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Jeffrey A. Toretsky
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Journal Articles

Abstract 2506: Exploring the complex etiology of oncogenic fusions in childhood cancer

Nathaniel D. Anderson, Richard de Borja, Matthew D. Young, Fabio Fuligni, Andrej Rosic, Nicola D. Roberts, Nischalan Pillay, Jeffrey A. Toretsky, Yoshida Akihiko, Tatsuhiro Shibata, Markus Metzler, Gino Somers, Stephen W. Scherer, Adrienne M. Flanagan, Peter J. Campbell, Joshua D. Schiffman, Mary Shago, Ludmil B. Alexandrov, Jay S. Wunder, Irene L. Andrulis, David Malkin, Sam Behjati, Adam Shlien
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2506.
https://doi.org/10.1158/1538-7445.AM2019-2506
Published: 01 July 2019
View articletitled, Abstract 2506: Exploring the complex etiology of oncogenic fusions in childhood cancer
Journal Articles

Abstract 3176: CD99 regulates ERK1/2-MSK1/2-CREB axis in Ewing sarcoma

Haydar Celik, Erin J. Conn, David V. Allegakoen, Jeff R. Petro, Jeffrey A. Toretsky, Aykut Uren
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 3176.
https://doi.org/10.1158/1538-7445.AM2018-3176
Published: 01 July 2018
View articletitled, Abstract 3176: CD99 regulates ERK1/2-MSK1/2-CREB axis in Ewing sarcoma
Journal Articles

Abstract 1933: Discovery of first-in-class small molecule CD99 inhibitors for targeted therapy of Ewing sarcoma

Haydar Celik, Marika Sciandra, Bess Flashner, Elif Gelmez, Neslihan Kayraklıoğlu, David V. Allegakoen, Jeff R. Petro, Erin J. Conn, Sarah Hour, Jenny Han, Lalehan Oktay, Purushottam B. Tiwari, Mutlu Hayran, Maria Cristina Manara, Jeffrey A. Toretsky, Katia Scotlandi, Aykut Uren
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1933.
https://doi.org/10.1158/1538-7445.AM2017-1933
Published: 01 July 2017
View articletitled, Abstract 1933: Discovery of first-in-class small molecule CD99 inhibitors for targeted therapy of Ewing sarcoma
Journal Articles

Abstract 694: TK-216: a novel, first-in-class, small molecule inhibitor of EWS-FLI1 in early clinical development, for the treatment of Ewing Sarcoma

Saravana P. Selvanathan, Eric Moseley, Garrett T. Graham, Katti Jessen, Brian Lannutti, Aykut Üren, Jeffrey A. Toretsky
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 694.
https://doi.org/10.1158/1538-7445.AM2017-694
Published: 01 July 2017
View articletitled, Abstract 694: TK-216: a novel, first-in-class, small molecule inhibitor of EWS-FLI1 in early clinical development, for the treatment of Ewing Sarcoma
Journal Articles

Abstract 2446: Ezrin inhibition up-regulates stress response gene expression and blocks osteosarcoma metastasis

Haydar Çelik, Gülay Bulut, Jenny Han, Garrett T. Graham, Tsion Z. Minas, Erin J. Conn, Sung-Hyeok Hong, Gary T. Pauly, Mutlu Hayran, Xin Li, Metin Özdemirli, Ayşe Ayhan, Michelle A. Rudek, Jeffrey A. Toretsky, Aykut Üren
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2446.
https://doi.org/10.1158/1538-7445.AM2016-2446
Published: 15 July 2016
View articletitled, Abstract 2446: Ezrin inhibition up-regulates stress response gene expression and blocks osteosarcoma metastasis
Journal Articles

Abstract 485: EWS-FLI1 targeted small molecule YK-4-279 synergizes with vinca alkaloids through double hit to mitotic machinery

Stefan K. Zöllner, Ryan Commins, Sung H. Hong, Hayriye V. Erkizan, Jeffrey A. Toretsky
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 485.
https://doi.org/10.1158/1538-7445.AM2015-485
Published: 01 August 2015
View articletitled, Abstract 485: EWS-FLI1 targeted small molecule YK-4-279 synergizes with vinca alkaloids through double hit to mitotic machinery
Journal Articles

Abstract 1654: The small molecule YK-4-279 shows anti-lymphoma activity in pre-clinical models

Elain YL Chung, Valdemar Priebe, Eugenio Gaudio, Ivo Kwee, Chiara Tarantelli, Andrea Rinaldi, Laura Carrassa, Monica Testoni, Luciano Cascione, Massimo Broggini, Jeffrey A. Toretsky, Emanuele Zucca, Francesco Bertoni
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 1654.
https://doi.org/10.1158/1538-7445.AM2015-1654
Published: 01 August 2015
View articletitled, Abstract 1654: The small molecule YK-4-279 shows anti-lymphoma activity in pre-clinical models
Journal Articles

Abstract 3269: Ezrin binds to DEAD-box RNA helicase DDX3 and regulates its function and protein level

Haydar Celik, Kamal P. Sajwan, Amrita V. Pai, Ben J. Marsh, Yasemin Saygideger Kont, Said Rahim, Jenny Han, Tsion Minas, Jeffrey A. Toretsky, Aykut Uren
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 3269.
https://doi.org/10.1158/1538-7445.AM2015-3269
Published: 01 August 2015
View articletitled, Abstract 3269: Ezrin binds to DEAD-box RNA helicase DDX3 and regulates its function and protein level
Journal Articles

Abstract 5453: YK-4-279 inhibits ETS-positive prostate cancer cell metastasis in a mouse xenograft model.

Said Rahim, Sarah Justvig, Sung-Hyeok Hong, Yali Kong, Milton L. Brown, Colm Morrissey, Jeffrey A. Toretsky, Aykut Uren
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 5453.
https://doi.org/10.1158/1538-7445.AM2013-5453
Published: 15 April 2013
View articletitled, Abstract 5453: YK-4-279 inhibits ETS-positive prostate cancer cell metastasis in a mouse xenograft model.
Journal Articles

Abstract 3950: Differential functions of neuropeptide Y in Ewing's sarcoma - hypoxia as a switch

Jason U. Tilan, Congyi Lu, Joshua Patrick Earnest, Lindsay M. Everhart, Asim Shabir, Alison O'Neill, Shuo Wang, Magdalena Czarnecka, Jeffrey A. Toretsky, Joanna Kitlinska
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 3950.
https://doi.org/10.1158/1538-7445.AM2012-3950
Published: 15 April 2012
View articletitled, Abstract 3950: Differential functions of neuropeptide Y in Ewing's sarcoma - hypoxia as a switch
Journal Articles

Abstract 4874: Small molecule inhibitor of ezrin inhibits metastasis in a transgenic mouse model of osteosarcoma

Jared T. Murdoch, Sung-Hyeok Hong, Gulay Bulut, George W. Kosturko, Lauren E. Drebing, Jeffrey A. Toretsky, Aykut Uren
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 4874.
https://doi.org/10.1158/1538-7445.AM2012-4874
Published: 15 April 2012
View articletitled, Abstract 4874: Small molecule inhibitor of ezrin inhibits metastasis in a transgenic mouse model of osteosarcoma
Journal Articles

Abstract LB-316: Pharmacokinetic modeling optimizes direct inhibition of the ‘undruggable’ target EWS-FLI1 of Ewing Sarcoma

S. Peter Hong, S. Ellen Gamble, Sung-Hyeok Hong, Christina L. Kobs, Karen E. Elsass, Natalie L. South, Philip J. Monroe, Aykut Üren, Jeffrey A. Toretsky
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): LB-316.
https://doi.org/10.1158/1538-7445.AM2012-LB-316
Published: 15 April 2012
View articletitled, Abstract LB-316: Pharmacokinetic modeling optimizes direct inhibition of the ‘undruggable’ target EWS-FLI1 of Ewing Sarcoma
Journal Articles

Abstract 663: YK-4-279 inhibits ERG and ETV1 mediated prostate cancer cell invasion

Said Rahim, Elspeth M. Beauchamp, Yali Kong, Milton L. Brown, Jeffrey A. Toretsky, Aykut Üren
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 663.
https://doi.org/10.1158/1538-7445.AM2011-663
Published: 15 April 2011
View articletitled, Abstract 663: YK-4-279 inhibits ERG and ETV1 mediated prostate cancer cell invasion
Journal Articles

Abstract 187: Dipeptidyl peptidases abolish growth inhibitory effect of neuropeptide Y in Ewing's sarcoma family of tumors

Congyi Lu, Lindsay Everhart, Jason U. Tilan, Magdalena Czarnecka, Jailan Hanafy, Dima Jeha, Jeffrey A. Toretsky, Joanna B. Kitlinska
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 187.
https://doi.org/10.1158/1538-7445.AM2011-187
Published: 15 April 2011
View articletitled, Abstract 187: Dipeptidyl peptidases abolish growth inhibitory effect of neuropeptide Y in Ewing's sarcoma family of tumors
Journal Articles

Abstract 4328: Beta-catenin accelerates human papillomavirus type16 -E7 mediated cervical carcinogenesis in transgenic mice

Gülay Bulut, Shannon Fallen, Elspeth M. Beauchamp, Lauren E. Drebing, Junfeng Sun, Deborah L. Berry, Bhaskar Kallakury, Christopher P. Crum, Jeffrey A. Toretsky, Richard Schlegel, Aykut Üren
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 4328.
https://doi.org/10.1158/1538-7445.AM2011-4328
Published: 15 April 2011
View articletitled, Abstract 4328: Beta-catenin accelerates human papillomavirus type16 -E7 mediated cervical carcinogenesis in transgenic mice
Journal Articles

Abstract 4505: Development of small molecules to target ezrin as anti-metastatic agents

Gülay Bulut, Sung-Hyeok Hong, Kevin Chen, Said Rahim, George W. Kosturko, Elspeth M. Beauchamp, Eric Glasgow, Jeffrey A. Toretsky, Chand Khanna, Aykut Uren
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 4505.
https://doi.org/10.1158/1538-7445.AM2011-4505
Published: 15 April 2011
View articletitled, Abstract 4505: Development of small molecules to target ezrin as anti-metastatic agents
Journal Articles

Abstract 3897: EWS-FLI1 is regulated by acetylation

Silke Schlottmann, Hayriye V. Erkizan, Julie Barber-Rotenberg, Aykut Uren, Maria L. Avantaggiati, Jeffrey A. Toretsky
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 3897.
https://doi.org/10.1158/1538-7445.AM10-3897
Published: 15 April 2010
View articletitled, Abstract 3897: EWS-FLI1 is regulated by acetylation
Journal Articles

Abstract 1550: Small molecule inhibitors of ezrin as anti-metastatic agents in osteosarcoma

Gulay Bulut, Kevin Chen, Eric Glasgow, Sung-Hyeok Hong, Hyun-Shik Lee, George Kosturko, Jeffrey A. Toretsky, Ira Daar, Chand Khanna, Aykut Uren
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 1550.
https://doi.org/10.1158/1538-7445.AM10-1550
Published: 15 April 2010
View articletitled, Abstract 1550: Small molecule inhibitors of ezrin as anti-metastatic agents in osteosarcoma
Journal Articles

Abstract 3412: Phage display identifies novel toxic binding peptides for the disordered oncoprotein EWS-FLI1

Lauren M. Jacobwitz, Hayriye V. Erkizan, Aykut Üren, Jeffrey A. Toretsky
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 3412.
https://doi.org/10.1158/1538-7445.AM10-3412
Published: 15 April 2010
View articletitled, Abstract 3412: Phage display identifies novel toxic binding peptides for the disordered oncoprotein EWS-FLI1
Journal Articles

Abstract 3409: Arsenic trioxide inhibits Ewing sarcoma growth by blocking Hedgehog/GLI pathway

Elspeth M. Beauchamp, Olga Rodriguez, Christopher Albanese, Jeffrey A. Toretsky, Aykut Üren
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 3409.
https://doi.org/10.1158/1538-7445.AM10-3409
Published: 15 April 2010
View articletitled, Abstract 3409: Arsenic trioxide inhibits Ewing sarcoma growth by blocking Hedgehog/GLI pathway