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Jeffrey W. Tyner
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Journal Articles

Abstract 721: The role of NCAM1(CD56) in mediating venetoclax resistance

Free
Bernhard Alber, Tania Q. Vu, Bridget Robinson, Daniel Chandra, Jessica Mulkey, Yoko Kosaka, Evan Lind, Jeffrey W. Tyner, Jennifer N. Saultz
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 721.
https://doi.org/10.1158/1538-7445.AM2025-721
Published: 21 April 2025
View articletitled, Abstract 721: The role of NCAM1(CD56) in mediating venetoclax resistance
Journal Articles

Abstract 7219: Targeting the RAS pathway with MEK and pan-RAF inhibition in Philadelphia-like acute lymphoblastic leukemia

Free
Hong A. De Sa, Isabel Kenna, Jeffrey W. Tyner, Bill H. Chang
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 7219.
https://doi.org/10.1158/1538-7445.AM2025-7219
Published: 21 April 2025
View articletitled, Abstract 7219: Targeting the RAS pathway with MEK and pan-RAF inhibition in Philadelphia-like acute lymphoblastic leukemia
Journal Articles

Abstract IA002: Functional omics for novel therapeutic combinations in myeloid malignancies

Free
Jeffrey W Tyner
Journal: Cancer Research
Cancer Res (2025) 85 (5_Supplement): IA002.
https://doi.org/10.1158/1538-7445.GENFUNC25-IA002
Published: 11 March 2025
View articletitled, Abstract IA002: Functional omics for novel therapeutic combinations in myeloid malignancies
Journal Articles

Abstract 7354: Proteogenomic and metabolomic characterization of acute myeloid leukemia

Free
Alec Chu, Yi Hsiao, Yamei Deng, Chenwei Wang, Jennifer Kyle, Yongchao Dou, James C. Pino, Camilo Posso, Leanne Henry, Lijun Chen, Ginny Xiaohe Li, Tung-Shing Mamie Lih, Yifat Geffen, Fengchao Yu, Li Ding, Gil Omenn, Chandan Kumar, Saravana M. Dhanasekaran, Elie Traer, Jeffrey W. Tyner, Hui Zhang, Tao Liu, Sara Gosline, Bing Zhang, Arul Chinnaiyan, Alexey I. Nesvizhskii, Marcin Cieslik, The CPTAC Consortium
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 7354.
https://doi.org/10.1158/1538-7445.AM2024-7354
Published: 22 March 2024
View articletitled, Abstract 7354: Proteogenomic and metabolomic characterization of acute myeloid leukemia
Journal Articles

Abstract 1844: Proteomic characterization of decitabine resistance in acute myeloid leukemia reveals signaling pathway crosstalk dampens the effectiveness of combination therapy

Free
James C. Pino, Camilo Posso, Setareh Sharzehi, Sara Gosline, Chelsea Hutchinson-Bunch, Elie Traer, Paul D. Piehowski, Karin D. D. Rodland, Jeffrey W. Tyner, Tao Liu, Anupriya Agarwal
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1844.
https://doi.org/10.1158/1538-7445.AM2024-1844
Published: 22 March 2024
View articletitled, Abstract 1844: Proteomic characterization of decitabine resistance in acute myeloid leukemia reveals signaling pathway crosstalk dampens the effectiveness of combination therapy
Journal Articles

Abstract 3172: Mapping the molecular landscape of acute myeloid leukemia enables prediction of drug response from proteogenomic data

Free
James C. Pino, Camilo Posso, Sunil K. Joshi, Michael Nestor, Jamie Moon, Joshua R. Hansen, Marina A. Gritsenko, Chelsea Hutchinson-Bunch, Karl K. Weitz, Kevin Watanabe-Smith, Jason E. McDermott, Brian J. Druker, Tao Liu, Jeffrey W. Tyner, Anupriya Agarwal, Elie Traer, Paul D. Piehowski, Cristina E. Tognon, Karin D. Rodland, Sara J. Gosline
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3172.
https://doi.org/10.1158/1538-7445.AM2023-3172
Published: 04 April 2023
View articletitled, Abstract 3172: Mapping the molecular landscape of acute myeloid leukemia enables prediction of drug response from proteogenomic data
Journal Articles

Abstract 3489: TNK1 is a ubiquitin sensing kinase that can be targeted in vivo to block tumor growth

Free
Tania Lopez-Palacios, Tsz-Yin Chan, Christina M. Egbert, Spencer Ashworth, Alec Vaughan, Tanya V. Forostyan, Adam Siddiqui, Jason M. Foulks, James Moody, Julia E. Maxson, Jeffrey W. Tyner, Steven L. Warner, Joshua Lyon Andersen
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3489.
https://doi.org/10.1158/1538-7445.AM2023-3489
Published: 04 April 2023
View articletitled, Abstract 3489: TNK1 is a ubiquitin sensing kinase that can be targeted in vivo to block tumor growth
Journal Articles

Understanding Drug Sensitivity and Tackling Resistance in Cancer

Open Access
Jeffrey W. Tyner, Franziska Haderk, Anbarasu Kumaraswamy, Linda B. Baughn, Brian Van Ness, Song Liu, Himangi Marathe, Joshi J. Alumkal, Trever G. Bivona, Keith Syson Chan, Brian J. Druker, Alan D. Hutson, Peter S. Nelson, Charles L. Sawyers, Christopher D. Willey
Journal: Cancer Research
Cancer Res (2022) 82 (8): 1448–1460.
https://doi.org/10.1158/0008-5472.CAN-21-3695
Published: 15 April 2022
View articletitled, Understanding Drug Sensitivity and Tackling Resistance in Cancer
Open the PDF for Understanding Drug Sensitivity and Tackling Resistance in Cancer in another window
Journal Articles

Abstract 1429: Characterization of trametinib combined with venetoclax in acute myeloid leukemia (AML) treatment

Free
Alisa Damnernsawad, Christopher A. Eide, Sofia Beer, Haijiao Zhang, Daniel Bottomly, Stephen E. Kurtz, Jeffrey W. Tyner
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1429.
https://doi.org/10.1158/1538-7445.AM2021-1429
Published: 01 July 2021
View articletitled, Abstract 1429: Characterization of trametinib combined with venetoclax in acute myeloid leukemia (AML) treatment
Journal Articles

Abstract 2306: The ubiquitin-binding non-receptor tyrosine kinase TNK1 is regulated by a MARK-mediated interaction with 14-3-3

Free
Christina Marie Egbert, Tsz Yin Chan, Logan Larsen, Eranga Roshan Balasooriya, Kristina Kohler, Jeremy Tsang, Madison Frey, Julia Maxson, David Huang, Kenneth A. Christensen, James Moody, Jeffrey W. Tyner, Joshua L. Andersen
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 2306.
https://doi.org/10.1158/1538-7445.AM2021-2306
Published: 01 July 2021
View articletitled, Abstract 2306: The ubiquitin-binding non-receptor tyrosine kinase TNK1 is regulated by a MARK-mediated interaction with 14-3-3
Journal Articles

Abstract LT022: The AML microenvironment catalyzes a step-wise evolution to gilteritinib resistance

Free
Sunil K. Joshi, Tamilla Nechiporuk, Daniel Bottomly, Paul Piehowski, Julie A. Reisz, Janét Pittsenbarger, Andy Kaempf, Sara J.C. Gosline, Yi-Ting Wang, Tao Liu, Cristina E. Tognon, Angelo D’Alessandro, Jeffrey W. Tyner, Shannon K. McWeeney, Karin D. Rodland, Brian J. Druker, Elie Traer
Journal: Cancer Research
Cancer Res (2021) 81 (5_Supplement): LT022.
https://doi.org/10.1158/1538-7445.TME21-LT022
Published: 01 March 2021
View articletitled, Abstract LT022: The AML microenvironment catalyzes a step-wise evolution to gilteritinib resistance
Journal Articles

Abstract 325: A genome-wide CRISPR screen on AML cells reveals the TP53 apoptotic network is a primary mediator of resistance to BCL2 inhibition

Free
Tamilla Nechiporuk, Stephen E. Kurtz, Olga Nikolova, Amanda d'Almeida, Kevin Watanabe-Smith, Mara Rosenberg, Brian Druker, Jeffrey W. Tyner, Shannon K. McWeeney
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 325.
https://doi.org/10.1158/1538-7445.AM2019-325
Published: 01 July 2019
View articletitled, Abstract 325: A genome-wide CRISPR screen on AML cells reveals the TP53 apoptotic network is a primary mediator of resistance to BCL2 inhibition
Journal Articles

Abstract 4763: Genome-wide CRISPR screening identifies TSC1 as a regulator of sorafenib resistance in acute myeloid leukemia

Free
Alisa Damnernsawad, Tamilla Nechiporuk, Steve E. Kurtz, Wesley R. Horton, Olga Nikolova, Shannon K. McWeeney, Jeffrey W. Tyner
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4763.
https://doi.org/10.1158/1538-7445.AM2019-4763
Published: 01 July 2019
View articletitled, Abstract 4763: Genome-wide CRISPR screening identifies TSC1 as a regulator of sorafenib resistance in acute myeloid leukemia
Journal Articles

Abstract 508: Combined MEK and PD-1 inhibition in acute myeloid leukemia: Effect on cell proliferation and phenotype

Free
Kaycee B. Moshofsky, Hyun J. Cho, Yoko Kosaka, Matthew T. Newman, Jeffrey W. Tyner, Evan F. Lind
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 508.
https://doi.org/10.1158/1538-7445.AM2019-508
Published: 01 July 2019
View articletitled, Abstract 508: Combined MEK and PD-1 inhibition in acute myeloid leukemia: Effect on cell proliferation and phenotype
Journal Articles

Abstract 926: Extrinsic and intrinsic activation of RAS/MAPK signaling enables resistance to FLT3 inhibitor, gilteritinib, in acute myeloid leukemia

Free
Sunil K. Joshi, Stephen Christy, Renata Scopim Ribeiro, Shannon McWeeney, Jeffrey W. Tyner, Cristina E. Tognon, Brian J. Druker, Elie Traer
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 926.
https://doi.org/10.1158/1538-7445.AM2019-926
Published: 01 July 2019
View articletitled, Abstract 926: Extrinsic and intrinsic activation of RAS/MAPK signaling enables resistance to FLT3 inhibitor, gilteritinib, in acute myeloid leukemia
Journal Articles

Abstract 4538: Global and phosphoproteomic analysis of AML cell line response to phosphatase inhibitor treatment

Free
Paul D. Piehowski, Jason E. McDermott, Joshua R. Hansen, Samantha L. Savage, Cristina E. Tognon, Anupriya Agarwal, Jeffrey W. Tyner, Brian J. Druker, Karin D. Rodland
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4538.
https://doi.org/10.1158/1538-7445.AM2019-4538
Published: 01 July 2019
View articletitled, Abstract 4538: Global and phosphoproteomic analysis of AML cell line response to phosphatase inhibitor treatment
Journal Articles

Abstract 1323: CG-806, a pan-FLT3 / pan-BTK inhibitor, demonstrates superior potency against cells from IDH-1 mutant and other non-favorable risk groups of AML patients

Free
Hongying Zhang, Andrea Local, Jeffrey W. Tyner, Stephen E. Kurtz, Beth Wilmot, Shannon Mcweeney, Brian J. Druker, Stephen B. Howell, William G. Rice
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 1323.
https://doi.org/10.1158/1538-7445.AM2019-1323
Published: 01 July 2019
View articletitled, Abstract 1323: CG-806, a pan-FLT3 / pan-BTK inhibitor, demonstrates superior potency against cells from IDH-1 mutant and other non-favorable risk groups of AML patients
Journal Articles

Abstract 791: CG'806, a first-in-class pan-FLT3/pan-BTK inhibitor, demonstrates superiority to other FLT3 and BTK inhibitors against primary patient samples

Free
Stephen E. Kurtz, Kevin Watanabe-Smith, Dan Bottomly, Beth Wilmot, Shannon Mcweeney, Andrea Local, Hongying Zhang, Stephen Howell, William Rice, Brian J. Druker, Jeffrey W. Tyner
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 791.
https://doi.org/10.1158/1538-7445.AM2018-791
Published: 01 July 2018
View articletitled, Abstract 791: CG'806, a first-in-class pan-FLT3/pan-BTK inhibitor, demonstrates superiority to other FLT3 and BTK inhibitors against primary patient samples
Journal Articles

Abstract 302: Selective Mcl-1 inhibition by AZD5991 induces on-target cell death and achieves antitumor activity in multiple myeloma and acute myeloid leukemia

Free
Adriana E. Tron, Matthew A. Belmonte, Steven Criscione, Edwin A. Clark, Eric Gangl, Francis D. Gibbons, Jeffrey W. Tyner, Stephen E. Kurtz, Qing Ye, Alexander W. Hird, Alwin Schuller, J. Paul Secrist
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 302.
https://doi.org/10.1158/1538-7445.AM2018-302
Published: 01 July 2018
View articletitled, Abstract 302: Selective Mcl-1 inhibition by AZD5991 induces on-target cell death and achieves antitumor activity in multiple myeloma and acute myeloid leukemia
Journal Articles

Abstract 3883: Gene expression predicts ex vivo drug sensitivity in acute myeloid leukemia

Free
Brian S. White, Suleiman A. Khan, Muhammad Ammad-ud-din, Swapnil Potdar, Mike J. Mason, Cristina E. Tognon, Brian J. Druker, Caroline A. Heckman, Olli P. Kallioniemi, Stephen E. Kurtz, Kimmo Porkka, Jeffrey W. Tyner, Tero Aittokallio, Krister Wennerberg, Justin Guinney
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 3883.
https://doi.org/10.1158/1538-7445.AM2018-3883
Published: 01 July 2018
View articletitled, Abstract 3883: Gene expression predicts ex vivo drug sensitivity in acute myeloid leukemia