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Jeffrey H. Hager
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Journal Articles

Abstract 2574: Werner syndrome helicase is required for the survival of cancer cells with microsatellite instability

Free
Lorn Kategaya, Senthil K. Perumal, Jeffrey H. Hager, Lisa D. Belmont
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2574.
https://doi.org/10.1158/1538-7445.AM2019-2574
Published: 01 July 2019
View articletitled, Abstract 2574: Werner syndrome helicase is required for the survival of cancer cells with microsatellite instability
Journal Articles

Abstract 1648: Discovery and evolution of orally bioavailable selective estrogen receptor degraders for ER+ breast cancer: From GDC-0810 to GDC-0927

Free
Mehmet Kahraman, Steven P. Govek, Johnny Y. Nagasawa, Andiliy Lai, Celine Bonnefous, Karensa Douglas, John Sensintaffar, Nhin Lu, KyoungJin Lee, Anna Aparicio, Josh Kaufman, Jing Qian, Gang Shao, Rene Prudente, James D. Joseph, Beatrice Darimont, Daniel Brigham, Richard Heyman, Peter J. Rix, Jeffrey H. Hager, Nicholas D. Smith, Robert A. Blake, Jae Chang, Edna Choo, Anneleen Daemen, Lori S. Friedman, Jane Guan, Steven Hartman, Ellen Ingalla, James R. Kiefer, Tracy Kleinheinz, Sharada Labadie, Ciara Metcalfe, Vidhi Mody, Michelle Nannini, Deepak Sampath, Amy Young, Maia Vinogradova, Wei Zhou, Jun Liang, Xiaojing Wang
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1648.
https://doi.org/10.1158/1538-7445.AM2018-1648
Published: 01 July 2018
View articletitled, Abstract 1648: Discovery and evolution of orally bioavailable selective estrogen receptor degraders for ER+ breast cancer: From GDC-0810 to GDC-0927
Journal Articles

Abstract 1943: PARG inhibitors exhibit synthetic lethality with XRCC1 deficiency and a cellular mechanism of action that is distinct from PARP inhibition

Free
Leenus Martin, Tzuling Cheng, Dominic I. James, Habiba Begum, Kate M. Smith, Allan Jordan, Ian Waddell, Kedar Vaidya, Marcus Fischer, Bing Yao, Jason Drummond, Leah Cleary, Ruben Martinez, James Sutton, Nandini Ravindran, James Joseph, Eleni Venetsanakos, Michael Dillon, Jeffrey H. Hager, Lisa D. Belmont
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1943.
https://doi.org/10.1158/1538-7445.AM2018-1943
Published: 01 July 2018
View articletitled, Abstract 1943: PARG inhibitors exhibit synthetic lethality with XRCC1 deficiency and a cellular mechanism of action that is distinct from PARP inhibition
Journal Articles

Abstract 4719: Small-molecule antagonists of the Aryl Hydrocarbon Receptor (AhR) promote activation of human PBMCs in vitro and demonstrate significant impact on tumor growth and immune modulation in vivo

Free
James Joseph, Marcos Gonzalez-Lopez, Christina Galang, Candy Garcia, Hadia Lemar, Jing Lu, Kedar Vaidya, Marcus Fischer, Christian Frey, Muzaffar Alam, Bing Yao, Michael Dillon, Jeffrey H. Hager, Eleni Venetsanakos, Fred Aswad
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 4719.
https://doi.org/10.1158/1538-7445.AM2018-4719
Published: 01 July 2018
View articletitled, Abstract 4719: Small-molecule antagonists of the Aryl Hydrocarbon Receptor (AhR) promote activation of human PBMCs in vitro and demonstrate significant impact on tumor growth and immune modulation in vivo
Journal Articles

Abstract 1864: Selective estrogen receptor degrader (SERD) activity in ESR1 mutant models

Free
Wei Zhou, Robert A. Blake, Jim Nonomiya, Jing Qian, Lorna Kategaya, Ingrid Wertz, Anneleen Daemen, Thomas O'Brien, John Sensintaffar, Michael Moon, Michelle A. Nannini, Jason Oeh, Deepak Sampath, Xiaojing Wang, Nicholas Smith, Daniel Brigham, James Joseph, Jeffrey H. Hager, Lori S. Friedman
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 1864.
https://doi.org/10.1158/1538-7445.AM2015-1864
Published: 01 August 2015
View articletitled, Abstract 1864: Selective estrogen receptor degrader (SERD) activity in ESR1 mutant models
Journal Articles

Abstract 5053: Discovery of GDC-0810 a novel, non-steroidal selective estrogen receptor degrader with robust activity in pre-clinical models of endocrine-resistant breast cancer

Free
James Joseph, Steven Govek, Beatrice Darimont, Daniel Brigham, Anna Aparicio, Eric Bischoff, Mehmet Kahraman, Michelle Nannini, Joshua Kaufman, Andily Lai, Kyoung-Jin Lee, Jason Oeh, Nhin Lu, Wei Zhou, Michael Moon, Jing Qian, John Sensintaffar, Gang Shao, Deepak Sampath, Lori S. Friedman, Peter Rix, Richard A. Heyman, Nicholas Smith, Jeffrey H. Hager
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 5053.
https://doi.org/10.1158/1538-7445.AM2015-5053
Published: 01 August 2015
View articletitled, Abstract 5053: Discovery of GDC-0810 a novel, non-steroidal selective estrogen receptor degrader with robust activity in pre-clinical models of endocrine-resistant breast cancer
Journal Articles

Abstract P1-13-01: Phase I study of ARN-810, a novel and potent oral selective estrogen receptor degrader, in postmenopausal women with metastatic estrogen receptor positive (ER+), HER2- breast cancer

Free
Aditya Bardia, Maura N Dickler, Ingrid A Mayer, Eric P Winer, Umar Mahmood, Gary Ulaner, H Charles Manning, Peter Rix, Jeffrey H Hager, Debasish Roychowdhury, Edna Chow Maneval, Carlos L Arteaga, Jose Baselga
Journal: Cancer Research
Cancer Res (2015) 75 (9_Supplement): P1-13-01.
https://doi.org/10.1158/1538-7445.SABCS14-P1-13-01
Published: 01 May 2015
View articletitled, Abstract P1-13-01: Phase I study of ARN-810, a novel and potent oral selective estrogen receptor degrader, in postmenopausal women with metastatic estrogen receptor positive (ER+), HER2- breast cancer
Journal Articles

Abstract C16: Targeting AR in castration-resistant prostate cancer: Development of ARN-509 and second-generation antiandrogen resistance models

Free
James D. Joseph, Anna Aparicio, Josh Kaufman, Jackie Julien, Celine Bonnefous, Nicholas D. Smith, Peter Rix, Michael E. Jung, Charles L. Sawyers, Richard A. Heyman, Jeffrey H. Hager, Nicola J. Clegg, John Sensintaffar, Nhin Lu, Kate Grillot, Eric Bischoff, Gang Shao, Jing Qian, Beatrice Darimont
Journal: Cancer Research
Cancer Res (2012) 72 (4_Supplement): C16.
https://doi.org/10.1158/1538-7445.PRCA2012-C16
Published: 09 May 2013
View articletitled, Abstract C16: Targeting AR in castration-resistant prostate cancer: Development of ARN-509 and second-generation antiandrogen resistance models
Journal Articles

ARN-509: A Novel Antiandrogen for Prostate Cancer Treatment

Free
Nicola J. Clegg, John Wongvipat, James D. Joseph, Chris Tran, Samedy Ouk, Anna Dilhas, Yu Chen, Kate Grillot, Eric D. Bischoff, Ling Cai, Anna Aparicio, Steven Dorow, Vivek Arora, Gang Shao, Jing Qian, Hong Zhao, Guangbin Yang, Chunyan Cao, John Sensintaffar, Teresa Wasielewska, Mark R. Herbert, Celine Bonnefous, Beatrice Darimont, Howard I. Scher, Peter Smith-Jones, Mark Klang, Nicholas D. Smith, Elisa De Stanchina, Nian Wu, Ouathek Ouerfelli, Peter J. Rix, Richard A. Heyman, Michael E. Jung, Charles L. Sawyers, Jeffrey H. Hager
Journal: Cancer Research
Cancer Res (2012) 72 (6): 1494–1503.
https://doi.org/10.1158/0008-5472.CAN-11-3948
Published: 14 March 2012
View articletitled, ARN-509: A Novel Antiandrogen for Prostate Cancer Treatment
Open the PDF for ARN-509: A Novel Antiandrogen for Prostate Cancer Treatment in another window
Includes: Supplementary data
Journal Articles

Oncogene Expression and Genetic Background Influence the Frequency of DNA Copy Number Abnormalities in Mouse Pancreatic Islet Cell Carcinomas

Free
Jeffrey H. Hager, J. Graeme Hodgson, Jane Fridlyand, Sujatmi Hariono, Joe W. Gray, Douglas Hanahan
Journal: Cancer Research
Cancer Res (2004) 64 (7): 2406–2410.
https://doi.org/10.1158/0008-5472.CAN-03-3522
Published: 01 April 2004
View articletitled, Oncogene Expression and Genetic Background Influence the Frequency of DNA Copy Number Abnormalities in Mouse Pancreatic Islet Cell Carcinomas
Open the PDF for Oncogene Expression and Genetic Background Influence the Frequency of DNA Copy Number Abnormalities in Mouse Pancreatic Islet Cell Carcinomas in another window
Includes: Supplementary data