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Journal Articles

SIRT2 Deacetylates and Inhibits the Peroxidase Activity of Peroxiredoxin-1 to Sensitize Breast Cancer Cells to Oxidant Stress-Inducing Agents

Warren Fiskus, Veena Coothankandaswamy, Jianguang Chen, Hongwei Ma, Kyungsoo Ha, Dyana T. Saenz, Stephanie S. Krieger, Christopher P. Mill, Baohua Sun, Peng Huang, Jeffrey S. Mumm, Ari M. Melnick, Kapil N. Bhalla
Journal: Cancer Research
Cancer Res (2016) 76 (18): 5467–5478.
https://doi.org/10.1158/0008-5472.CAN-16-0126
Published: 15 September 2016
View article titled, SIRT2 Deacetylates and Inhibits the Peroxidase Activity of Peroxiredoxin-1 to Sensitize Breast Cancer Cells to Oxidant Stress-Inducing Agents
Open the PDF for SIRT2 Deacetylates and Inhibits the Peroxidase Activity of Peroxiredoxin-1 to Sensitize Breast Cancer Cells to Oxidant Stress-Inducing Agents in another window
Includes: Supplementary data
Journal Articles

Abstract 640: SIRT2 deacetylates peroxiredoxin and increases sensitivity to oxidative stress in human breast cancer cells

Veena CoothanKandaswamy, Jianguang Chen, Atul Joshi, Rekha Rao, Warren Fiskus, Kathleen M. Buckley, Srilatha Nalluri, Kapil N. Bhalla
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 640.
https://doi.org/10.1158/1538-7445.AM10-640
Published: 15 April 2010
View article titled, Abstract 640: SIRT2 deacetylates peroxiredoxin and increases sensitivity to oxidative stress in human breast cancer cells
Journal Articles

Abstract #4544: Synergistic pre-clinical activity of combined epigenetic therapy with the EZH2 antagonist 3-Deazaneplanocin   and HDAC inhibitor panobinostat against human AML and Mantle Cell Lymphoma cells

Warren Fiskus, Yongchao Wang, Rekha Rao, Yonghua Yang, Jianguang Chen, Atul Joshi, Sanjay Koul, Sunil Upadhyay, Ramesh Balusu, Pravina Fernandez, Rajeshree Joshi, Kate Buckley, Anand Jillella, Celalettin Ustun, Peter Atadja, Victor Marquez, Kapil Bhalla
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 4544.
Published: 01 May 2009
View article titled, Abstract #4544: Synergistic pre-clinical activity of combined epigenetic therapy with the EZH2 antagonist 3-Deazaneplanocin   and HDAC inhibitor panobinostat against human AML and Mantle Cell Lymphoma cells
Journal Articles

Abstract #1872: Mechanistic role of acetylated heat shock protein 70 in the VPS34/Beclin-1 triggered autophagy in breast cancer cells

Yonghua Yang, Rekha Rao, Warren Fiskus, Jianguang Chen, Sanjay Koul, Atul Joshi, Ramesh Balusu, Pravina Fernandez, Yongchao Wang, Kate Buckley, Peter Atadja, Kapil Bhalla
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 1872.
Published: 01 May 2009
View article titled, Abstract #1872: Mechanistic role of acetylated heat shock protein 70 in the VPS34/Beclin-1 triggered autophagy in breast cancer cells
Journal Articles

Abstract #3722: Co-treatment with pan-HDAC inhibitor panobinostat or heat shock protein (hsp) 90 inhibitor AUY922 with JAK2 inhibitor TG101209 is highly active against bone marrow progenitor cells from myeloproliferative neoplasms (MPN)

Yongchao Wang, Warren Fiskus, Kavita Natarajan, Yonghua Yang, Rekha Rao, Jianguang Chen, Atul Joshi, Sanjay Koul, Sunil Upadhyay, Ramesh Balusu, Pravina Fernandez, Kate Buckley, Anand Jillella, Cornelia Quadt, Peter Atadja, Ross Levine, Kapil Bhalla
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 3722.
Published: 01 May 2009
View article titled, Abstract #3722: Co-treatment with pan-HDAC inhibitor panobinostat or heat shock protein (hsp) 90 inhibitor AUY922 with JAK2 inhibitor TG101209 is highly active against bone marrow progenitor cells from myeloproliferative neoplasms (MPN)
Journal Articles

Co-treatment with vorinostat and Aurora kinase inhibitor MK-0457 exerts synergistic antileukemia activity against AML and CML cells, including those expressing mutant Bcr-AblT315I

Warren Fiskus, Yongchao Wang, Rajeshree Joshi, Rekha Rao, Pearl Lee, Yonghua Yang, Kelly Eaton, Jianguang Chen, Ravindra Kolhe, Pravina Fernandez, Anand Jillella, Carolyn Buser, Kapil Bhalla
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 2558.
Published: 01 May 2008
View article titled, Co-treatment with vorinostat and Aurora kinase inhibitor MK-0457 exerts synergistic antileukemia activity against AML and CML cells, including those expressing mutant Bcr-AblT315I
Journal Articles

LBH589 mediated depletion of HDAC7 and de-repression of Nur77 levels and pro-death activity: a mechanism underlying sensitivity of human CTCL cells to panobinostat (LBH589)

Jianguang Chen, Kelly Eaton, Warren Fiskus, Yongchao Wang, Rekha Rao, Pearl Lee, Rajeshree Joshi, Yonghua Yang, Ravindra Kolhe, Pravina Fernandez, Kavita Natarajan, Anand Jillella, Peter Atadja, Kapil Bhalla
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 2441.
Published: 01 May 2008
View article titled, LBH589 mediated depletion of HDAC7 and de-repression of Nur77 levels and pro-death activity: a mechanism underlying sensitivity of human CTCL cells to panobinostat (LBH589)
Journal Articles

Perturbations in levels and hyperacetylation of GRP78: Role in panobinostat (LBH589)-induced unfolded protein response (UPR) and cell death of human breast cancer cells

Rekha Rao, Ravindra Kolhe, Yonghua Yang, Jianguang Chen, Pearl Lee, Warren Fiskus, Yongchao Wang, Kelly Eaton, Rajeshree Joshi, Pravina Fernandez, Peter Atadja, Kapil Bhalla
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 2334.
Published: 01 May 2008
View article titled, Perturbations in levels and hyperacetylation of GRP78: Role in panobinostat (LBH589)-induced unfolded protein response (UPR) and cell death of human breast cancer cells
Journal Articles

Potent antileukemia activity of the combination of the heat shock protein 90 inhibitor NVP-AUY922 and the histone deacetylase inhibitor LBH589 (panobinostat) against human AML and CML cells

Warren Fiskus, Yongchao Wang, Rekha Rao, Jianguang Chen, Ravindra Kolhe, Yonghua Yang, Kelly Eaton, Pearl Lee, Rajeshree Joshi, Pravina Fernandez, Peter Atadja, Cornelia Quadt, Michael Rugaard Jensen, Kapil Bhalla
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 5632.
Published: 01 May 2008
View article titled, Potent antileukemia activity of the combination of the heat shock protein 90 inhibitor NVP-AUY922 and the histone deacetylase inhibitor LBH589 (panobinostat) against human AML and CML cells
Journal Articles

Characterization of the loss of BAF155 of the SWI/SNF chromatin remodeling complex in human cancer cell lines

Jessica N. Delbove, Matthew W. Stroebeck, Erik S. Knudsen, Weidong Wang, Trevor K. Archer, Jianguang Chen, Bernard E. Weissman
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 23.
Published: 15 April 2006
View article titled, Characterization of the loss of BAF155 of the SWI/SNF chromatin remodeling complex in human cancer cell lines