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Jennifer K. Richer
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Journal Articles

Abstract CT144: Randomized phase II trial of preoperative fulvestrant with or without enzalutamide for ER+/Her2- breast cancer

Anthony D. Elias, Alyse Staley, Monica Fornier, Gregory A. Vidal, Sharon Sams, Nicole Spoelstra, Peter Kabos, Jennifer R. Diamond, Elena Shagisultanova, Rosa I. Gallagher, Julia Wulfkuhle, Emanuel Petricoin, Kathryn Zolman, Stephanie Biller, Vida Alami, Tessa McSpadden, Virginia Borges, Lyndsey S. Crump, Dexiang Gao, Jennifer K. Richer
Journal: Cancer Research
Cancer Res (2023) 83 (8_Supplement): CT144.
https://doi.org/10.1158/1538-7445.AM2023-CT144
Published: 14 April 2023
View article titled, Abstract CT144: Randomized phase II trial of preoperative fulvestrant with or without enzalutamide for ER+/Her2- breast cancer
Journal Articles

Abstract B008: The role of the androgen receptor in reciprocal activation of breast cancer metastases and the lung epithelium during metastatic outgrowth

Jessica L. Christenson, Nicole S. Spoelstra, G. Devon Trahan, Kathleen I. O'Neill, Michelle M. Williams, Jennifer K. Richer
Journal: Cancer Research
Cancer Res (2023) 83 (2_Supplement_2): B008.
https://doi.org/10.1158/1538-7445.METASTASIS22-B008
Published: 15 January 2023
View article titled, Abstract B008: The role of the androgen receptor in reciprocal activation of breast cancer metastases and the lung epithelium during metastatic outgrowth
Journal Articles

Abstract 1639: Human immune system mouse model of ER+ metastatic breast cancer

Ayodeji Olukoya, Shaymaa Bahnassy, Nicole S. Spoelstra, Lu Jin, Suman Ranjit, Anthony Elias, Jennifer K. Richer, Rebecca B. Riggins
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1639.
https://doi.org/10.1158/1538-7445.AM2022-1639
Published: 15 June 2022
View article titled, Abstract 1639: Human immune system mouse model of ER+ metastatic breast cancer
Journal Articles

Hotspot ESR1 Mutations Are Multimodal and Contextual Modulators of Breast Cancer Metastasis

Zheqi Li, Yang Wu, Megan E. Yates, Nilgun Tasdemir, Amir Bahreini, Jian Chen, Kevin M. Levine, Nolan M. Priedigkeit, Azadeh Nasrazadani, Simak Ali, Laki Buluwela, Spencer Arnesen, Jason Gertz, Jennifer K. Richer, Benjamin Troness, Dorraya El-Ashry, Qiang Zhang, Lorenzo Gerratana, Youbin Zhang, Massimo Cristofanilli, Maritza A. Montanez, Prithu Sundd, Callen T. Wallace, Simon C. Watkins, Caterina Fumagalli, Elena Guerini-Rocco, Li Zhu, George C. Tseng, Nikhil Wagle, Jason S. Carroll, Paul Jank, Carsten Denkert, Maria M. Karsten, Jens-Uwe Blohmer, Ben H. Park, Peter C. Lucas, Jennifer M. Atkinson, Adrian V. Lee, Steffi Oesterreich
Journal: Cancer Research
Cancer Res (2022) 82 (7): 1321–1339.
https://doi.org/10.1158/0008-5472.CAN-21-2576
Published: 01 April 2022
View article titled, Hotspot <em>ESR1</em> Mutations Are Multimodal and Contextual Modulators of Breast Cancer Metastasis
Open the PDF for Hotspot <em>ESR1</em> Mutations Are Multimodal and Contextual Modulators of Breast Cancer Metastasis in another window
Includes: Supplementary data
Journal Articles

Abstract PD1-08: Esr1 mutant breast cancers show elevated basal cytokeratins and immune activation

Zheqi Li, Yang Wu, Olivia Mcginn, Amir Bahreini, Nolan M. Priedigkeit, Kai Ding, Sayali Onkar, Carol A. Sartorius, Lori Miller, Margaret Rosenzweig, Nikhil Wagle, Jennifer K. Richer, William J. Muller, Laki Buluwela, Simak Ali, Dario A.A. Vignali, Yusi Fang, Li Zhu, George C. Tseng, Jason Gertz, Jennifer M. Atkinson, Adrian V. Lee, Steffi Oesterreich
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): PD1-08.
https://doi.org/10.1158/1538-7445.SABCS21-PD1-08
Published: 15 February 2022
View article titled, Abstract PD1-08: <em>Esr1</em> mutant breast cancers show elevated basal cytokeratins and immune activation
Journal Articles

Abstract 1076: Hormonal regulation of SEMA7A promotes therapeutic resistance in ER+ breast cancer

Lyndsey S. Crump, Garhett L. Wyatt, Taylor R. Rutherford, Jennifer K. Richer, Weston W. Porter, Traci R. Lyons
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1076.
https://doi.org/10.1158/1538-7445.AM2021-1076
Published: 01 July 2021
View article titled, Abstract 1076: Hormonal regulation of SEMA7A promotes therapeutic resistance in ER+ breast cancer
Journal Articles

Abstract 2867: Laboratory analyses of metastatic ER+/Her2- breast cancer treated with fulvestrant plus enzalutamide

Jennifer K. Richer, Nicole S. Spoelstra, Alyse Winchester, Julia Wulfkuhle, Sharon B. Sams, Gregory Vidal, Peter Kabos, Jennifer Diamond, Elena Shagisultanova, Anosheh Afghahi, Jose Mayordomo, Tessa McSpadden, Gloria Crawford, Virginia Borges, Dexiang Gao, Emanuel Petricoin, Anthony D. Elias
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 2867.
https://doi.org/10.1158/1538-7445.AM2021-2867
Published: 01 July 2021
View article titled, Abstract 2867: Laboratory analyses of metastatic ER+/Her2- breast cancer treated with fulvestrant plus enzalutamide
Journal Articles

Steroid Hormone Receptor and Infiltrating Immune Cell Status Reveals Therapeutic Vulnerabilities of ESR1-Mutant Breast Cancer

Michelle M. Williams, Nicole S. Spoelstra, Spencer Arnesen, Kathleen I. O'Neill, Jessica L. Christenson, Jordan Reese, Kathleen C. Torkko, Andrew Goodspeed, Emmanuel Rosas, Toru Hanamura, Sharon B. Sams, Zheqi Li, Steffi Oesterreich, Rebecca B. Riggins, Britta M. Jacobsen, Anthony Elias, Jason Gertz, Jennifer K. Richer
Journal: Cancer Research
Cancer Res (2021) 81 (3): 732–746.
https://doi.org/10.1158/0008-5472.CAN-20-1200
Published: 01 February 2021
View article titled, Steroid Hormone Receptor and Infiltrating Immune Cell Status Reveals Therapeutic Vulnerabilities of <em>ESR1</em>-Mutant Breast Cancer
Open the PDF for Steroid Hormone Receptor and Infiltrating Immune Cell Status Reveals Therapeutic Vulnerabilities of <em>ESR1</em>-Mutant Breast Cancer in another window
Includes: Supplementary data
Journal Articles

Estrogen Receptor Alpha Mutations in Breast Cancer Cells Cause Gene Expression Changes through Constant Activity and Secondary Effects

Spencer Arnesen, Zannel Blanchard, Michelle M. Williams, Kristofer C. Berrett, Zheqi Li, Steffi Oesterreich, Jennifer K. Richer, Jason Gertz
Journal: Cancer Research
Cancer Res (2021) 81 (3): 539–551.
https://doi.org/10.1158/0008-5472.CAN-20-1171
Published: 01 February 2021
View article titled, Estrogen Receptor Alpha Mutations in Breast Cancer Cells Cause Gene Expression Changes through Constant Activity and Secondary Effects
Open the PDF for Estrogen Receptor Alpha Mutations in Breast Cancer Cells Cause Gene Expression Changes through Constant Activity and Secondary Effects in another window
Includes: Supplementary data
Journal Articles

Hormonal Regulation of Semaphorin 7a in ER+ Breast Cancer Drives Therapeutic Resistance

Lyndsey S. Crump, Garhett L. Wyatt, Taylor R. Rutherford, Jennifer K. Richer, Weston W. Porter, Traci R. Lyons
Journal: Cancer Research
Cancer Res (2021) 81 (1): 187–198.
https://doi.org/10.1158/0008-5472.CAN-20-1601
Published: 04 January 2021
View article titled, Hormonal Regulation of Semaphorin 7a in ER<sup>+</sup> Breast Cancer Drives Therapeutic Resistance
Open the PDF for Hormonal Regulation of Semaphorin 7a in ER<sup>+</sup> Breast Cancer Drives Therapeutic Resistance in another window
Includes: Supplementary data
Journal Articles

Abstract 5305: Characterization of the ovarian tumor transcriptome and microenvironment in pre and post-chemotherapy treated patients

Kimberly R. Jordan, Jill Slansky, Angela Minic, Jennifer K. Richer, James C. Costello, Aaron J. Clauset, Rajendra T. Kumar, Kian Behbakht, Matthew J. Sikora, Benjamin G. Bitler
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 5305.
https://doi.org/10.1158/1538-7445.AM2020-5305
Published: 15 August 2020
View article titled, Abstract 5305: Characterization of the ovarian tumor transcriptome and microenvironment in pre and post-chemotherapy treated patients
Journal Articles

Abstract 5029: Targeting fatty acid oxidation to promote anoikis and inhibit ovarian cancer progression

Benjamin Guy Bitler, Brandon Sawyer, Lubna Qamar, Jennifer K. Richer, Kian Behbakht, Isabel R. Schlaepfer
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 5029.
https://doi.org/10.1158/1538-7445.AM2020-5029
Published: 15 August 2020
View article titled, Abstract 5029: Targeting fatty acid oxidation to promote anoikis and inhibit ovarian cancer progression
Journal Articles

Abstract P6-04-13: Preclinical and clinical analyses of estrogen receptor alpha mutant metastatic breast cancer

Jennifer K Richer, Michelle M Williams, Nicole S Spoelstra, Spencer Arnesen, Jessica L Christenson, Kathleen O’Neill, Jordan M Reese, Zannel D Blanchard, Toru Hanamura, Britta M Jacobsen, Jason Gertz, Anthony Elias
Journal: Cancer Research
Cancer Res (2020) 80 (4_Supplement): P6-04-13.
https://doi.org/10.1158/1538-7445.SABCS19-P6-04-13
Published: 15 February 2020
View article titled, Abstract P6-04-13: Preclinical and clinical analyses of estrogen receptor alpha mutant metastatic breast cancer
Journal Articles

Abstract P6-05-06: Significance of prostate specific antigen as a predictor of androgen receptor activity in breast cancer

Toru Hanamura, Jessica L Christenson, Kathleen I O’Neill, Emmanuel Rosas, Nicole S Spoelstra, Michelle M Williams, Jennifer K Richer
Journal: Cancer Research
Cancer Res (2020) 80 (4_Supplement): P6-05-06.
https://doi.org/10.1158/1538-7445.SABCS19-P6-05-06
Published: 15 February 2020
View article titled, Abstract P6-05-06: Significance of prostate specific antigen as a predictor of androgen receptor activity in breast cancer
Journal Articles

Abstract 5137: Tryptophan catabolism in ovarian cancer

Lynelle P. Smith, Lucas M. Harrell, Jessica L. Christenson, Benjamin Bitler, Jill Slansky, Jennifer K. Richer
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5137.
https://doi.org/10.1158/1538-7445.AM2018-5137
Published: 01 July 2018
View article titled, Abstract 5137: Tryptophan catabolism in ovarian cancer
Journal Articles

Androgen Receptor Supports an Anchorage-Independent, Cancer Stem Cell-like Population in Triple-Negative Breast Cancer

Valerie N. Barton, Jessica L. Christenson, Michael A. Gordon, Lisa I. Greene, Thomas J. Rogers, Kiel Butterfield, Beatrice Babbs, Nicole S. Spoelstra, Nicholas C. D'Amato, Anthony Elias, Jennifer K. Richer
Journal: Cancer Research
Cancer Res (2017) 77 (13): 3455–3466.
https://doi.org/10.1158/0008-5472.CAN-16-3240
Published: 02 July 2017
View article titled, Androgen Receptor Supports an Anchorage-Independent, Cancer Stem Cell-like Population in Triple-Negative Breast Cancer
Open the PDF for Androgen Receptor Supports an Anchorage-Independent, Cancer Stem Cell-like Population in Triple-Negative Breast Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 3610: Synergy between androgen receptor (AR)-targeting agents seviteronel (SEVI) or enzalutamide (ENZA) and mTOR or HER2 pathway-targeting agents in breast cancer

Michael A. Gordon, Nicholas D'Amato, Jessica Christenson, Beatrice Babbs, Haihua Gu, Julia Wulfkuhle, Emmanuel Petricoin, Anthoy Elias, Jennifer K. Richer
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 3610.
https://doi.org/10.1158/1538-7445.AM2017-3610
Published: 01 July 2017
View article titled, Abstract 3610: Synergy between androgen receptor (AR)-targeting agents seviteronel (SEVI) or enzalutamide (ENZA) and mTOR or HER2 pathway-targeting agents in breast cancer
Journal Articles

A TDO2-AhR Signaling Axis Facilitates Anoikis Resistance and Metastasis in Triple-Negative Breast Cancer

Nicholas C. D'Amato, Thomas J. Rogers, Michael A. Gordon, Lisa I. Greene, Dawn R. Cochrane, Nicole S. Spoelstra, Travis G. Nemkov, Angelo D'Alessandro, Kirk C. Hansen, Jennifer K. Richer
Journal: Cancer Research
Cancer Res (2015) 75 (21): 4651–4664.
https://doi.org/10.1158/0008-5472.CAN-15-2011
Published: 01 November 2015
View article titled, A TDO2-AhR Signaling Axis Facilitates Anoikis Resistance and Metastasis in Triple-Negative Breast Cancer
Open the PDF for A TDO2-AhR Signaling Axis Facilitates Anoikis Resistance and Metastasis in Triple-Negative Breast Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract P6-03-07: Targeting multiple pathways in breast cancer: Androgen receptor, HER2, and mTOR

Michael A Gordon, Nicholas D'Amato, Haihua Gu, Darren Wong, Anthony Elias, Jennifer K Richer
Journal: Cancer Research
Cancer Res (2015) 75 (9_Supplement): P6-03-07.
https://doi.org/10.1158/1538-7445.SABCS14-P6-03-07
Published: 01 May 2015
View article titled, Abstract P6-03-07: Targeting multiple pathways in breast cancer: Androgen receptor, HER2, and mTOR
Journal Articles

Abstract P1-08-02: Metformin blocks de novo synthesis of cholesterol in triple negative breast cancer cells

Ann D Thor, Zeying Fan, Reema Wahdan-Alaswad, Steve M Anderson, Jennifer K Richer, Susan M Edgerton
Journal: Cancer Research
Cancer Res (2015) 75 (9_Supplement): P1-08-02.
https://doi.org/10.1158/1538-7445.SABCS14-P1-08-02
Published: 01 May 2015
View article titled, Abstract P1-08-02: Metformin blocks de novo synthesis of cholesterol in triple negative breast cancer cells