Page 1 | Search Results | Cancer Research | American Association for Cancer Research

1-13 of 13

Sort by

Sort Order Select

Journal Articles

Abstract 698: CPI-based Crizotinib systemic study on discovery of phenotypic off-target

Jiazhi Sun, Lun Yang, Minghua Li, Shimin Zhang, Ian E. Heller, Johnathan Samuelson, Steven Cindric, Kunal Mishra, Eslam Mohamed, Feng Cheng, Kevin B. Sneed, Lin He, Shu-Feng Zhou

Cancer Res (2015) 75 (15_Supplement): 698.

https://doi.org/10.1158/1538-7445.AM2015-698

Published: 01 August 2015

View article titled, Abstract 698: CPI-based Crizotinib systemic study on discovery of phenotypic off-target

Journal Articles

Abstract 3738: Crizotinib induces tumor suppressor miR-146a, autophagy and p21 waf1/cip1 by alternative targeting non-TK target Akt-mTOR-Foxo axis: A CPI-based systemic study on discovery of phenotypic off-target

Jiazhi Sun, Lun Yang, Minghua Li, Ian E. Heller, Issac Raplee, Steven Guzman, John P. Pasciak, Feng Cheng, Kevin B. Sneed, Lin He, Shu-Feng Zhou

Cancer Res (2014) 74 (19_Supplement): 3738.

https://doi.org/10.1158/1538-7445.AM2014-3738

Published: 01 October 2014

View article titled, Abstract 3738: Crizotinib induces tumor suppressor miR-146a, autophagy and p21 waf1/cip1 by alternative targeting non-TK target Akt-mTOR-Foxo axis: A CPI-based systemic study on discovery of phenotypic off-target

Journal Articles

Abstract 2040: Indication switching of the FDA-approved anticancer tyrosine kinase inhibitors to treat metabolic diseases.

Jiazhi Sun, Lun Yang, Minghua Li, Zhixin Wang, Amy Haynes, Qian Wang, Isaac Raplee, Jean Melchisedek, Anand Prasad, Kevin B. Sneed, Lin He, Shufeng Zhou

Cancer Res (2013) 73 (8_Supplement): 2040.

https://doi.org/10.1158/1538-7445.AM2013-2040

Published: 15 April 2013

View article titled, Abstract 2040: Indication switching of the FDA-approved anticancer tyrosine kinase inhibitors to treat metabolic diseases.

Journal Articles

Abstract #3656: The BH3 alpha helical mimic BH3M-6 disrupts Bcl-xL/Bax and Mcl-1/Bax binding and induces apoptosis in human cancer cells in a Bcl-xL, Bcl2 and Mcl-1 dependent manner.

Aslamuzzaman Kazi, Jiazhi Sun, Hang Yin, Andrew Hamilton, Hong-Gang Wang, Said Sebti

Cancer Res (2009) 69 (9_Supplement): 3656.

Published: 01 May 2009

View article titled, Abstract #3656: The BH3 alpha helical mimic BH3M-6 disrupts Bcl-xL/Bax and Mcl-1/Bax binding and induces apoptosis in human cancer cells in a Bcl-xL, Bcl2 and Mcl-1 dependent manner.

Journal Articles

Blocking Angiogenesis and Tumorigenesis with GFA-116, a Synthetic Molecule that Inhibits Binding of Vascular Endothelial Growth Factor to its Receptor

Jiazhi Sun, Michelle A. Blaskovich, Rishi K. Jain, Frederic Delarue, Daniel Paris, Steven Brem, Marguerite Wotoczek-Obadia, Qing Lin, Domenico Coppola, Kihang Choi, Michael Mullan, Andrew D. Hamilton, Saïd M. Sebti

Cancer Res (2004) 64 (10): 3586–3592.

https://doi.org/10.1158/0008-5472.CAN-03-2673

Published: 17 May 2004

View article titled, Blocking Angiogenesis and Tumorigenesis with GFA-116, a Synthetic Molecule that Inhibits Binding of Vascular Endothelial Growth Factor to its Receptor

Journal Articles

Inhibiting angiogenesis and tumorigenesis by a synthetic molecule that blocks binding of both VEGF and PDGF to their receptors

Jiazhi Sun, De-An Wang, Rishi Jain, Steve Paquette, Eileen Ennis, Michelle Blaskovich, Laura Baldini, Domenico Coppola, Andrew D. Hamilton, Said M. Sebti

Cancer Res (2004) 64 (7_Supplement): 1046–1047.

Published: 01 April 2004

View article titled, Inhibiting angiogenesis and tumorigenesis by a synthetic molecule that blocks binding of both VEGF and PDGF to their receptors

Journal Articles

Geranylgeranyltransferase i inhibitor, GGTI-2154, induces breast carcinoma apoptosis and tumor regression in H-Ras transgenic mice

Jiazhi Sun, Junko Ohkanda, Domenico Coppola, Hang Yin, Mohit Kothare, Brian Busiglio, Andrew D. Hamilton, Said M. Sebti

Cancer Res (2004) 64 (7_Supplement): 893.

Published: 01 April 2004

View article titled, Geranylgeranyltransferase i inhibitor, GGTI-2154, induces breast carcinoma apoptosis and tumor regression in H-Ras transgenic mice

Journal Articles

Geranylgeranyltransferase I Inhibitor GGTI-2154 Induces Breast Carcinoma Apoptosis and Tumor Regression in H-Ras Transgenic Mice

Jiazhi Sun, Junko Ohkanda, Domenico Coppola, Hang Yin, Mohit Kothare, Brian Busciglio, Andrew D. Hamilton, Saïd M. Sebti

Cancer Res (2003) 63 (24): 8922–8929.

Published: 24 December 2003

View article titled, Geranylgeranyltransferase I Inhibitor GGTI-2154 Induces Breast Carcinoma Apoptosis and Tumor Regression in H-Ras Transgenic Mice

Journal Articles

Discovery of JSI-124 (Cucurbitacin I), a Selective Janus Kinase/Signal Transducer and Activator of Transcription 3 Signaling Pathway Inhibitor with Potent Antitumor Activity against Human and Murine Cancer Cells in Mice

Michelle A. Blaskovich, Jiazhi Sun, Alan Cantor, James Turkson, Richard Jove, Saïd M. Sebti

Cancer Res (2003) 63 (6): 1270–1279.

Published: 15 March 2003

View article titled, Discovery of JSI-124 (Cucurbitacin I), a Selective Janus Kinase/Signal Transducer and Activator of Transcription 3 Signaling Pathway Inhibitor with Potent Antitumor Activity against Human and Murine Cancer Cells in Mice

Journal Articles

CEP1612, a Dipeptidyl Proteasome Inhibitor, Induces p21^WAF1 and p27^KIP1 Expression and Apoptosis and Inhibits the Growth of the Human Lung Adenocarcinoma A-549 in Nude Mice

Jiazhi Sun, Sangkil Nam, Chang-Sun Lee, Benyi Li, Domenico Coppola, Andrew D. Hamilton, Q. Ping Dou, Saïd M. Sebti

Cancer Res (2001) 61 (4): 1280–1284.

Published: 02 February 2001

View article titled, CEP1612, a Dipeptidyl Proteasome Inhibitor, Induces p21WAF1 and p27KIP1 Expression and Apoptosis and Inhibits the Growth of the Human Lung Adenocarcinoma A-549 in Nude Mice

Journal Articles

Antitumor Efficacy of a Novel Class of Non-thiol-containing Peptidomimetic Inhibitors of Farnesyltransferase and Geranylgeranyltransferase I: Combination Therapy with the Cytotoxic Agents Cisplatin, Taxol, and Gemcitabine

Jiazhi Sun, Michelle A. Blaskovich, David Knowles, Yimin Qian, Junko Ohkanda, Ratna D. Bailey, Andrew D. Hamilton, Saïd M. Sebti

Cancer Res (1999) 59 (19): 4919–4926.

Published: 01 October 1999

View article titled, Antitumor Efficacy of a Novel Class of Non-thiol-containing Peptidomimetic Inhibitors of Farnesyltransferase and Geranylgeranyltransferase I: <subtitle>Combination Therapy with the Cytotoxic Agents Cisplatin, Taxol, and Gemcitabine</subtitle>

Journal Articles

GGTI-298 Induces G₀-G₁ Block and Apoptosis Whereas FTI-277 Causes G₂-M Enrichment in A549 Cells

Karine Miquel, Anne Pradines, Jiazhi Sun, Yimin Qian, Andrew D. Hamilton, Saïd M. Sebti, Gilles Favre

Cancer Res (1997) 57 (10): 1846–1850.

Published: 01 May 1997

View article titled, GGTI-298 Induces G0-G1 Block and Apoptosis Whereas FTI-277 Causes G2-M Enrichment in A549 Cells

Journal Articles

Ras CAAX Peptidomimetic FTI 276 Selectively Blocks Tumor Growth in Nude Mice of a Human Lung Carcinoma with K-Ras Mutation and p53 Deletion

Jiazhi Sun, Yimin Qian, Andrew D. Hamilton, Saïd M. Sebti

Cancer Res (1995) 55 (19): 4243–4247.

Published: 01 October 1995

View article titled, Ras CAAX Peptidomimetic FTI 276 Selectively Blocks Tumor Growth in Nude Mice of a Human Lung Carcinoma with K-Ras Mutation and p53 Deletion

NARROW

Abstract 698: CPI-based Crizotinib systemic study on discovery of phenotypic off-target

Abstract 3738: Crizotinib induces tumor suppressor miR-146a, autophagy and p21 waf1/cip1 by alternative targeting non-TK target Akt-mTOR-Foxo axis: A CPI-based systemic study on discovery of phenotypic off-target

Abstract 2040: Indication switching of the FDA-approved anticancer tyrosine kinase inhibitors to treat metabolic diseases.

Abstract #3656: The BH3 alpha helical mimic BH3M-6 disrupts Bcl-xL/Bax and Mcl-1/Bax binding and induces apoptosis in human cancer cells in a Bcl-xL, Bcl2 and Mcl-1 dependent manner.

Blocking Angiogenesis and Tumorigenesis with GFA-116, a Synthetic Molecule that Inhibits Binding of Vascular Endothelial Growth Factor to its Receptor

Inhibiting angiogenesis and tumorigenesis by a synthetic molecule that blocks binding of both VEGF and PDGF to their receptors

Geranylgeranyltransferase i inhibitor, GGTI-2154, induces breast carcinoma apoptosis and tumor regression in H-Ras transgenic mice

Geranylgeranyltransferase I Inhibitor GGTI-2154 Induces Breast Carcinoma Apoptosis and Tumor Regression in H-Ras Transgenic Mice

Discovery of JSI-124 (Cucurbitacin I), a Selective Janus Kinase/Signal Transducer and Activator of Transcription 3 Signaling Pathway Inhibitor with Potent Antitumor Activity against Human and Murine Cancer Cells in Mice

CEP1612, a Dipeptidyl Proteasome Inhibitor, Induces p21^WAF1 and p27^KIP1 Expression and Apoptosis and Inhibits the Growth of the Human Lung Adenocarcinoma A-549 in Nude Mice

Antitumor Efficacy of a Novel Class of Non-thiol-containing Peptidomimetic Inhibitors of Farnesyltransferase and Geranylgeranyltransferase I: Combination Therapy with the Cytotoxic Agents Cisplatin, Taxol, and Gemcitabine

GGTI-298 Induces G₀-G₁ Block and Apoptosis Whereas FTI-277 Causes G₂-M Enrichment in A549 Cells

Ras CAAX Peptidomimetic FTI 276 Selectively Blocks Tumor Growth in Nude Mice of a Human Lung Carcinoma with K-Ras Mutation and p53 Deletion

Email alerts

AACR Journals

Email alerts

AACR Journals

This Feature Is Available To Subscribers Only