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Jian Yu
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Journal Articles

Abstract 5946: ZM-412, a potent and selective KIF18A inhibitor with robust efficacy as monotherapy in CIN-positive tumors and in combination with MMAE-conjugated ADC in CIN-negative tumors

Feng Zhou, Lei Zhou, Ruina Wang, Liting Xue, Xiaokang Qin, Zhengtao Li, Jian Yu, Renhong Tang
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 5946.
https://doi.org/10.1158/1538-7445.AM2024-5946
Published: 22 March 2024
View article titled, Abstract 5946: ZM-412, a potent and selective KIF18A inhibitor with robust efficacy as monotherapy in CIN-positive tumors and in combination with MMAE-conjugated ADC in CIN-negative tumors
Journal Articles

Abstract 6001: Repurposing dihydroergotamine mesylate as a potential MCL-1 inhibitor and its antitumor effect in pancreatic cancer cells

Pooja Mittal, Jae Ho Lo, Shivani Soni, Francesca Battaglin, Shradheya RR Gupta, Lesly Torres-Gonzalez, Yan Yang, Sandra Algaze, Priya Jayachandran, Karam Ashouri, Alexandra Wong, Wu Zhang, Jian Yu, Lin Zhang, Joshua Millstein, Indrakant Kumar Singh, Heinz Josef Lenz
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6001.
https://doi.org/10.1158/1538-7445.AM2024-6001
Published: 22 March 2024
View article titled, Abstract 6001: Repurposing dihydroergotamine mesylate as a potential MCL-1 inhibitor and its antitumor effect in pancreatic cancer cells
Journal Articles

Abstract 5910: Developing a novel humanized anti-FABP4 antibody for breast cancer treatment

Jiaqing Hao, Matthew Yorek, Jian yu, Anthony Avellino, Bing Li
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 5910.
https://doi.org/10.1158/1538-7445.AM2024-5910
Published: 22 March 2024
View article titled, Abstract 5910: Developing a novel humanized anti-FABP4 antibody for breast cancer treatment
Journal Articles

Abstract 4466: Omega-3 fatty acid-induced ferroptosis in 4T1 breast cancer through CD36/FABP5 axis

Anthony Avellino, Jiaqing Hao, Matthew Yorek, Jian yu, Bing Li
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 4466.
https://doi.org/10.1158/1538-7445.AM2024-4466
Published: 22 March 2024
View article titled, Abstract 4466: Omega-3 fatty acid-induced ferroptosis in 4T1 breast cancer through CD36/FABP5 axis
Journal Articles

Abstract 2534: Targeting defective necroptosis in colorectal cancer to overcome therapeutic resistance

Kaylee Ermine, Dongshi Chen, Xinyan Lu, Jian Yu, Lin Zhang
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 2534.
https://doi.org/10.1158/1538-7445.AM2023-2534
Published: 04 April 2023
View article titled, Abstract 2534: Targeting defective necroptosis in colorectal cancer to overcome therapeutic resistance
Journal Articles

Abstract A015: Targeting necroptosis and RIP3 in colorectal cancer to overcome chemotherapeutic resistance

Kaylee A. Ermine, Dongshi Chen, Peng Wang, Jian Yu, Lin Zhang
Journal: Cancer Research
Cancer Res (2022) 82 (23_Supplement_1): A015.
https://doi.org/10.1158/1538-7445.CRC22-A015
Published: 01 December 2022
View article titled, Abstract A015: Targeting necroptosis and RIP3 in colorectal cancer to overcome chemotherapeutic resistance
Journal Articles

Abstract 358: Restoring necroptosis in colorectal cancer cells to overcome chemotherapeutic resistance

Kaylee Ermine, Dongshi Chen, Peng Wang, Jian Yu, Lin Zhang
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 358.
https://doi.org/10.1158/1538-7445.AM2022-358
Published: 15 June 2022
View article titled, Abstract 358: Restoring necroptosis in colorectal cancer cells to overcome chemotherapeutic resistance
Journal Articles

Abstract 1930: Unsupervised sub-cellular segmentation of complex tissue and cell samples using highly multiplexed imaging-derived a priori knowledge

Bogdan Kochetov, Phoenix D. Bell, Rebecca Raphael, Benjamin J. Raymond, Brian J. Leibowitz, Jingshan Tong, Brenda Diergaarde, Jian Yu, Reetesh K. Pai, Robert E. Schoen, Lin Zhang, Aatur Singhi, Shikhar Uttam
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1930.
https://doi.org/10.1158/1538-7445.AM2022-1930
Published: 15 June 2022
View article titled, Abstract 1930: Unsupervised sub-cellular segmentation of complex tissue and cell samples using highly multiplexed imaging-derived <em>a priori</em> knowledge
Journal Articles

CDK4/6 Inhibition Suppresses p73 Phosphorylation and Activates DR5 to Potentiate Chemotherapy and Immune Checkpoint Blockade

Jingshan Tong, Xiao Tan, Xiangping Song, Man Gao, Denise Risnik, Suisui Hao, Kaylee Ermine, Peng Wang, Hua Li, Yi Huang, Jian Yu, Lin Zhang
Journal: Cancer Research
Cancer Res (2022) 82 (7): 1340–1352.
https://doi.org/10.1158/0008-5472.CAN-21-3062
Published: 01 April 2022
View article titled, CDK4/6 Inhibition Suppresses p73 Phosphorylation and Activates DR5 to Potentiate Chemotherapy and Immune Checkpoint Blockade
Open the PDF for CDK4/6 Inhibition Suppresses p73 Phosphorylation and Activates DR5 to Potentiate Chemotherapy and Immune Checkpoint Blockade in another window
Includes: Supplementary data
Journal Articles

PDSS1-Mediated Activation of CAMK2A-STAT3 Signaling Promotes Metastasis in Triple-Negative Breast Cancer

Tian-Jian Yu, Ying-Ying Liu, Xiao-Guang Li, Bi Lian, Xun-Xi Lu, Xi Jin, Zhi-Ming Shao, Xin Hu, Gen-Hong Di, Yi-Zhou Jiang
Journal: Cancer Research
Cancer Res (2021) 81 (21): 5491–5505.
https://doi.org/10.1158/0008-5472.CAN-21-0747
Published: 01 November 2021
View article titled, PDSS1-Mediated Activation of CAMK2A-STAT3 Signaling Promotes Metastasis in Triple-Negative Breast Cancer
Open the PDF for PDSS1-Mediated Activation of CAMK2A-STAT3 Signaling Promotes Metastasis in Triple-Negative Breast Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 1622: Microsatellite instability causes colorectal cancer cell death to trigger anti-tumor immune response

Darleny Y. Lizardo, Yi-Jun Wang, Liheng Yang, Jian Yu, Lin Zhang
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 1622.
https://doi.org/10.1158/1538-7445.AM2020-1622
Published: 15 August 2020
View article titled, Abstract 1622: Microsatellite instability causes colorectal cancer cell death to trigger anti-tumor immune response
Journal Articles

Perineural Invasion Reprograms the Immune Microenvironment through Cholinergic Signaling in Pancreatic Ductal Adenocarcinoma

Min-Wei Yang, Ling-Ye Tao, Yong-Sheng Jiang, Jian-Yu Yang, Yan-Miao Huo, De-Jun Liu, Jiao Li, Xue-Liang Fu, Ruizhe He, Chaoyi Lin, Wei Liu, Jun-Feng Zhang, Rong Hua, Qing Li, Shu-Heng Jiang, Li-Peng Hu, Guang-Ang Tian, Xiao-Xin Zhang, Ningning Niu, Ping Lu, Juanjuan Shi, Gary G. Xiao, Li-Wei Wang, Jing Xue, Zhi-Gang Zhang, Yong-Wei Sun
Journal: Cancer Research
Cancer Res (2020) 80 (10): 1991–2003.
https://doi.org/10.1158/0008-5472.CAN-19-2689
Published: 15 May 2020
View article titled, Perineural Invasion Reprograms the Immune Microenvironment through Cholinergic Signaling in Pancreatic Ductal Adenocarcinoma
Open the PDF for Perineural Invasion Reprograms the Immune Microenvironment through Cholinergic Signaling in Pancreatic Ductal Adenocarcinoma in another window
Includes: Supplementary data
Journal Articles

BET Inhibitors Potentiate Chemotherapy and Killing of SPOP-Mutant Colon Cancer Cells via Induction of DR5

Xiao Tan, Jingshan Tong, Yi-Jun Wang, Rochelle Fletcher, Robert E. Schoen, Jian Yu, Liangfang Shen, Lin Zhang
Journal: Cancer Research
Cancer Res (2019) 79 (6): 1191–1203.
https://doi.org/10.1158/0008-5472.CAN-18-3223
Published: 15 March 2019
View article titled, BET Inhibitors Potentiate Chemotherapy and Killing of <em>SPOP</em>-Mutant Colon Cancer Cells via Induction of DR5
Open the PDF for BET Inhibitors Potentiate Chemotherapy and Killing of <em>SPOP</em>-Mutant Colon Cancer Cells via Induction of DR5 in another window
Includes: Supplementary data
Journal Articles

Mcl-1 Phosphorylation without Degradation Mediates Sensitivity to HDAC Inhibitors by Liberating BH3-Only Proteins

Jingshan Tong, Xingnan Zheng, Xiao Tan, Rochelle Fletcher, Zaneta Nikolovska-Coleska, Jian Yu, Lin Zhang
Journal: Cancer Research
Cancer Res (2018) 78 (16): 4704–4715.
https://doi.org/10.1158/0008-5472.CAN-18-0399
Published: 14 August 2018
View article titled, Mcl-1 Phosphorylation without Degradation Mediates Sensitivity to HDAC Inhibitors by Liberating BH3-Only Proteins
Open the PDF for Mcl-1 Phosphorylation without Degradation Mediates Sensitivity to HDAC Inhibitors by Liberating BH3-Only Proteins in another window
Includes: Supplementary data
Journal Articles

Abstract 1970: Novel Mcl-1 inhibitor effectively restores in vivo regorafenib sensitivity in resistant colorectal cancer

Karson J. Kump, Jingshan Tong, Ahmed S. Mady, Lei Miao, Siwei Li, Duxin Sun, Jian Yu, Lin Zhang, Zaneta Nikolovska-Coleska
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1970.
https://doi.org/10.1158/1538-7445.AM2018-1970
Published: 01 July 2018
View article titled, Abstract 1970: Novel Mcl-1 inhibitor effectively restores <em>in vivo</em> regorafenib sensitivity in resistant colorectal cancer
Journal Articles

Abstract LB-191: BET inhibitors kill colorectal cancer cells by activating death receptor 5 through the ER stress response pathway

Xiao Tan, Jingshan Tong, Jian Yu, Liangfang Shen, Lin Zhang
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): LB-191.
https://doi.org/10.1158/1538-7445.AM2018-LB-191
Published: 01 July 2018
View article titled, Abstract LB-191: BET inhibitors kill colorectal cancer cells by activating death receptor 5 through the ER stress response pathway
Journal Articles

Abstract 267: Nonsteroidal anti-inflammatory drugs induce ER stress- and BID-dependent immunogenic cell death to suppress colorectal tumorigenesis

Rochelle Elayne Fletcher, Brian Leibowitz, Yijun Wang, Fernando Concha-Benavente, Robert Ferris, Robert Schoen, Jian Yu, Lin Zhang
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 267.
https://doi.org/10.1158/1538-7445.AM2018-267
Published: 01 July 2018
View article titled, Abstract 267: Nonsteroidal anti-inflammatory drugs induce ER stress- and BID-dependent immunogenic cell death to suppress colorectal tumorigenesis
Journal Articles

Abstract 2861: PUMA induction by p73 mediates response and resistance of colorectal cancer to anti-EGFR antibody therapy

Kyle Knickelbein, Jingshan Tong, Dongshi Chen, Yi-Jun Wang, Sandra Misale, Alberto Bardelli, Jian Yu, Lin Zhang
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 2861.
https://doi.org/10.1158/1538-7445.AM2018-2861
Published: 01 July 2018
View article titled, Abstract 2861: PUMA induction by p73 mediates response and resistance of colorectal cancer to anti-EGFR antibody therapy
Journal Articles

Abstract 2417: eIF4E phosphorylation licenses Myc-driven metabolic and stress reprogramming

Hang Ruan, Xiangyun Li, Brian Leibowitz, Jingshan Tong, Xinghua Lu, Nahum Sonenberg, Xiang Xu, Lin Zhang, Jian Yu
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 2417.
https://doi.org/10.1158/1538-7445.AM2018-2417
Published: 01 July 2018
View article titled, Abstract 2417: eIF4E phosphorylation licenses Myc-driven metabolic and stress reprogramming
Journal Articles

Abstract 3288: Effects of concomitant metformin and statins on overall survival of pancreatic cancer patients: results from SEER-Medicare data analyses

Jian-Yu E, Shou-En Lu, Yong Lin, Judith M. Graber, David Rotter, Lanjing Zhang, Gloria M. Petersen, Kitaw Demissie, Grace Lu-Yao, Xiang-Lin Tan
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 3288.
https://doi.org/10.1158/1538-7445.AM2017-3288
Published: 01 July 2017
View article titled, Abstract 3288: Effects of concomitant metformin and statins on overall survival of pancreatic cancer patients: results from SEER-Medicare data analyses