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Journal Articles

Abstract 1688: Nuclear receptor coactivator SRC-1 promotes colorectal cancer immune escape by enhancing PD-L1 transcription and protein stability

Yilin Hong, Qiang Chen, Zinan Wang, Yong Zhang, Bei Li, Xu Kong, Pingli Mo, Nengming Xiao, Jianming Xu, Yunbin Ye, Chundong Yu
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1688.
https://doi.org/10.1158/1538-7445.AM2024-1688
Published: 22 March 2024
View article titled, Abstract 1688: Nuclear receptor coactivator SRC-1 promotes colorectal cancer immune escape by enhancing PD-L1 transcription and protein stability
Journal Articles

Abstract 1433: FOXA1 alterations distinctively drive prostate tumorigenesis or therapy resistance in mice

Sanjana Eyunni, Abhijit Parolia, Eleanor Young, James Matthew George, Rahul Mannan, Sandra E. Carson, Yuping Zhang, Jean Tien, Mustapha Jaber, Jie Luo, Matthew Pang, Rohit Mehra, Xuhong Cao, Fengyun Su, Rui Wang, Marcin Cieslik, Dong Kee Lee, Jianming Xu, Arul M. Chinnaiyan
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1433.
https://doi.org/10.1158/1538-7445.AM2024-1433
Published: 22 March 2024
View article titled, Abstract 1433: FOXA1 alterations distinctively drive prostate tumorigenesis or therapy resistance in mice
Journal Articles

Abstract CT152: A multicenter Phase II study of savolitinib in patients with MET-amplified gastroesophogeal junction adenocarcinomas or gastric cancer

Zhi Peng, Hua Wang, Baorui Liu, Huiting Xu, Zhenyang Liu, Tianshu Liu, Jun Zhang, Yuxian Bai, Ying Yuan, Tao Wu, Feng Ye, Qinghua Pan, Jufeng Wang, Enxiao Li, Diansheng Zhong, Yueyin Pan, Yanru Qin, Yan Yang, Yusheng Wang, Aiping Zhou, Yongshun Chen, Dianbao Zhang, Hongli Liu, Xiujuan Qu, Shubin Wang, Ning Liu, Jinsheng Wu, Wei Li, Kejun Nan, Hongming Pan, Jianming Xu, Chunmei Bai, Heling Liu, Jia Wei, Runzhi Chen, Rongrong Li, Wei Li, Jinghong Zhou, Hongyan Yin, Qian Xu, Songhua Fan, Yongxin Ren, Weiguo Su, Lin Shen
Journal: Cancer Research
Cancer Res (2023) 83 (8_Supplement): CT152.
https://doi.org/10.1158/1538-7445.AM2023-CT152
Published: 14 April 2023
View article titled, Abstract CT152: A multicenter Phase II study of savolitinib in patients with MET-amplified gastroesophogeal junction adenocarcinomas or gastric cancer
Journal Articles

Abstract CT076: Randomized, global, phase 3 study of tislelizumab plus chemotherapy versus chemotherapy as first-line treatment for advanced or metastatic esophageal squamous cell carcinoma (RATIONALE-306): China subgroup analysis

Yongqian Shu, Yueyin Pan, Ping Lu, Yi Jiang, Jingdong Zhang, Xiaohong Wu, Yuanhu Yao, Lin Shen, Yi Ba, Zhiyong He, Yuxian Bai, Jianhua Chen, Guohua Yu, Yanyan Peng, Hongqian Wu, Lei Wang, Liyun Li, Jianming Xu
Journal: Cancer Research
Cancer Res (2023) 83 (8_Supplement): CT076.
https://doi.org/10.1158/1538-7445.AM2023-CT076
Published: 14 April 2023
View article titled, Abstract CT076: Randomized, global, phase 3 study of tislelizumab plus chemotherapy versus chemotherapy as first-line treatment for advanced or metastatic esophageal squamous cell carcinoma (RATIONALE-306): China subgroup analysis
Journal Articles

Abstract CT078: First-line treatment with sintilimab (sin) vs placebo in combination with chemotherapy (chemo) in patients (pts) with unresectable gastric or gastroesophageal junction (G/GEJ) cancer: Final overall survival (OS) results from the randomized, phase III ORIENT-16 trial

Jianming Xu, Haiping Jiang, Yueyin Pan, Kangsheng Gu, Shundong Cang, Lei Han, Yongqian Shu, Jiayi Li, Junhui Zhao, Hongming Pan, Suxia Luo, Yanru Qin, Qunyi Guo, Yuxian Bai, Yang Ling, Yingmei Guo, Yuling Chen, Yan Wang, Hui Zhou
Journal: Cancer Research
Cancer Res (2023) 83 (8_Supplement): CT078.
https://doi.org/10.1158/1538-7445.AM2023-CT078
Published: 14 April 2023
View article titled, Abstract CT078: First-line treatment with sintilimab (sin) vs placebo in combination with chemotherapy (chemo) in patients (pts) with unresectable gastric or gastroesophageal junction (G/GEJ) cancer: Final overall survival (OS) results from the randomized, phase III ORIENT-16 trial
Journal Articles

Abstract 3970: NCG-hIL15 humanized mice: an ideal model for human immune reconstitution of NK cells

Xing Liu, Meirong Wu, Huiyi Wang, Weiwei Yu, Jianming Xu, Hongyan Sun, Cunxiang Ju, Hongyu Wang, Santi Suryani Chen, Zhiying Li, Mark Wade Moore, Jing Zhao, Xiang Gao
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3970.
https://doi.org/10.1158/1538-7445.AM2023-3970
Published: 04 April 2023
View article titled, Abstract 3970: NCG-hIL15 humanized mice: an ideal model for human immune reconstitution of NK cells
Journal Articles

Abstract 6653: Analysis of selective response of anti-PD-L1 treatment in huPBMC-NCG mice reconstituted with different donors

Tingting Gu, Weiwei Yu, Hongyan Sun, Fang Zhu, Huiyi Wang, Mengting Wang, Shuai Li, Jianming Xu, Santi Chen, Zhiying Li, Mark Wade Moore, Cunxiang Ju, Hongyu Wang, Jing Zhao, Xiang Gao
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 6653.
https://doi.org/10.1158/1538-7445.AM2023-6653
Published: 04 April 2023
View article titled, Abstract 6653: Analysis of selective response of anti-PD-L1 treatment in huPBMC-NCG mice reconstituted with different donors
Journal Articles

Abstract 4472: A mouse model for GvHD: an excellent tool for evaluating the efficacy of anti-GvHD drugs and testing mechanisms of immunoregulation

Meirong Wu, Shiru Zhang, Fang Zhu, Hongyan Sun, Jianming Xu, Cunxiang Ju, Hongyu Wang, Santi Suryani Chen, Zhiying Li, Mark Wade Moore, Jing Zhao, Xiang Gao
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4472.
https://doi.org/10.1158/1538-7445.AM2023-4472
Published: 04 April 2023
View article titled, Abstract 4472: A mouse model for GvHD: an excellent tool for evaluating the efficacy of anti-GvHD drugs and testing mechanisms of immunoregulation
Journal Articles

Abstract 3242: Efficacy evaluation by novel humanized mouse models for preclinical study of ADCs combined with immunotherapy

Fang Zhu, Hongyan Sun, Qian Lu, Yuan Fang, Jianming Xu, Cunxiang Ju, Hongyu Wang, Santi Suryani Chen, Zhiying Li, Mark Wade Moore, Jing Zhao, Xiang Gao
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3242.
https://doi.org/10.1158/1538-7445.AM2023-3242
Published: 04 April 2023
View article titled, Abstract 3242: Efficacy evaluation by novel humanized mouse models for preclinical study of ADCs combined with immunotherapy
Journal Articles

Abstract 5199: B7-H3 & PD-L1 double-humanized BALB/c mouse: a novel animal model for preclinical studies of human B7-H3 antibodies or bispecific antibodies

Shiying Guo, Lingyu Song, Xin Qin, Jianming Xu, Hongyan Sun, Cunxiang Ju, Hongyu Wang, Santi Suryani Chen, Zhiying Li, Mark Wade Moore, Jing Zhao, Xiang Gao
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5199.
https://doi.org/10.1158/1538-7445.AM2023-5199
Published: 04 April 2023
View article titled, Abstract 5199: B7-H3 & PD-L1 double-humanized BALB/c mouse: a novel animal model for preclinical studies of human B7-H3 antibodies or bispecific antibodies
Journal Articles

Abstract 5198: Humanized mice for preclinical efficacy evaluation of drugs targeting GARP

Xing Liu, Meirong Wu, Huiyi Wang, Weiwei Yu, Jianming Xu, Hongyan Sun, Cunxiang Ju, Hongyu Wang, Santi Suryani Chen, Zhiying Li, Mark Wade Moore, Jing Zhao, Xiang Gao
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5198.
https://doi.org/10.1158/1538-7445.AM2023-5198
Published: 04 April 2023
View article titled, Abstract 5198: Humanized mice for preclinical efficacy evaluation of drugs targeting GARP
Journal Articles

Abstract 5197: NCG-hIL2 mice: a novel model to support the development of T regulatory and NK cells

Xinxin Zhang, Meirong Wu, Huiyi Wang, Weiwei Yu, Fang Zhu, Jianming Xu, Hongyan Sun, Hongyu Wang, Cunxiang Ju, Santi Suryani Chen, Zhiying Li, Mark Wade Moore, Jing Zhao, Xiang Gao
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5197.
https://doi.org/10.1158/1538-7445.AM2023-5197
Published: 04 April 2023
View article titled, Abstract 5197: NCG-hIL2 mice: a novel model to support the development of T regulatory and NK cells
Journal Articles

Abstract 4607: Androgen signaling is essential for prostate cancer development initiated from prostatic basal cells

Yongfeng He, Erika Hooker, Eun-Jeong Yu, Gerald R. Cunha, Lan Liao, Jianming Xu, Andrew Earl, Huiqing Wu, Michael L. Gonzalgo, Zijie Sun
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4607.
https://doi.org/10.1158/1538-7445.AM2019-4607
Published: 01 July 2019
View article titled, Abstract 4607: Androgen signaling is essential for prostate cancer development initiated from prostatic basal cells
Journal Articles

Abstract CT213: ORIENT-16: Sintilimab plus XELOX vs placebo plus XELOX as 1st line treatment for unresectable advanced gastric and GEJ adenocarcinoma

Jianming Xu, Yongshuai Jin, Ying Liu, Hui Zhou, Yan Wang
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): CT213.
https://doi.org/10.1158/1538-7445.AM2019-CT213
Published: 01 July 2019
View article titled, Abstract CT213: ORIENT-16: Sintilimab plus XELOX vs placebo plus XELOX as 1<sup>st</sup> line treatment for unresectable advanced gastric and GEJ adenocarcinoma
Journal Articles

Targeting SRC Coactivators Blocks the Tumor-Initiating Capacity of Cancer Stem-like Cells

Aarti D. Rohira, Fei Yan, Lei Wang, Jin Wang, Suoling Zhou, Andrew Lu, Yang Yu, Jianming Xu, David M. Lonard, Bert W. O'Malley
Journal: Cancer Research
Cancer Res (2017) 77 (16): 4293–4304.
https://doi.org/10.1158/0008-5472.CAN-16-2982
Published: 14 August 2017
View article titled, Targeting SRC Coactivators Blocks the Tumor-Initiating Capacity of Cancer Stem-like Cells
Open the PDF for Targeting SRC Coactivators Blocks the Tumor-Initiating Capacity of Cancer Stem-like Cells in another window
Includes: Supplementary data
Journal Articles

Abstract 2204: A proteomic landscape of diffuse-type gastric cancer

Sai Ge, Xia Xia, Chen Ding, Bei Zhen, Quan Zhou, Jinwen Feng, Jiajia Yuan, Rui Chen, Yumei Li, Zhongqi Ge, Jiafu Ji, Lianhai Zhang, Jiayuan Wang, Zhongwu Li, Yumei Lai, Ying Hu, Yanyan Li, Yilin Li, Jing Gao, Lin Chen, Jianming Xu, Chunchao Zhang, Sung Yun Jung, Mingwei Liu, Lei Song, Wanlin Liu, Gaigai Guo, Tongqing Gong, Yin Huang, Yang Qiu, Tieliu Shi, Weimin Zhu, Yi Wang, Fuchu He, Lin Shen, Jun Qin, CNHPP
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 2204.
https://doi.org/10.1158/1538-7445.AM2017-2204
Published: 01 July 2017
View article titled, Abstract 2204: A proteomic landscape of diffuse-type gastric cancer
Journal Articles

Abstract 1577: GRK3 is a direct target of ADT-induced CREB1 activation and it promotes neuroendocrine differentiation of prostate cancer cells

Dayong Zheng, Mohit Hulsurkar, Meixiang Sang, Songlin Zhang, Jianming Xu, Martin Gleave, Michael Ittmann, Wenliang Li
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1577.
https://doi.org/10.1158/1538-7445.AM2017-1577
Published: 01 July 2017
View article titled, Abstract 1577: GRK3 is a direct target of ADT-induced CREB1 activation and it promotes neuroendocrine differentiation of prostate cancer cells
Journal Articles

Abstract CT305: Phase I studies of a selective cMet inhibitor AZD6094 (HMPL504/volitinib) in patients with advanced solid tumors

Ye Hua, Lin Shen, Hui Gan, Jason Lickliter, Michael Millward, Jianming Xu, Jian Wang, Yang Sai, Weiguo Su, Melanie M. Frigault, Chuan Qi
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): CT305.
https://doi.org/10.1158/1538-7445.AM2015-CT305
Published: 01 August 2015
View article titled, Abstract CT305: Phase I studies of a selective cMet inhibitor AZD6094 (HMPL504/volitinib) in patients with advanced solid tumors
Journal Articles

Bufalin Is a Steroid Receptor Coactivator Inhibitor—Response

David M. Lonard, Jianming Xu, Bert W. O'Malley
Journal: Cancer Research
Cancer Res (2015) 75 (6): 1157.
https://doi.org/10.1158/0008-5472.CAN-14-2648
Published: 12 March 2015
View article titled, Bufalin Is a Steroid Receptor Coactivator Inhibitor—Response
Open the PDF for Bufalin Is a Steroid Receptor Coactivator Inhibitor—Response in another window
Journal Articles

NCOA1 Directly Targets M-CSF1 Expression to Promote Breast Cancer Metastasis

Li Qin, Ye-Lin Wu, Michael J. Toneff, Dabing Li, Lan Liao, Xiuhua Gao, Fiona T. Bane, Jean C.-Y. Tien, Yixiang Xu, Zhen Feng, Zhihui Yang, Yan Xu, Sarah M. Theissen, Yi Li, Leonie Young, Jianming Xu
Journal: Cancer Research
Cancer Res (2014) 74 (13): 3477–3488.
https://doi.org/10.1158/0008-5472.CAN-13-2639
Published: 30 June 2014
View article titled, NCOA1 Directly Targets <em>M-CSF1</em> Expression to Promote Breast Cancer Metastasis
Open the PDF for NCOA1 Directly Targets <em>M-CSF1</em> Expression to Promote Breast Cancer Metastasis in another window
Includes: Supplementary data