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Jens T. Siveke
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Journal Articles

Abstract 4436: Phenotypic heterogeneity in pancreatic ductal adenocarcinoma revealed by single-cell lipidomics

Marija Trajkovic-Arsic, Jeany Delafiori, Mohammed Shahraz, Corinna Münch, Smiths S. Lueong, Sven T. Liffers, Doris Hellerschmied, Theodore Alexandrov, Jens T. Siveke
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 4436.
https://doi.org/10.1158/1538-7445.AM2024-4436
Published: 22 March 2024
View article titled, Abstract 4436: Phenotypic heterogeneity in pancreatic ductal adenocarcinoma revealed by single-cell lipidomics
Journal Articles

Abstract 5019: Comprehensive pan-cancer analysis of cfDNA methylation marks in tumors reveals complex epigenetic regulatory circuits and diagnostic biomarkers

Smiths Sengkwawoh Lueong, Martin Metzenmacher, Gregor Zaun, Gina Lauren Mayer, Erik Jan Hemmer, Katharina Lückerath, Kelsey Pomykala, Balazs Hegedüs, Peter A. Horn, Marija Trajkovic-Arsic, Tibor Szarvas, Renáta Váraljai, Corinna Keup, Ingeborg Tinhofer, Stephen George, Sabine Kasimir-Bauer, Samuel Peña-Llopis, Alexander Roesch, Cornelius Kürten, Lukas Boosfeld, Kirsten Bruderek, Christopher Darr, Thomas Hilser, Viktor Grünwald, Sven Brandau, Boris Hadaschik, Hans Neubauer, Irene Irene Esposito Irene Esposito, Tanja Fehm, Csilla Oláh, Anita Csizmarik, Fabinshy Thangarajah, Laura Reetz, Ghanam Jamal, Basant Kumar Thakur, Halime Kalkavan, Alexander Schramm, Martin Schuler, Jens T. Siveke
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 5019.
https://doi.org/10.1158/1538-7445.AM2024-5019
Published: 22 March 2024
View article titled, Abstract 5019: Comprehensive pan-cancer analysis of cfDNA methylation marks in tumors reveals complex epigenetic regulatory circuits and diagnostic biomarkers
Journal Articles

Abstract 1598: Individualized longitudinal assessment reveals therapy-induced tumor and microenvironment dynamics in preclinical pancreatic cancer models

Jens T. Siveke, Rui Fang, Phyllis Fung-Yi Cheung, Jiajin Yang, Juanfei Peng, Kristina Althoff, Konstantinos Savvatakis
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1598.
https://doi.org/10.1158/1538-7445.AM2024-1598
Published: 22 March 2024
View article titled, Abstract 1598: Individualized longitudinal assessment reveals therapy-induced tumor and microenvironment dynamics in preclinical pancreatic cancer models
Journal Articles

Abstract 3929: Comparative genomics of breast cancer in indigenous African and western populations first results from the E-Predict study

Smiths Sengkwawoh Lueong, Pamela Derliche Tonouo Derliche Tonouo, Arnol Auvaker Tiofack, Rovaldo Nguims Kenfack, Jules Roger Kuiate, Esther Dina Mbassi, Sidonie Noa Ananga, Etienne Okobalemba Atenguena, Gustave Simo, Abdel Jelil Njouendou, Walters Ndaka, Zacharie Sando, Emmanuella Mayemi, Rachel Tayou, Gilles Gael Aghoagni, Anne Sango, Benjamin Pokam, Augustin Tozoula Bambara, Jens T. Siveke
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3929.
https://doi.org/10.1158/1538-7445.AM2024-3929
Published: 22 March 2024
View article titled, Abstract 3929: Comparative genomics of breast cancer in indigenous African and western populations first results from the E-Predict study
Journal Articles

Abstract CT195: Interim safety results from SEPION/AIO-PAK-0118: A multicenter, Phase I/II study of sequential epigenetic and immune targeting in combination with nab-paclitaxel/gemcitabine in patients with advanced pancreatic ductal adenocarcinoma

Jens T. Siveke, Marianne Sinn, Stefan Boeck, Gabriele Siegler, Thomas Seufferlein, Joerg Trojan, Dirk Waldschmidt, Alexander Koenig, Dorothea Schipp, Ines Winkler, Sven Thorsten Liffers, Volker Kunzmann
Journal: Cancer Research
Cancer Res (2023) 83 (8_Supplement): CT195.
https://doi.org/10.1158/1538-7445.AM2023-CT195
Published: 14 April 2023
View article titled, Abstract CT195: Interim safety results from SEPION/AIO-PAK-0118: A multicenter, Phase I/II study of sequential epigenetic and immune targeting in combination with nab-paclitaxel/gemcitabine in patients with advanced pancreatic ductal adenocarcinoma
Journal Articles

Abstract 4539: Tumor evolution and immune microenvironment dynamics define response to neoadjuvant treatment of esophageal adenocarcinoma

Melissa Barroux, Jacob Househam, Eszter Lakatos, Tahel Ronel, Ann-Marie Baker, Henrike Salié, Max Mossner, Kane Smith, Chris Kimberley, Salpie Nowinski, Alison Berner, Vinaya Gunasri, Marnix Jansen, Giulio Caravagna, Julia Slotta-Huspenina, Wilko Weichert, Markus Alberstmeier, Benny Chain, Helmut Friess, Bertram Bengsch, Roland M. Schmid, Jens T. Siveke, Michael Quante, Trevor A. Graham
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4539.
https://doi.org/10.1158/1538-7445.AM2023-4539
Published: 04 April 2023
View article titled, Abstract 4539: Tumor evolution and immune microenvironment dynamics define response to neoadjuvant treatment of esophageal adenocarcinoma
Journal Articles

Preclinical Efficacy of Covalent-Allosteric AKT Inhibitor Borussertib in Combination with Trametinib in KRAS-Mutant Pancreatic and Colorectal Cancer

Jörn Weisner, Ina Landel, Christoph Reintjes, Niklas Uhlenbrock, Marija Trajkovic-Arsic, Niklas Dienstbier, Julia Hardick, Swetlana Ladigan, Marius Lindemann, Steven Smith, Lena Quambusch, Rebekka Scheinpflug, Laura Depta, Rajesh Gontla, Anke Unger, Heiko Müller, Matthias Baumann, Carsten Schultz-Fademrecht, Georgia Günther, Abdelouahid Maghnouj, Matthias P. Müller, Michael Pohl, Christian Teschendorf, Heiner Wolters, Richard Viebahn, Andrea Tannapfel, Waldemar Uhl, Jan G. Hengstler, Stephan A. Hahn, Jens T. Siveke, Daniel Rauh
Journal: Cancer Research
Cancer Res (2019) 79 (9): 2367–2378.
https://doi.org/10.1158/0008-5472.CAN-18-2861
Published: 01 May 2019
View article titled, Preclinical Efficacy of Covalent-Allosteric AKT Inhibitor Borussertib in Combination with Trametinib in <em>KRAS</em>-Mutant Pancreatic and Colorectal Cancer
Open the PDF for Preclinical Efficacy of Covalent-Allosteric AKT Inhibitor Borussertib in Combination with Trametinib in <em>KRAS</em>-Mutant Pancreatic and Colorectal Cancer in another window
Includes: Supplementary data
Journal Articles

Notch-Induced Myeloid Reprogramming in Spontaneous Pancreatic Ductal Adenocarcinoma by Dual Genetic Targeting

Phyllis F. Cheung, Florian Neff, Christian Neander, Anna Bazarna, Konstantinos Savvatakis, Sven-Thorsten Liffers, Kristina Althoff, Chang-Lung Lee, Everett J. Moding, David G Kirsch, Dieter Saur, Alexandr V. Bazhin, Marija Trajkovic-Arsic, Mathias F. Heikenwalder, Jens T. Siveke
Journal: Cancer Research
Cancer Res (2018) 78 (17): 4997–5010.
https://doi.org/10.1158/0008-5472.CAN-18-0052
Published: 04 September 2018
View article titled, Notch-Induced Myeloid Reprogramming in Spontaneous Pancreatic Ductal Adenocarcinoma by Dual Genetic Targeting
Open the PDF for Notch-Induced Myeloid Reprogramming in Spontaneous Pancreatic Ductal Adenocarcinoma by Dual Genetic Targeting in another window
Includes: Supplementary data
Journal Articles

Selective In Vivo Imaging of Syngeneic, Spontaneous, and Xenograft Tumors Using a Novel Tumor Cell–Specific Hsp70 Peptide-Based Probe

Stefan Stangl, Julia Varga, Bianca Freysoldt, Marija Trajkovic-Arsic, Jens T. Siveke, Florian R. Greten, Vasilis Ntziachristos, Gabriele Multhoff
Journal: Cancer Research
Cancer Res (2014) 74 (23): 6903–6912.
https://doi.org/10.1158/0008-5472.CAN-14-0413
Published: 30 November 2014
View article titled, Selective <em>In Vivo</em> Imaging of Syngeneic, Spontaneous, and Xenograft Tumors Using a Novel Tumor Cell–Specific Hsp70 Peptide-Based Probe
Open the PDF for Selective <em>In Vivo</em> Imaging of Syngeneic, Spontaneous, and Xenograft Tumors Using a Novel Tumor Cell–Specific Hsp70 Peptide-Based Probe in another window
Includes: Supplementary data
Journal Articles

Abstract A32: Notch pathway regulates pancreatic acinar-to-ductal metaplasia

Roxanne Leontine Brodylo, Marcel Lee, Clara Lubeseder-Martellato, Pawel K. Mazur, Franziska Hampel, Ulrike Zimber-Strobel, Lothar J. Strobel, Roland M. Schmid, Jens T. Siveke
Journal: Cancer Research
Cancer Res (2011) 71 (18_Supplement): A32.
https://doi.org/10.1158/1538-7445.FBCR11-A32
Published: 28 October 2014
View article titled, Abstract A32: Notch pathway regulates pancreatic acinar-to-ductal metaplasia
Journal Articles

Abstract C8: Endogenous mouse models of pancreatic adenocarcinoma as a preclinical trial platform characterized by multiparametric magnetic resonance imaging

Irina Heid, Marija Trajkovic-Arsic, Jens T. Siveke, Rickmer Braren, Manuela Gretzinger, Yvonne Kosanke, Andreas Steingoetter, Sufyan Sayyed, Peter Noel, Bernhard Haller, Ernst J. Rummeny, Roland M. Schmid
Journal: Cancer Research
Cancer Res (2011) 71 (18_Supplement): C8.
https://doi.org/10.1158/1538-7445.FBCR11-C8
Published: 28 October 2014
View article titled, Abstract C8: Endogenous mouse models of pancreatic adenocarcinoma as a preclinical trial platform characterized by multiparametric magnetic resonance imaging
Journal Articles

Abstract PR11: Egfr is essential for Ras-driven pancreatic cancer development

Barbara M. Grüner, Clara Lubeseder-Martellato, Thomas Briel, Pawel K. Mazur, Roland M. Schmid, Jens T. Siveke
Journal: Cancer Research
Cancer Res (2011) 71 (18_Supplement): PR11.
https://doi.org/10.1158/1538-7445.FBCR11-PR11
Published: 28 October 2014
View article titled, Abstract PR11: Egfr is essential for Ras-driven pancreatic cancer development
Journal Articles

Abstract PR16: Important bidirectional function in the Notch-Delta signaling in pancreatic carcinogenesis and metastasis

Pawel K. Mazur, Clara Lubeseder-Martellato, Barbara M. Grüner, Ewa Kaznowska, Bence Sipos, Martin Hrabé de Angelis, Roland M. Schmid, Julien Sage, Jens T. Siveke
Journal: Cancer Research
Cancer Res (2011) 71 (18_Supplement): PR16.
https://doi.org/10.1158/1538-7445.FBCR11-PR16
Published: 28 October 2014
View article titled, Abstract PR16: Important bidirectional function in the Notch-Delta signaling in pancreatic carcinogenesis and metastasis
Journal Articles

Abstract B84: EGFR activation by the ADAM17 sheddase is required for Kras-induced pancreatic tumorigenesis.

Christopher J. Halbrook, Kenneth K. Takeuchi, Christine M. Ardito, Barbara M. Gruener, Jens T. Siveke, Howard C. Crawford
Journal: Cancer Research
Cancer Res (2012) 72 (14_Supplement): B84.
https://doi.org/10.1158/1538-7445.PANCA2012-B84
Published: 03 April 2014
View article titled, Abstract B84: EGFR activation by the ADAM17 sheddase is required for Kras-induced pancreatic tumorigenesis.
Journal Articles

Abstract A5: Imaging heterogeneity of endogenous mouse models of pancreatic cancer.

Irina Heid, Marija Trajkovic-Arsic, Irene Esposito, Manuela R. Gretzinger, Andreas Steingoetter, Bernhard Haller, Markus Schwaiger, Ernst J. Rummeny, Jens T. Siveke, Rickmer F. Braren
Journal: Cancer Research
Cancer Res (2012) 72 (14_Supplement): A5.
https://doi.org/10.1158/1538-7445.PANCA2012-A5
Published: 03 April 2014
View article titled, Abstract A5: Imaging heterogeneity of endogenous mouse models of pancreatic cancer.
Journal Articles

Abstract A55: Dual role of the Notch ligand Delta-1 in pancreatic carcinogenesis and metastasis.

Pawel K. Mazur, Clara Lubeseder-Martellato, Barbara M. Grüner, Bence Sipos, Martin Hrabé de Angelis, Julien Sage, Roland M. Schmid, Jens T. Siveke
Journal: Cancer Research
Cancer Res (2012) 72 (14_Supplement): A55.
https://doi.org/10.1158/1538-7445.PANCA2012-A55
Published: 03 April 2014
View article titled, Abstract A55: Dual role of the Notch ligand Delta-1 in pancreatic carcinogenesis and metastasis.
Journal Articles

Abstract B41: MEK1/2 inhibition with the novel chemotherapeutic agent BAY 86-9766 (RDEA119): A promising treatment strategy for pancreatic cancer.

Nicole Teichmann, Marija Trajkovic-Arsic, Arne Scholz, Schmid M. Roland, Braren Rickmer, Jens T. Siveke
Journal: Cancer Research
Cancer Res (2012) 72 (14_Supplement): B41.
https://doi.org/10.1158/1538-7445.PANCA2012-B41
Published: 03 April 2014
View article titled, Abstract B41: MEK1/2 inhibition with the novel chemotherapeutic agent BAY 86-9766 (RDEA119): A promising treatment strategy for pancreatic cancer.
Journal Articles

ADAM17 Regulates Epidermal Growth Factor Receptor Expression through the Activation of Notch1 in Non–Small Cell Lung Cancer

Anja Baumgart, Stefan Seidl, Petros Vlachou, Lars Michel, Nadya Mitova, Nicole Schatz, Katja Specht, Ina Koch, Tibor Schuster, Rebekka Grundler, Marcus Kremer, Falko Fend, Jens T. Siveke, Christian Peschel, Justus Duyster, Tobias Dechow
Journal: Cancer Research
Cancer Res (2010) 70 (13): 5368–5378.
https://doi.org/10.1158/0008-5472.CAN-09-3763
Published: 30 June 2010
View article titled, ADAM17 Regulates Epidermal Growth Factor Receptor Expression through the Activation of Notch1 in Non–Small Cell Lung Cancer
Open the PDF for ADAM17 Regulates Epidermal Growth Factor Receptor Expression through the Activation of Notch1 in Non–Small Cell Lung Cancer in another window
Includes: Supplementary data