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Journal Articles

Abstract CT186: A first-in-human phase 1 dose-escalation and expansion study of intratumoral oncolytic reovirus (RC402) as a monotherapy or in combination with pembrolizumab in advanced solid tumors

Mark Voskoboynik, Jia Liu, Ki-Hoon Song, Dong-Guk Park, Min-Hee Ryu, Hong Jae Chon, Chan Kim
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): CT186.
https://doi.org/10.1158/1538-7445.AM2024-CT186
Published: 05 April 2024
View article titled, Abstract CT186: A first-in-human phase 1 dose-escalation and expansion study of intratumoral oncolytic reovirus (RC402) as a monotherapy or in combination with pembrolizumab in advanced solid tumors
Journal Articles

Abstract 775: Underlying germline genetic architecture of pediatric sarcomas: Evaluating the role of common and rare variants in 4,160 patients

Lisa Mirabello, Laura E. Egolf, Bin Zhu, D. Matthew Gianferante, Kevin Wang, Shengchao Alfred Li, Mitchell J. Machiela, Logan G. Spector, Joshua D. Schiffman, Aniko Sabo, Alexander Renwick, Bailey Martin-Giacalone, Michael E. Scheurer, Sharon Plon, Douglas Hawkins, Rajkumar Venkatramani, Douglas Stewart, Lindsay M. Morton, Melissa M. Hudson, Gregory T. Armstrong, Smita Bhatia, Michael Dean, Katherine A. Janeway, Ana Patiño-Garcia, Fernando Lecanda, Massimo Serra, Claudia Hattinger, Katia Scotlandi, Adrienne M. Flanagan, Fernanda Amary, Irene L. Andrulis, Jay S. Wunder, Mandy L. Ballinger, David M. Thomas, Olivier Delattre, Aubrey K. Hubbard, Jia Liu, Wen Luo, Belynda D. Hicks, Meredith Yeager, Maryam Rafati, Wen-Yi Huang, Maria T. Landi, Adriana Lori, Ryan Diver, Sharon A. Savage, Stephen J. Chanock, Philip J. Lupo
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 775.
https://doi.org/10.1158/1538-7445.AM2024-775
Published: 22 March 2024
View article titled, Abstract 775: Underlying germline genetic architecture of pediatric sarcomas: Evaluating the role of common and rare variants in 4,160 patients
Journal Articles

The Macrophage-Associated LncRNA MALR Facilitates ILF3 Liquid–Liquid Phase Separation to Promote HIF1α Signaling in Esophageal Cancer

Jia Liu, Ze-Xian Liu, Jia-Jun Li, Zhao-Lei Zeng, Jin-Hong Wang, Xiao-Jing Luo, Chau-Wei Wong, Jia-Bo Zheng, Heng-Ying Pu, Hai-Yu Mo, Hui Sheng, Qi-Nian Wu, Hao Li, Gang Wan, Bo Li, De-shen Wang, Rui-Hua Xu, Huai-Qiang Ju
Journal: Cancer Research
Cancer Res (2023) 83 (9): 1476–1489.
https://doi.org/10.1158/0008-5472.CAN-22-1922
Published: 02 May 2023
View article titled, The Macrophage-Associated LncRNA <em>MALR</em> Facilitates ILF3 Liquid–Liquid Phase Separation to Promote HIF1α Signaling in Esophageal Cancer
Open the PDF for The Macrophage-Associated LncRNA <em>MALR</em> Facilitates ILF3 Liquid–Liquid Phase Separation to Promote HIF1α Signaling in Esophageal Cancer in another window
Includes: Multimedia, Supplementary data
Journal Articles

Abstract CT031: A first-in-human, phase 1a/1b, open-label, dose-escalation and expansion study to investigate the safety, pharmacokinetics, and antitumor activity of the RAF dimer inhibitor BGB-3245 in patients with advanced or refractory tumors

Alison M. Schram, Vivek Subbiah, Ryan Sullivan, Rasha Cosman, Jia Liu, Eric I. Sbar, Thuy Hoang, Jiarong Chen, Mark Johnson, Vincent Amoruccio, Todd Shearer, Adeela Kamal, Jocelyn Lewis, Wenlin Shao, Badreddin Edris, Lusong Luo, Jayesh Desai
Journal: Cancer Research
Cancer Res (2023) 83 (8_Supplement): CT031.
https://doi.org/10.1158/1538-7445.AM2023-CT031
Published: 14 April 2023
View article titled, Abstract CT031: A first-in-human, phase 1a/1b, open-label, dose-escalation and expansion study to investigate the safety, pharmacokinetics, and antitumor activity of the RAF dimer inhibitor BGB-3245 in patients with advanced or refractory tumors
Journal Articles

Abstract 4859: Bi-steric mTORC1 inhibitors are superior to rapamycin and induce apoptotic cell death in tumor models with hyperactivated mTORC1

Heng Du, Yu Chi Yang, Heng-Jia Liu, Min Yuan, John Asara, Kwok-Kin Wong, Mallika Singh, David Kwiatkowski
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4859.
https://doi.org/10.1158/1538-7445.AM2023-4859
Published: 04 April 2023
View article titled, Abstract 4859: Bi-steric mTORC1 inhibitors are superior to rapamycin and induce apoptotic cell death in tumor models with hyperactivated mTORC1
Journal Articles

Abstract OT3-24-01: ReFocus: A Phase 1/2 Study of the Highly Selective FGFR2 Inhibitor, RLY-4008, in Patients with Advanced Solid Tumors Including Breast Cancer

Suneel Kamath, David Tai, Irene Moreno, Hani Babiker, Zhaohui Jin, Changhoon Yoo, Fabien Ricard, Kai Yu Jen, Jim Coward, Jia Liu, Frans Opdam, Michael Millward, Mariano Ponz-Sarvise, Jeffrey Yachnin, Richard Kim, Joon Oh Park, Vivek Subbiah, Alison M. Schram
Journal: Cancer Research
Cancer Res (2023) 83 (5_Supplement): OT3-24-01.
https://doi.org/10.1158/1538-7445.SABCS22-OT3-24-01
Published: 01 March 2023
View article titled, Abstract OT3-24-01: ReFocus: A Phase 1/2 Study of the Highly Selective FGFR2 Inhibitor, RLY-4008, in Patients with Advanced Solid Tumors Including Breast Cancer
Journal Articles

Hydrogen Sulfide Creates a Favorable Immune Microenvironment for Colon Cancer

Taohua Yue, Jichang Li, Jing Zhu, Shuai Zuo, Xin Wang, Yucun Liu, Jia Liu, Xiaoyun Liu, Pengyuan Wang, Shanwen Chen
Journal: Cancer Research
Cancer Res (2023) 83 (4): 595–612.
https://doi.org/10.1158/0008-5472.CAN-22-1837
Published: 15 February 2023
View article titled, Hydrogen Sulfide Creates a Favorable Immune Microenvironment for Colon Cancer
Open the PDF for Hydrogen Sulfide Creates a Favorable Immune Microenvironment for Colon Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract CT196: Early results of a safety and efficacy study of allogeneic TruUCAR™ GC502 in patients with relapsed/refractory B-cell acute lymphoblastic leukemia (r/r B-ALL)

Shiqi Li, Xinxin Wang, Zhongtao Yuan, Lin Liu, Yu Li, Jia Liu, Jiaping He, Zhimin Li, Wei Zhao, Jianning Ge, Yajin Ni, Lianjun Shen, Wei Cao, Xi Zhang, Martina Sersch, Sanbin Wang
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): CT196.
https://doi.org/10.1158/1538-7445.AM2022-CT196
Published: 15 June 2022
View article titled, Abstract CT196: Early results of a safety and efficacy study of allogeneic TruUCAR™ GC502 in patients with relapsed/refractory B-cell acute lymphoblastic leukemia (r/r B-ALL)
Journal Articles

Abstract LB147: Updates on clinical safety and efficacy result of GC027, the first-in-human, “Off-the-Shelf” CD7 CAR-T stand-alone therapy for adult patients with relapsed/refractory T-cell lymphoblastic leukemia (r/r T-ALL)

Shiqi Li, Lei Gao, Zhongtao Yuan, Kun Wu, Lin Liu, Le Luo, Yao Liu, Cheng Zhang, Yu Li, Duanpeng Wang, Zhimin Li, Xu Tan, Ruihao Huang, Dingsong Zhang, Youcheng Wang, Xinxin Wang, Jia Liu, Martina Sersch, Sanbin Wang, Xi Zhang
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): LB147.
https://doi.org/10.1158/1538-7445.AM2021-LB147
Published: 01 July 2021
View article titled, Abstract LB147: Updates on clinical safety and efficacy result of GC027, the first-in-human, “Off-the-Shelf” CD7 CAR-T stand-alone therapy for adult patients with relapsed/refractory T-cell lymphoblastic leukemia (r/r T-ALL)
Journal Articles

Abstract 834: Association between ABO and Duffy blood types and circulating chemokines and cytokines

Sarah C. Van Alsten, John Aversa, Loredana Santo, M. Constanza Camargo, Wen-Yi Huang, Troy Kemp, Jia Liu, Joshua Samspon, Charles S. Rabkin
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 834.
https://doi.org/10.1158/1538-7445.AM2021-834
Published: 01 July 2021
View article titled, Abstract 834: Association between ABO and Duffy blood types and circulating chemokines and cytokines
Journal Articles

Abstract 1026: Bi-steric mTORC1-selective inhibitors demonstrate improved potency and efficacy in tumors with mTORC1 hyperactivation

Heng Du, Yu Chi Yang, Mallika Singh, Heng-jia Liu, David Kwiatkowski
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1026.
https://doi.org/10.1158/1538-7445.AM2021-1026
Published: 01 July 2021
View article titled, Abstract 1026: Bi-steric mTORC1-selective inhibitors demonstrate improved potency and efficacy in tumors with mTORC1 hyperactivation
Journal Articles

MYC-Activated LncRNA MNX1-AS1 Promotes the Progression of Colorectal Cancer by Stabilizing YB1

Qi-Nian Wu, Xiao-Jing Luo, Jia Liu, Yun-Xin Lu, Yun Wang, Jingjing Qi, Ze-Xian Liu, Qi-Tao Huang, Ze-Kun Liu, Jia-Bin Lu, Ying Jin, Heng-Ying Pu, Pei-Shan Hu, Jia-Bo Zheng, Zhao-Lei Zeng, Huai-Qiang Ju, Dan Xie, Qi Zhao, Ruihua Xu
Journal: Cancer Research
Cancer Res (2021) 81 (10): 2636–2650.
https://doi.org/10.1158/0008-5472.CAN-20-3747
Published: 15 May 2021
View article titled, MYC-Activated LncRNA <em>MNX1-AS1</em> Promotes the Progression of Colorectal Cancer by Stabilizing YB1
Open the PDF for MYC-Activated LncRNA <em>MNX1-AS1</em> Promotes the Progression of Colorectal Cancer by Stabilizing YB1 in another window
Includes: Supplementary data
Journal Articles

Correction: p62/SQSTM1 Cooperates with Hyperactive mTORC1 to Regulate Glutathione Production, Maintain Mitochondrial Integrity, and Promote Tumorigenesis

Hilaire C. Lam, Christian V. Baglini, Alicia Llorente Lope, Andrey A. Parkhitko, Heng-Jia Liu, Nicola Alesi, Izabela A. Malinowska, Darius Ebrahimi-Fakhari, Afshin Saffari, Jane J. Yu, Ana Pereira, Damir Khabibullin, Barbara Ogorek, Julie Nijmeh, Taylor Kavanagh, Adam Handen, Stephen Y. Chan, John M. Asara, William M. Oldham, Maria T. Diaz-Meco, Jorge Moscat, Mustafa Sahin, Carmen Priolo, Elizabeth P. Henske
Journal: Cancer Research
Cancer Res (2020) 80 (23): 5424.
https://doi.org/10.1158/0008-5472.CAN-20-3417
Published: 02 December 2020
View article titled, Correction: p62/SQSTM1 Cooperates with Hyperactive mTORC1 to Regulate Glutathione Production, Maintain Mitochondrial Integrity, and Promote Tumorigenesis
Open the PDF for Correction: p62/SQSTM1 Cooperates with Hyperactive mTORC1 to Regulate Glutathione Production, Maintain Mitochondrial Integrity, and Promote Tumorigenesis in another window
Journal Articles

Abstract 912: Synergistic combination of oncolytic virotherapy and immunotherapy for glioma

Bingtao Tang, Zong Sheng Guo, David Bartlett, Jia Liu, Grant McFadden, Joanna Shisler, Kari Foss, Heidi Phillips, Terence Lichtor, Edward Roy
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 912.
https://doi.org/10.1158/1538-7445.AM2020-912
Published: 15 August 2020
View article titled, Abstract 912: Synergistic combination of oncolytic virotherapy and immunotherapy for glioma
Journal Articles

Abstract 3737: Mutant isocitrate dehydrogenase driven metabolic reprogramming results in therapeutic vulnerability to lactate dehydrogenase inhibition

Aiwei Bi, Jun Xu, Nan Jin, Xiaojing Lan, Shuai Tang, Matthew Shou, Jia Liu, Jian Ding, Meiyu Geng, Shuhai Lin, Min Huang
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 3737.
https://doi.org/10.1158/1538-7445.AM2020-3737
Published: 15 August 2020
View article titled, Abstract 3737: Mutant isocitrate dehydrogenase driven metabolic reprogramming results in therapeutic vulnerability to lactate dehydrogenase inhibition
Journal Articles

Abstract CT052: Clinical safety and efficacy study of TruUCAR™ GC027: The first-in-human, universal CAR-T therapy for adult relapsed/refractory T-cell acute lymphoblastic leukemia (r/r T-ALL)

Xinxin Wang, Shiqi Li, Lei Gao, Zhongtao Yuan, Kun Wu, Lin Liu, Le Luo, Yao Liu, Cheng Zhang, Jia Liu, Chunhui Yang, Yu Li, Zhimin Li, Jiaping He, Duanpeng Wang, Xun Ye, Xu Tan, Ruihao Huang, Jianning Ge, Yu Han, Dingsong Zhang, Youcheng Wang, Lihua Fang, Yingnian Chen, Wei Cao, Sanbin Wang, Xi Zhang
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): CT052.
https://doi.org/10.1158/1538-7445.AM2020-CT052
Published: 15 August 2020
View article titled, Abstract CT052: Clinical safety and efficacy study of TruUCAR™ GC027: The first-in-human, universal CAR-T therapy for adult relapsed/refractory T-cell acute lymphoblastic leukemia (r/r T-ALL)
Journal Articles

Abstract 2264: Synergistic combination of oncolytic virotherapy and immunotherapy for glioma

Bingtao Tang, Zong Sheng Guo, David L. Bartlett, David Yan, Claire P. Schane, Jia Liu, Grant McFadden, Joanna L. Shisler, Edward J. Roy
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2264.
https://doi.org/10.1158/1538-7445.AM2019-2264
Published: 01 July 2019
View article titled, Abstract 2264: Synergistic combination of oncolytic virotherapy and immunotherapy for glioma
Journal Articles

Abstract 739: Whole-exome sequencing of neuroendocrine neoplasm of the liver reveals recurrent mutations in components of RTK-RAS pathways

Lingli Chen, Yuan Ji, Jing Zhao, Lingtong Hao, Yixue Li, Xi Zhang, Huichuan Sun, Rongkui Luo, Jing Han, Jie Huang, Yingyong Hou, Jia Liu
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 739.
https://doi.org/10.1158/1538-7445.AM2019-739
Published: 01 July 2019
View article titled, Abstract 739: Whole-exome sequencing of neuroendocrine neoplasm of the liver reveals recurrent mutations in components of RTK-RAS pathways
Journal Articles

Abstract 5096: Pre- and early postnatal loss of tsc1/2 induces kidney hybrid oncocytic/chromophobe tumors (HOCT) via c-JUN

Heng Du, Heng-jia Liu, Damir Khabibullin, Mahsa Zarei, John Dreier, Chin-Lee Wu, Elizabeth Henske, David Kwiatkowski
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5096.
https://doi.org/10.1158/1538-7445.AM2018-5096
Published: 01 July 2018
View article titled, Abstract 5096: Pre- and early postnatal loss of tsc1/2 induces kidney hybrid oncocytic/chromophobe tumors (HOCT) via c-JUN
Journal Articles

Abstract 1686: TSC2 enhances antitumor immunity and potentiates PD-1 and CTLA-4 blockade

Heng-Jia Liu, Patrick Lizotte, Heng Du, Maria Speranza, Spencer Vaughan, Nicola Alesi, Kwok-Kin Wong, Gordon Freeman, Arlene Sharpe, Elizabeth Henske
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1686.
https://doi.org/10.1158/1538-7445.AM2018-1686
Published: 01 July 2018
View article titled, Abstract 1686: TSC2 enhances antitumor immunity and potentiates PD-1 and CTLA-4 blockade