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Jeffrey Schlom
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Journal Articles

Abstract 5540: Tumor phenotypic plasticity and resistance to immune-mediated cytotoxicity in models of castration resistant prostate cancer

Madeline Dahut, Kristen Fousek, Lucas Horn, Haiyan Qin, Jeffrey Schlom, Claudia Palena
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5540.
DOI: https://doi.org/10.1158/1538-7445.AM2022-5540
Published: 15 June 2022
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Journal Articles

Abstract 6100: Chemotherapy reduces TGF-beta signaling triggered by blockade of the PD-1/PD-L1 axis

Masafumi Iida, Lucas A Horn, Haiyan Qin, Kristen Fousek, Jeffrey Schlom, Claudia Palena
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 6100.
DOI: https://doi.org/10.1158/1538-7445.AM2022-6100
Published: 15 June 2022
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Abstract PD9-02: Peripheral immune subsets and circulating tumor DNA (ctDNA) in patients (pts) with residual triple negative breast cancer (TNBC) treated with adjuvant immunotherapy and/or chemotherapy (chemo): The OXEL study

Filipa Lynce, Candace Mainor, Xue Geng, Greg Jones, Ilana Schlam, Hongkun Wang, Ute Feger, Renee Donahue, Nicole Toney, Caroline Jochems, Jeffrey Schlom, Christopher Gallagher, Rita Nanda, Deena Graham, Erica M Stringer-Reasor, Neelima Denduluri, Julie Collins, Asma A Dilawari, Ami Chitalia, Shruti Tiwari, Raquel Nunes, Rebecca Kaltman, Katia Khoury, Margaret Gatti-Mays, Sandra M Swain, Heather A. Parsons, Paula Pohlmann, Claudine Isaacs
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): PD9-02.
DOI: https://doi.org/10.1158/1538-7445.SABCS21-PD9-02
Published: 15 February 2022
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Journal Articles

Abstract OT2-03-04: A trial of induction Talazoparib followed by a combination of Talazoparib and Avelumab in advanced breast cancer: The TALAVE study

Arielle L Heeke, Michael Pishvaian, Hongkun Wang, Adam Cohen, Jeffrey Schlom, Renee Donahue, Caroline Jochems, Margaret Gatti-Mays, Paula Pohlmann, Antoinette Tan, Claudine Isaacs, Filipa Lynce
Journal: Cancer Research
Cancer Res (2020) 80 (4_Supplement): OT2-03-04.
DOI: https://doi.org/10.1158/1538-7445.SABCS19-OT2-03-04
Published: 15 February 2020
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Journal Articles

Abstract OT1-08-01: A phase Ib trial of sequential combinations of BN-brachyury, entinostat, ado-trastuzumab emtansine (T-DM1) and bintrafusp alfa (M7824) in advanced stage breast cancer (BrEAsT)

Margaret E Gatti-Mays, Claudia Palena, Sofia R Gameiro, Renee N Donahue, Caroline Jochems, Seth Steinberg, Stan Lipkowitz, Alexandra Zimmer, Deneise Francis, Julius Strauss, Houssein Abdul Sater, Lisa Cordes, Jason Redman, Fatima Karzai, Marijo Bilusic, Ravi A Madan, James L Gulley, Jeffrey Schlom
Journal: Cancer Research
Cancer Res (2020) 80 (4_Supplement): OT1-08-01.
DOI: https://doi.org/10.1158/1538-7445.SABCS19-OT1-08-01
Published: 15 February 2020
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Journal Articles

Abstract CT075: Phase I evaluation of M7824, a bifunctional fusion protein targeting TGF-β and PD-L1, in patients with human papillomavirus (HPV)-associated malignancies

Julius Strauss, Margaret E. Gatti-Mays, Byoung Cho, Sébastien Salas, Edward McClay, Jason Redman, Houssein Abdul Sater, Renee N. Donahue, Elizabeth Lamping, Andrea Burmeister, Jennifer L. Marté, Lisa Cordes, Laureen S. Ojalvo, Christoph Helwig, Alex Rolfe, Christian S. Hinrichs, Ravi A. Madan, Jeffrey Schlom, James Gulley
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): CT075.
DOI: https://doi.org/10.1158/1538-7445.AM2019-CT075
Published: 01 July 2019
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Journal Articles

Abstract 1740: Epigenetic reprogramming of the tumor microenvironment by entinostat increases tumor sensitivity to multivalent immunotherapy combinations with an IL-15 superagonist plus vaccine or immune checkpoint blockade

Kristin C. Hicks, Karin M. Knudson, Frank R. Jones, Peter Ordentlich, Shahrooz Rabizadeh, Hing C. Wong, James W. Hodge, Jeffrey Schlom, Sofia R. Gameiro
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1740.
DOI: https://doi.org/10.1158/1538-7445.AM2018-1740
Published: 01 July 2018
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Journal Articles

Abstract 3644: Combination of OX40L fusion protein with an anti-tumor vaccine reduces lung metastasis and prolongs survival in a murine model of metastatic triple negative breast cancer

Anthony S. Malamas, Scott A. Hammond, Jeffrey Schlom, James W. Hodge
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 3644.
DOI: https://doi.org/10.1158/1538-7445.AM2017-3644
Published: 01 July 2017
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Journal Articles

Abstract LB-059: Neoadjuvant immunotherapy with androgen deprivation therapy (ADT) prior to radiation in prostate cancer: Impact on multiparametric prostate MRI and immune responses

Ravi A. Madan, Baris Turkbey, Lauren M. Lepone, Renee N. Donahue, Italia Grenga, Samuel Samuel Borofsky, Peter A. Pinto, Deborah Citrin, Aradhana Kaushal, Andra Krauze, Sheri McMahon, Myrna Rauchhorst, Anna Couvillon, Martin H. Falk, S Peter Eggleton, Stephen C. Greco, Peter L. Choyke, William L. Dahut, Jeffrey Schlom, James L. Gulley
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): LB-059.
DOI: https://doi.org/10.1158/1538-7445.AM2017-LB-059
Published: 01 July 2017
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Journal Articles

Abstract 611: Reversion of mesenchymal features in NSCLC cells using M7824, a first-in-class bi-functional immunotherapeutic agent targeting PD-L1 and TGFβ1 (TGFβ TRAP)

Justin M. David, Jeffrey Schlom, Yan Lan, Claudia Palena
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 611.
DOI: https://doi.org/10.1158/1538-7445.AM2017-611
Published: 01 July 2017
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Journal Articles

Abstract 594: Dual targeting of TGFb and PD-L1 promotes potent anti-tumor efficacy in multiple murine models of solid carcinomas

Karin M. Knudson, Sofia R. Gameiro, Kin-Ming Lo, Jeffrey Schlom
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 594.
DOI: https://doi.org/10.1158/1538-7445.AM2017-594
Published: 01 July 2017
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Journal Articles

Abstract 1480: Systemic immunotherapeutic efficacy of an immunocytokine, NHS-muIL12, in a superficial murine orthotopic bladder cancer model

Amanda J. Vandeveer, Jeffrey Schlom, John W. Greiner
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 1480.
DOI: https://doi.org/10.1158/1538-7445.AM2016-1480
Published: 15 July 2016
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Journal Articles

Abstract 1406: Analysis of immune responses as a consequence of androgen deprivation therapy in patients with biochemical progression of prostate cancer

Caroline Jochems, Ravi A. Madan, Romaine I. Fernando, James L. Gulley, Kwong Y. Tsang, Jeffrey Schlom
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 1406.
DOI: https://doi.org/10.1158/1538-7445.AM2016-1406
Published: 15 July 2016
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Abstract 1403: Correlations between overall survival and patient regulatory T-cell levels at initiation of Folfiri therapy in colorectal cancer

Caroline Jochems, Vittore Cereda, Romaine I. Fernando, Jacob Richards, Italia Grenga, Patrizia Ferroni, Fiorella Guadagni, Jeffrey Schlom, Mario Roselli
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 1403.
DOI: https://doi.org/10.1158/1538-7445.AM2016-1403
Published: 15 July 2016
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Journal Articles

Abstract 3245: IL-15 superagonist/IL-15RαSushi-Fc fusion complex (IL-15SA/IL-15RαSu-Fc; ALT-803) markedly enhances specific subpopulations of NK and memory CD8+ T cells, and mediates potent anti-tumor activity of murine breast and colon carcinomas

Peter S. Kim, Anna R. Kwilas, Wenxin Xu, Sarah Alter, Emily K. Jeng, Hing C. Wong, Jeffrey Schlom, James W. Hodge
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 3245.
DOI: https://doi.org/10.1158/1538-7445.AM2016-3245
Published: 15 July 2016
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Journal Articles

Abstract 4901: Short-course enzalutamide reveals immune activating properties in patients with biochemically recurrent prostate cancer

Renee N. Donahue, Ravi A. Madan, Jacob Richards, Italia Grenga, Lauren M. Lepone, Christopher R. Heery, James L. Gulley, Jeffrey Schlom
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 4901.
DOI: https://doi.org/10.1158/1538-7445.AM2016-4901
Published: 15 July 2016
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Journal Articles

Abstract 4032: Modulation of tumor PD-L1 expression by epithelial-mesenchymal phenotypic plasticity

Justin M. David, Charli L. Dominguez, Jeffrey Schlom, Claudia Palena
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 4032.
DOI: https://doi.org/10.1158/1538-7445.AM2016-4032
Published: 15 July 2016
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Journal Articles

Abstract 1316: Evaluation of immune cell subsets of cancer patients treated with a fully human IgG1 anti-PD-L1 MAb (MSB0010718C) capable of mediating ADCC of human tumor cells

Lauren M. Lepone, Renee N. Donahue, Benedetto Farsaci, Italia Grenga, Benjamin Boyerinas, Caroline Jochems, Kwong-Yok Tsang, Christopher R. Heery, Ravi A. Madan, Geraldine O'Sullivan Coyne, Harpreet Singh, James L. Gulley, Jeffrey Schlom
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 1316.
DOI: https://doi.org/10.1158/1538-7445.AM2015-1316
Published: 01 August 2015
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Journal Articles

Abstract 1586: Recovery and characterization of circulating tumor cells (CTCs) in cryopreserved metastatic castrate-resistant prostate cancer (mCRPC) patient samples

David Lu, Melissa Harvey, Ravi Madan, Christopher Heery, Jennifer Marte, Sharon Beasley, Mark Landers, Rachel Krupa, Jessica Louw, Justin Wahl, Natalee Bales, Dena Marrinucci, Jeffrey Schlom, James Gulley, Ryan Dittamore
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 1586.
DOI: https://doi.org/10.1158/1538-7445.AM2015-1586
Published: 01 August 2015
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Journal Articles

Abstract A64: Brachyury-mediated epithelial-mesenchymal transition of human carcinoma cells is associated with an increased resistance to immune-mediated attack

Duane H. Hamilton, Romaine Fernando, Bruce Huang, Kwong-Yok Tsang, Jeffrey Schlom, Claudia Palena
Journal: Cancer Research
Cancer Res (2011) 71 (18_Supplement): A64.
DOI: https://doi.org/10.1158/1538-7445.FBCR11-A64
Published: 28 October 2014
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