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Jeffrey A. Moscow
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Journal Articles

A Pan-Cancer Patient-Derived Xenograft Histology Image Repository with Genomic and Pathologic Annotations Enables Deep Learning Analysis

Brian S. White, Xing Yi Woo, Soner Koc, Todd Sheridan, Steven B. Neuhauser, Shidan Wang, Yvonne A. Evrard, Li Chen, Ali Foroughi pour, John D. Landua, R. Jay Mashl, Sherri R. Davies, Bingliang Fang, Maria Gabriela Raso, Kurt W. Evans, Matthew H. Bailey, Yeqing Chen, Min Xiao, Jill C. Rubinstein, Brian J. Sanderson, Michael W. Lloyd, Sergii Domanskyi, Lacey E. Dobrolecki, Maihi Fujita, Junya Fujimoto, Guanghua Xiao, Ryan C. Fields, Jacqueline L. Mudd, Xiaowei Xu, Melinda G. Hollingshead, Shahanawaz Jiwani, Saul Acevedo, PDXNet Consortium, Brandi N. Davis-Dusenbery, Peter N. Robinson, Jeffrey A. Moscow, James H. Doroshow, Nicholas Mitsiades, Salma Kaochar, Chong-xian Pan, Luis G. Carvajal-Carmona, Alana L. Welm, Bryan E. Welm, Ramaswamy Govindan, Shunqiang Li, Michael A. Davies, Jack A. Roth, Funda Meric-Bernstam, Yang Xie, Meenhard Herlyn, Li Ding, Michael T. Lewis, Carol J. Bult, Dennis A. Dean, II, Jeffrey H. Chuang
Journal: Cancer Research
Cancer Res (2024) 84 (13): 2060–2072.
https://doi.org/10.1158/0008-5472.CAN-23-1349
Published: 02 July 2024
View articletitled, A Pan-Cancer Patient-Derived Xenograft Histology Image Repository with Genomic and Pathologic Annotations Enables Deep Learning Analysis
Open the PDF for A Pan-Cancer Patient-Derived Xenograft Histology Image Repository with Genomic and Pathologic Annotations Enables Deep Learning Analysis in another window
Includes: Supplementary data
Journal Articles

Combining the Tyrosine Kinase Inhibitor Cabozantinib and the mTORC1/2 Inhibitor Sapanisertib Blocks ERK Pathway Activity and Suppresses Tumor Growth in Renal Cell Carcinoma

Yige Wu, Siqi Chen, Xiaolu Yang, Kazuhito Sato, Preet Lal, Yuefan Wang, Andrew T. Shinkle, Michael C. Wendl, Tina M. Primeau, Yanyan Zhao, Alanna Gould, Hua Sun, Jacqueline L. Mudd, Jeremy Hoog, R. Jay Mashl, Matthew A. Wyczalkowski, Chia-Kuei Mo, Ruiyang Liu, John M. Herndon, Sherri R. Davies, Di Liu, Xi Ding, Yvonne A. Evrard, Bryan E. Welm, David Lum, Mei Yee Koh, Alana L. Welm, Jeffrey H. Chuang, Jeffrey A. Moscow, Funda Meric-Bernstam, Ramaswamy Govindan, Shunqiang Li, James Hsieh, Ryan C. Fields, Kian-Huat Lim, Cynthia X. Ma, Hui Zhang, Li Ding, Feng Chen
Journal: Cancer Research
Cancer Res (2023) 83 (24): 4161–4178.
https://doi.org/10.1158/0008-5472.CAN-23-0604
Published: 15 December 2023
View articletitled, Combining the Tyrosine Kinase Inhibitor Cabozantinib and the mTORC1/2 Inhibitor Sapanisertib Blocks ERK Pathway Activity and Suppresses Tumor Growth in Renal Cell Carcinoma
Open the PDF for Combining the Tyrosine Kinase Inhibitor Cabozantinib and the mTORC1/2 Inhibitor Sapanisertib Blocks ERK Pathway Activity and Suppresses Tumor Growth in Renal Cell Carcinoma in another window
Includes: Supplementary data
Journal Articles

Abstract 4555: Aryl-hydrocarbon receptor inhibitors in combination with anticancer agents, especially proteasome pathway inhibitors, in a complex spheroid screen using patient-derived cell lines can result in greater-than additive cytotoxicity

BEVERLY A. TEICHER, Jeffrey A. Moscow, Joel Morris, James H. Doroshow, Thomas S. Dexheimer, Nathan P. Coussens, Thomas Silvers, Rene Delosh, Zahra Davoudi, Russel Reinhart, Chad Ogle, Eric Jones
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4555.
https://doi.org/10.1158/1538-7445.AM2023-4555
Published: 04 April 2023
View articletitled, Abstract 4555: Aryl-hydrocarbon receptor inhibitors in combination with anticancer agents, especially proteasome pathway inhibitors, in a complex spheroid screen using patient-derived cell lines can result in greater-than additive cytotoxicity
Journal Articles

Abstract 5407: A pan-cancer PDX histology image repository with genomic and pathological annotations for deep learning analysis

Brian S. White, Xing Yi Woo, Soner Koc, Todd Sheridan, Steven B. Neuhauser, Shidan Wang, Yvonne A. Evrard, John David Landua, R Jay Mashl, Sherri R. Davies, Bingliang Fang, Maria Gabriela Raso, Kurt W. Evans, Matthew H. Bailey, Yeqing Chen, Min Xiao, Jill Rubinstein, Ali Foroughi pour, Lacey Elizabeth Dobrolecki, Maihi Fujita, Junya Fujimoto, Guanghua Xiao, Ryan C. Fields, Jacqueline L. Mudd, Xiaowei Xu, Melinda G. Hollingshead, Shahanawaz Jiwani, PDXNet consortium, Tiffany A. Wallace, Jeffrey A. Moscow, James H. Doroshow, Nicholas Mitsiades, Salma Kaochar, Chong-xian Pan, Moon S. Chen, Luis G. Carvajal-Carmona, Alana L. Welm, Bryan E. Welm, Ramaswamy Govindan, Shunqiang Li, Michael A. Davies, Jack A. Roth, Funda Meric-Bernstam, Yang Xie, Meenhard Herlyn, Li Ding, Michael T. Lewis, Carol J. Bolt, Dennis A. Dean, Jeffrey H. Chuang
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5407.
https://doi.org/10.1158/1538-7445.AM2023-5407
Published: 04 April 2023
View articletitled, Abstract 5407: A pan-cancer PDX histology image repository with genomic and pathological annotations for deep learning analysis
Journal Articles

Abstract 2665: Biochemical inhibition profiles of 370 wild type human kinases provide a basis for selecting alternative combinations of EGFR and VEGFR inhibitors

Nathan P. Coussens, Thomas S. Dexheimer, Thomas Silvers, Shannon Uzelac, Kyle Georgius, John Carter, Tia Shearer, Rekha Rao, Karen Gray, Apurva K. Srivastava, Robert J. Kinders, Yvonne A. Evrard, Melinda G. Hollingshead, Joel Morris, Jeffrey A. Moscow, Ralph E. Parchment, Beverly A. Teicher, James H. Doroshow
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 2665.
https://doi.org/10.1158/1538-7445.AM2023-2665
Published: 04 April 2023
View articletitled, Abstract 2665: Biochemical inhibition profiles of 370 wild type human kinases provide a basis for selecting alternative combinations of EGFR and VEGFR inhibitors
Journal Articles

Abstract 1202: A repository of PDX histology images for exploring spatial heterogeneity and cancer dynamics

Brian S. White, Xingyi Woo, Soner Koc, Todd Sheridan, Steven B. Neuhauser, Akshat M. Savaliya, Lacey E. Dobrolecki, John D. Landua, Matthew H. Bailey, Maihi Fujita, Kurt W. Evans, Bingliang Fang, Junya Fujimoto, Maria Gabriela Raso, Shidan Wang, Guanghua Xiao, Yang Xie, Sherri R. Davies, Ryan C. Fields, R Jay Mashl, Jacqueline L. Mudd, Yeqing Chen, Min Xiao, Xiaowei Xu, Melinda G. Hollingshead, Shahanawaz Jiwani, PDXNet Consortium, Yvonne A. Evrard, Tiffany A. Wallace, Jeffrey A. Moscow, James H. Doroshow, Nicholas Mitsiades, Salma Kaochar, Chong-xian Pan, Moon S. Chen, Luis G. Carvajal-Carmona, Alana L. Welm, Bryan E. Welm, Michael T. Lewis, Ramaswamy Govindan, Li Ding, Shunqiang Li, Meenhard Herlyn, Michael A. Davies, Jack A. Roth, Funda Meric-Bernstam, Carol J. Bult, Brandi Davis-Dusenbery, Dennis A. Dean, Jeffrey H. Chuang
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1202.
https://doi.org/10.1158/1538-7445.AM2022-1202
Published: 15 June 2022
View articletitled, Abstract 1202: A repository of PDX histology images for exploring spatial heterogeneity and cancer dynamics
Journal Articles

Abstract 3009: A systematic review of the tumor growth metrics of patient-derived xenograft (PDX) models in the literature and in NCI PDXNet centers

Dali Li, Min Jin Ha, Yvonne A. Evrard, Huiqin Chen, Lisa M. McShane, Jeffrey Grover, Jing Wang, Bingliang Fang, Timothy DiPeri, Michael T. Lewis, Lawrence Rubinstein, Jack A. Roth, Jeffrey H. Chuang, James H. Doroshow, Jeffrey A. Moscow, Funda Meric-Bernstam
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 3009.
https://doi.org/10.1158/1538-7445.AM2021-3009
Published: 01 July 2021
View articletitled, Abstract 3009: A systematic review of the tumor growth metrics of patient-derived xenograft (PDX) models in the literature and in NCI PDXNet centers
Journal Articles

Abstract 1072: Combination screening of DNA damaging agents temozolomide and trabectedin with inhibitors of DNA repair using a complex spheroid model with a panel of patient-derived and established tumor cell lines

Nathan P. Coussens, Ralph E. Parchment, Jeffrey A. Moscow, L. Austin Doyle, René Delosh, Julie Laudeman, Russell Reinhart, Chad Ogle, Thomas Silvers, Thomas S. Dexheimer, Joel Morris, Beverly A. Teicher, James H. Doroshow
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1072.
https://doi.org/10.1158/1538-7445.AM2021-1072
Published: 01 July 2021
View articletitled, Abstract 1072: Combination screening of DNA damaging agents temozolomide and trabectedin with inhibitors of DNA repair using a complex spheroid model with a panel of patient-derived and established tumor cell lines
Journal Articles

Abstract 1118: Absence of mouse-specific tumor evolution in patient-derived cancer xenografts

Jessica Giordano, Xing Yi Woo, Anuj Srivastava, Zi-Ming Zhao, Michael W. Lloyd, Roebi de Bruijn, Yun-Suhk Suh, Francesco Galimi, Andrea Bertotti, Adam Lafferty, Alice C. O'Farrell, Elodie Modave, Diether Lambrechts, Petra ter Brugge, Violeta Serra, Elisabetta Marangoni, Rania El Botty, Jong-Il Kim, Han-Kwang Yang, Charles Lee, Dennis A. Dean, Brandi Davis-Dusenbery, Yvonne A. Evrard, James H. Doroshow, Alana L. Welm, Bryan E. Welm, Michael T. Lewis, Bingliang Fang, Jack Roth, Funda Meric-Bernstam, Meenhard Herlyn, Michael Davies, Li Ding, Shunqiang Li, Ramaswamy Govindan, Jeffrey A. Moscow, Carol J. Bult, Claudio Isella, Livio Trusolino, Annette T. Byrne, Jos Jonkers, Jeffrey H. Chuang, Enzo Medico, EurOPDX consortium & PDXNET consortium
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 1118.
https://doi.org/10.1158/1538-7445.AM2020-1118
Published: 15 August 2020
View articletitled, Abstract 1118: Absence of mouse-specific tumor evolution in patient-derived cancer xenografts
Journal Articles

Abstract 1673: Conservation of copy number profiles during engraftment and passaging of patient-derived cancer xenografts

Xing Yi Woo, Jessica Giordano, Anuj Srivastava, Zi-Ming Zhao, Michael W. Lloyd, Roebi de Bruijn, Yun-Suhk Suh, Jong-Il Kim, Han-Kwang Yang, Charles Lee, Dennis A. Dean, Brandi Davis-Dusenbery, Yvonne A. Evrard, James H. Doroshow, Alana L. Welm, Bryan Welm, Michael T. Lewis, Bingliang Fang, Jack A. Roth, Funda Meric-Bernstam, Meenhard Herlyn, Michael Davies, Li Ding, Shunqiang Li, Ramaswamy Govindan, Claudio Isella, Jeffrey A. Moscow, Livio Trusolino, Annette Byrne, Jos Jonkers, Carol J. Bult, Enzo Medico, Jeffrey H. Chuang, PDXNET consortium & EurOPDX consortium
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 1673.
https://doi.org/10.1158/1538-7445.AM2020-1673
Published: 15 August 2020
View articletitled, Abstract 1673: Conservation of copy number profiles during engraftment and passaging of patient-derived cancer xenografts
Journal Articles

Abstract 1074: The PDX Data Commons and Coordinating Center (PDCCC) for PDXNet in support of preclinical research

Jacqueline Rosains, Anuj Srivastava, Wingyi Woo, Vishal Sarsani, ZiMing Zhao, Javad Noorbakhsh, Ogan D. Abaan, Christian Frech, Jack DiGiovanna, Ryan Jeon, Steve Neuhauser, Peter Robinson, Yvonne A. Evrard, Carol Bult, Jeffrey A. Moscow, Brandi Davis-Dusenbery, Jeffrey H. Chuang
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 1074.
https://doi.org/10.1158/1538-7445.AM2019-1074
Published: 01 July 2019
View articletitled, Abstract 1074: The PDX Data Commons and Coordinating Center (PDCCC) for PDXNet in support of preclinical research
Journal Articles

Abstract 1029: The PDX Data Commons and Coordinating Center (PDCCC) for PDXNet

Anurag Sethi, Anuj Srivastava, Xingyi Woo, Vishal Sarsani, Ziming Zhao, Javad Noorbakhsh, Christian French, Jack DiGiovanna, Ogan D. Abaan, Steve Neuhauser, Peter Robinson, Yvonne A. Evrard, Carol J. Bult, Jeffrey A. Moscow, Brandi Davis-Dusenbery, Jeffrey H. Chuang
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1029.
https://doi.org/10.1158/1538-7445.AM2018-1029
Published: 01 July 2018
View articletitled, Abstract 1029: The PDX Data Commons and Coordinating Center (PDCCC) for PDXNet
Journal Articles

Abstract 1439: Asparagine stimulates growth and endoplasmic reticulum stress response in a fumarate hydratase-deficient renal cell carcinoma cell line

Rony Panarsky, Youfeng Yang, W. Marston Linehan, Jeffrey A. Moscow
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1439.
https://doi.org/10.1158/1538-7445.AM2018-1439
Published: 01 July 2018
View articletitled, Abstract 1439: Asparagine stimulates growth and endoplasmic reticulum stress response in a fumarate hydratase-deficient renal cell carcinoma cell line
Journal Articles

Abstract 35: Metabolomic analysis of MCF-7 and MCF-10 cells after thiaminase I exposure

Adam D. Richardson, Shuqian Liu, Jeffrey A. Moscow
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 35.
https://doi.org/10.1158/1538-7445.AM10-35
Published: 15 April 2010
View articletitled, Abstract 35: Metabolomic analysis of MCF-7 and MCF-10 cells after thiaminase I exposure
Journal Articles

Human rRNA Gene Clusters Are Recombinational Hotspots in Cancer

Dawn M. Stults, Michael W. Killen, Erica P. Williamson, Jon S. Hourigan, H. David Vargas, Susanne M. Arnold, Jeffrey A. Moscow, Andrew J. Pierce
Journal: Cancer Research
Cancer Res (2009) 69 (23): 9096–9104.
https://doi.org/10.1158/0008-5472.CAN-09-2680
Published: 30 November 2009
View articletitled, Human rRNA Gene Clusters Are Recombinational Hotspots in Cancer
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Journal Articles

Organic anion transporting polypeptide gene expression imparts selective sensitivity to the cytotoxic effects of microcystins.

Noel R. Monks, Shuqian Liu, Hui Yu, Adam S. Bendelow, Jeffrey A. Moscow
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 1283.
Published: 15 April 2006
View articletitled, Organic anion transporting polypeptide gene expression imparts selective sensitivity to the cytotoxic effects of microcystins.
Journal Articles

Response to thiamine starvation in breast cancer cells

Shuqian Liu, Noel R. Monks, Hui Yu, Jeffrey A. Moscow
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 1099.
Published: 15 April 2006
View articletitled, Response to thiamine starvation in breast cancer cells
Journal Articles

Thiamine transporter gene expression and exogenous thiamine modulate expression of genes in breast and lung cancers

Shuqian Liu, Arnold Stromberg, Hsin-Hsiung Tai, Jeffrey A. Moscow
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 316.
Published: 01 April 2004
View articletitled, Thiamine transporter gene expression and exogenous thiamine modulate expression of genes in breast and lung cancers
Journal Articles

Isolation of a Gene Encoding a Human Reduced Folate Carrier (RFC1) and Analysis of Its Expression in Transport-deficient, Methotrexate-resistant Human Breast Cancer Cells

Jeffrey A. Moscow, Maokai Gong, Rui He, Magdalene K. Sgagias, Katharine H. Dixon, Sarah L. Anzick, Paul S. Meltzer, Kenneth H. Cowan
Journal: Cancer Research
Cancer Res (1995) 55 (17): 3790–3794.
Published: 01 September 1995
View articletitled, Isolation of a Gene Encoding a Human Reduced Folate Carrier (RFC1) and Analysis of Its Expression in Transport-deficient, Methotrexate-resistant Human Breast Cancer Cells
Open the PDF for Isolation of a Gene Encoding a Human Reduced Folate Carrier (RFC1) and Analysis of Its Expression in Transport-deficient, Methotrexate-resistant Human Breast Cancer Cells in another window
Journal Articles

Expression of Anionic Glutathione-S-transferase and P-Glycoprotein Genes in Human Tissues and Tumors

Jeffrey A. Moscow, Craig R. Fairchild, Mary Jane Madden, David T. Ransom, Harry S. Wieand, Erin E. O'Brien, David G. Poplack, Jeffrey Cossman, Charles E. Myers, Kenneth H. Cowan
Journal: Cancer Research
Cancer Res (1989) 49 (6): 1422–1428.
Published: 01 March 1989
View articletitled, Expression of Anionic Glutathione-S-transferase and P-Glycoprotein Genes in Human Tissues and Tumors
Open the PDF for Expression of Anionic Glutathione-S-transferase and P-Glycoprotein Genes in Human Tissues and Tumors in another window