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Jeffrey W. Tyner
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Journal Articles

Understanding Drug Sensitivity and Tackling Resistance in Cancer

Jeffrey W. Tyner, Franziska Haderk, Anbarasu Kumaraswamy, Linda B. Baughn, Brian Van Ness, Song Liu, Himangi Marathe, Joshi J. Alumkal, Trever G. Bivona, Keith Syson Chan, Brian J. Druker, Alan D. Hutson, Peter S. Nelson, Charles L. Sawyers, Christopher D. Willey
Journal: Cancer Research
Cancer Res (2022) 82 (8): 1448–1460.
DOI: https://doi.org/10.1158/0008-5472.CAN-21-3695
Published: 15 April 2022
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Abstract 1429: Characterization of trametinib combined with venetoclax in acute myeloid leukemia (AML) treatment

Alisa Damnernsawad, Christopher A. Eide, Sofia Beer, Haijiao Zhang, Daniel Bottomly, Stephen E. Kurtz, Jeffrey W. Tyner
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1429.
DOI: https://doi.org/10.1158/1538-7445.AM2021-1429
Published: 01 July 2021
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Abstract 2306: The ubiquitin-binding non-receptor tyrosine kinase TNK1 is regulated by a MARK-mediated interaction with 14-3-3

Christina Marie Egbert, Tsz Yin Chan, Logan Larsen, Eranga Roshan Balasooriya, Kristina Kohler, Jeremy Tsang, Madison Frey, Julia Maxson, David Huang, Kenneth A. Christensen, James Moody, Jeffrey W. Tyner, Joshua L. Andersen
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 2306.
DOI: https://doi.org/10.1158/1538-7445.AM2021-2306
Published: 01 July 2021
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Journal Articles

Abstract LT022: The AML microenvironment catalyzes a step-wise evolution to gilteritinib resistance

Sunil K. Joshi, Tamilla Nechiporuk, Daniel Bottomly, Paul Piehowski, Julie A. Reisz, Janét Pittsenbarger, Andy Kaempf, Sara J.C. Gosline, Yi-Ting Wang, Tao Liu, Cristina E. Tognon, Angelo D’Alessandro, Jeffrey W. Tyner, Shannon K. McWeeney, Karin D. Rodland, Brian J. Druker, Elie Traer
Journal: Cancer Research
Cancer Res (2021) 81 (5_Supplement): LT022.
DOI: https://doi.org/10.1158/1538-7445.TME21-LT022
Published: 01 March 2021
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Journal Articles

Abstract 4538: Global and phosphoproteomic analysis of AML cell line response to phosphatase inhibitor treatment

Paul D. Piehowski, Jason E. McDermott, Joshua R. Hansen, Samantha L. Savage, Cristina E. Tognon, Anupriya Agarwal, Jeffrey W. Tyner, Brian J. Druker, Karin D. Rodland
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4538.
DOI: https://doi.org/10.1158/1538-7445.AM2019-4538
Published: 01 July 2019
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Abstract 926: Extrinsic and intrinsic activation of RAS/MAPK signaling enables resistance to FLT3 inhibitor, gilteritinib, in acute myeloid leukemia

Sunil K. Joshi, Stephen Christy, Renata Scopim Ribeiro, Shannon McWeeney, Jeffrey W. Tyner, Cristina E. Tognon, Brian J. Druker, Elie Traer
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 926.
DOI: https://doi.org/10.1158/1538-7445.AM2019-926
Published: 01 July 2019
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Journal Articles

Abstract 1323: CG-806, a pan-FLT3 / pan-BTK inhibitor, demonstrates superior potency against cells from IDH-1 mutant and other non-favorable risk groups of AML patients

Hongying Zhang, Andrea Local, Jeffrey W. Tyner, Stephen E. Kurtz, Beth Wilmot, Shannon Mcweeney, Brian J. Druker, Stephen B. Howell, William G. Rice
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 1323.
DOI: https://doi.org/10.1158/1538-7445.AM2019-1323
Published: 01 July 2019
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Journal Articles

Abstract 325: A genome-wide CRISPR screen on AML cells reveals the TP53 apoptotic network is a primary mediator of resistance to BCL2 inhibition

Tamilla Nechiporuk, Stephen E. Kurtz, Olga Nikolova, Amanda d'Almeida, Kevin Watanabe-Smith, Mara Rosenberg, Brian Druker, Jeffrey W. Tyner, Shannon K. McWeeney
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 325.
DOI: https://doi.org/10.1158/1538-7445.AM2019-325
Published: 01 July 2019
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Abstract 4763: Genome-wide CRISPR screening identifies TSC1 as a regulator of sorafenib resistance in acute myeloid leukemia

Alisa Damnernsawad, Tamilla Nechiporuk, Steve E. Kurtz, Wesley R. Horton, Olga Nikolova, Shannon K. McWeeney, Jeffrey W. Tyner
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4763.
DOI: https://doi.org/10.1158/1538-7445.AM2019-4763
Published: 01 July 2019
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Journal Articles

Abstract 508: Combined MEK and PD-1 inhibition in acute myeloid leukemia: Effect on cell proliferation and phenotype

Kaycee B. Moshofsky, Hyun J. Cho, Yoko Kosaka, Matthew T. Newman, Jeffrey W. Tyner, Evan F. Lind
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 508.
DOI: https://doi.org/10.1158/1538-7445.AM2019-508
Published: 01 July 2019
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Abstract 302: Selective Mcl-1 inhibition by AZD5991 induces on-target cell death and achieves antitumor activity in multiple myeloma and acute myeloid leukemia

Adriana E. Tron, Matthew A. Belmonte, Steven Criscione, Edwin A. Clark, Eric Gangl, Francis D. Gibbons, Jeffrey W. Tyner, Stephen E. Kurtz, Qing Ye, Alexander W. Hird, Alwin Schuller, J. Paul Secrist
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 302.
DOI: https://doi.org/10.1158/1538-7445.AM2018-302
Published: 01 July 2018
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Journal Articles

Abstract 791: CG'806, a first-in-class pan-FLT3/pan-BTK inhibitor, demonstrates superiority to other FLT3 and BTK inhibitors against primary patient samples

Stephen E. Kurtz, Kevin Watanabe-Smith, Dan Bottomly, Beth Wilmot, Shannon Mcweeney, Andrea Local, Hongying Zhang, Stephen Howell, William Rice, Brian J. Druker, Jeffrey W. Tyner
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 791.
DOI: https://doi.org/10.1158/1538-7445.AM2018-791
Published: 01 July 2018
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Journal Articles

Abstract 3883: Gene expression predicts ex vivo drug sensitivity in acute myeloid leukemia

Brian S. White, Suleiman A. Khan, Muhammad Ammad-ud-din, Swapnil Potdar, Mike J. Mason, Cristina E. Tognon, Brian J. Druker, Caroline A. Heckman, Olli P. Kallioniemi, Stephen E. Kurtz, Kimmo Porkka, Jeffrey W. Tyner, Tero Aittokallio, Krister Wennerberg, Justin Guinney
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 3883.
DOI: https://doi.org/10.1158/1538-7445.AM2018-3883
Published: 01 July 2018
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Journal Articles

Super-Enhancers Promote Transcriptional Dysregulation in Nasopharyngeal Carcinoma

Jiang Yuan, Yan-Yi Jiang, Anand Mayakonda, Moli Huang, Ling-Wen Ding, Han Lin, Fenggang Yu, Yanan Lu, Thomas Kwok Seng Loh, Marilynn Chow, Samantha Savage, Jeffrey W. Tyner, De-Chen Lin, H. Phillip Koeffler
Journal: Cancer Research
Cancer Res (2017) 77 (23): 6614–6626.
DOI: https://doi.org/10.1158/0008-5472.CAN-17-1143
Published: 30 November 2017
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Includes: Supplementary data
Journal Articles

Unpaired Extracellular Cysteine Mutations of CSF3R Mediate Gain or Loss of Function

Haijiao Zhang, Sophie Means, Anna Reister Schultz, Kevin Watanabe-Smith, Bruno C. Medeiros, Daniel Bottomly, Beth Wilmot, Shannon K. McWeeney, Tim Kükenshöner, Oliver Hantschel, Jeffrey W. Tyner
Journal: Cancer Research
Cancer Res (2017) 77 (16): 4258–4267.
DOI: https://doi.org/10.1158/0008-5472.CAN-17-1052
Published: 14 August 2017
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Includes: Supplementary data
Journal Articles

Abstract 1087: CPX-351 works synergistically in combination with FLT3 inhibitors against AML with FLT3-ITD

David K. Edwards, Nathalie Javidi-Sharifi, Angela Rofelty, Max Gordon, Riley Roth-Carter, Paul Tardi, Lawrence Mayer, Jeffrey W. Tyner
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1087.
DOI: https://doi.org/10.1158/1538-7445.AM2017-1087
Published: 01 July 2017
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Abstract DDT01-02: AZD5991: A potent and selective macrocyclic inhibitor of Mcl-1 for treatment of hematologic cancers

Alexander W. Hird, J. Paul Secrist, Ammar Adam, Matthew A. Belmonte, Eric Gangl, Frank Gibbons, David Hargreaves, Jeffrey W. Johannes, Stephen L. Kazmirski, Jason G. Kettle, Stephen E. Kurtz, Michelle L. Lamb, Martin J. Packer, Bo Peng, Craig R. Stewart, Jeffrey W. Tyner, Wenzhan Yang, Qing Ye, XiaoLan Zheng, Edwin A. Clark
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): DDT01-02.
DOI: https://doi.org/10.1158/1538-7445.AM2017-DDT01-02
Published: 01 July 2017
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Abstract 532: Identification of unpaired cysteine-mediated gain and loss of function CSF3R extracellular mutations

Haijiao Zhang, Sophie Means, Anna R. Schultz, Kevin Watanabe-Smith, Bruno C. Medeiros, Tim Kükenshöner, Oliver Hantschel, Daniel Bottomly, Beth Wilmot, Shannon K. McWeeney, Jeffrey W. Tyner
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 532.
DOI: https://doi.org/10.1158/1538-7445.AM2017-532
Published: 01 July 2017
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Abstract 2569: BCL6 promotes glioma and serves as a novel therapeutic target

Liang Xu, Ye CHEN, Marina Dutra-Clarke, Anand Mayakonda, Masaharu Hazawa, Steve E. Savinoff, Ngan Doan, Jonathan W. Said, William H. Yong, Henry Yang, Ling-Wen Ding, Yan-Yi Jiang, Jeffrey W. Tyner, Jianhong Ching, Jean-Paul Kovalik, Markus Müschen, Joshua J. Breunig, De-Chen Lin, Phillip Koeffler
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 2569.
DOI: https://doi.org/10.1158/1538-7445.AM2017-2569
Published: 01 July 2017
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Abstract 2023: Artemisinins enhanced the antileukemic efficacy of BCL2 inhibitors

Blake S. Moses, Jennifer M. Fox, Xiaochun Chen, Jeffrey W. Tyner, Gary H. Posner, Patrick Bailey, Curt I. Civin
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 2023.
DOI: https://doi.org/10.1158/1538-7445.AM2017-2023
Published: 01 July 2017
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