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Jeffrey A. Knauf
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Journal Articles

Abstract 986: RBM10 loss in thyroid cancer leads to aberrant splicing of cytoskeletal and extracellular matrix mRNAs and increased metastatic fitness

Free
Gnana P. Krishnamoorthy, Anthony Glover, Brian Untch, Mahesh Saqcena, Dina Vukel, Katherine Berman, Omar Abdel-Wahab, Robert K. Bradley, Jeffrey A. Knauf, James A. Fagin
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 986.
https://doi.org/10.1158/1538-7445.AM2022-986
Published: 15 June 2022
View articletitled, Abstract 986: RBM10 loss in thyroid cancer leads to aberrant splicing of cytoskeletal and extracellular matrix mRNAs and increased metastatic fitness
Journal Articles

Abstract 913: Tert mutant promoter mouse model induces cancer progression in BrafV600E-driven thyroid tumors: A novel tool to understand the biology of telomerase-reactivated cancers

Free
Inigo Landa, Jingzhu Hao, Bin Xu, Joseph Giacalone, Zach Herbert, Maria A. Blasco, Jeffrey A. Knauf, Ronald Ghossein, James A. Fagin
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 913.
https://doi.org/10.1158/1538-7445.AM2022-913
Published: 15 June 2022
View articletitled, Abstract 913: Tert mutant promoter mouse model induces cancer progression in BrafV600E-driven thyroid tumors: A novel tool to understand the biology of telomerase-reactivated cancers
Journal Articles

Tipifarnib Inhibits HRAS-Driven Dedifferentiated Thyroid Cancers

Free
Brian R. Untch, Vanessa Dos Anjos, Maria E.R. Garcia-Rendueles, Jeffrey A. Knauf, Gnana P. Krishnamoorthy, Mahesh Saqcena, Umeshkumar K. Bhanot, Nicholas D. Socci, Alan L. Ho, Ronald Ghossein, James A. Fagin
Journal: Cancer Research
Cancer Res (2018) 78 (16): 4642–4657.
https://doi.org/10.1158/0008-5472.CAN-17-1925
Published: 14 August 2018
View articletitled, Tipifarnib Inhibits HRAS-Driven Dedifferentiated Thyroid Cancers
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Journal Articles

Abstract 892: Functional characterization of EIF1AX mutations in thyroid cancer predicts for gain of function by increasing translational rate with concomitant derepression of upstream inputs from mTOR

Free
Gnana P. Krishnamoorthy, Inigo Landa, Jeffrey A. Knauf, James Nagarajah, Gunnar Rätsch, Hans-Guido Wendel, James A. Fagin
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 892.
https://doi.org/10.1158/1538-7445.AM2016-892
Published: 15 July 2016
View articletitled, Abstract 892: Functional characterization of EIF1AX mutations in thyroid cancer predicts for gain of function by increasing translational rate with concomitant derepression of upstream inputs from mTOR
Journal Articles

Abstract 3402: Relief of feedback inhibition of HER3 transcription by RAF and MEK inhibitors attenuates their antitumor effects in BRAF mutant thyroid carcinomas.

Free
Cristina Montero-Conde, Sergio Ruiz-Llorente, Jose M. Dominguez, Jeffrey A. Knauf, Agnes Viale, Eric J. Sherman, Mabel Ryder, Ronald A. Ghossein, Neal Rosen, James A. Fagin
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 3402.
https://doi.org/10.1158/1538-7445.AM2013-3402
Published: 15 April 2013
View articletitled, Abstract 3402: Relief of feedback inhibition of HER3 transcription by RAF and MEK inhibitors attenuates their antitumor effects in BRAF mutant thyroid carcinomas.
Journal Articles

Proto-oncogene PBF/PTTG1IP Regulates Thyroid Cell Growth and Represses Radioiodide Treatment

Free
Martin L. Read, Greg D. Lewy, Jim C.W. Fong, Neil Sharma, Robert I. Seed, Vicki E. Smith, Erica Gentilin, Adrian Warfield, Margaret C. Eggo, Jeffrey A. Knauf, Wendy E. Leadbeater, John C. Watkinson, Jayne A. Franklyn, Kristien Boelaert, Christopher J. McCabe
Journal: Cancer Research
Cancer Res (2011) 71 (19): 6153–6164.
https://doi.org/10.1158/0008-5472.CAN-11-0720
Published: 29 September 2011
View articletitled, Proto-oncogene PBF/PTTG1IP Regulates Thyroid Cell Growth and Represses Radioiodide Treatment
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Includes: Supplementary data
Journal Articles

Abstract 4290: The farnesyl transferase inhibitor SCH 66336 induces regression of Hras-driven tumors in mice with widespread endogenous expression of HrasG12V

Free
Xu Chen, Linda K. Johnson, Jeffrey A. Knauf, James A. Fagin
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 4290.
https://doi.org/10.1158/1538-7445.AM2011-4290
Published: 15 April 2011
View articletitled, Abstract 4290: The farnesyl transferase inhibitor SCH 66336 induces regression of Hras-driven tumors in mice with widespread endogenous expression of HrasG12V
Journal Articles

Mutational Profile of Advanced Primary and Metastatic Radioactive Iodine-Refractory Thyroid Cancers Reveals Distinct Pathogenetic Roles for BRAF, PIK3CA, and AKT1

Free
Julio C. Ricarte-Filho, Mabel Ryder, Dhananjay A. Chitale, Michael Rivera, Adriana Heguy, Marc Ladanyi, Manickam Janakiraman, David Solit, Jeffrey A. Knauf, R. Michael Tuttle, Ronald A. Ghossein, James A. Fagin
Journal: Cancer Research
Cancer Res (2009) 69 (11): 4885–4893.
https://doi.org/10.1158/0008-5472.CAN-09-0727
Published: 01 June 2009
View articletitled, Mutational Profile of Advanced Primary and Metastatic Radioactive Iodine-Refractory Thyroid Cancers Reveals Distinct Pathogenetic Roles for BRAF, PIK3CA, and AKT1
Open the PDF for Mutational Profile of Advanced Primary and Metastatic Radioactive Iodine-Refractory Thyroid Cancers Reveals Distinct Pathogenetic Roles for BRAF, PIK3CA, and AKT1 in another window
Includes: Supplementary data
Journal Articles

RET/PTC-Induced Cell Growth Is Mediated in Part by Epidermal Growth Factor Receptor (EGFR) Activation: Evidence for Molecular and Functional Interactions between RET and EGFR

Free
Michelle Croyle, Nagako Akeno, Jeffrey A. Knauf, Doriano Fabbro, Xu Chen, Jacqueline E. Baumgartner, Heidi A. Lane, James A. Fagin
Journal: Cancer Research
Cancer Res (2008) 68 (11): 4183–4191.
https://doi.org/10.1158/0008-5472.CAN-08-0413
Published: 02 June 2008
View articletitled, RET/PTC-Induced Cell Growth Is Mediated in Part by Epidermal Growth Factor Receptor (EGFR) Activation: Evidence for Molecular and Functional Interactions between RET and EGFR
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Journal Articles

The RET Kinase Inhibitor NVP-AST487 Blocks Growth and Calcitonin Gene Expression through Distinct Mechanisms in Medullary Thyroid Cancer Cells

Free
Nagako Akeno-Stuart, Michelle Croyle, Jeffrey A. Knauf, Roberta Malaguarnera, Donata Vitagliano, Massimo Santoro, Christine Stephan, Konstantina Grosios, Markus Wartmann, Robert Cozens, Giorgio Caravatti, Doriano Fabbro, Heidi A. Lane, James A. Fagin
Journal: Cancer Research
Cancer Res (2007) 67 (14): 6956–6964.
https://doi.org/10.1158/0008-5472.CAN-06-4605
Published: 17 July 2007
View articletitled, The RET Kinase Inhibitor NVP-AST487 Blocks Growth and Calcitonin Gene Expression through Distinct Mechanisms in Medullary Thyroid Cancer Cells
Open the PDF for The RET Kinase Inhibitor NVP-AST487 Blocks Growth and Calcitonin Gene Expression through Distinct Mechanisms in Medullary Thyroid Cancer Cells in another window
Journal Articles

Conditional Activation of RET/PTC3 and BRAFV600E in Thyroid Cells Is Associated with Gene Expression Profiles that Predict a Preferential Role of BRAF in Extracellular Matrix Remodeling

Free
Cleo Mesa, Jr., Mana Mirza, Norisato Mitsutake, Maureen Sartor, Mario Medvedovic, Craig Tomlinson, Jeffrey A Knauf, Georg F. Weber, James A. Fagin
Journal: Cancer Research
Cancer Res (2006) 66 (13): 6521–6529.
https://doi.org/10.1158/0008-5472.CAN-06-0739
Published: 03 July 2006
View articletitled, Conditional Activation of RET/PTC3 and BRAFV600E in Thyroid Cells Is Associated with Gene Expression Profiles that Predict a Preferential Role of BRAF in Extracellular Matrix Remodeling
Open the PDF for Conditional Activation of RET/PTC3 and BRAFV600E in Thyroid Cells Is Associated with Gene Expression Profiles that Predict a Preferential Role of BRAF in Extracellular Matrix Remodeling in another window
Journal Articles

Targeted Expression of BRAFV600E in Thyroid Cells of Transgenic Mice Results in Papillary Thyroid Cancers that Undergo Dedifferentiation

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Jeffrey A. Knauf, Xiaolan Ma, Eric P. Smith, Lei Zhang, Norisato Mitsutake, Xiao-Hui Liao, Samuel Refetoff, Yuri E. Nikiforov, James A. Fagin
Journal: Cancer Research
Cancer Res (2005) 65 (10): 4238–4245.
https://doi.org/10.1158/0008-5472.CAN-05-0047
Published: 16 May 2005
View articletitled, Targeted Expression of BRAFV600E in Thyroid Cells of Transgenic Mice Results in Papillary Thyroid Cancers that Undergo Dedifferentiation
Open the PDF for Targeted Expression of BRAFV600E in Thyroid Cells of Transgenic Mice Results in Papillary Thyroid Cancers that Undergo Dedifferentiation in another window
Journal Articles

Conditional BRAFV600E Expression Induces DNA Synthesis, Apoptosis, Dedifferentiation, and Chromosomal Instability in Thyroid PCCL3 Cells

Free
Norisato Mitsutake, Jeffrey A. Knauf, Shin Mitsutake, Cleo Mesa, Jr., Lei Zhang, James A. Fagin
Journal: Cancer Research
Cancer Res (2005) 65 (6): 2465–2473.
https://doi.org/10.1158/0008-5472.CAN-04-3314
Published: 21 March 2005
View articletitled, Conditional BRAFV600E Expression Induces DNA Synthesis, Apoptosis, Dedifferentiation, and Chromosomal Instability in Thyroid PCCL3 Cells
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Journal Articles

High Prevalence of BRAF Mutations in Thyroid Cancer: Genetic Evidence for Constitutive Activation of the RET/PTC-RAS-BRAF Signaling Pathway in Papillary Thyroid Carcinoma

Free
Edna T. Kimura, Marina N. Nikiforova, Zhaowen Zhu, Jeffrey A. Knauf, Yuri E. Nikiforov, James A. Fagin
Journal: Cancer Research
Cancer Res (2003) 63 (7): 1454–1457.
Published: 01 April 2003
View articletitled, High Prevalence of BRAF Mutations in Thyroid Cancer: Genetic Evidence for Constitutive Activation of the RET/PTC-RAS-BRAF Signaling Pathway in Papillary Thyroid Carcinoma
Open the PDF for High Prevalence of BRAF Mutations in Thyroid Cancer: Genetic Evidence for Constitutive Activation of the RET/PTC-RAS-BRAF Signaling Pathway in Papillary Thyroid Carcinoma in another window