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Journal Articles

A Single-Step, High-Dose Selection Scheme Reveals Distinct Mechanisms of Acquired Resistance to Oncogenic Kinase Inhibition in Cancer Cells

Kenneth J. Finn, Scott E. Martin, Jeff Settleman

Cancer Res (2020) 80 (1): 79–90.

https://doi.org/10.1158/0008-5472.CAN-19-0729

Published: 03 January 2020

View articletitled, A Single-Step, High-Dose Selection Scheme Reveals Distinct Mechanisms of Acquired Resistance to Oncogenic Kinase Inhibition in Cancer Cells

Includes: Supplementary data

Journal Articles

Abstract A1-19: A comprehensive transcriptional portrait of human cancer cell lines

Christiaan Klijn, Jeff Settleman, Somasekar Seshagiri, Zemin Zhang

Cancer Res (2015) 75 (22_Supplement_1): A1-19.

https://doi.org/10.1158/1538-7445.TRANSCAGEN-A1-19

Published: 15 November 2015

View articletitled, Abstract A1-19: A comprehensive transcriptional portrait of human cancer cell lines

Journal Articles

Abstract NG08: Transcriptional mechanisms for autophagy regulation and metabolic reprogramming in pancreatic cancer

Rushika M. Perera, Svetlana Stoykova, Brandon N. Nicolay, Kenneth N. Ross, Julien Fitamant, Myriam Boukhali, Vikram Deshpande, Martin K. Selig, Cristina R. Ferrone, Jeff Settleman, Gregory Stephanopoulos, Nicholas J. Dyson, Roberto Zoncu, Sridhar Ramaswamy, Wilhelm Haas, Nabeel M. Bardeesy

Cancer Res (2015) 75 (15_Supplement): NG08.

https://doi.org/10.1158/1538-7445.AM2015-NG08

Published: 01 August 2015

View articletitled, Abstract NG08: Transcriptional mechanisms for autophagy regulation and metabolic reprogramming in pancreatic cancer

Journal Articles

AXL Inhibition Sensitizes Mesenchymal Cancer Cells to Antimitotic Drugs

Catherine Wilson, Xiaofen Ye, Thinh Pham, Eva Lin, Sara Chan, Erin McNamara, Richard M. Neve, Lisa Belmont, Hartmut Koeppen, Robert L. Yauch, Avi Ashkenazi, Jeff Settleman

Cancer Res (2014) 74 (20): 5878–5890.

https://doi.org/10.1158/0008-5472.CAN-14-1009

Published: 14 October 2014

View articletitled, AXL Inhibition Sensitizes Mesenchymal Cancer Cells to Antimitotic Drugs

Includes: Multimedia, Supplementary data

Journal Articles

Abstract LB-209: Chromatin condensation in KRAS-mutant lung cancer as a therapeutic target: challenging the paradigm of associating KRAS mutation with EGFR inhibitor resistance

Meng Wang, Ashley M. Kern, Marieke Hülskötter, Patricia Greninger, Anurag Singh, Yunfeng Pan, Dipanjan Chowdhury, Mechthild Krause, Michael Baumann, Cyril H. Benes, Jason A. Efstathiou, Jeff Settleman, Henning Willers

Cancer Res (2014) 74 (19_Supplement): LB-209.

https://doi.org/10.1158/1538-7445.AM2014-LB-209

Published: 01 October 2014

View articletitled, Abstract LB-209: Chromatin condensation in KRAS-mutant lung cancer as a therapeutic target: challenging the paradigm of associating KRAS mutation with EGFR inhibitor resistance

Journal Articles

Abstract 1430: Identification of distinct metabolic subtypes within pancreatic ductal adenocarcinoma through broad metabolite profiling

Anneleen Daemen, David Peterson, Nisebita Sahu, Ron McCord, Kaska Kowanetz, Anna Hitz, Xiangnan Du, Bonnie Liu, Min Gao, John Moffat, Rebecca Hong, Deepak Sampath, Mark Merchant, Thomas O'Brien, Bob Yauch, Jeff Settleman, Jing Qing, Georgia Hatzivassiliou, Marie A. Evangelista

Cancer Res (2014) 74 (19_Supplement): 1430.

https://doi.org/10.1158/1538-7445.AM2014-1430

Published: 01 October 2014

View articletitled, Abstract 1430: Identification of distinct metabolic subtypes within pancreatic ductal adenocarcinoma through broad metabolite profiling

Journal Articles

Abstract 2631: Neuregulin-1 expression correlates with sensitivity to the PI3K inhibitor, GDC-0032, outside of PIK3CA mutations in head and neck cancer

Heidi M. Savage, Carol O'Brien, Bob Yauch, Jeff Settleman, Mark R. Lackner, Timothy R. Wilson

Cancer Res (2014) 74 (19_Supplement): 2631.

https://doi.org/10.1158/1538-7445.AM2014-2631

Published: 01 October 2014

View articletitled, Abstract 2631: Neuregulin-1 expression correlates with sensitivity to the PI3K inhibitor, GDC-0032, outside of PIK3CA mutations in head and neck cancer

Journal Articles

Abstract 693: AXL tyrosine kinase inhibition selectively sensitizes mesenchymal cancer cells to antimitotic agents

Catherine Wilson, Thinh Pham, Xiaofen Ye, Eva Lin, Sara Chan, Erin McNamara, Richard M. Neve, Lisa Belmont, Hartmut Koeppen, Robert L. Yauch, Avi Ashkenazi, Jeff Settleman

Cancer Res (2014) 74 (19_Supplement): 693.

https://doi.org/10.1158/1538-7445.AM2014-693

Published: 01 October 2014

View articletitled, Abstract 693: AXL tyrosine kinase inhibition selectively sensitizes mesenchymal cancer cells to antimitotic agents

Journal Articles

Abstract 4425: Drug resistance via feedback activation of Stat3 in oncogene-addicted cancer cells

Ho-June Lee, Guanglei Zhuang, Yi Cao, Pan Du, Hyo-Jin Kim, Jeff Settleman

Cancer Res (2014) 74 (19_Supplement): 4425.

https://doi.org/10.1158/1538-7445.AM2014-4425

Published: 01 October 2014

View articletitled, Abstract 4425: Drug resistance via feedback activation of Stat3 in oncogene-addicted cancer cells

Journal Articles

The Cancer Stem Cell Marker Aldehyde Dehydrogenase Is Required to Maintain a Drug-Tolerant Tumor Cell Subpopulation

Debasish Raha, Timothy R. Wilson, Jing Peng, David Peterson, Peng Yue, Marie Evangelista, Catherine Wilson, Mark Merchant, Jeff Settleman

Cancer Res (2014) 74 (13): 3579–3590.

https://doi.org/10.1158/0008-5472.CAN-13-3456

Published: 30 June 2014

View articletitled, The Cancer Stem Cell Marker Aldehyde Dehydrogenase Is Required to Maintain a Drug-Tolerant Tumor Cell Subpopulation

Includes: Supplementary data

Journal Articles

EGFR-Mediated Chromatin Condensation Protects KRAS-Mutant Cancer Cells against Ionizing Radiation

Cancer Res (2014) 74 (10): 2825–2834.

https://doi.org/10.1158/0008-5472.CAN-13-3157

Published: 14 May 2014

View articletitled, EGFR-Mediated Chromatin Condensation Protects KRAS-Mutant Cancer Cells against Ionizing Radiation

Includes: Supplementary data

Journal Articles

Abstract 4463: Activation of FGFR signaling as a mechanism of acquired resistance to erlotinib in EGFR-mutant lung cancer associated with an EMT.

Xiaofen Ye, Peng Yue, Rajesh Patel, Zora Modrusan, Jeff Settleman, Avi Ashkenazi, Robert L. Yauch

Cancer Res (2013) 73 (8_Supplement): 4463.

https://doi.org/10.1158/1538-7445.AM2013-4463

Published: 15 April 2013

View articletitled, Abstract 4463: Activation of FGFR signaling as a mechanism of acquired resistance to erlotinib in EGFR-mutant lung cancer associated with an EMT.

Journal Articles

Abstract LB-309: Non-covalent wild-type-sparing inhibitors of EGFR T790M .

Ho-June Lee, Gabriele Schaefer, Tim Heffron, Shiva Malek, Mark Merchant, Robert L. Yauch, Valentina Pirazzoli, Katerina Politi, Jeff Settleman

Cancer Res (2013) 73 (8_Supplement): LB-309.

https://doi.org/10.1158/1538-7445.AM2013-LB-309

Published: 15 April 2013

View articletitled, Abstract LB-309: Non-covalent wild-type-sparing inhibitors of EGFR T790M .

Journal Articles

Abstract LB-427: TAK1 (MAP3K7) inhibition promotes apoptosis in KRAS dependent colon cancers

Anurag Singh, Michael F. Sweeney, Min Yu, Alexa Burger, Patricia Greninger, Cyril Benes, Daniel A. Haber, Jeff Settleman

Cancer Res (2012) 72 (8_Supplement): LB-427.

https://doi.org/10.1158/1538-7445.AM2012-LB-427

Published: 15 April 2012

View articletitled, Abstract LB-427: TAK1 (MAP3K7) inhibition promotes apoptosis in KRAS dependent colon cancers

Journal Articles

Abstract 1615: Gene expression profile predicts response to smoothened inhibitors in epithelial cancers

Fabrizio Galimberti, Alex Busch, Fadzai Chinyengetere, Tian Ma, David Sekula, Vincent Memoli, Konstantin Dragnev, Fang Liu, Angeline S. Andrew, Patricia Greninger, David Robbins, Jeff Settleman, Cyril Benes, Ethan Dmitrovsky

Cancer Res (2011) 71 (8_Supplement): 1615.

https://doi.org/10.1158/1538-7445.AM2011-1615

Published: 15 April 2011

View articletitled, Abstract 1615: Gene expression profile predicts response to smoothened inhibitors in epithelial cancers

Journal Articles

Acquired Resistance of Non–Small Cell Lung Cancer Cells to MET Kinase Inhibition Is Mediated by a Switch to Epidermal Growth Factor Receptor Dependency

Ultan McDermott, Raju V. Pusapati, James G. Christensen, Nathanael S. Gray, Jeff Settleman

Cancer Res (2010) 70 (4): 1625–1634.

https://doi.org/10.1158/0008-5472.CAN-09-3620

Published: 14 February 2010

View articletitled, Acquired Resistance of Non–Small Cell Lung Cancer Cells to MET Kinase Inhibition Is Mediated by a Switch to Epidermal Growth Factor Receptor Dependency

Includes: Supplementary data

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A Single-Step, High-Dose Selection Scheme Reveals Distinct Mechanisms of Acquired Resistance to Oncogenic Kinase Inhibition in Cancer Cells

Abstract A1-19: A comprehensive transcriptional portrait of human cancer cell lines

Abstract NG08: Transcriptional mechanisms for autophagy regulation and metabolic reprogramming in pancreatic cancer

AXL Inhibition Sensitizes Mesenchymal Cancer Cells to Antimitotic Drugs

Abstract LB-209: Chromatin condensation in KRAS-mutant lung cancer as a therapeutic target: challenging the paradigm of associating KRAS mutation with EGFR inhibitor resistance

Abstract 1430: Identification of distinct metabolic subtypes within pancreatic ductal adenocarcinoma through broad metabolite profiling

Abstract 2631: Neuregulin-1 expression correlates with sensitivity to the PI3K inhibitor, GDC-0032, outside of PIK3CA mutations in head and neck cancer

Abstract 693: AXL tyrosine kinase inhibition selectively sensitizes mesenchymal cancer cells to antimitotic agents

Abstract 4425: Drug resistance via feedback activation of Stat3 in oncogene-addicted cancer cells

The Cancer Stem Cell Marker Aldehyde Dehydrogenase Is Required to Maintain a Drug-Tolerant Tumor Cell Subpopulation

EGFR-Mediated Chromatin Condensation Protects KRAS-Mutant Cancer Cells against Ionizing Radiation

Abstract 4463: Activation of FGFR signaling as a mechanism of acquired resistance to erlotinib in EGFR-mutant lung cancer associated with an EMT.

Abstract LB-309: Non-covalent wild-type-sparing inhibitors of EGFR T790M .

Abstract LB-427: TAK1 (MAP3K7) inhibition promotes apoptosis in KRAS dependent colon cancers

Abstract 1615: Gene expression profile predicts response to smoothened inhibitors in epithelial cancers

Acquired Resistance of Non–Small Cell Lung Cancer Cells to MET Kinase Inhibition Is Mediated by a Switch to Epidermal Growth Factor Receptor Dependency

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