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Jean J. Zhao
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Journal Articles

Editor’s Note: Androgen-Induced Differentiation and Tumorigenicity of Human Prostate Epithelial Cells

Raanan Berger, Phillip G. Febbo, Pradip K. Majumder, Jean J. Zhao, Shayan Mukherjee, Sabina Signoretti, K. Thirza Campbell, William R. Sellers, Thomas M. Roberts, Massimo Loda, Todd R. Golub, William C. Hahn
Journal: Cancer Research
Cancer Res (2024) 84 (15): 2561.
https://doi.org/10.1158/0008-5472.CAN-24-1910
Published: 01 August 2024
View article titled, Editor’s Note: Androgen-Induced Differentiation and Tumorigenicity of Human Prostate Epithelial Cells
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Journal Articles

Abstract PD4-05: Preclinical and clinical efficacy of trastuzumab deruxtecan in breast cancer brain metastases (BCBM)

Sheheryar Kabraji, Jing Ni, Sarah Sammons, Amanda ED Van Swearingen, Yanzhi Wang, Alyssa M Pereslete, Liangge Hsu, Chris Lascola, Heather Moore, Melissa Hughes, Akshara S Raghavendra, Maria Gule-Monroe, Rashmi K Murthy, Eric P Winer, Carey K Anders, Jean J Zhao, Nancy U Lin
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): PD4-05.
https://doi.org/10.1158/1538-7445.SABCS21-PD4-05
Published: 15 February 2022
View article titled, Abstract PD4-05: Preclinical and clinical efficacy of trastuzumab deruxtecan in breast cancer brain metastases (BCBM)
Journal Articles

How Compensatory Mechanisms and Adaptive Rewiring Have Shaped Our Understanding of Therapeutic Resistance in Cancer

Johann S. Bergholz, Jean J. Zhao
Journal: Cancer Research
Cancer Res (2021) 81 (24): 6074–6077.
https://doi.org/10.1158/0008-5472.CAN-21-3605
Published: 15 December 2021
View article titled, How Compensatory Mechanisms and Adaptive Rewiring Have Shaped Our Understanding of Therapeutic Resistance in Cancer
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Journal Articles

Abstract 4: Temporal and spatial topography of cell proliferation in cancer

Giorgio Gaglia, Sheheryar Kabraji, Danae Argyropoulou, Yang Dai, Johann Bergholz, Shannon Coy, Jia-Ren Lin, Eric P. Winer, Deborah Dillon, Jean J. Zhao, Peter K. Sorger, Sandro Santagata
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 4.
https://doi.org/10.1158/1538-7445.AM2021-4
Published: 01 July 2021
View article titled, Abstract 4: Temporal and spatial topography of cell proliferation in cancer
Journal Articles

Abstract LB159: Overcoming immunosuppression and therapeutic resistance to PARP inhibition in BRCA1-deficient breast cancer with STING agonists

Qiwei Wang, Johann S. Bergholz, Liya Ding, Ziying Lin, Shaozhen Xie, Tao Jiang, Hye-Jung Kim, Thomas M. Roberts, Jean J. Zhao
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): LB159.
https://doi.org/10.1158/1538-7445.AM2021-LB159
Published: 01 July 2021
View article titled, Abstract LB159: Overcoming immunosuppression and therapeutic resistance to PARP inhibition in BRCA1-deficient breast cancer with STING agonists
Journal Articles

Abstract 5712: Nutrient scarcity confers breast cancer brain metastasis sensitivity to serine synthesis pathway inhibition

Bryan Ngo, Eugenie Kim, Sophia Doll, Sophia Bustraan, Alba Luengo, Shawn M. Davidson, Ahmed Ali, Gino Ferraro, Diane Kang, Jing Ni, Roger Liang, Ariana Plasger, Edward R. Kastenhuber, Roozbeh Eskandari, Sarah Bacha, Roshan Sriram, Benjamin D. Stein, Samuel F. Bakhoum, Edouard Mullarky, Matija Snuderl, Nello Mainolfi, Vipin Suri, Adam Friedman, Mark Manfredi, David M. Sabatini, Drew Jones, Min Yu, Jean J. Zhao, Rakesh K. Jain, Matthew G. Vander Heiden, Matthias Mann, Lewis C. Cantley, Michael E. Pacold
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 5712.
https://doi.org/10.1158/1538-7445.AM2020-5712
Published: 15 August 2020
View article titled, Abstract 5712: Nutrient scarcity confers breast cancer brain metastasis sensitivity to serine synthesis pathway inhibition
Journal Articles

Abstract LB-279: Artificial intelligence aided diagnosis of breast cancer molecular classification based on immunohistochemical images

Jean J. Zhao, Minzi Ruan, Quancai Cui
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): LB-279.
https://doi.org/10.1158/1538-7445.AM2019-LB-279
Published: 01 July 2019
View article titled, Abstract LB-279: Artificial intelligence aided diagnosis of breast cancer molecular classification based on immunohistochemical images
Journal Articles

Oncogenic Kinase–Induced PKM2 Tyrosine 105 Phosphorylation Converts Nononcogenic PKM2 to a Tumor Promoter and Induces Cancer Stem–like Cells

Zhifen Zhou, Min Li, Lin Zhang, Hong Zhao, Özgür Şahin, Jing Chen, Jean J. Zhao, Zhou Songyang, Dihua Yu
Journal: Cancer Research
Cancer Res (2018) 78 (9): 2248–2261.
https://doi.org/10.1158/0008-5472.CAN-17-2726
Published: 30 April 2018
View article titled, Oncogenic Kinase–Induced PKM2 Tyrosine 105 Phosphorylation Converts Nononcogenic PKM2 to a Tumor Promoter and Induces Cancer Stem–like Cells
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Includes: Supplementary data
Journal Articles

Abstract 1634: CDK4/6 inhibition directly enhances an anti-tumor immune response in breast cancer

Molly J. DeCristo*, Shom Goel*, April C. Watt, Haley BrinJones, Jaclyn Sceneay, Ben Li, Jessalyn M. Ubellacker, Shaozhen Xie, Susanne Ramm, Hye-Jung Kim, Sandra S. McAllister, Jean J. Zhao
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1634.
https://doi.org/10.1158/1538-7445.AM2017-1634
Published: 01 July 2017
View article titled, Abstract 1634: CDK4/6 inhibition directly enhances an anti-tumor immune response in breast cancer
Journal Articles

Abstract 4775: PI3K-p110β is required for leukemic transformation and HSC depletion in the absence of Pten

Haluk Yuzugullu, Lukas Baitsch, Allison Steiner, Linda K. Clayton, Kira Gritsman, Jean J. Zhao
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 4775.
https://doi.org/10.1158/1538-7445.AM2014-4775
Published: 01 October 2014
View article titled, Abstract 4775: PI3K-p110β is required for leukemic transformation and HSC depletion in the absence of Pten
Journal Articles

Abstract 94: The role of Pik3ca in uterine gland morphogenesis and fertility in mice

Heesung Shin, Tae Hoon Kim, Jung-Yoon Yoo, Jean J. Zhao, John P. Lydon, Un-Hwan Ha, Jae-Wook Jeong
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 94.
https://doi.org/10.1158/1538-7445.AM2014-94
Published: 01 October 2014
View article titled, Abstract 94: The role of <em>Pik3ca</em> in uterine gland morphogenesis and fertility in mice
Journal Articles

A Genetic Mouse Model of Invasive Endometrial Cancer Driven by Concurrent Loss of Pten and Lkb1 Is Highly Responsive to mTOR Inhibition

Hailing Cheng, Pixu Liu, Fan Zhang, Erbo Xu, Lynn Symonds, Carolynn E. Ohlson, Roderick T. Bronson, Sauveur-Michel Maira, Emmanuelle Di Tomaso, Jane Li, Andrea P. Myers, Lewis C. Cantley, Gordon B. Mills, Jean J. Zhao
Journal: Cancer Research
Series: Author Choice
Cancer Res (2014) 74 (1): 15–23.
https://doi.org/10.1158/0008-5472.CAN-13-0544
Published: 05 January 2014
View article titled, A Genetic Mouse Model of Invasive Endometrial Cancer Driven by Concurrent Loss of Pten and Lkb1 Is Highly Responsive to mTOR Inhibition
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Includes: Supplementary data
Journal Articles

Conditional Loss of ErbB3 Delays Mammary Gland Hyperplasia Induced by Mutant PIK3CA without Affecting Mammary Tumor Latency, Gene Expression, or Signaling

Christian D. Young, Adam D. Pfefferle, Philip Owens, María G. Kuba, Brent N. Rexer, Justin M. Balko, Violeta Sánchez, Hailing Cheng, Charles M. Perou, Jean J. Zhao, Rebecca S. Cook, Carlos L. Arteaga
Journal: Cancer Research
Cancer Res (2013) 73 (13): 4075–4085.
https://doi.org/10.1158/0008-5472.CAN-12-4579
Published: 30 June 2013
View article titled, Conditional Loss of ErbB3 Delays Mammary Gland Hyperplasia Induced by Mutant <em>PIK3CA</em> without Affecting Mammary Tumor Latency, Gene Expression, or Signaling
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Includes: Supplementary data
Journal Articles

Abstract LB-103: Conditional loss of ErbB3 delays mammary gland hyperplasias induced by mutant PIK3CA in transgenic mice, but does not affect mammary tumor latency, gene expression or signaling

Christian D. Young, Maria G. Kuba, Philip Owens, Justin M. Balko, Adam Pfefferle, Violeta Sanchez, Charles M. Perou, Jean J. Zhao, Rebecca S. Cook, Carlos L. Arteaga
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): LB-103.
https://doi.org/10.1158/1538-7445.AM2012-LB-103
Published: 15 April 2012
View article titled, Abstract LB-103: Conditional loss of ErbB3 delays mammary gland hyperplasias induced by mutant <em>PIK3CA</em> in transgenic mice, but does not affect mammary tumor latency, gene expression or signaling
Journal Articles

Lysosomal Transmembrane Protein LAPTM4B Promotes Autophagy and Tolerance to Metabolic Stress in Cancer Cells

Yang Li, Qing Zhang, Ruiyang Tian, Qi Wang, Jean J. Zhao, J. Dirk Iglehart, Zhigang Charles Wang, Andrea L. Richardson
Journal: Cancer Research
Cancer Res (2011) 71 (24): 7481–7489.
https://doi.org/10.1158/0008-5472.CAN-11-0940
Published: 15 December 2011
View article titled, Lysosomal Transmembrane Protein LAPTM4B Promotes Autophagy and Tolerance to Metabolic Stress in Cancer Cells
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Includes: Supplementary data
Journal Articles

Abstract 5769: A novel, high-throughput approach to discovering drug-resistance genes identifies CRAF, CrkL, and TPL2/COT as drivers of resistance to BRAFV600E inhibition

Cory M. Johannessen, Leslie Wardwell, So Young Kim, Jesse Boehm, Sapana Thomas, Laura A. Johnson, Haley Hieronymus, Kourosh Salehi-Ashtiani, David E. Hill, Jean J. Zhao, Marc Vidal, Todd R. Golub, William C. Hahn, Levi A. Garraway
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 5769.
https://doi.org/10.1158/1538-7445.AM10-5769
Published: 15 April 2010
View article titled, Abstract 5769: A novel, high-throughput approach to discovering drug-resistance genes identifies CRAF, CrkL, and TPL2/COT as drivers of resistance to BRAFV600E inhibition
Journal Articles

3-Phosphoinositide–Dependent Kinase 1 Potentiates Upstream Lesions on the Phosphatidylinositol 3-Kinase Pathway in Breast Carcinoma

Matthew Maurer, Tao Su, Lao H. Saal, Susan Koujak, Benjamin D. Hopkins, Christina R. Barkley, Jiaping Wu, Subhadra Nandula, Bhaskar Dutta, Yuli Xie, Y. Rebecca Chin, Da-In Kim, Jennifer S. Ferris, Sofia K. Gruvberger-Saal, Mervi Laakso, Xiaomei Wang, Lorenzo Memeo, Albert Rojtman, Tulio Matos, Jennifer S. Yu, Carlos Cordon-Cardo, Jorma Isola, Mary Beth Terry, Alex Toker, Gordon B. Mills, Jean J. Zhao, Vundavalli V.V.S. Murty, Hanina Hibshoosh, Ramon Parsons
Journal: Cancer Research
Cancer Res (2009) 69 (15): 6299–6306.
https://doi.org/10.1158/0008-5472.CAN-09-0820
Published: 29 July 2009
View article titled, 3-Phosphoinositide–Dependent Kinase 1 Potentiates Upstream Lesions on the Phosphatidylinositol 3-Kinase Pathway in Breast Carcinoma
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Includes: Supplementary data
Journal Articles

Genetic studies to facilitate targeting the PI3 kinase pathway in cancer

Jean J. Zhao, Zhenning Liu, Sen Zhang, Hailing Cheng, Shidong Jia, Thomas M. Roberts
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 998.
Published: 15 April 2006
View article titled, Genetic studies to facilitate targeting the PI3 kinase pathway in cancer
Journal Articles

The role of PI3K-p110α in breast cancer

Jean J. Zhao, Zhenning Liu, Alexander Miron, Xin Lu, Li Wang, J. Dirk Iglehart, Thomas M. Roberts
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 609.
Published: 01 May 2005
View article titled, The role of PI3K-p110α in breast cancer
Journal Articles

Androgen-Induced Differentiation and Tumorigenicity of Human Prostate Epithelial Cells

Raanan Berger, Phillip G. Febbo, Pradip K. Majumder, Jean J. Zhao, Shayan Mukherjee, Sabina Signoretti, K. Thirza Campbell, William R. Sellers, Thomas M. Roberts, Massimo Loda, Todd R. Golub, William C. Hahn
Journal: Cancer Research
Cancer Res (2004) 64 (24): 8867–8875.
https://doi.org/10.1158/0008-5472.CAN-04-2938
Published: 16 December 2004
View article titled, Androgen-Induced Differentiation and Tumorigenicity of Human Prostate Epithelial Cells
Open the PDF for Androgen-Induced Differentiation and Tumorigenicity of Human Prostate Epithelial Cells in another window
Includes: Supplementary data