquired Resistance to Anti-PD-1 Immunotherapy in another window
Includes: Supplementary data
Journal Articles

Abstract PO1-22-09: Current margin assessment practice for breast-conserving surgery in China: a single institution audit

Feilin Qu, Cheng-Jia Shen, Wen-Tao Yang, Jun-Jie Li, Guangyu Liu, Zhi-Ming Shao
Journal: Cancer Research
Cancer Res (2024) 84 (9_Supplement): PO1-22-09.
https://doi.org/10.1158/1538-7445.SABCS23-PO1-22-09
Published: 02 May 2024
View articletitled, Abstract PO1-22-09: Current margin assessment practice for breast-conserving surgery in China: a single institution audit
Journal Articles

Abstract CT189: A first-in-human, phase 1a, dose-escalation study of BGB-10188, a phosphatidylinositol 3-kinase delta (PI3Kδ) inhibitor, + tislelizumab (anti-PD-1) in patients with solid tumors

Rasha Cosman, Elizabeth Ahern, Jie Li, Hui K. Gan, Yu Chen, Bo Gao, Yongsheng Wang, Xiyan Mu, Huan Cheng, Yanrong Qian, Heather Zhang, Ke Cao
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): CT189.
https://doi.org/10.1158/1538-7445.AM2024-CT189
Published: 05 April 2024
View articletitled, Abstract CT189: A first-in-human, phase 1a, dose-escalation study of BGB-10188, a phosphatidylinositol 3-kinase delta (PI3Kδ) inhibitor, + tislelizumab (anti-PD-1) in patients with solid tumors
Journal Articles

Abstract CT266: Initial efficacy of surufatinib plus sintilimab and IBI310 for patients with high-grade advanced-neuroendocrine neoplasm: A multicenter, single arm phase 2 stud

Panpan Zhang, Yakun Wang, Jie Li, Lin Shen, Ming Lu
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): CT266.
https://doi.org/10.1158/1538-7445.AM2024-CT266
Published: 05 April 2024
View articletitled, Abstract CT266: Initial efficacy of surufatinib plus sintilimab and IBI310 for patients with high-grade advanced-neuroendocrine neoplasm: A multicenter, single arm phase 2 stud
Journal Articles

Abstract 1999: DCAF7 acts as a scaffold to recruit USP10 for G3BP1 deubiquitylation and facilitates chemoresistance and metastasis in nasopharyngeal carcinoma

Qing-Jie Li, Xue-Liang Fang, Ying-Qin Li, Jia-Yi Lin, Cheng-Long Huang, Shi-Wei He, Sheng-Yan Huang, Jun-Yan Li, Sha Gong, Kai-Lin Chen, Na Liu, Jun Ma, Yin Zhao, Ling-Long Tang
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1999.
https://doi.org/10.1158/1538-7445.AM2024-1999
Published: 22 March 2024
View articletitled, Abstract 1999: DCAF7 acts as a scaffold to recruit USP10 for G3BP1 deubiquitylation and facilitates chemoresistance and metastasis in nasopharyngeal carcinoma
Journal Articles

Abstract 2371: BGB-B167, a first-in-class 4-1BB/CEACAM5 bispecific antibody, exhibits potent in vitro and < for vivo antitumor activity and < for superior safety profile in preclinical models

Zhuo Li, Liang Qu, Xin Chen, Liu Xue, Jie Li, Qi Liu, Jian Sun, Hanzi Sun, Yun Chen, Yuanyuan Xie, Wanyi Wang, Lin Zhu, Penghao Wang, Xiaosui Zhou, Hongjia Hou, Jie Chen, Xinyi Liu, Yilu Zhang, Ning Liu, Xinyi Liang, Shuo Zhang, Xiaoyan Tang, Jing Song, Tong Zhang, Xiaomin Song, Xuesong Liu, Kang Li, Chichi Huang
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 2371.
https://doi.org/10.1158/1538-7445.AM2024-2371
Published: 22 March 2024
View articletitled, Abstract 2371: BGB-B167, a first-in-class 4-1BB/CEACAM5 bispecific antibody, exhibits potent in vitro and &amp;lt; for vivo antitumor activity and &amp;lt; for superior safety profile in preclinical models
Journal Articles

Abstract 1113: USP18 impairs the sensitivity of radiotherapy for nasopharyngeal carcinoma by promoting the ubiquitination and nuclear translocation of TRIM29

Jia-Yi Lin, Wei-Wei Zhang, Qing-Jie Li, Xue-Liang Fang, Jun-Yan Li, Shi-Wei He, Ying-Qin Li, Jun Ma, Na Liu, Yin Zhao, Rui Guo
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1113.
https://doi.org/10.1158/1538-7445.AM2024-1113
Published: 22 March 2024
View articletitled, Abstract 1113: USP18 impairs the sensitivity of radiotherapy for nasopharyngeal carcinoma by promoting the ubiquitination and nuclear translocation of TRIM29
Journal Articles

AKT Blocks SIK1-Mediated Repression of STAT3 to Promote Breast Tumorigenesis

Zicheng Sun, Qiwei Jiang, Bing Gao, Xiaomei Zhang, Lang Bu, Lei Wang, Ying Lin, Wei Xie, Jie Li, Jianping Guo
Journal: Cancer Research
Cancer Res (2023) 83 (8): 1264–1279.
https://doi.org/10.1158/0008-5472.CAN-22-3407
Published: 14 April 2023
View articletitled, AKT Blocks SIK1-Mediated Repression of STAT3 to Promote Breast Tumorigenesis
Open the PDF for AKT Blocks SIK1-Mediated Repression of STAT3 to Promote Breast Tumorigenesis in another window
Includes: Supplementary data
Journal Articles

Abstract LB270: LINGO2-microRNA cluster controls oral cancer stemness ability and cancer progression

Wei-Min Chang, Li-Jie Li, Che-Hsuan Lin, Michael Hsiao, Peter Mu-Hsin Chang
Journal: Cancer Research
Cancer Res (2023) 83 (8_Supplement): LB270.
https://doi.org/10.1158/1538-7445.AM2023-LB270
Published: 14 April 2023
View articletitled, Abstract LB270: LINGO2-microRNA cluster controls oral cancer stemness ability and cancer progression
Journal Articles

Abstract 6398: Targeting ENPP1 to boost anti-tumor immunity during PARP inhibition

Jie Li, Charlotte Mason, Kay Hanggi, Vincent Luca, Brian Ruffell
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 6398.
https://doi.org/10.1158/1538-7445.AM2023-6398
Published: 04 April 2023
View articletitled, Abstract 6398: Targeting ENPP1 to boost anti-tumor immunity during PARP inhibition
Journal Articles

Abstract 6357: Generation of a mutant SIRPa fusion protein with highly-improved affinity and favorable safety profile

Yingying Hu, Yayuan Fu, Lei Liu, Wenjing Li, Liting Xue, Zhiyong Yu, Yun Zhang, Meijuan Gao, Yixin Tan, Fudong Wang, Yadan Wu, Jie Li, Zhenzhen Li, Feng Zhou, Wenqing Yang, Zhuoxiao Cao, Renhong Tang
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 6357.
https://doi.org/10.1158/1538-7445.AM2023-6357
Published: 04 April 2023
View articletitled, Abstract 6357: Generation of a mutant SIRPa fusion protein with highly-improved affinity and favorable safety profile
Journal Articles

Abstract 6040: The CHST11-CP-iron axis contributes to NSCLC stemness

Li-Jie Li, Wei-Min Chang, Michael Hsiao
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 6040.
https://doi.org/10.1158/1538-7445.AM2023-6040
Published: 04 April 2023
View articletitled, Abstract 6040: The CHST11-CP-iron axis contributes to NSCLC stemness
Journal Articles

Abstract 655: Necroptosis promotes tumor growth through IL1-alpha release and recruitment of immunosuppressive myeloid cells

Kay Hänggi, Aysenur Keske, Alycia Gardner, Jie Li, Olabisi Osunmakinde, Daiana Celias, Amer Beg, Brian Ruffell
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 655.
https://doi.org/10.1158/1538-7445.AM2023-655
Published: 04 April 2023
View articletitled, Abstract 655: Necroptosis promotes tumor growth through IL1-alpha release and recruitment of immunosuppressive myeloid cells
Journal Articles

Abstract 6158: BGB-24714, a novel oral IAP antagonist, displayed significant anti-tumor activities in preclinical models as a monotherapy and in combination with paclitaxel

Jie Li, Nan Hu, Yilu Zhang, Xiaolong Yang, Minjuan Deng, Wenfeng Gong, Longbo Yin, Yong Liu, Yajuan Gao, Wei Wei, Xing Wang, Xinyi Liang, Yanwen Ma, Xuxing Sang, Chang Liu, Jingyuan Wang, Qianqian Lu, Fengtao Song, Xi Yuan, Yibing Wang, Jing Li, Wei Jin, Xuesong Liu, Xiaomin Song
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 6158.
https://doi.org/10.1158/1538-7445.AM2023-6158
Published: 04 April 2023
View articletitled, Abstract 6158: BGB-24714, a novel oral IAP antagonist, displayed significant anti-tumor activities in preclinical models as a monotherapy and in combination with paclitaxel
Journal Articles

Phagocytosis of Glioma Cells Enhances the Immunosuppressive Phenotype of Bone Marrow–Derived Macrophages

Min Wu, Lingxiang Wu, Wei Wu, Mengyan Zhu, Jianyu Li, Ziyu Wang, Jie Li, Rong Ding, Yuan Liang, Liangyu Li, Tingting Zhang, Bin Huang, Yun Cai, Kening Li, Lu Li, Rui Zhang, Baoli Hu, Fan Lin, Xiuxing Wang, Siyuan Zheng, Jian Chen, Yongping You, Tao Jiang, Junxia Zhang, Hongshan Chen, Qianghu Wang
Journal: Cancer Research
Cancer Res (2023) 83 (5): 771–785.
https://doi.org/10.1158/0008-5472.CAN-22-1570
Published: 02 March 2023
View articletitled, Phagocytosis of Glioma Cells Enhances the Immunosuppressive Phenotype of Bone Marrow–Derived Macrophages
Open the PDF for Phagocytosis of Glioma Cells Enhances the Immunosuppressive Phenotype of Bone Marrow–Derived Macrophages in another window
Includes: Multimedia, Supplementary data