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Jeffrey Settleman
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Journal Articles

Abstract 1209: FGFR inhibition re-sensitizes BRAF/MEK dual resistant cells to the BRAF/MEK inhibitor combination

Victoria E. Wang, Jeffrey Settleman, Frank McCormic
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1209.
DOI: https://doi.org/10.1158/1538-7445.AM2017-1209
Published: 01 July 2017
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Journal Articles

Abstract 3182: Cytoskeletal modulation results in increased tumor survival and drug resistance through attenuation of p53 dependent apoptosis

Victoria E. Wang, John Doench, David Root, Rene Bernards, Jeffrey Settleman, Frank McCormick
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 3182.
DOI: https://doi.org/10.1158/1538-7445.AM2017-3182
Published: 01 July 2017
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Abstract 2524: MiR-124 suppresses p62 and p65/NFkB to regulate autophagy, inflammation and cell death in KRAS mutant mesenchymal NSCLC cells

Anita K. Mehta, Kevin Hua, William Whipple, Mihn-Thuy Nguyen, Rushika M. Perera, Johanns Haybaeck, Joanne Weidhass, Jeffrey Settleman, Anurag Singh
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 2524.
DOI: https://doi.org/10.1158/1538-7445.AM2017-2524
Published: 01 July 2017
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Abstract 372: Taselisib enhances the potency of ERBB inhibitors in biomarker-defined subsets of head and neck squamous carcinoma cell lines

Heidi M. Savage, Carol O’Brien, Heather Moore, Mark R. Lackner, Robert Yauch, Jeffrey Settleman, Timothy R. Wilson
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 372.
DOI: https://doi.org/10.1158/1538-7445.AM2016-372
Published: 15 July 2016
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Journal Articles

Abstract 3698: Hyperactive AKT pathway and reactivation of the MAPK/ERK pathway in melanoma cells resistant to dual BRAF and MEK inhibition

Victoria E. Wang, Frank McCormick, Jeffrey Settleman
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 3698.
DOI: https://doi.org/10.1158/1538-7445.AM2014-3698
Published: 01 October 2014
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Journal Articles

Comparative Oncogenomics Identifies PSMB4 and SHMT2 as Potential Cancer Driver Genes

Genee Y. Lee, Peter M. Haverty, Li Li, Noelyn M. Kljavin, Richard Bourgon, James Lee, Howard Stern, Zora Modrusan, Somasekar Seshagiri, Zemin Zhang, David Davis, David Stokoe, Jeffrey Settleman, Frederic J. de Sauvage, Richard M. Neve
Journal: Cancer Research
Cancer Res (2014) 74 (11): 3114–3126.
DOI: https://doi.org/10.1158/0008-5472.CAN-13-2683
Published: 29 May 2014
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Includes: Supplementary data
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EGFR-Activating Mutations Correlate with a Fanconi Anemia–like Cellular Phenotype That Includes PARP Inhibitor Sensitivity

Heike N. Pfäffle, Meng Wang, Liliana Gheorghiu, Natalie Ferraiolo, Patricia Greninger, Kerstin Borgmann, Jeffrey Settleman, Cyril H. Benes, Lecia V. Sequist, Lee Zou, Henning Willers
Journal: Cancer Research
Cancer Res (2013) 73 (20): 6254–6263.
DOI: https://doi.org/10.1158/0008-5472.CAN-13-0044
Published: 14 October 2013
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Includes: Supplementary data
Journal Articles

Abstract 4568: Rapid assessment of TORC1 suppression predicts responsiveness to RAF and MEK inhibition in BRAF mutant melanoma.

Ryan B. Corcoran, Stephen M. Rothenberg, Aaron N. Hata, Anthony C. Faber, Daniel Winokur, Adriano Piris, Rosalynn M. Nazarian, Ronald D. Brown, Jason T. Godfrey, Mari Mino-Kenudson, Jeffrey Settleman, Jennifer A. Wargo, Keith T. Flaherty, Daniel A. Haber, Jeffrey A. Engelman
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 4568.
DOI: https://doi.org/10.1158/1538-7445.AM2013-4568
Published: 15 April 2013
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Journal Articles

Abstract 4462: Resistance to selective kinase inhibitors upon epithelial to mesenchymal transition.

Catherine R. Wilson, Katrina Nicholes, Daisy Bustos, Eva Lin, Lily Shi, Donald Kirkpatrick, Jeffrey Settleman
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 4462.
DOI: https://doi.org/10.1158/1538-7445.AM2013-4462
Published: 15 April 2013
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Journal Articles

Abstract LB-350: EGFR-mediated re-activation of MAPK signaling contributes to insensitivity of BRAF mutant colorectal cancers to RAF inhibition by vemurafenib

Ryan B. Corcoran, Hiromichi Ebi, Alexa B. Turke, Erin M. Coffee, Michiya Nishino, Alexandra P. Cogdill, Ronald D. Brown, Dora Dias-Santagata, Patricia Della Pelle, Kenneth E. Hung, Keith T. Flaherty, Adriano Piris, Jennifer A. Wargo, Jeffrey Settleman, Mari Mino-Kenudson, Jeffrey A. Engelman
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): LB-350.
DOI: https://doi.org/10.1158/1538-7445.AM2012-LB-350
Published: 15 April 2012
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Journal Articles

Androgen Deprivation Causes Epithelial–Mesenchymal Transition in the Prostate: Implications for Androgen-Deprivation Therapy

Yuting Sun, Bu-Er Wang, Kevin G. Leong, Peng Yue, Li Li, Suchit Jhunjhunwala, Darrell Chen, Kyounghee Seo, Zora Modrusan, Wei-Qiang Gao, Jeffrey Settleman, Leisa Johnson
Journal: Cancer Research
Cancer Res (2012) 72 (2): 527–536.
DOI: https://doi.org/10.1158/0008-5472.CAN-11-3004
Published: 16 January 2012
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Includes: Supplementary data
Journal Articles

EGF Receptor Inhibition Radiosensitizes NSCLC Cells by Inducing Senescence in Cells Sustaining DNA Double-Strand Breaks

Meng Wang, Fabian Morsbach, David Sander, Liliana Gheorghiu, Akash Nanda, Cyril Benes, Malte Kriegs, Mechthild Krause, Ekkehard Dikomey, Michael Baumann, Jochen Dahm-Daphi, Jeffrey Settleman, Henning Willers
Journal: Cancer Research
Cancer Res (2011) 71 (19): 6261–6269.
DOI: https://doi.org/10.1158/0008-5472.CAN-11-0213
Published: 29 September 2011
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Includes: Supplementary data
Journal Articles

STAT3 Plays a Critical Role in KRAS-Induced Pancreatic Tumorigenesis

Ryan B. Corcoran, Gianmarco Contino, Vikram Deshpande, Alexandros Tzatsos, Claudius Conrad, Cyril H. Benes, David E. Levy, Jeffrey Settleman, Jeffrey A. Engelman, Nabeel Bardeesy
Journal: Cancer Research
Cancer Res (2011) 71 (14): 5020–5029.
DOI: https://doi.org/10.1158/0008-5472.CAN-11-0908
Published: 14 July 2011
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Includes: Supplementary data
Journal Articles

Abstract 956: Receptor tyrosine kinases, not KRAS, activate PI3K in KRAS mutant colorectal cancers

Hiromichi Ebi, Ryan B. Corcoran, Anurag Singh, Zhao Chen, Youngchul Song, Eugene Lifshits, David P. Ryan, Jeffrey A. Meyerhardt, Cyril Benes, Jeffrey Settleman, Lewis C. Cantley, Kwok-Kin Wong, Jeffrey A. Engelman
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 956.
DOI: https://doi.org/10.1158/1538-7445.AM2011-956
Published: 15 April 2011
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Abstract 2210: Activation of PI3K in Merkel cell carcinoma

Valentina Nardi, Young Chul Song, Arjola K. Cosper, Quynh Lam, Juan Antonio Santamaria Barria, Genevieve Marie Boland, Beow Yeap, Kristin Bergethon, Vanessa L. Scialabba, Jeffrey Settleman, David P. Ryan, Darrell R. Borger, Mai P. Hoang, Atul K. Bhan, Anthony J. Iafrate, James C. Cusack, Jeffrey A. Engelman, Dora Dias-Santagata
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 2210.
DOI: https://doi.org/10.1158/1538-7445.AM2011-2210
Published: 15 April 2011
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Journal Articles

Abstract 2203: Integrative analysis for efficient candidate oncogene discovery in cancer cell lines

Andrew J. Yee, Ben S. Wittner, Jeff Gentry, Crystal Mahoney, Kaitlin McCutcheon, Anurag Singh, Patricia Greninger, Xiao-Jun Ma, Mark G. Erlander, Sreenath V. Sharma, Daniel A. Haber, Toshi Shioda, Jeffrey Settleman, Sridhar Ramaswamy
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 2203.
DOI: https://doi.org/10.1158/1538-7445.AM10-2203
Published: 15 April 2010
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Abstract 5757: A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers

Stephen M. Rothenberg, Gayatry Mohapatra, Miguel N. Rivera, Daniel Winokur, Patricia Greninger, Ezra E.W. Cohen, David N. Louis, Jeffrey Settleman, Daniel A. Haber
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 5757.
DOI: https://doi.org/10.1158/1538-7445.AM10-5757
Published: 15 April 2010
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Journal Articles

A Genome-Wide Screen for Microdeletions Reveals Disruption of Polarity Complex Genes in Diverse Human Cancers

S. Michael Rothenberg, Gayatry Mohapatra, Miguel N. Rivera, Daniel Winokur, Patricia Greninger, Mai Nitta, Peter M. Sadow, Gaya Sooriyakumar, Brian W. Brannigan, Matthew J. Ulman, Rushika M. Perera, Rui Wang, Angela Tam, Xiao-Jun Ma, Mark Erlander, Dennis C. Sgroi, James W. Rocco, Mark W. Lingen, Ezra E.W. Cohen, David N. Louis, Jeffrey Settleman, Daniel A. Haber
Journal: Cancer Research
Cancer Res (2010) 70 (6): 2158–2164.
DOI: https://doi.org/10.1158/0008-5472.CAN-09-3458
Published: 14 March 2010
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Includes: Supplementary data
Journal Articles

Abstract #3962: The role of activating K-RAS mutation status in predicting radiosensitization to epidermal growth factor receptor (EGFR) inhibitors in non-small cell lung cancer (NSCLC) cells

Akash Nanda, David Sander, Loreen Fournier, Anurag Singh, Lisa Kachnic, Jeffrey Settleman, Henning Willers
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 3962.
Published: 01 May 2009
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Journal Articles

Abstract #3344: Genome-wide analysis of causal genetic alterations in human cancer cell lines

Stephen Rothenberg, Miguel Rivera, Daniel Winokur, Jeffrey Settleman, Daniel Haber
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 3344.
Published: 01 May 2009
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