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Jean-Pierre J. Issa
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Journal Articles

Abstract 6265: Do epigenetic outliers impact racial disparities in colorectal cancer

Jayashri Ghosh, Bryant M. Schultz, Joe Chan, Claudia Wultsch, Imad Shureiqi, Stephanie Chow, Ahmet Doymaz, Sophia Varriano, Melissa Driscoll, Jen Muse, Frida E. Kleiman, Konstantinos Krampis, Jean-Pierre J. Issa, Carmen Sapienza
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 6265.
DOI: https://doi.org/10.1158/1538-7445.AM2022-6265
Published: 15 June 2022
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Abstract CT121: A Phase II trial of guadecitabine (G) plus atezolizumab (A) in patients with metastatic urothelial carcinoma (UC) progressing after initial checkpoint inhibitor therapy

Elizabeth R. Plimack, Kerry Campbell, Jean-Pierre J. Issa, Noah M. Hahn, David I. Quinn, Hyo Sik Jang, Galen Hostetter, Peter W. Nichols, Woonbok Chung, Jozef Madzo, Hitoshi Ohtani, Hui Shen, Toshinori Hinoue, Stephen B. Baylin, Peter A. Jones
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): CT121.
DOI: https://doi.org/10.1158/1538-7445.AM2021-CT121
Published: 01 July 2021
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Abstract LB-141: CIMP is associated with altered microbiota composition in colorectal cancer patients

Pyoung Hwa Park, Raad Z. Gharaibeh, Lauren Cole, Ang Sun, Woonbok Chung, Jaroslav Jelinek, Jillian L. Pope, Christian Jobin, Jean-Pierre J. Issa
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): LB-141.
DOI: https://doi.org/10.1158/1538-7445.AM2019-LB-141
Published: 01 July 2019
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Journal Articles

TET1-Mediated Hypomethylation Activates Oncogenic Signaling in Triple-Negative Breast Cancer

Charly Ryan Good, Shoghag Panjarian, Andrew D. Kelly, Jozef Madzo, Bela Patel, Jaroslav Jelinek, Jean-Pierre J. Issa
Journal: Cancer Research
Cancer Res (2018) 78 (15): 4126–4137.
DOI: https://doi.org/10.1158/0008-5472.CAN-17-2082
Published: 31 July 2018
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Includes: Supplementary data
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Abstract 2952: Targeting CDK9 reactivates epigenetically silenced genes in cancer

Hanghang Zhang, Somnath Pandey, Meghan Travers, Jittasak Khowsathit, George Morton, Hongxing Sum, Carlos A. Barrero, Carmen Merali, Yasuyuki Okamoto, Takahiro Sato, Judit Garriga, Natarajan V. Bhanu, Johayra Simithy, Bela Patel, Jozef Madzo, Noël Raynal, Benjamin A. Garcia, Marlene A. Jacobson, Salim Merali, Yi Zhang, Wayne Childers, Magid Abou-Gharbia, John Karanicolas, Stephen B. Baylin, Cynthia A. Zahnow, Jaroslav Jelinek, Xavier Graña, Jean-Pierre J. Issa
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 2952.
DOI: https://doi.org/10.1158/1538-7445.AM2018-2952
Published: 01 July 2018
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Abstract 4677: Integrated molecular profiles and guadecitabine response in relapsed/refractory acute myeloid leukemia

Woonbok Chung, Andrew D. Kelly, Patricia Kropf, Pietro Taverna, Sue Naim, Mohammad Azab, Jaroslav Jelinek, Hagop M. Kantarjian, Jean-Pierre J. Issa
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 4677.
DOI: https://doi.org/10.1158/1538-7445.AM2017-4677
Published: 01 July 2017
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Abstract 5064: Identifying novel potential epigenetic anti-cancer drugs from natural compounds using a phenotypic-based screening

Hanghang Zhang, Noël J.-M Raynal, Takahiro Sato, Yasuyuki Okamoto, Judith Garriga, Benjamin Garcia, George Morton, Wayne Childers, Marlene A. Jacobson, Stephen B. Baylin, Xavier Graña, Magid Abou-Gharbia, Jean-Pierre J. Issa
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 5064.
DOI: https://doi.org/10.1158/1538-7445.AM2017-5064
Published: 01 July 2017
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Abstract 5382: A DNMT3A-independent hypomethylator phenotype is a unifying epigenetic signature of AML with good risk cytogenetics

Andrew D. Kelly, Jozef Madzo, Priyanka Madireddi, Patricia Kropf, Charly R. Good, Jaroslav Jelinek, Jean-Pierre J. Issa
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 5382.
DOI: https://doi.org/10.1158/1538-7445.AM2017-5382
Published: 01 July 2017
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Journal Articles

Transcriptional Selectivity of Epigenetic Therapy in Cancer

Takahiro Sato, Matteo Cesaroni, Woonbok Chung, Shoghag Panjarian, Anthony Tran, Jozef Madzo, Yasuyuki Okamoto, Hanghang Zhang, Xiaowei Chen, Jaroslav Jelinek, Jean-Pierre J. Issa
Journal: Cancer Research
Cancer Res (2017) 77 (2): 470–481.
DOI: https://doi.org/10.1158/0008-5472.CAN-16-0834
Published: 16 January 2017
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Includes: Supplementary data
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Abstract 2657: Target specificity of epigenetic therapy in cancer

Takahiro Sato, Matteo Cesaroni, Shoghag Panjarian, Anthony Tran, Jozef Madzo, Yasuyuki Okamoto, Hanghang Zhang, Xiaowei Chen, Jaroslav Jelinek, Jean-Pierre J. Issa
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2657.
DOI: https://doi.org/10.1158/1538-7445.AM2016-2657
Published: 15 July 2016
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Abstract 2779: A CpG island methylator phenotype in acute myeloid leukemia independent of IDH mutations and associated with a favorable outcome

Andrew D. Kelly, Heike Kroeger, Jumpei Yamazaki, Rodolphe Taby, Frank Neumann, Sijia Yu, Justin T. Lee, Rong He, Shoudan Liang, Yue Lu, Matteo Cesaroni, Sherry A. Pierce, Steven M. Kornblau, Carlos E. Bueso-Ramos, Farhad Ravandi, Hagop M. Kantarjain, Jaroslav Jelinek, Jean-Pierre J. Issa
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2779.
DOI: https://doi.org/10.1158/1538-7445.AM2016-2779
Published: 15 July 2016
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Abstract 4701: A phenotypic cell-based screen to identify novel potential epigenetic anti-cancer drugs from natural compounds

Hanghang Zhang, Noël J.-M Raynal, Takahiro Sato, Yasuyuki Okamoto, Judit Garriga, George Morton, Wayne Childers, Marlene A. Jacobson, Stephen B. Baylin, Xavier Graña, Magid Abou-Gharbia, Jean-Pierre J. Issa
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 4701.
DOI: https://doi.org/10.1158/1538-7445.AM2016-4701
Published: 15 July 2016
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Targeting Calcium Signaling Induces Epigenetic Reactivation of Tumor Suppressor Genes in Cancer

Noël J.-M. Raynal, Justin T. Lee, Youjun Wang, Annie Beaudry, Priyanka Madireddi, Judith Garriga, Gabriel G. Malouf, Sarah Dumont, Elisha J. Dettman, Vazganush Gharibyan, Saira Ahmed, Woonbok Chung, Wayne E. Childers, Magid Abou-Gharbia, Ryan A. Henry, Andrew J. Andrews, Jaroslav Jelinek, Ying Cui, Stephen B. Baylin, Donald L. Gill, Jean-Pierre J. Issa
Journal: Cancer Research
Cancer Res (2016) 76 (6): 1494–1505.
DOI: https://doi.org/10.1158/0008-5472.CAN-14-2391
Published: 14 March 2016
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Includes: Supplementary data
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Abstract B50: A phenotypic screen to identify novel potential epigenetic anticancer drugs from natural compounds

Hanghang Zhang, Noël J.-M Raynal, Takahiro Sato, Yasuyuki Okamoto, Benjamin Garcia, George Morton, Wayne Childers, Marlene A. Jacobson, Stephen B. Baylin, Magid Abou-Gharbia, Jean-Pierre J. Issa
Journal: Cancer Research
Cancer Res (2016) 76 (2_Supplement): B50.
DOI: https://doi.org/10.1158/1538-7445.CHROMEPI15-B50
Published: 14 January 2016
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Abstract IA23: Multiple targetable pathways for epigenetic therapy

Jean-Pierre J. Issa
Journal: Cancer Research
Cancer Res (2016) 76 (2_Supplement): IA23.
DOI: https://doi.org/10.1158/1538-7445.CHROMEPI15-IA23
Published: 14 January 2016
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Abstract 5302: Genome-wide methylation analysis reveals multiple epigenetic subtypes of acute myeloid leukemia

Andrew D. Kelly, Heike Kroeger, Jumpei Yamazaki, Rodolphe Taby, Frank Neumann, Justin T. Lee, Rong He, Shoudan Liang, Yue Lu, Matteo Cesaroni, Sherry A. Pierce, Steven M. Kornblau, Carlos E. Bueso-Ramos, Farhad Ravandi, Hagop M. Kantarjian, Jaroslav Jelinek, Jean-Pierre J. Issa
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 5302.
DOI: https://doi.org/10.1158/1538-7445.AM2015-5302
Published: 01 August 2015
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Abstract 2958: Discovering therapeutic epigenetic targets using whole genome siRNA screening

Yasuyuki Okamoto, Woonbok Chung, Judith Garriga, Jaroslav Jelinek, Jean-Pierre J. Issa
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 2958.
DOI: https://doi.org/10.1158/1538-7445.AM2015-2958
Published: 01 August 2015
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Abstract 3519: A phenotypic screen to discover novel epigenetic anticancer drugs from natural compounds

Hanghang Zhang, Noël Raynal, Takahiro Sato, Yasuyuki Okamoto, Ryan Henry, Andrew J. Andrews, George Morton, Wayne Childers, Marlene A. Jacobson, Magid Abou-Gharbia, Jean-Pierre J. Issa
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 3519.
DOI: https://doi.org/10.1158/1538-7445.AM2015-3519
Published: 01 August 2015
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TET2 Mutations Affect Non-CpG Island DNA Methylation at Enhancers and Transcription Factor–Binding Sites in Chronic Myelomonocytic Leukemia

Jumpei Yamazaki, Jaroslav Jelinek, Yue Lu, Matteo Cesaroni, Jozef Madzo, Frank Neumann, Rong He, Rodolphe Taby, Aparna Vasanthakumar, Trisha Macrae, Kelly R. Ostler, Hagop M. Kantarjian, Shoudan Liang, Marcos R. Estecio, Lucy A. Godley, Jean-Pierre J. Issa
Journal: Cancer Research
Cancer Res (2015) 75 (14): 2833–2843.
DOI: https://doi.org/10.1158/0008-5472.CAN-14-0739
Published: 14 July 2015
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Includes: Supplementary data
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Abstract 2302: CpG hypermethylation marks potentially curable acute myeloid leukemia

Jaroslav Jelinek, Heike Kroeger, Jumpei Yamazaki, Rodolphe Taby, Frank Neumann, Justin T. Lee, Rong He, Shoudan Liang, Yue Lu, Matteo Cesaroni, Sherry A. Pierce, Steven M. Kornblau, Carlos E. Bueso-Ramos, Farhad Ravandi-Kashani, Hagop M. Kantarjian, Jean-Pierre J. Issa
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 2302.
DOI: https://doi.org/10.1158/1538-7445.AM2014-2302
Published: 01 October 2014
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