Page 1 | Search Results | Cancer Research | American Association for Cancer Research

1-18 of 18

Sort by

Sort Order Select

Journal Articles

The Imipridone ONC213 Targets α-Ketoglutarate Dehydrogenase to Induce Mitochondrial Stress and Suppress Oxidative Phosphorylation in Acute Myeloid Leukemia

Cancer Res (2024) 84 (7): 1084–1100.

https://doi.org/10.1158/0008-5472.CAN-23-2659

Published: 01 April 2024

View article titled, The Imipridone ONC213 Targets α-Ketoglutarate Dehydrogenase to Induce Mitochondrial Stress and Suppress Oxidative Phosphorylation in Acute Myeloid Leukemia

Includes: Supplementary data

Journal Articles

Abstract 3785: ME-344, a novel isoflavone mitochondrial inhibitor, in combination with venetoclax constitutes a new metabolism-targeted approach to overcome resistance to Bcl-2 inhibition and standard of care treatment in AML

Katie H. Hurrish, Yongwei Su, Shraddha Patel, Sandra E. Wiley, Zhanjun Hou, Jenna Carter, Hasini Kalpage, Maik Hüttemann, Connie Weng, Holly Edwards, Lisa Polin, Jing Li, Jay Yang, Larry H. Matherly, Sergej Naumovich Konoplev, Jeffrey W. Taub, Marina Konopleva, Yubin Ge, Natalia Baran

Cancer Res (2022) 82 (12_Supplement): 3785.

https://doi.org/10.1158/1538-7445.AM2022-3785

Published: 15 June 2022

View article titled, Abstract 3785: ME-344, a novel isoflavone mitochondrial inhibitor, in combination with venetoclax constitutes a new metabolism-targeted approach to overcome resistance to Bcl-2 inhibition and standard of care treatment in AML

Journal Articles

Abstract 2463: Enhancing the antileukemic activity of venetoclax against leukemia stem cells by targeting oxidative phosphorylation through dual inhibition of PI3K and HDAC

Katie Hege, Hasini Kalpage, Maik Hüttemann, Holly Pitman, Jeffrey W. Taub, Lisa Polin, Jing Li, Yubin Ge

Cancer Res (2021) 81 (13_Supplement): 2463.

https://doi.org/10.1158/1538-7445.AM2021-2463

Published: 01 July 2021

View article titled, Abstract 2463: Enhancing the antileukemic activity of venetoclax against leukemia stem cells by targeting oxidative phosphorylation through dual inhibition of PI3K and HDAC

Journal Articles

Abstract 222: Genome-wide association study of acute lymphoblastic leukemia in children with Down syndrome

Cancer Res (2018) 78 (13_Supplement): 222.

https://doi.org/10.1158/1538-7445.AM2018-222

Published: 01 July 2018

View article titled, Abstract 222: Genome-wide association study of acute lymphoblastic leukemia in children with Down syndrome

Journal Articles

Abstract 4116: Notch1 regulates AKT-T308 dephosphorylation through modulation of the PP2A phosphatase in GSI-resistant T-cell acute lymphoblastic leukemia (T-ALL) cells.

Eric Christopher Hales, Steven M. Orr, Amanda Larson Gedman, Jeffrey W. Taub, Larry H. Matherly

Cancer Res (2013) 73 (8_Supplement): 4116.

https://doi.org/10.1158/1538-7445.AM2013-4116

Published: 15 April 2013

View article titled, Abstract 4116: Notch1 regulates AKT-T308 dephosphorylation through modulation of the PP2A phosphatase in GSI-resistant T-cell acute lymphoblastic leukemia (T-ALL) cells.

Journal Articles

Abstract 2739: Panobinostat potentiates the cytotoxic effects of ara-C and daunorubicin on acute myeloid leukemia cells through suppressing the DNA damage response

Chengzhi Xie, Holly Edwards, Christina Drenberg, Sharyn D. Baker, Hiroto Inaba, Steven A. Buck, Jeffrey W. Taub, Yubin Ge

Cancer Res (2012) 72 (8_Supplement): 2739.

https://doi.org/10.1158/1538-7445.AM2012-2739

Published: 15 April 2012

View article titled, Abstract 2739: Panobinostat potentiates the cytotoxic effects of ara-C and daunorubicin on acute myeloid leukemia cells through suppressing the DNA damage response

Journal Articles

Abstract 1830: Both class I and class II histone deacetylases are required for proliferation and survival of human pancreatic cancer cells

Guan Wang, Jing He, Jeffrey W. Taub, Yingjie Guo, Yubin Ge

Cancer Res (2012) 72 (8_Supplement): 1830.

https://doi.org/10.1158/1538-7445.AM2012-1830

Published: 15 April 2012

View article titled, Abstract 1830: Both class I and class II histone deacetylases are required for proliferation and survival of human pancreatic cancer cells

Journal Articles

Abstract 2881: Posttranslational inactivation of PTEN promoted by loss of Notch1 signaling in T-ALL

Eric C. Hales, Amanda Larson Gedman, Yubin Ge, Jeffrey W. Taub, Larry H. Matherly

Cancer Res (2011) 71 (8_Supplement): 2881.

https://doi.org/10.1158/1538-7445.AM2011-2881

Published: 15 April 2011

View article titled, Abstract 2881: Posttranslational inactivation of PTEN promoted by loss of Notch1 signaling in T-ALL

Journal Articles

Abstract 4360: Loss of NOTCH1 is associated with decreased expression of hsa-miR-125a-5p in T-cell acute lymphoblastic leukemia: Implications for using NOTCH1 inhibition in chemotherapy

Amanda L. Larson Gedman, Alan Dombkowski, Yubin Ge, Jeffrey W. Taub, Larry H. Matherly

Cancer Res (2010) 70 (8_Supplement): 4360.

https://doi.org/10.1158/1538-7445.AM10-4360

Published: 15 April 2010

View article titled, Abstract 4360: Loss of NOTCH1 is associated with decreased expression of hsa-miR-125a-5p in T-cell acute lymphoblastic leukemia: Implications for using NOTCH1 inhibition in chemotherapy

Journal Articles

Identification and characterization of novel AML1-ETO fusion transcripts in pediatric t(8;21) acute myeloid leukemia

Yubin Ge, Katherine M. Lafiura, Larry H. Matherly, Jeffrey W. Taub, Yaddanapudi Ravindranath

Cancer Res (2006) 66 (8_Supplement): 1016.

Published: 15 April 2006

View article titled, Identification and characterization of novel AML1-ETO fusion transcripts in pediatric t(8;21) acute myeloid leukemia

Journal Articles

Gene expression profiles in childhood acute lymphoblastic leukemia identify prognostic roles for multidrug resistance-associated protein 2 and reduced folate carrier

Yubin Ge, Christina Haska, Katherine Lafiura, Meenakshi Devidas, Stephen B. Linda, Jeffrey W. Taub, Larry H. Matherly

Cancer Res (2006) 66 (8_Supplement): 1015.

Published: 15 April 2006

View article titled, Gene expression profiles in childhood acute lymphoblastic leukemia identify prognostic roles for multidrug resistance-associated protein 2 and reduced folate carrier

Journal Articles

GATA1 target genes and the differential chemotherapy sensitivity of down syndrome and non-down syndrome megakaryoblasts

Yubin Ge, Tanya L. Jensen, Dana A. Tatman, Mark L. Stout, Steven A. Buck, Yaddanapudi Ravindranath, Larry H. Matherly, Jeffrey W. Taub

Cancer Res (2005) 65 (9_Supplement): 1026.

Published: 01 May 2005

View article titled, GATA1 target genes and the differential chemotherapy sensitivity of down syndrome and non-down syndrome megakaryoblasts

Journal Articles

The human reduced folate carrier (hRFC) in childhood acute lymphoblastic leukemia (ALL) cells is regulated by a novel A1/A2 non-coding region and promoter including multiple E-box consensus elements

Scott G. Payton, Yubin Ge, Robin M. Flatley, Jeffrey W. Taub, Larry H. Matherly

Cancer Res (2004) 64 (7_Supplement): 1067.

Published: 01 April 2004

View article titled, The human reduced folate carrier (hRFC) in childhood acute lymphoblastic leukemia (ALL) cells is regulated by a novel A1/A2 non-coding region and promoter including multiple E-box consensus elements

Journal Articles

Mutations of the GATA-1 transcription factor alter the cytosine arabinoside sensitivity of Down syndrome megakaryoblasts.

Yubin Ge, Dana Tatman-Lilly, Mark L. Stout, Tanya L. Jensen, Steven Buck, Yaddanapudi Ravindranath, Larry H. Matherly, Jeffrey W. Taub

Cancer Res (2004) 64 (7_Supplement): 717.

Published: 01 April 2004

View article titled, Mutations of the GATA-1 transcription factor alter the cytosine arabinoside sensitivity of Down syndrome megakaryoblasts.

Journal Articles

The human reduced folate carrier promoter B is a major promoter in childhood acute lymphoblastic leukemia cells and is regulated by Sp, USF, and Ikaros proteins.

Mingjun Liu, Robin M. Flatley, Scott G. Payton, Johnathan R. Whetstine, Yubin Ge, Jeffrey W. Taub, Larry H. Matherly

Cancer Res (2004) 64 (7_Supplement): 717–718.

Published: 01 April 2004

View article titled, The human reduced folate carrier promoter B is a major promoter in childhood acute lymphoblastic leukemia cells and is regulated by Sp, USF, and Ikaros proteins.

Journal Articles

Prenatal origin of GATA1 mutations as an initiating step in the development of megakaryocytic leukemia in Down syndrome

Jeffrey W. Taub, Gina Mundschau, Yubin Ge, Janet Poulik, Faisal Qureshi, Tanya L. Jensen, Larry H. Matherly, Jill James, Joshua Weschler, John D. Crispino

Cancer Res (2004) 64 (7_Supplement): 909.

Published: 01 April 2004

View article titled, Prenatal origin of GATA1 mutations as an initiating step in the development of megakaryocytic leukemia in Down syndrome

Journal Articles

The Role of Cytidine Deaminase and GATA1 Mutations in the Increased Cytosine Arabinoside Sensitivity of Down Syndrome Myeloblasts and Leukemia Cell Lines

Yubin Ge, Tanya L. Jensen, Mark L. Stout, Robin M. Flatley, Patrick J. Grohar, Yaddanapudi Ravindranath, Larry H. Matherly, Jeffrey W. Taub

Cancer Res (2004) 64 (2): 728–735.

https://doi.org/10.1158/0008-5472.CAN-03-2456

Published: 26 January 2004

View article titled, The Role of Cytidine Deaminase and GATA1 Mutations in the Increased Cytosine Arabinoside Sensitivity of Down Syndrome Myeloblasts and Leukemia Cell Lines

Journal Articles

Cystathionine-β-Synthase cDNA Transfection Alters the Sensitivity and Metabolism of 1-β-d-Arabinofuranosylcytosine in CCRF-CEM Leukemia Cells in Vitro and in Vivo: A Model of Leukemia in Down Syndrome1

Jeffrey W. Taub, Xi Huang, Yubin Ge, Julie A. Dutcher, Mark L. Stout, Ramzi M. Mohammad, Yaddanapudi Ravindranath, Larry H. Matherly

Cancer Res (2000) 60 (22): 6421–6426.

Published: 15 November 2000

View article titled, Cystathionine-β-Synthase cDNA Transfection Alters the Sensitivity and Metabolism of 1-β-<sc>d</sc>-Arabinofuranosylcytosine in CCRF-CEM Leukemia Cells <em>in Vitro</em> and <em>in Vivo</em>: A Model of Leukemia in Down Syndrome1

NARROW

The Imipridone ONC213 Targets α-Ketoglutarate Dehydrogenase to Induce Mitochondrial Stress and Suppress Oxidative Phosphorylation in Acute Myeloid Leukemia

Abstract 3785: ME-344, a novel isoflavone mitochondrial inhibitor, in combination with venetoclax constitutes a new metabolism-targeted approach to overcome resistance to Bcl-2 inhibition and standard of care treatment in AML

Abstract 2463: Enhancing the antileukemic activity of venetoclax against leukemia stem cells by targeting oxidative phosphorylation through dual inhibition of PI3K and HDAC

Abstract 222: Genome-wide association study of acute lymphoblastic leukemia in children with Down syndrome

Abstract 4116: Notch1 regulates AKT-T308 dephosphorylation through modulation of the PP2A phosphatase in GSI-resistant T-cell acute lymphoblastic leukemia (T-ALL) cells.

Abstract 2739: Panobinostat potentiates the cytotoxic effects of ara-C and daunorubicin on acute myeloid leukemia cells through suppressing the DNA damage response

Abstract 1830: Both class I and class II histone deacetylases are required for proliferation and survival of human pancreatic cancer cells

Abstract 2881: Posttranslational inactivation of PTEN promoted by loss of Notch1 signaling in T-ALL

Abstract 4360: Loss of NOTCH1 is associated with decreased expression of hsa-miR-125a-5p in T-cell acute lymphoblastic leukemia: Implications for using NOTCH1 inhibition in chemotherapy

Identification and characterization of novel AML1-ETO fusion transcripts in pediatric t(8;21) acute myeloid leukemia

Gene expression profiles in childhood acute lymphoblastic leukemia identify prognostic roles for multidrug resistance-associated protein 2 and reduced folate carrier

GATA1 target genes and the differential chemotherapy sensitivity of down syndrome and non-down syndrome megakaryoblasts

The human reduced folate carrier (hRFC) in childhood acute lymphoblastic leukemia (ALL) cells is regulated by a novel A1/A2 non-coding region and promoter including multiple E-box consensus elements

Mutations of the GATA-1 transcription factor alter the cytosine arabinoside sensitivity of Down syndrome megakaryoblasts.

The human reduced folate carrier promoter B is a major promoter in childhood acute lymphoblastic leukemia cells and is regulated by Sp, USF, and Ikaros proteins.

Prenatal origin of GATA1 mutations as an initiating step in the development of megakaryocytic leukemia in Down syndrome

The Role of Cytidine Deaminase and GATA1 Mutations in the Increased Cytosine Arabinoside Sensitivity of Down Syndrome Myeloblasts and Leukemia Cell Lines

Cystathionine-β-Synthase cDNA Transfection Alters the Sensitivity and Metabolism of 1-β-d-Arabinofuranosylcytosine in CCRF-CEM Leukemia Cells in Vitro and in Vivo: A Model of Leukemia in Down Syndrome1

Email alerts

AACR Journals

Email alerts

AACR Journals

This Feature Is Available To Subscribers Only