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Jeffrey Settleman
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Journal Articles

Abstract 1209: FGFR inhibition re-sensitizes BRAF/MEK dual resistant cells to the BRAF/MEK inhibitor combination

Free
Victoria E. Wang, Jeffrey Settleman, Frank McCormic
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1209.
https://doi.org/10.1158/1538-7445.AM2017-1209
Published: 01 July 2017
View articletitled, Abstract 1209: FGFR inhibition re-sensitizes BRAF/MEK dual resistant cells to the BRAF/MEK inhibitor combination
Journal Articles

Abstract 2524: MiR-124 suppresses p62 and p65/NFkB to regulate autophagy, inflammation and cell death in KRAS mutant mesenchymal NSCLC cells

Free
Anita K. Mehta, Kevin Hua, William Whipple, Mihn-Thuy Nguyen, Rushika M. Perera, Johanns Haybaeck, Joanne Weidhass, Jeffrey Settleman, Anurag Singh
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 2524.
https://doi.org/10.1158/1538-7445.AM2017-2524
Published: 01 July 2017
View articletitled, Abstract 2524: MiR-124 suppresses p62 and p65/NFkB to regulate autophagy, inflammation and cell death in KRAS mutant mesenchymal NSCLC cells
Journal Articles

Abstract 3182: Cytoskeletal modulation results in increased tumor survival and drug resistance through attenuation of p53 dependent apoptosis

Free
Victoria E. Wang, John Doench, David Root, Rene Bernards, Jeffrey Settleman, Frank McCormick
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 3182.
https://doi.org/10.1158/1538-7445.AM2017-3182
Published: 01 July 2017
View articletitled, Abstract 3182: Cytoskeletal modulation results in increased tumor survival and drug resistance through attenuation of p53 dependent apoptosis
Journal Articles

Abstract 372: Taselisib enhances the potency of ERBB inhibitors in biomarker-defined subsets of head and neck squamous carcinoma cell lines

Free
Heidi M. Savage, Carol O’Brien, Heather Moore, Mark R. Lackner, Robert Yauch, Jeffrey Settleman, Timothy R. Wilson
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 372.
https://doi.org/10.1158/1538-7445.AM2016-372
Published: 15 July 2016
View articletitled, Abstract 372: Taselisib enhances the potency of ERBB inhibitors in biomarker-defined subsets of head and neck squamous carcinoma cell lines
Journal Articles

Abstract 3698: Hyperactive AKT pathway and reactivation of the MAPK/ERK pathway in melanoma cells resistant to dual BRAF and MEK inhibition

Free
Victoria E. Wang, Frank McCormick, Jeffrey Settleman
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 3698.
https://doi.org/10.1158/1538-7445.AM2014-3698
Published: 01 October 2014
View articletitled, Abstract 3698: Hyperactive AKT pathway and reactivation of the MAPK/ERK pathway in melanoma cells resistant to dual BRAF and MEK inhibition
Journal Articles

Comparative Oncogenomics Identifies PSMB4 and SHMT2 as Potential Cancer Driver Genes

Free
Genee Y. Lee, Peter M. Haverty, Li Li, Noelyn M. Kljavin, Richard Bourgon, James Lee, Howard Stern, Zora Modrusan, Somasekar Seshagiri, Zemin Zhang, David Davis, David Stokoe, Jeffrey Settleman, Frederic J. de Sauvage, Richard M. Neve
Journal: Cancer Research
Cancer Res (2014) 74 (11): 3114–3126.
https://doi.org/10.1158/0008-5472.CAN-13-2683
Published: 29 May 2014
View articletitled, Comparative Oncogenomics Identifies PSMB4 and SHMT2 as Potential Cancer Driver Genes
Open the PDF for Comparative Oncogenomics Identifies PSMB4 and SHMT2 as Potential Cancer Driver Genes in another window
Includes: Supplementary data
Journal Articles

EGFR-Activating Mutations Correlate with a Fanconi Anemia–like Cellular Phenotype That Includes PARP Inhibitor Sensitivity

Free
Heike N. Pfäffle, Meng Wang, Liliana Gheorghiu, Natalie Ferraiolo, Patricia Greninger, Kerstin Borgmann, Jeffrey Settleman, Cyril H. Benes, Lecia V. Sequist, Lee Zou, Henning Willers
Journal: Cancer Research
Cancer Res (2013) 73 (20): 6254–6263.
https://doi.org/10.1158/0008-5472.CAN-13-0044
Published: 14 October 2013
View articletitled, EGFR-Activating Mutations Correlate with a Fanconi Anemia–like Cellular Phenotype That Includes PARP Inhibitor Sensitivity
Open the PDF for EGFR-Activating Mutations Correlate with a Fanconi Anemia–like Cellular Phenotype That Includes PARP Inhibitor Sensitivity in another window
Includes: Supplementary data
Journal Articles

Abstract 4462: Resistance to selective kinase inhibitors upon epithelial to mesenchymal transition.

Free
Catherine R. Wilson, Katrina Nicholes, Daisy Bustos, Eva Lin, Lily Shi, Donald Kirkpatrick, Jeffrey Settleman
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 4462.
https://doi.org/10.1158/1538-7445.AM2013-4462
Published: 15 April 2013
View articletitled, Abstract 4462: Resistance to selective kinase inhibitors upon epithelial to mesenchymal transition.
Journal Articles

Abstract 4568: Rapid assessment of TORC1 suppression predicts responsiveness to RAF and MEK inhibition in BRAF mutant melanoma.

Free
Ryan B. Corcoran, Stephen M. Rothenberg, Aaron N. Hata, Anthony C. Faber, Daniel Winokur, Adriano Piris, Rosalynn M. Nazarian, Ronald D. Brown, Jason T. Godfrey, Mari Mino-Kenudson, Jeffrey Settleman, Jennifer A. Wargo, Keith T. Flaherty, Daniel A. Haber, Jeffrey A. Engelman
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 4568.
https://doi.org/10.1158/1538-7445.AM2013-4568
Published: 15 April 2013
View articletitled, Abstract 4568: Rapid assessment of TORC1 suppression predicts responsiveness to RAF and MEK inhibition in BRAF mutant melanoma.
Journal Articles

Abstract LB-350: EGFR-mediated re-activation of MAPK signaling contributes to insensitivity of BRAF mutant colorectal cancers to RAF inhibition by vemurafenib

Free
Ryan B. Corcoran, Hiromichi Ebi, Alexa B. Turke, Erin M. Coffee, Michiya Nishino, Alexandra P. Cogdill, Ronald D. Brown, Dora Dias-Santagata, Patricia Della Pelle, Kenneth E. Hung, Keith T. Flaherty, Adriano Piris, Jennifer A. Wargo, Jeffrey Settleman, Mari Mino-Kenudson, Jeffrey A. Engelman
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): LB-350.
https://doi.org/10.1158/1538-7445.AM2012-LB-350
Published: 15 April 2012
View articletitled, Abstract LB-350: EGFR-mediated re-activation of MAPK signaling contributes to insensitivity of BRAF mutant colorectal cancers to RAF inhibition by vemurafenib
Journal Articles

Androgen Deprivation Causes Epithelial–Mesenchymal Transition in the Prostate: Implications for Androgen-Deprivation Therapy

Free
Yuting Sun, Bu-Er Wang, Kevin G. Leong, Peng Yue, Li Li, Suchit Jhunjhunwala, Darrell Chen, Kyounghee Seo, Zora Modrusan, Wei-Qiang Gao, Jeffrey Settleman, Leisa Johnson
Journal: Cancer Research
Cancer Res (2012) 72 (2): 527–536.
https://doi.org/10.1158/0008-5472.CAN-11-3004
Published: 16 January 2012
View articletitled, Androgen Deprivation Causes Epithelial–Mesenchymal Transition in the Prostate: Implications for Androgen-Deprivation Therapy
Open the PDF for Androgen Deprivation Causes Epithelial–Mesenchymal Transition in the Prostate: Implications for Androgen-Deprivation Therapy in another window
Includes: Supplementary data
Journal Articles

EGF Receptor Inhibition Radiosensitizes NSCLC Cells by Inducing Senescence in Cells Sustaining DNA Double-Strand Breaks

Free
Meng Wang, Fabian Morsbach, David Sander, Liliana Gheorghiu, Akash Nanda, Cyril Benes, Malte Kriegs, Mechthild Krause, Ekkehard Dikomey, Michael Baumann, Jochen Dahm-Daphi, Jeffrey Settleman, Henning Willers
Journal: Cancer Research
Cancer Res (2011) 71 (19): 6261–6269.
https://doi.org/10.1158/0008-5472.CAN-11-0213
Published: 29 September 2011
View articletitled, EGF Receptor Inhibition Radiosensitizes NSCLC Cells by Inducing Senescence in Cells Sustaining DNA Double-Strand Breaks
Open the PDF for EGF Receptor Inhibition Radiosensitizes NSCLC Cells by Inducing Senescence in Cells Sustaining DNA Double-Strand Breaks in another window
Includes: Supplementary data
Journal Articles

STAT3 Plays a Critical Role in KRAS-Induced Pancreatic Tumorigenesis

Free
Ryan B. Corcoran, Gianmarco Contino, Vikram Deshpande, Alexandros Tzatsos, Claudius Conrad, Cyril H. Benes, David E. Levy, Jeffrey Settleman, Jeffrey A. Engelman, Nabeel Bardeesy
Journal: Cancer Research
Cancer Res (2011) 71 (14): 5020–5029.
https://doi.org/10.1158/0008-5472.CAN-11-0908
Published: 14 July 2011
View articletitled, STAT3 Plays a Critical Role in KRAS-Induced Pancreatic Tumorigenesis
Open the PDF for STAT3 Plays a Critical Role in KRAS-Induced Pancreatic Tumorigenesis in another window
Includes: Supplementary data
Journal Articles

Abstract 956: Receptor tyrosine kinases, not KRAS, activate PI3K in KRAS mutant colorectal cancers

Free
Hiromichi Ebi, Ryan B. Corcoran, Anurag Singh, Zhao Chen, Youngchul Song, Eugene Lifshits, David P. Ryan, Jeffrey A. Meyerhardt, Cyril Benes, Jeffrey Settleman, Lewis C. Cantley, Kwok-Kin Wong, Jeffrey A. Engelman
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 956.
https://doi.org/10.1158/1538-7445.AM2011-956
Published: 15 April 2011
View articletitled, Abstract 956: Receptor tyrosine kinases, not KRAS, activate PI3K in KRAS mutant colorectal cancers
Journal Articles

Abstract 2210: Activation of PI3K in Merkel cell carcinoma

Free
Valentina Nardi, Young Chul Song, Arjola K. Cosper, Quynh Lam, Juan Antonio Santamaria Barria, Genevieve Marie Boland, Beow Yeap, Kristin Bergethon, Vanessa L. Scialabba, Jeffrey Settleman, David P. Ryan, Darrell R. Borger, Mai P. Hoang, Atul K. Bhan, Anthony J. Iafrate, James C. Cusack, Jeffrey A. Engelman, Dora Dias-Santagata
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 2210.
https://doi.org/10.1158/1538-7445.AM2011-2210
Published: 15 April 2011
View articletitled, Abstract 2210: Activation of PI3K in Merkel cell carcinoma
Journal Articles

Abstract 5757: A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers

Free
Stephen M. Rothenberg, Gayatry Mohapatra, Miguel N. Rivera, Daniel Winokur, Patricia Greninger, Ezra E.W. Cohen, David N. Louis, Jeffrey Settleman, Daniel A. Haber
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 5757.
https://doi.org/10.1158/1538-7445.AM10-5757
Published: 15 April 2010
View articletitled, Abstract 5757: A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers
Journal Articles

Abstract 2203: Integrative analysis for efficient candidate oncogene discovery in cancer cell lines

Free
Andrew J. Yee, Ben S. Wittner, Jeff Gentry, Crystal Mahoney, Kaitlin McCutcheon, Anurag Singh, Patricia Greninger, Xiao-Jun Ma, Mark G. Erlander, Sreenath V. Sharma, Daniel A. Haber, Toshi Shioda, Jeffrey Settleman, Sridhar Ramaswamy
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 2203.
https://doi.org/10.1158/1538-7445.AM10-2203
Published: 15 April 2010
View articletitled, Abstract 2203: Integrative analysis for efficient candidate oncogene discovery in cancer cell lines
Journal Articles

A Genome-Wide Screen for Microdeletions Reveals Disruption of Polarity Complex Genes in Diverse Human Cancers

Free
S. Michael Rothenberg, Gayatry Mohapatra, Miguel N. Rivera, Daniel Winokur, Patricia Greninger, Mai Nitta, Peter M. Sadow, Gaya Sooriyakumar, Brian W. Brannigan, Matthew J. Ulman, Rushika M. Perera, Rui Wang, Angela Tam, Xiao-Jun Ma, Mark Erlander, Dennis C. Sgroi, James W. Rocco, Mark W. Lingen, Ezra E.W. Cohen, David N. Louis, Jeffrey Settleman, Daniel A. Haber
Journal: Cancer Research
Cancer Res (2010) 70 (6): 2158–2164.
https://doi.org/10.1158/0008-5472.CAN-09-3458
Published: 14 March 2010
View articletitled, A Genome-Wide Screen for Microdeletions Reveals Disruption of Polarity Complex Genes in Diverse Human Cancers
Open the PDF for A Genome-Wide Screen for Microdeletions Reveals Disruption of Polarity Complex Genes in Diverse Human Cancers in another window
Includes: Supplementary data
Journal Articles

Abstract #1882: A gene expression signature associated with \#8220;K-Ras addiction\#8221; reveals novel candidate therapeutic targets that regulate EMT

Free
Anurag Singh, Patricia Greninger, Daniel Rhodes, Louise Koopman, Sheila Violette, Nabeel Bardeesy, Jeffrey Settleman
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 1882.
Published: 01 May 2009
View articletitled, Abstract #1882: A gene expression signature associated with \#8220;K-Ras addiction\#8221; reveals novel candidate therapeutic targets that regulate EMT
Journal Articles

Abstract #3962: The role of activating K-RAS mutation status in predicting radiosensitization to epidermal growth factor receptor (EGFR) inhibitors in non-small cell lung cancer (NSCLC) cells

Free
Akash Nanda, David Sander, Loreen Fournier, Anurag Singh, Lisa Kachnic, Jeffrey Settleman, Henning Willers
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 3962.
Published: 01 May 2009
View articletitled, Abstract #3962: The role of activating K-RAS mutation status in predicting radiosensitization to epidermal growth factor receptor (EGFR) inhibitors in non-small cell lung cancer (NSCLC) cells