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Journal Articles

Abstract 683: Identification of common germline variants associated with pediatric rhabdomyosarcoma survival: A report from the Children's Oncology Group (COG)

Bailey A. Martin-Giacalone, Michael E. Scheurer, Javed Khan, Stephen J. Chanock, Shengchao Alfred Li, Meredith Yeager, Deborah A. Marquez-Do, Donald A. Barkauskas, David Hall, Matthew T. McEvoy, Melissa A. Richard, Pagna Sok, Austin L. Brown, Aniko Sabo, Stephen X. Skapek, Douglas S. Hawkins, Rajkumar Venkatramani, Lisa Mirabello, Philip J. Lupo
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 683.
DOI: https://doi.org/10.1158/1538-7445.AM2022-683
Published: 15 June 2022
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Journal Articles

Abstract 703: Novel histone lysine demethylase inhibitors disrupt PAX3-FOXO1-driven transcriptional output in fusion-positive rhabdomyosarcoma

Yong Yean Kim, Girma Woldemichael, Berkley Gryder, Silvia Pomella, Ranuka Sinniah, Josh Kowalczyk, Young Song, Mehal Churiwal, Joseph Barchi, John Schneekloth, Xinyu Wen, Hsein-Chao Chou, Barry Okeefe, John Shern, Robert Hawley, Javed Khan
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 703.
DOI: https://doi.org/10.1158/1538-7445.AM2022-703
Published: 15 June 2022
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Journal Articles

Abstract LB213: Potent antitumor activity of a FGFR4 CAR-T in rhabdomyosarcoma

Adam Tai Chi Cheuk, Meijie Tian, Nityashree Shivaprasad, Steven Highfill, David Milewski, G Tom Brown, Peter Azorsa, Dina Schneider, Berkley Gryder, Jun S Wei, Young Kwok Song, Hsien-Chao Chou, Jerry Wu, Joon-Yong Chung, Brian Belyea, Corinne Linardic, Stephen M Hewitt, Boro Dropulic, Rimas Orentas, Javed Khan
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): LB213.
DOI: https://doi.org/10.1158/1538-7445.AM2022-LB213
Published: 15 June 2022
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Journal Articles

Abstract 579: Anti-myeloid poly-pharmacy allows FGFR4-targeted chimeric antigen receptors to effectively treat an orthotopic model of rhabdomyosarcoma

Peter M. Sullivan, Rajesh Kumar, Wei Li, Lingyang Wang, Yue Zhang, Sophie Jamet, Adam Cheuk, Javed Khan, Dimiter S. Dimitrov, Rimas J. Orentas
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 579.
DOI: https://doi.org/10.1158/1538-7445.AM2022-579
Published: 15 June 2022
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Journal Articles

Abstract 466: Predicting survival of rhabdomyosarcoma patients based on deep learning of H&E images

David Milewski, Hyun Jung, G. Thomas Brown, Yanling Liu, Jack Collins, Marc Ladanyi, Erin Rudzinski, Javed Khan
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 466.
DOI: https://doi.org/10.1158/1538-7445.AM2022-466
Published: 15 June 2022
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Journal Articles

Abstract 3581: Multi-omic analysis identifies mechanisms of resistance to CD19 CAR T-cell therapy in children with acute lymphoblastic leukemia

Katherine E. Masih, Rebecca Gardner, Hsien-Chao Chou, Abdalla Abdelmaksoud, Young K. Song, Luca Mariani, Vineela Gangalapudi, Berkley E. Gryder, Ashley Wilson, Serifat O. Adebola, Benjamin Z. Stanton, Chaoyu Wang, Xinyu Wen, Gregoire Altan-Bonnet, Michael C. Kelly, Jun S. Wei, Martha L. Bulyk, Michael C. Jensen, Rimas J. Orentas, Javed Khan
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3581.
DOI: https://doi.org/10.1158/1538-7445.AM2022-3581
Published: 15 June 2022
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Journal Articles

Abstract LB062: Profiling of pediatric neuroblastoma reveals a dynamic and clinically significant tumor immune microenvironment

Katherine E. Masih, Zahin Islam, Paul Aiyetan, Igor B. Kuznetsov, Stephen M. Hewitt, Daniel Catchpoole, Jun S. Wei, William Bocik, Javed Khan
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): LB062.
DOI: https://doi.org/10.1158/1538-7445.AM2022-LB062
Published: 15 June 2022
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Journal Articles

Abstract 552: FGFR4 and CD276 dualtargeting CAR-T cells for treating rhabdomyosarcoma and other solid tumors

Meijie Tian, Adam Cheuk, David Milewski, Jun S. Wei, Hsien-Chao Chou, Yong Yean Kim, Young K. Song, Brad St. Croix, Mitchell Ho, Javed Khan
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 552.
DOI: https://doi.org/10.1158/1538-7445.AM2022-552
Published: 15 June 2022
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Journal Articles

Genomic and Transcriptomic Analysis of Relapsed and Refractory Childhood Solid Tumors Reveals a Diverse Molecular Landscape and Mechanisms of Immune Evasion

Sara A. Byron, William P.D. Hendricks, Abhinav B. Nagulapally, Jacqueline M. Kraveka, William S. Ferguson, Valerie I. Brown, Don E. Eslin, Deanna Mitchell, Albert Cornelius, William Roberts, Michael S. Isakoff, Javier E. Oesterheld, Randal K. Wada, Jawhar Rawwas, Kathleen Neville, Peter E. Zage, Virginia L. Harrod, Genevieve Bergendahl, Elizabeth VanSickle, Karl Dykema, Jeffrey Bond, Hsien-Chao Chou, Jun S. Wei, Xinyu Wen, Hue V. Reardon, Alison Roos, Sara Nasser, Tyler Izatt, Daniel Enriquez, Apurva M. Hegde, Faith Cisneros, Austin Christofferson, Bryce Turner, Szabolcs Szelinger, Jonathan J. Keats, Rebecca F. Halperin, Javed Khan, Giselle L. Saulnier Sholler, Jeffrey M. Trent
Journal: Cancer Research
Cancer Res (2021) 81 (23): 5818–5832.
DOI: https://doi.org/10.1158/0008-5472.CAN-21-1033
Published: 01 December 2021
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Includes: Supplementary data
Journal Articles

SNAI2-Mediated Repression of BIM Protects Rhabdomyosarcoma from Ionizing Radiation

Long Wang, Nicole R. Hensch, Kathryn Bondra, Prethish Sreenivas, Xiang R. Zhao, Jiangfei Chen, Rodrigo Moreno Campos, Kunal Baxi, Angelina V. Vaseva, Benjamin D. Sunkel, Berkley E. Gryder, Silvia Pomella, Benjamin Z. Stanton, Siyuan Zheng, Eleanor Y. Chen, Rossella Rota, Javed Khan, Peter J. Houghton, Myron S. Ignatius
Journal: Cancer Research
Cancer Res (2021) 81 (21): 5451–5463.
DOI: https://doi.org/10.1158/0008-5472.CAN-20-4191
Published: 01 November 2021
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Includes: Supplementary data
Journal Articles

Abstract 1545: Development of FGFR4-targeted chimeric antigen receptors (CARs) for the treatment of rhabdomyosarcoma

Peter Sullivan, Rajesh Kumar, Wei Li, Lingyang Wang, Yue Zhang, Adam Cheuk, Nityashree Shivaprasad, Javed Khan, Dimiter S. Dimitrov, Rimas J. Orentas
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1545.
DOI: https://doi.org/10.1158/1538-7445.AM2021-1545
Published: 01 July 2021
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Journal Articles

Abstract 667: Genomic and transcriptomic profiling of malignant mesothelioma patients identifies gene signatures predictive of survival and response to immuno and chemotherapy

Nishanth Ulhas Nair, Qun Jiang, Jun S. Wei, Vikram A. Misra, Betsy Morrow, Leandro C. Hermida, Joo Sang Lee, Idrees Mian, Jingli Zhang, Manjistha Sengupta, Javed Khan, Eytan Ruppin, Raffit Hassan
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 667.
DOI: https://doi.org/10.1158/1538-7445.AM2021-667
Published: 01 July 2021
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Journal Articles

Abstract 47: Identification of first-in-class KDM3B inhibitors that suppress PAX3-FOXO1 oncogene activity in fusion positive rhabdomyosarcoma

Yong Yean Kim, Robert G. Hawley, Berkley Gryder, Silvia Pomella, Joshua Kowalczyk, Joseph Barchi, Young Song, Javed Khan
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 47.
DOI: https://doi.org/10.1158/1538-7445.AM2021-47
Published: 01 July 2021
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Journal Articles

Abstract 212: Sarcoma-CellMiner: An extensive resource for patient-derived sarcoma cell line epigenetics, genomics and pharmacology

Camille Tlemsani, Lorinc Pongor, Javed Khan, Fathi Elloumi, Sudhir Varma, Augustin Luna, Vinodh Rajapakse, Kurt Kohn, Julia Krushkal, Mirit Aladjem, Beverly Teicher, Paul Meltzer, William Reinhold, Christine Heske, Yves Pommier
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 212.
DOI: https://doi.org/10.1158/1538-7445.AM2021-212
Published: 01 July 2021
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Abstract 1885: Potent tumoricidal activity of a FGFR4 CART in rhabdomyosarcoma

Adam Cheuk, Meijie Tian, Jeetendra Kumar, Peter Azorsa, Nityashree Shivaprasad, Dina Schneider, Berkley Gryder, Jun Wei, Young Song, Xinyu Wen, Sivasish Sindiri, Joon-Yong Chung, Zhongyu Zhu, Dimiter Dimitrov, Stephen Hewitt, Boro Dropulic, Rimas Orentas, Javed Khan
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1885.
DOI: https://doi.org/10.1158/1538-7445.AM2021-1885
Published: 01 July 2021
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Journal Articles

Abstract LB193: Lysine demethylase 5A is required for MYC driven transcription in multiple myeloma

Jun Qi, hiroto Ohguchi, Paul MC Park, tingjian wang, Kenneth C. Anderson, Teru Hideshima, Catrine Johansson, Udo Oppermann, Adam D. Durbin, Berkley Gryder, Javed Khan, xiaofeng zhang
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): LB193.
DOI: https://doi.org/10.1158/1538-7445.AM2021-LB193
Published: 01 July 2021
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Abstract PO-009: Disrupting chromatin architecture: The NuRD subunit and ATPase CHD4 as a new therapeutic target in pediatric sarcoma

Joana G. Marques, Berkley Gryder, Blaz Pavlovic, Yeonjoo Chung, Quy Ngo, Marco Wachtel, Javed Khan, Beat Schäfer
Journal: Cancer Research
Cancer Res (2020) 80 (23_Supplement): PO-009.
DOI: https://doi.org/10.1158/1538-7445.EPIMETAB20-PO-009
Published: 02 December 2020
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Abstract 3445: Immuno-transcriptomic profiling identifies actionable genomic alterations in pediatric solid malignancies

Jun S. Wei, Andrew S. Brohl, Sivasish Sindiri, David Milewski, Young K. Song, Sushma Nagaraj, Vineela Gangalapudi, Xinyu Wen, Marc Ladanyi, Javed Khan
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 3445.
DOI: https://doi.org/10.1158/1538-7445.AM2020-3445
Published: 15 August 2020
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Abstract 4175: Identification of novel inhibitors of the PAX3-FOXO1 fusion oncogene in rhabdomyosarcoma

Yong Yean Kim, Robert Hawley, Berkley Gryder, Silvia Pomella, Josh Kowalczyk, Ranu Sinniah, Young Song, Javed Khan
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 4175.
DOI: https://doi.org/10.1158/1538-7445.AM2020-4175
Published: 15 August 2020
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Abstract 3900: The BRG1 ATPase helps to maintain the de-differentiation phenotype in alveolar rhabdomyosarcoma

Dominik Laubscher, Benjamin Z. Stanton, Berkley Gryder, Sudipto Das, Thorkell Andresson, Bernd Roschitzki, Witold Wolski, QuyAi Ngo, Joana G. Marques, Marco Wachtel, Christopher Vakoc, Javed Khan, Beat Schäfer
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 3900.
DOI: https://doi.org/10.1158/1538-7445.AM2020-3900
Published: 15 August 2020
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