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Jennifer A. Chan
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Journal Articles

Abstract B007: High-risk pediatric cancer models in zebrafish, mouse and short-term culture predict individual patient responses to therapy

Nadine Azzam, Jamie I. Fletcher, Nicole Melong, Loretta Lau, Emmy M. Dolman, Jie Mao, Gabor Tax, Roxanne Cadiz, Lissandra Tuzi, Alvin Kamili, Biljana Dumevska, Jinhan Xie, Jennifer A. Chan, Donna L. Senger, Stephanie A. Grover, David Malkin, Michelle Haber, Jason N. Berman
Journal: Cancer Research
Cancer Res (2024) 84 (17_Supplement): B007.
https://doi.org/10.1158/1538-7445.PEDIATRIC24-B007
Published: 05 September 2024
View article titled, Abstract B007: High-risk pediatric cancer models in zebrafish, mouse and short-term culture predict individual patient responses to therapy
Journal Articles

Abstract 6812: Durable control of brain tumors by glioma inhibitory macrophages and IL33

Shyam V. Menon, Xueqing Lun, Peipei Zeng, Jianbo Zhang, Bo Young Ahn, Henry Yu, Alisha Poole, Ngoc Ha Dang, Katalin Osz, Jennifer A. Chan, Daniela F. Quail, Stephen M. Robbins, Donna L. Senger
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6812.
https://doi.org/10.1158/1538-7445.AM2024-6812
Published: 22 March 2024
View article titled, Abstract 6812: Durable control of brain tumors by glioma inhibitory macrophages and IL33
Journal Articles

Abstract 5002: Next-generation mRNA-LNP vaccine prototype achieves tumor clearance in a GBM mouse model

Robert Nechanitzky, Shannon Snelling Snelling, Kristofor Ellestad, Xueqing Lun, Kirstin Olsen, Yu Wu, Yury Karpov, Jun Liu, Matthew Gold, Haritha Menon, Rajesh Krishnan, Robert Georgantas, Pamela S. Ohashi, Douglas J. Mahoney, Jennifer A. Chan, Natalia Martin-Orozco
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 5002.
https://doi.org/10.1158/1538-7445.AM2024-5002
Published: 22 March 2024
View article titled, Abstract 5002: Next-generation mRNA-LNP vaccine prototype achieves tumor clearance in a GBM mouse model
Journal Articles

Abstract 937: Prioritizing treatment targets for an adolescent with metastatic processive malignancy using proteomics and personalized xenograft models within an actionable timeframe

Georgina D. Barnabas, Tariq A. Bhat, Verena Goebeler, Pascal Leclair, Nadine Azzam, Nicole Melong, Jason N. Berman, Jennifer A. Chan, Donna L. Senger, Seth Parker, Christopher A. Maxwell, Gregor S. Reid, Jonathan Bush, Caron Strahlendorf, Rebecca Deyell, C James Lim, Philipp F. Lange
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 937.
https://doi.org/10.1158/1538-7445.AM2024-937
Published: 22 March 2024
View article titled, Abstract 937: Prioritizing treatment targets for an adolescent with metastatic processive malignancy using proteomics and personalized xenograft models within an actionable timeframe
Journal Articles

Abstract CT155: Long term results and ctDNA correlatives for CAPOX BETR: A multi-center phase II trial of capecitabine, oxaliplatin, bevacizumab and trastuzumab for previously untreated HER2 positive metastatic gastroesophageal adenocarcinoma

Harshabad Singh, Kristen E. Lowder, Kevin Kapner, Ronan J. Kelly, Hui Zheng, Nadine J. McCleary, Thomas A. Abrams, Jennifer A. Chan, Eileen M. Regan, Samuel J. Klempner, Alison M. Hannigan, Lauren K. Brais, Elizabeth A. Andrews, Matthew B. Yurgelun, James M. Cleary, Douglas A. Rubinson, Lauren L. Ritterhouse, Garrett E. Maron, Andrew J. Aguirre, Lu Tan, Pan Du, Jeffrey A. Meyerhardt, Emma Gardecki, Jochen K. Lennerz, Shidong Jia, Brian M. Wolpin, Peter C. Enzinger
Journal: Cancer Research
Cancer Res (2023) 83 (8_Supplement): CT155.
https://doi.org/10.1158/1538-7445.AM2023-CT155
Published: 14 April 2023
View article titled, Abstract CT155: Long term results and ctDNA correlatives for CAPOX BETR: A multi-center phase II trial of capecitabine, oxaliplatin, bevacizumab and trastuzumab for previously untreated HER2 positive metastatic gastroesophageal adenocarcinoma
Journal Articles

Abstract 4509: A pan-Canadian precision oncology program for children, adolescents and young adults with hard-to-cure cancer: The PRecision Oncology For Young peopLE (PROFYLE) Program

Stephanie A. Grover, Lesleigh Abbott, Jason N. Berman, Guillaume Bourque, Jennifer A. Chan, Avram E. Denburg, Rebecca J. Deyell, Conrad V. Fernandez, Cynthia Hawkins, Jan-Willem Henning, Meredith S. Irwin, Nada Jabado, Steven J. Jones, Philipp F. Lange, Paul Moorehead, Michael F. Moran, Daniel A. Morgenstern, Sapna Oberoi, Antonia Palmer, Shahrad R. Rassekh, Donna L. Senger, Adam Shlien, Daniel Sinnett, Caron Strahlendorf, Patrick J. Sullivan, Michael D. Taylor, Suzanne Vercauteren, Anita Villani, Stephanie Villeneuve, James A. Whitlock, David Malkin, on behalf of the PROFYLE Consortium
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4509.
https://doi.org/10.1158/1538-7445.AM2023-4509
Published: 04 April 2023
View article titled, Abstract 4509: A pan-Canadian precision oncology program for children, adolescents and young adults with hard-to-cure cancer: The PRecision Oncology For Young peopLE (PROFYLE) Program
Journal Articles

Abstract 4670: True bench-to-bedside science: An international pilot study modeling hard-to-cure pediatric cancers to prioritize therapeutic intervention

Nadine Azzam, Nicole Melong, Lissandra Tuzi, Lisa Pinto, Jamie I. Fletcher, Alvin Kamili, Biljana Dumevska, Loretta Lau, Jennifer A. Chan, Donna L. Senger, Stephanie A. Grover, Michelle Haber, David Malkin, Jason N. Berman
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4670.
https://doi.org/10.1158/1538-7445.AM2023-4670
Published: 04 April 2023
View article titled, Abstract 4670: True bench-to-bedside science: An international pilot study modeling hard-to-cure pediatric cancers to prioritize therapeutic intervention
Journal Articles

Abstract 6397: Understanding the glioblastoma microenvironment with spatial resolution in PDX models

Aly O. Abdelkareem, Katalin Osz, Donna Senger, Jennifer A. Chan, Sorana Morrissy
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 6397.
https://doi.org/10.1158/1538-7445.AM2022-6397
Published: 15 June 2022
View article titled, Abstract 6397: Understanding the glioblastoma microenvironment with spatial resolution in PDX models
Journal Articles

Abstract 5224: The PRecision Oncology For Young peopLE (PROFYLE) Program: A national precision oncology program for children, adolescents and young adults with hard-to-cure cancer in Canada

Stephanie A. Grover, Lesleigh Abbott, Jason N. Berman, Jennifer A. Chan, Avram E. Denburg, Rebecca J. Deyell, Conrad V. Fernandez, Cynthia Hawkins, Jan-Willem Henning, Meredith S. Irwin, Nada Jabado, Steven J. Jones, Philipp F. Lange, Michael F. Moran, Daniel A. Morgenstern, Antonia Palmer, Shahrad R. Rassekh, Donna L. Senger, Adam Shlien, Daniel Sinnett, Caron Strahlendorf, Patrick J. Sullivan, Michael D. Taylor, Suzanne Vercauteren, Anita Villani, James A. Whitlock, David Malkin, on behalf of the Terry Fox PROFYLE Consortium
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5224.
https://doi.org/10.1158/1538-7445.AM2022-5224
Published: 15 June 2022
View article titled, Abstract 5224: The PRecision Oncology For Young peopLE (PROFYLE) Program: A national precision oncology program for children, adolescents and young adults with hard-to-cure cancer in Canada
Journal Articles

Abstract 636: PROFYLE: The pan-Canadian precision oncology program for children, adolescents and young adults with hard-to-treat cancer

Stephanie A. Grover, Thierry Alcindor, Jason N. Berman, Jennifer A. Chan, Avram E. Denburg, Rebecca J. Deyell, David D. Eisenstat, Conrad V. Fernandez, Paul E. Grundy, Abha Gupta, Cynthia Hawkins, Meredith S. Irwin, Nada Jabado, Steven J. Jones, Michael F. Moran, Daniel A. Morgenstern, Shahrad R. Rassekh, Adam Shlien, Daniel Sinnett, Poul H. Sorensen, Patrick J. Sullivan, Michael D. Taylor, Anita Villani, James A. Whitlock, David Malkin, on behalf of the Terry Fox PROFYLE Consortium
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 636.
https://doi.org/10.1158/1538-7445.AM2021-636
Published: 01 July 2021
View article titled, Abstract 636: PROFYLE: The pan-Canadian precision oncology program for children, adolescents and young adults with hard-to-treat cancer
Journal Articles

Abstract SY09-03: PROFYLEing Cancer for KiCS: The Canadian Pediatric Precision Oncology Initiative

David Malkin, Jason N. Berman, Jennifer A. Chan, Avram Denburg, Rebecca Deyell, David Eisenstadt, Conrad Fernandez, Stephanie Grover, Abha Gupta, Cynthia Hawkings, Meredith Irwin, Nada Jabado, Steven Jones, Daniel Morgenstern, Michael Moran, Rod Rasesekh, Adam Shlien, Daniel Sinnett, Poul Sorensen, Patrick Sullivan, Michael Taylor, Anita Villani, Jim Whitlock
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): SY09-03.
https://doi.org/10.1158/1538-7445.AM2020-SY09-03
Published: 15 August 2020
View article titled, Abstract SY09-03: PROFYLEing Cancer for KiCS: The Canadian Pediatric Precision Oncology Initiative
Journal Articles

Abstract 5413: Terry Fox PRecision Oncology For Young peopLE (PROFYLE): A Canadian precision medicine program for children, adolescents and young adults with hard-to-treat cancer

Stephanie A. Grover, Jason N. Berman, Jennifer A. Chan, Rebecca J. Deyell, David D. Eisenstat, Conrad V. Fernandez, Paul E. Grundy, Cynthia Hawkins, Meredith S. Irwin, Nada Jabado, Steven J. Jones, Michael Moran, Shahrad R. Rassekh, Adam Shlien, Daniel Sinnett, Poul H. Sorensen, Patrick J. Sullivan, Michael D. Taylor, Anita Villani, James A. Whitlock, David Malkin, on behalf of the Terry Fox PROFYLE Consortium
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 5413.
https://doi.org/10.1158/1538-7445.AM2020-5413
Published: 15 August 2020
View article titled, Abstract 5413: Terry Fox PRecision Oncology For Young peopLE (PROFYLE): A Canadian precision medicine program for children, adolescents and young adults with hard-to-treat cancer
Journal Articles

Intratumoral Genetic and Functional Heterogeneity in Pediatric Glioblastoma

Mary Hoffman, Aaron H. Gillmor, Daniel J. Kunz, Michael J. Johnston, Ana Nikolic, Kiran Narta, Mehdi Zarrei, Jennifer King, Katrina Ellestad, Ngoc Ha Dang, Florence M.G. Cavalli, Michelle M. Kushida, Fiona J. Coutinho, Yuankun Zhu, Betty Luu, Yussanne Ma, Andrew J. Mungall, Richard Moore, Marco A. Marra, Michael D. Taylor, Trevor J. Pugh, Peter B. Dirks, Douglas Strother, Lucie Lafay-Cousin, Adam C. Resnick, Stephen Scherer, Donna L. Senger, Benjamin D. Simons, Jennifer A. Chan, A. Sorana Morrissy, Marco Gallo
Journal: Cancer Research
Cancer Res (2019) 79 (9): 2111–2123.
https://doi.org/10.1158/0008-5472.CAN-18-3441
Published: 01 May 2019
View article titled, Intratumoral Genetic and Functional Heterogeneity in Pediatric Glioblastoma
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Includes: Supplementary data
Journal Articles

CD271+ Cells Are Diagnostic and Prognostic and Exhibit Elevated MAPK Activity in SHH Medulloblastoma

Lisa Liang, Ludivine Coudière-Morrison, Nazanin Tatari, Margaret Stromecki, Agnes Fresnoza, Christopher J. Porter, Marc R. Del Bigio, Cynthia Hawkins, Jennifer A. Chan, Timothy C. Ryken, Michael D. Taylor, Vijay Ramaswamy, Tamra E. Werbowetski-Ogilvie
Journal: Cancer Research
Cancer Res (2018) 78 (16): 4745–4759.
https://doi.org/10.1158/0008-5472.CAN-18-0027
Published: 14 August 2018
View article titled, CD271<sup>+</sup> Cells Are Diagnostic and Prognostic and Exhibit Elevated MAPK Activity in SHH Medulloblastoma
Open the PDF for CD271<sup>+</sup> Cells Are Diagnostic and Prognostic and Exhibit Elevated MAPK Activity in SHH Medulloblastoma in another window
Journal Articles

RAS/MAPK Activation Drives Resistance to Smo Inhibition, Metastasis, and Tumor Evolution in Shh Pathway–Dependent Tumors

Xuesong Zhao, Tatyana Ponomaryov, Kimberly J. Ornell, Pengcheng Zhou, Sukriti K. Dabral, Ekaterina Pak, Wei Li, Scott X. Atwood, Ramon J. Whitson, Anne Lynn S. Chang, Jiang Li, Anthony E. Oro, Jennifer A. Chan, Joseph F. Kelleher, Rosalind A. Segal
Journal: Cancer Research
Cancer Res (2015) 75 (17): 3623–3635.
https://doi.org/10.1158/0008-5472.CAN-14-2999-T
Published: 31 August 2015
View article titled, RAS/MAPK Activation Drives Resistance to Smo Inhibition, Metastasis, and Tumor Evolution in Shh Pathway–Dependent Tumors
Open the PDF for RAS/MAPK Activation Drives Resistance to Smo Inhibition, Metastasis, and Tumor Evolution in Shh Pathway–Dependent Tumors in another window
Includes: Supplementary data
Journal Articles

Abstract 2199: Associations of genetic polymorphisms in VEGFR1 with progression-free and overall survival in patients with neuroendocrine tumors treated with the VEGFA inhibitor bevacizumab.

Monica Ter-Minassian, ZhiRong R. Qian, Jennifer A. Chan, Susanne M. Hooshmand, Lauren K. Brais, Rachel Heafield, Xihong Lin, Geoffrey Liu, David C. Christiani, Matthew H. Kulke
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 2199.
https://doi.org/10.1158/1538-7445.AM2013-2199
Published: 15 April 2013
View article titled, Abstract 2199: Associations of genetic polymorphisms in <em>VEGFR1</em> with progression-free and overall survival in patients with neuroendocrine tumors treated with the VEGFA inhibitor bevacizumab.
Journal Articles

Abstract 3633: Prognostic value of chromogranin A and alkaline phosphatase in patients with advanced neuroendocrine tumor

Monica Ter-Minassian, Jennifer A. Chan, Susanne M. Hooshmand, Lauren K. Brais, Anastassia Daskalova, Rachel Heafield, Zhiron Qian, Xihong Lin, David C. Christiani, Matthew H. Kulke
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 3633.
https://doi.org/10.1158/1538-7445.AM2012-3633
Published: 15 April 2012
View article titled, Abstract 3633: Prognostic value of chromogranin A and alkaline phosphatase in patients with advanced neuroendocrine tumor
Journal Articles

Genetic Screen Identifies Insulin-like Growth Factor Binding Protein 5 as a Modulator of Tamoxifen Resistance in Breast Cancer

Bo Young Ahn, Adam N. Elwi, Byoungchun Lee, Diane L.N. Trinh, Alexander C. Klimowicz, Annie Yau, Jennifer A. Chan, Anthony Magliocco, Sung-Woo Kim
Journal: Cancer Research
Cancer Res (2010) 70 (8): 3013–3019.
https://doi.org/10.1158/0008-5472.CAN-09-3108
Published: 14 April 2010
View article titled, Genetic Screen Identifies Insulin-like Growth Factor Binding Protein 5 as a Modulator of Tamoxifen Resistance in Breast Cancer
Open the PDF for Genetic Screen Identifies Insulin-like Growth Factor Binding Protein 5 as a Modulator of Tamoxifen Resistance in Breast Cancer in another window
Includes: Supplementary data
Journal Articles

Integrative Transcriptome Analysis Reveals Common Molecular Subclasses of Human Hepatocellular Carcinoma

Yujin Hoshida, Sebastian M.B. Nijman, Masahiro Kobayashi, Jennifer A. Chan, Jean-Philippe Brunet, Derek Y. Chiang, Augusto Villanueva, Philippa Newell, Kenji Ikeda, Masaji Hashimoto, Goro Watanabe, Stacey Gabriel, Scott L. Friedman, Hiromitsu Kumada, Josep M. Llovet, Todd R. Golub
Journal: Cancer Research
Cancer Res (2009) 69 (18): 7385–7392.
https://doi.org/10.1158/0008-5472.CAN-09-1089
Published: 14 September 2009
View article titled, Integrative Transcriptome Analysis Reveals Common Molecular Subclasses of Human Hepatocellular Carcinoma
Open the PDF for Integrative Transcriptome Analysis Reveals Common Molecular Subclasses of Human Hepatocellular Carcinoma in another window
Includes: Supplementary data
Journal Articles

Evaluation of the 8q24 Prostate Cancer Risk Locus and MYC Expression

Mark M. Pomerantz, Christine A. Beckwith, Meredith M. Regan, Stacia K. Wyman, Gyorgy Petrovics, Yongmei Chen, Dorota J. Hawksworth, Fredrick R. Schumacher, Lorelei Mucci, Kathryn L. Penney, Meir J. Stampfer, Jennifer A. Chan, Kristin G. Ardlie, Brian R. Fritz, Rachael K. Parkin, Daniel W. Lin, Michelle Dyke, Paula Herman, Steve Lee, William K. Oh, Philip W. Kantoff, Muneesh Tewari, David G. McLeod, Shiv Srivastava, Matthew L. Freedman
Journal: Cancer Research
Cancer Res (2009) 69 (13): 5568–5574.
https://doi.org/10.1158/0008-5472.CAN-09-0387
Published: 01 July 2009
View article titled, Evaluation of the 8q24 Prostate Cancer Risk Locus and <em>MYC</em> Expression
Open the PDF for Evaluation of the 8q24 Prostate Cancer Risk Locus and <em>MYC</em> Expression in another window
Includes: Supplementary data