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Jeffrey Schlom
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Journal Articles

Abstract CT257: Hyperprogressive disease following bintrafusp alfa and DNA damaging chemotherapy in relapsed small cell lung cancer

Brett Schroeder, Nobuyuki Takahashi, Howard Yang, Renee Donahue, Zachary Skidmore, Alissa Konicki, Michael Nirula, Max Greenberg, George Chrisafis, Yang Zhang, Yo-Ting Tsai, Linda Sciuto, Samantha Nichols, Melissa Abel, Parth Desai, Rajesh Kumar, Christopher Schultz, Danielle Pinkiert, Chante Graham, Ajit Sharma, Justin Malin, Manan Krishnamurthy, Sophie Zhuang, Maxwell Lee, Lorenzo Rinaldi, Jeffrey Schlom, Lalage Wakefield, Anish Thomas
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): CT257.
https://doi.org/10.1158/1538-7445.AM2024-CT257
Published: 05 April 2024
View article titled, Abstract CT257: Hyperprogressive disease following bintrafusp alfa and DNA damaging chemotherapy in relapsed small cell lung cancer
Journal Articles

Abstract 4092: Characterizing the endogenous retroviral envelope protein ERVMER34-1 as a target for a therapeutic cancer vaccine

Maria Del Mar Maldonado, Masafumi Iida, Maria Del Mar Gracia Hernandez, Loc Le, Renee N. Donahue, Claudia Palena, Jeffrey Schlom, Duane H. Hamilton
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 4092.
https://doi.org/10.1158/1538-7445.AM2024-4092
Published: 22 March 2024
View article titled, Abstract 4092: Characterizing the endogenous retroviral envelope protein ERVMER34-1 as a target for a therapeutic cancer vaccine
Journal Articles

Abstract 1425: Epigenetic modulation synergizes with a novel TCR β chain directed antibody-fusion molecule to suppress checkpoint-refractory tumors irrespective of MHC I status

Katherine E. Lothstein, Asma S. Khelifa, Masaya Miyamoto, Christine M. Minnar, Lisa Poppe, Nicholas Roller, Andrew Bayliffe, Ke Liu, Jacques Moisan, Madan Katragadda, Zhen Su, Jeffrey Schlom, Sofia R. Gameiro
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1425.
https://doi.org/10.1158/1538-7445.AM2024-1425
Published: 22 March 2024
View article titled, Abstract 1425: Epigenetic modulation synergizes with a novel TCR β chain directed antibody-fusion molecule to suppress checkpoint-refractory tumors irrespective of MHC I status
Journal Articles

Abstract 4082: Anchored IL-12 synergizes with an epigenetic modulator to promote immune remodeling and overcome anti-PD1-refractory murine tumors

Asma S. Khelifa, Katherine L. Lothstein, Masaya Miyamoto, Rob Tighe, Sailaja Battula, Howard L. Kaufman, Jeffrey Schlom, Sofia R. Gameiro
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 4082.
https://doi.org/10.1158/1538-7445.AM2024-4082
Published: 22 March 2024
View article titled, Abstract 4082: Anchored IL-12 synergizes with an epigenetic modulator to promote immune remodeling and overcome anti-PD1-refractory murine tumors
Journal Articles

Abstract 4065: Entinostat synergizes with the IL-15 superagonist N-803 and anti-PD-1 to engage cDC1 and stem-like TCF-1+ CD8+ T and NK cells to overcome colorectal tumors refractory to anti-PD-1 therapy

Christine M. Minnar, Masaya Miyamoto, Asma S. Khelifa, Grace Lui, Katherine L. Lothstein, Paul L. Chariou, Thomas J. Meyer, Alexei Lobanov, Margaret Cam, Jeffrey Schlom, Sofia R. Gameiro
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 4065.
https://doi.org/10.1158/1538-7445.AM2024-4065
Published: 22 March 2024
View article titled, Abstract 4065: Entinostat synergizes with the IL-15 superagonist N-803 and anti-PD-1 to engage cDC1 and stem-like TCF-1<sup>+</sup> CD8<sup>+</sup> T and NK cells to overcome colorectal tumors refractory to anti-PD-1 therapy
Journal Articles

Abstract 1193: Peripheral immune analyses from phase I trial of HPV vaccine PRGN-2009 in combination with bintrafusp alfa in patients with HPV-associated cancers

Meghali Goswami, Charalampos S. Floudas, Julius Strauss, Douglas E. Brough, Amy R. Lankford, Caroline Jochems, James L. Gulley, Jeffrey Schlom, Renee N. Donahue
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1193.
https://doi.org/10.1158/1538-7445.AM2024-1193
Published: 22 March 2024
View article titled, Abstract 1193: Peripheral immune analyses from phase I trial of HPV vaccine PRGN-2009 in combination with bintrafusp alfa in patients with HPV-associated cancers
Journal Articles

Abstract 1196: Peripheral immune analyses correlate with clinical outcome: A phase II trial of nivolumab, capecitabine, or the combination in patients with triple negative breast cancer

Nicole J. Toney, Filipa Lynce, Candace Mainor, Claudine Isaacs, Jeffrey Schlom, Renee N. Donahue
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1196.
https://doi.org/10.1158/1538-7445.AM2024-1196
Published: 22 March 2024
View article titled, Abstract 1196: Peripheral immune analyses correlate with clinical outcome: A phase II trial of nivolumab, capecitabine, or the combination in patients with triple negative breast cancer
Journal Articles

Abstract 5085: Blockade of tumor derived CSF1 promotes an immune-permissive tumor microenvironment

Maria Del Mar Maldonado, Duane H. Hamilton, Jeffrey Schlom
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5085.
https://doi.org/10.1158/1538-7445.AM2023-5085
Published: 04 April 2023
View article titled, Abstract 5085: Blockade of tumor derived CSF1 promotes an immune-permissive tumor microenvironment
Journal Articles

Abstract 6100: Chemotherapy reduces TGF-beta signaling triggered by blockade of the PD-1/PD-L1 axis

Masafumi Iida, Lucas A Horn, Haiyan Qin, Kristen Fousek, Jeffrey Schlom, Claudia Palena
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 6100.
https://doi.org/10.1158/1538-7445.AM2022-6100
Published: 15 June 2022
View article titled, Abstract 6100: Chemotherapy reduces TGF-beta signaling triggered by blockade of the PD-1/PD-L1 axis
Journal Articles

Abstract 5540: Tumor phenotypic plasticity and resistance to immune-mediated cytotoxicity in models of castration resistant prostate cancer

Madeline Dahut, Kristen Fousek, Lucas Horn, Haiyan Qin, Jeffrey Schlom, Claudia Palena
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5540.
https://doi.org/10.1158/1538-7445.AM2022-5540
Published: 15 June 2022
View article titled, Abstract 5540: Tumor phenotypic plasticity and resistance to immune-mediated cytotoxicity in models of castration resistant prostate cancer
Journal Articles

Abstract PD9-02: Peripheral immune subsets and circulating tumor DNA (ctDNA) in patients (pts) with residual triple negative breast cancer (TNBC) treated with adjuvant immunotherapy and/or chemotherapy (chemo): The OXEL study

Filipa Lynce, Candace Mainor, Xue Geng, Greg Jones, Ilana Schlam, Hongkun Wang, Ute Feger, Renee Donahue, Nicole Toney, Caroline Jochems, Jeffrey Schlom, Christopher Gallagher, Rita Nanda, Deena Graham, Erica M Stringer-Reasor, Neelima Denduluri, Julie Collins, Asma A Dilawari, Ami Chitalia, Shruti Tiwari, Raquel Nunes, Rebecca Kaltman, Katia Khoury, Margaret Gatti-Mays, Sandra M Swain, Heather A. Parsons, Paula Pohlmann, Claudine Isaacs
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): PD9-02.
https://doi.org/10.1158/1538-7445.SABCS21-PD9-02
Published: 15 February 2022
View article titled, Abstract PD9-02: Peripheral immune subsets and circulating tumor DNA (ctDNA) in patients (pts) with residual triple negative breast cancer (TNBC) treated with adjuvant immunotherapy and/or chemotherapy (chemo): The OXEL study
Journal Articles

Abstract OT1-08-01: A phase Ib trial of sequential combinations of BN-brachyury, entinostat, ado-trastuzumab emtansine (T-DM1) and bintrafusp alfa (M7824) in advanced stage breast cancer (BrEAsT)

Margaret E Gatti-Mays, Claudia Palena, Sofia R Gameiro, Renee N Donahue, Caroline Jochems, Seth Steinberg, Stan Lipkowitz, Alexandra Zimmer, Deneise Francis, Julius Strauss, Houssein Abdul Sater, Lisa Cordes, Jason Redman, Fatima Karzai, Marijo Bilusic, Ravi A Madan, James L Gulley, Jeffrey Schlom
Journal: Cancer Research
Cancer Res (2020) 80 (4_Supplement): OT1-08-01.
https://doi.org/10.1158/1538-7445.SABCS19-OT1-08-01
Published: 15 February 2020
View article titled, Abstract OT1-08-01: A phase Ib trial of sequential combinations of BN-brachyury, entinostat, ado-trastuzumab emtansine (T-DM1) and bintrafusp alfa (M7824) in advanced stage breast cancer (BrEAsT)
Journal Articles

Abstract OT2-03-04: A trial of induction Talazoparib followed by a combination of Talazoparib and Avelumab in advanced breast cancer: The TALAVE study

Arielle L Heeke, Michael Pishvaian, Hongkun Wang, Adam Cohen, Jeffrey Schlom, Renee Donahue, Caroline Jochems, Margaret Gatti-Mays, Paula Pohlmann, Antoinette Tan, Claudine Isaacs, Filipa Lynce
Journal: Cancer Research
Cancer Res (2020) 80 (4_Supplement): OT2-03-04.
https://doi.org/10.1158/1538-7445.SABCS19-OT2-03-04
Published: 15 February 2020
View article titled, Abstract OT2-03-04: A trial of induction Talazoparib followed by a combination of Talazoparib and Avelumab in advanced breast cancer: The TALAVE study
Journal Articles

Abstract CT075: Phase I evaluation of M7824, a bifunctional fusion protein targeting TGF-β and PD-L1, in patients with human papillomavirus (HPV)-associated malignancies

Julius Strauss, Margaret E. Gatti-Mays, Byoung Cho, Sébastien Salas, Edward McClay, Jason Redman, Houssein Abdul Sater, Renee N. Donahue, Elizabeth Lamping, Andrea Burmeister, Jennifer L. Marté, Lisa Cordes, Laureen S. Ojalvo, Christoph Helwig, Alex Rolfe, Christian S. Hinrichs, Ravi A. Madan, Jeffrey Schlom, James Gulley
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): CT075.
https://doi.org/10.1158/1538-7445.AM2019-CT075
Published: 01 July 2019
View article titled, Abstract CT075: Phase I evaluation of M7824, a bifunctional fusion protein targeting TGF-β and PD-L1, in patients with human papillomavirus (HPV)-associated malignancies
Journal Articles

Abstract 1740: Epigenetic reprogramming of the tumor microenvironment by entinostat increases tumor sensitivity to multivalent immunotherapy combinations with an IL-15 superagonist plus vaccine or immune checkpoint blockade

Kristin C. Hicks, Karin M. Knudson, Frank R. Jones, Peter Ordentlich, Shahrooz Rabizadeh, Hing C. Wong, James W. Hodge, Jeffrey Schlom, Sofia R. Gameiro
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1740.
https://doi.org/10.1158/1538-7445.AM2018-1740
Published: 01 July 2018
View article titled, Abstract 1740: Epigenetic reprogramming of the tumor microenvironment by entinostat increases tumor sensitivity to multivalent immunotherapy combinations with an IL-15 superagonist plus vaccine or immune checkpoint blockade
Journal Articles

Abstract 611: Reversion of mesenchymal features in NSCLC cells using M7824, a first-in-class bi-functional immunotherapeutic agent targeting PD-L1 and TGFβ1 (TGFβ TRAP)

Justin M. David, Jeffrey Schlom, Yan Lan, Claudia Palena
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 611.
https://doi.org/10.1158/1538-7445.AM2017-611
Published: 01 July 2017
View article titled, Abstract 611: Reversion of mesenchymal features in NSCLC cells using M7824, a first-in-class bi-functional immunotherapeutic agent targeting PD-L1 and TGFβ1 (TGFβ TRAP)
Journal Articles

Abstract 594: Dual targeting of TGFb and PD-L1 promotes potent anti-tumor efficacy in multiple murine models of solid carcinomas

Karin M. Knudson, Sofia R. Gameiro, Kin-Ming Lo, Jeffrey Schlom
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 594.
https://doi.org/10.1158/1538-7445.AM2017-594
Published: 01 July 2017
View article titled, Abstract 594: Dual targeting of TGFb and PD-L1 promotes potent anti-tumor efficacy in multiple murine models of solid carcinomas
Journal Articles

Abstract LB-059: Neoadjuvant immunotherapy with androgen deprivation therapy (ADT) prior to radiation in prostate cancer: Impact on multiparametric prostate MRI and immune responses

Ravi A. Madan, Baris Turkbey, Lauren M. Lepone, Renee N. Donahue, Italia Grenga, Samuel Samuel Borofsky, Peter A. Pinto, Deborah Citrin, Aradhana Kaushal, Andra Krauze, Sheri McMahon, Myrna Rauchhorst, Anna Couvillon, Martin H. Falk, S Peter Eggleton, Stephen C. Greco, Peter L. Choyke, William L. Dahut, Jeffrey Schlom, James L. Gulley
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): LB-059.
https://doi.org/10.1158/1538-7445.AM2017-LB-059
Published: 01 July 2017
View article titled, Abstract LB-059: Neoadjuvant immunotherapy with androgen deprivation therapy (ADT) prior to radiation in prostate cancer: Impact on multiparametric prostate MRI and immune responses
Journal Articles

Abstract 3644: Combination of OX40L fusion protein with an anti-tumor vaccine reduces lung metastasis and prolongs survival in a murine model of metastatic triple negative breast cancer

Anthony S. Malamas, Scott A. Hammond, Jeffrey Schlom, James W. Hodge
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 3644.
https://doi.org/10.1158/1538-7445.AM2017-3644
Published: 01 July 2017
View article titled, Abstract 3644: Combination of OX40L fusion protein with an anti-tumor vaccine reduces lung metastasis and prolongs survival in a murine model of metastatic triple negative breast cancer
Journal Articles

Abstract 1406: Analysis of immune responses as a consequence of androgen deprivation therapy in patients with biochemical progression of prostate cancer

Caroline Jochems, Ravi A. Madan, Romaine I. Fernando, James L. Gulley, Kwong Y. Tsang, Jeffrey Schlom
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 1406.
https://doi.org/10.1158/1538-7445.AM2016-1406
Published: 15 July 2016
View article titled, Abstract 1406: Analysis of immune responses as a consequence of androgen deprivation therapy in patients with biochemical progression of prostate cancer