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Abstract 2673: Copper chelation overcomes the immunosuppressive neuroblastoma microenvironment to potentiate anti-GD2 antibody therapy

Jourdin R. Rouaen, Antonella Salerno, Fabio Luciani, Jayne Murray, Tyler Shai-Hee, Nicodemus Tedla, Michelle Haber, Toby N. Trahair, Orazio Vittorio

Cancer Res (2024) 84 (6_Supplement): 2673.

https://doi.org/10.1158/1538-7445.AM2024-2673

Published: 22 March 2024

View articletitled, Abstract 2673: Copper chelation overcomes the immunosuppressive neuroblastoma microenvironment to potentiate anti-GD2 antibody therapy

Journal Articles

Abstract IA13: Molecular targeted therapies and precision medicine for children with neuroblastoma and other refractory malignancies

Michelle Haber, Laura Gamble, Lin Xiao, Ruby Pandher, Klaartje Somers, Jayne Murray, Aaminah Khan, Denise Yu, Laura Franshaw, Mark R. Burns, Maria Tsoli, Anahid Ehteda, Anthony Cesare, Aisling O’Connor, Francis Mussai, Carmela de Santo, Paul Cheng, Lioubov Korotchkina, Katerina Gurova, Vanessa Tyrrell, Emily Mould, Loretta Lau, Dong Anh Khuong Quang, Chelsea Mayoh, Greg Arndt, Paulette Barahona, Tim Failes, Jamie Fletcher, Noemi Fuentes- Bolanos, Marie-Emilie Gauthier, Andrew Gifford, Dylan Grebert-Wade, Alvin Kamili, Amit Kumar, Sumanth Nagabushan, Tracey O’Brien, Patrick Strong, Alexandra Sherstyuk, David Thomas, Toby Trahair, Katherine Tucker, Meera Warby, Marie Wong, Jinhan Xie, Kathryn Evans, Richard Lock, Olga B. Chernova, Michelle Henderson, Andrei V Gudkov, Paul Ekert, Mark J. Cowley, Glenn M. Marshall, David S. Ziegler, Murray D. Norris

Cancer Res (2020) 80 (14_Supplement): IA13.

https://doi.org/10.1158/1538-7445.PEDCA19-IA13

Published: 15 July 2020

View articletitled, Abstract IA13: Molecular targeted therapies and precision medicine for children with neuroblastoma and other refractory malignancies

Journal Articles

Macrophage-Derived IL1β and TNFα Regulate Arginine Metabolism in Neuroblastoma

Cancer Res (2019) 79 (3): 611–624.

https://doi.org/10.1158/0008-5472.CAN-18-2139

Published: 01 February 2019

View articletitled, Macrophage-Derived IL1β and TNFα Regulate Arginine Metabolism in Neuroblastoma

Includes: Supplementary data

Journal Articles

Abstract 2006: AMX-513 polyamine depletion therapy inhibits tumor growth and reverses immunosuppression in cancers including MYC-driven neuroblastoma and pancreatic cancer

Mark R. Burns, Kathy Fosnaugh, Michael G. Palfreyman, Laura Gamble, Jayne Murray, Sophie Allan, Georgina Eden, Sara Sarraf, Murray Norris, David Ziegler, Michelle Haber

Cancer Res (2017) 77 (13_Supplement): 2006.

https://doi.org/10.1158/1538-7445.AM2017-2006

Published: 01 July 2017

View articletitled, Abstract 2006: AMX-513 polyamine depletion therapy inhibits tumor growth and reverses immunosuppression in cancers including MYC-driven neuroblastoma and pancreatic cancer

Journal Articles

MYC-Driven Neuroblastomas Are Addicted to a Telomerase-Independent Function of Dyskerin

Rosemary O'Brien, Sieu L. Tran, Michelle F. Maritz, Bing Liu, Cheng Fei Kong, Stefania Purgato, Chen Yang, Jayne Murray, Amanda J. Russell, Claudia L. Flemming, Georg von Jonquieres, Hilda A. Pickett, Wendy B. London, Michelle Haber, Preethi H. Gunaratne, Murray D. Norris, Giovanni Perini, Jamie I. Fletcher, Karen L. MacKenzie

Cancer Res (2016) 76 (12): 3604–3617.

https://doi.org/10.1158/0008-5472.CAN-15-0879

Published: 14 June 2016

View articletitled, MYC-Driven Neuroblastomas Are Addicted to a Telomerase-Independent Function of Dyskerin

Includes: Supplementary data

Journal Articles

Abstract 1611: The FACT histone chaperone complex is highly expressed in aggressive drug refractory childhood cancers and the anti-FACT compound CBL0137 represents a highly promising therapeutic approach in this setting

Cancer Res (2015) 75 (15_Supplement): 1611.

https://doi.org/10.1158/1538-7445.AM2015-1611

Published: 01 August 2015

View articletitled, Abstract 1611: The FACT histone chaperone complex is highly expressed in aggressive drug refractory childhood cancers and the anti-FACT compound CBL0137 represents a highly promising therapeutic approach in this setting

Journal Articles

Abstract 488: High DKC1 expression supports neuroblastoma tumor cell proliferation and is strongly associated with poor patient outcomes

Rosemary O'Brien, Michelle F. Maritz, Cheng Fei Kong, Stefania Purgato, Bing Liu, Chen Yang, Amanda Russell, Jayne Murray, Claudia Flemming, Michelle Haber, Giovanni Perini, Murray D. Norris, Jamie I. Fletcher, Karen L. Mackenzie

Cancer Res (2015) 75 (15_Supplement): 488.

https://doi.org/10.1158/1538-7445.AM2015-488

Published: 01 August 2015

View articletitled, Abstract 488: High DKC1 expression supports neuroblastoma tumor cell proliferation and is strongly associated with poor patient outcomes

Journal Articles

Abstract 2759: Anticancer compound curaxin CBL0137, that simultaneously suppresses NF-κB and activates p53, is highly effective in two independent mouse models of neuroblastoma.

Michelle Haber, Jayne Murray, Ashleigh Carnegie-Clark, Hannah Webber, Glenn M. Marshall, Katerina V. Gurova, Catherine A. Burkhart, Andrei Purmal, Andrei V. Gudkov, Murray D. Norris

Cancer Res (2013) 73 (8_Supplement): 2759.

https://doi.org/10.1158/1538-7445.AM2013-2759

Published: 15 April 2013

View articletitled, Abstract 2759: Anticancer compound curaxin CBL0137, that simultaneously suppresses NF-κB and activates p53, is highly effective in two independent mouse models of neuroblastoma.

Journal Articles

Abstract 5043: The facilitates chromatin transcription (FACT) protein complex promotes neuroblastoma tumor initiation.

Daniel R. Carter, Belamy B. Cheung, Tao Liu, Carol Au, Murray D. Norris, Michelle Haber, Jayne Murray, Katerina V. Gurova, Andrei V. Gudkov, Glenn M. Marshall

Cancer Res (2013) 73 (8_Supplement): 5043.

https://doi.org/10.1158/1538-7445.AM2013-5043

Published: 15 April 2013

View articletitled, Abstract 5043: The facilitates chromatin transcription (FACT) protein complex promotes neuroblastoma tumor initiation.

Journal Articles

Abstract 3808: MYCN coordinately regulates the entire polyamine gene pathway to drive polyamine biosynthesis in neuroblastoma, with expression of every synthetic and catabolic polyamine pathway gene being highly prognostic of clinical outcome.

Murray D. Norris, Laura D. Gamble, Jayne Murray, Stefania Purgato, Giorgio Milazzo, Lesley J. Ashton, Andrei Oberthuer, Wendy B. London, Mike D. Hogarty, Mattias Fischer, David Ziegler, Glenn M. Marshall, Giovanni Perini, Michelle Haber

Cancer Res (2013) 73 (8_Supplement): 3808.

https://doi.org/10.1158/1538-7445.AM2013-3808

Published: 15 April 2013

View articletitled, Abstract 3808: MYCN coordinately regulates the entire polyamine gene pathway to drive polyamine biosynthesis in neuroblastoma, with expression of every synthetic and catabolic polyamine pathway gene being highly prognostic of clinical outcome.

Journal Articles

Abstract 789: GSTP1 expression is regulated by MycN and is a marker of poor outcome in childhood neuroblastoma

Murray D. Norris, Jamie I. Fletcher, Samuele Gherardi, Jayne Murray, Catherine Burkhart, Amanda Russell, Emanuele Valli, Andre Oberthuer, Lesley J. Ashton, Wendy B. London, Glenn M. Marshall, Giovanni Perini, Michelle Haber

Cancer Res (2012) 72 (8_Supplement): 789.

https://doi.org/10.1158/1538-7445.AM2012-789

Published: 15 April 2012

View articletitled, Abstract 789: GSTP1 expression is regulated by MycN and is a marker of poor outcome in childhood neuroblastoma

Journal Articles

N-Myc Regulates Expression of the Detoxifying Enzyme Glutathione Transferase GSTP1, a Marker of Poor Outcome in Neuroblastoma

Jamie I. Fletcher, Samuele Gherardi, Jayne Murray, Catherine A. Burkhart, Amanda Russell, Emanuele Valli, Janice Smith, André Oberthuer, Lesley J. Ashton, Wendy B. London, Glenn M. Marshall, Murray D. Norris, Giovanni Perini, Michelle Haber

Cancer Res (2012) 72 (4): 845–853.

https://doi.org/10.1158/0008-5472.CAN-11-1885

Published: 14 February 2012

View articletitled, N-Myc Regulates Expression of the Detoxifying Enzyme Glutathione Transferase GSTP1, a Marker of Poor Outcome in Neuroblastoma

Includes: Supplementary data

Journal Articles

Abstract 954: ABCC/MRP multidrug transporters contribute to neuroblastoma biology, pathogenesis and clinical outcome, independently of any role in cytotoxic drug efflux

Cancer Res (2011) 71 (8_Supplement): 954.

https://doi.org/10.1158/1538-7445.AM2011-954

Published: 15 April 2011

View articletitled, Abstract 954: ABCC/MRP multidrug transporters contribute to neuroblastoma biology, pathogenesis and clinical outcome, independently of any role in cytotoxic drug efflux

Journal Articles

Abstract 5237: Development of organ-selective neuroblastoma cell lines to identify genes mediating bone marrow and liver colonization

Zillan Neiron, Kacper Jankowski, Jayne Murray, Sophia Champion, Murray D. Norris, Michelle Haber, Jamie I. Fletcher

Cancer Res (2011) 71 (8_Supplement): 5237.

https://doi.org/10.1158/1538-7445.AM2011-5237

Published: 15 April 2011

View articletitled, Abstract 5237: Development of organ-selective neuroblastoma cell lines to identify genes mediating bone marrow and liver colonization

Journal Articles

Abstract 888: Reduced folate carrier gene polymorphism (RFC 80G>A): Associations with clinical outcome in NMYC amplified neuroblastoma patients

Diana T. Lau, Jayne Murray, Murray Norris, Glenn M. Marshall, Michelle Haber, Lesley J. Ashton

Cancer Res (2010) 70 (8_Supplement): 888.

https://doi.org/10.1158/1538-7445.AM10-888

Published: 15 April 2010

View articletitled, Abstract 888: Reduced folate carrier gene polymorphism (RFC 80G>A): Associations with clinical outcome in NMYC amplified neuroblastoma patients

Journal Articles

Small-Molecule Multidrug Resistance–Associated Protein 1 Inhibitor Reversan Increases the Therapeutic Index of Chemotherapy in Mouse Models of Neuroblastoma

Catherine A. Burkhart, Fujiko Watt, Jayne Murray, Marina Pajic, Anatoly Prokvolit, Chengyuan Xue, Claudia Flemming, Janice Smith, Andrei Purmal, Nadezhda Isachenko, Pavel G. Komarov, Katerina V. Gurova, Alan C. Sartorelli, Glenn M. Marshall, Murray D. Norris, Andrei V. Gudkov, Michelle Haber

Cancer Res (2009) 69 (16): 6573–6580.

https://doi.org/10.1158/0008-5472.CAN-09-1075

Published: 12 August 2009

View articletitled, Small-Molecule Multidrug Resistance–Associated Protein 1 Inhibitor Reversan Increases the Therapeutic Index of Chemotherapy in Mouse Models of Neuroblastoma

Includes: Supplementary data

Journal Articles

Abstract #3449: A specific transcription signature of ABC transporter genes is dictated by Myc-family oncogenes: A powerful tool to predict clinical outcome

Michelle Haber, Antonio Porro, Daniel Diolaiti, Nunzio Iraci, Michelle Henderson, Marcia Munoz, Chengyuan Xue, Claudia Flemming, Jayne Murray, Wendy London, Allen Buxton, Lesley Ashton, Susan Cohn, Manfred Schwab, Glenn Marshall, Giuliano Della Valle, Giovanni Perini, Murray Norris

Cancer Res (2009) 69 (9_Supplement): 3449.

Published: 01 May 2009

View articletitled, Abstract #3449: A specific transcription signature of ABC transporter genes is dictated by Myc-family oncogenes: A powerful tool to predict clinical outcome

Journal Articles

ODC1 Is a Critical Determinant of MYCN Oncogenesis and a Therapeutic Target in Neuroblastoma

Cancer Res (2008) 68 (23): 9735–9745.

https://doi.org/10.1158/0008-5472.CAN-07-6866

Published: 01 December 2008

View articletitled, ODC1 Is a Critical Determinant of MYCN Oncogenesis and a Therapeutic Target in Neuroblastoma

Includes: Supplementary data

Journal Articles

Abstract 5832: Overexpression of ODC1 is associated with poor outcome in childhood neuroblastoma and represents an important therapeutic target

Michelle Haber, Ngan Cheng, Janice Smith, Jayne Murray, Michael D. Hogarty, Wendy B London, Glenn M Marshall, Murray D. Norris

Cancer Res (2008) 68 (9_Supplement): 5832.

https://doi.org/10.1158/1538-7445.AM2008-5832

Published: 15 May 2008

View articletitled, Abstract 5832: Overexpression of ODC1 is associated with poor outcome in childhood neuroblastoma and represents an important therapeutic target

Journal Articles

Reversan, a novel inhibitor of MRP1, increases the therapeutic index of conventional chemotherapeutic agents

Catherine Burkhart, Jayne Murray, Nadezhda Isachenko, Marina Pajic, Fujiko Watt, Claudia Flemming, Janice Smith, Katerina Gurova, Glenn Marshall, Murray Norris, Andrei Gudkov, Michelle Haber

Cancer Res (2008) 68 (9_Supplement): 3242.

Published: 01 May 2008

View articletitled, Reversan, a novel inhibitor of MRP1, increases the therapeutic index of conventional chemotherapeutic agents

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Abstract 2673: Copper chelation overcomes the immunosuppressive neuroblastoma microenvironment to potentiate anti-GD2 antibody therapy

Abstract IA13: Molecular targeted therapies and precision medicine for children with neuroblastoma and other refractory malignancies

Macrophage-Derived IL1β and TNFα Regulate Arginine Metabolism in Neuroblastoma

Abstract 2006: AMX-513 polyamine depletion therapy inhibits tumor growth and reverses immunosuppression in cancers including MYC-driven neuroblastoma and pancreatic cancer

MYC-Driven Neuroblastomas Are Addicted to a Telomerase-Independent Function of Dyskerin

Abstract 1611: The FACT histone chaperone complex is highly expressed in aggressive drug refractory childhood cancers and the anti-FACT compound CBL0137 represents a highly promising therapeutic approach in this setting

Abstract 488: High DKC1 expression supports neuroblastoma tumor cell proliferation and is strongly associated with poor patient outcomes

Abstract 2759: Anticancer compound curaxin CBL0137, that simultaneously suppresses NF-κB and activates p53, is highly effective in two independent mouse models of neuroblastoma.

Abstract 5043: The facilitates chromatin transcription (FACT) protein complex promotes neuroblastoma tumor initiation.

Abstract 3808: MYCN coordinately regulates the entire polyamine gene pathway to drive polyamine biosynthesis in neuroblastoma, with expression of every synthetic and catabolic polyamine pathway gene being highly prognostic of clinical outcome.

Abstract 789: GSTP1 expression is regulated by MycN and is a marker of poor outcome in childhood neuroblastoma

N-Myc Regulates Expression of the Detoxifying Enzyme Glutathione Transferase GSTP1, a Marker of Poor Outcome in Neuroblastoma

Abstract 954: ABCC/MRP multidrug transporters contribute to neuroblastoma biology, pathogenesis and clinical outcome, independently of any role in cytotoxic drug efflux

Abstract 5237: Development of organ-selective neuroblastoma cell lines to identify genes mediating bone marrow and liver colonization

Abstract 888: Reduced folate carrier gene polymorphism (RFC 80G>A): Associations with clinical outcome in NMYC amplified neuroblastoma patients

Small-Molecule Multidrug Resistance–Associated Protein 1 Inhibitor Reversan Increases the Therapeutic Index of Chemotherapy in Mouse Models of Neuroblastoma

Abstract #3449: A specific transcription signature of ABC transporter genes is dictated by Myc-family oncogenes: A powerful tool to predict clinical outcome

ODC1 Is a Critical Determinant of MYCN Oncogenesis and a Therapeutic Target in Neuroblastoma

Abstract 5832: Overexpression of ODC1 is associated with poor outcome in childhood neuroblastoma and represents an important therapeutic target

Reversan, a novel inhibitor of MRP1, increases the therapeutic index of conventional chemotherapeutic agents

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