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Journal Articles

Abstract B049: Oncolytic HSV1716-GMCSF combination strategies to remodel the immunosuppressive osteosarcoma tumor-microenvironment and promote anti-tumor immunity

Tyler K. Barr, Victoria A. Jennings, Alison Taylor, Jessica Murby, Natasha J. Caplen, Javed Khan, Richard Baugh, Heather E. Owston, Dennis McGonagle, Fiona Errington-Mais, Graham P. Cook
Journal: Cancer Research
Cancer Res (2024) 84 (17_Supplement): B049.
https://doi.org/10.1158/1538-7445.PEDIATRIC24-B049
Published: 05 September 2024
View article titled, Abstract B049: Oncolytic HSV1716-GMCSF combination strategies to remodel the immunosuppressive osteosarcoma tumor-microenvironment and promote anti-tumor immunity
Journal Articles

Abstract LB042: A potent FGFR4-targeted antibody-drug conjugate therapy for patients with rhabdomyosarcoma and other cancers expressing FGFR4

Meijie Tian, Katrina Jia, Jerry T. Wu, Jun S. Wei, Adam T. Cheuk, Zhongmei Zhang, Eleanor G. Pope, Boris Shor, L. Nathan Tumey, Javed Khan
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): LB042.
https://doi.org/10.1158/1538-7445.AM2024-LB042
Published: 05 April 2024
View article titled, Abstract LB042: A potent FGFR4-targeted antibody-drug conjugate therapy for patients with rhabdomyosarcoma and other cancers expressing FGFR4
Journal Articles

Abstract LB403: Suppression of antigen presentation in pediatric rhabdomyosarcoma

David Milewski, Hsien-Chao Chou, Vineela Gangalapudi, Meijie Tian, Yong Kim, Young Song, Jun Wei, Javed Khan
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): LB403.
https://doi.org/10.1158/1538-7445.AM2024-LB403
Published: 05 April 2024
View article titled, Abstract LB403: Suppression of antigen presentation in pediatric rhabdomyosarcoma
Journal Articles

Abstract 5835: Genome-Wide CRISPR gene knockout screens combined with selpercatinib identifies potent combination therapies for RET driven medullary thyroid carcinoma

Abdelrahman Rahmy, Arwa Fallatah, David Milewski, Meijie Tian, Young Song, Yong Kim, Hsien-Chao Chou, Xinyu Wen, Chaoyu Wang, Jun Wei, Robert Hawley, John Glod, Javed Khan
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 5835.
https://doi.org/10.1158/1538-7445.AM2024-5835
Published: 22 March 2024
View article titled, Abstract 5835: Genome-Wide CRISPR gene knockout screens combined with selpercatinib identifies potent combination therapies for RET driven medullary thyroid carcinoma
Journal Articles

Abstract 6148: Multiple new Ewing sarcoma susceptibility loci expand knowledge of germline genetic etiology and nominate mechanisms of risk

Aubrey K. Hubbard, Weiyin Zhou, Carrie Boyce, Javed Khan, Melissa M. Hudson, Kirsten K. Ness, Zhaoming Wang, Katherine A. Janeway, Philip J. Lupo, Lindsay M. Morton, Stephen J. Chanock, Thomas G. Grünewald, Olivier Delattre, Mitchell J. Machiela, Ewing Sarcoma Germline Genetics Group
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6148.
https://doi.org/10.1158/1538-7445.AM2024-6148
Published: 22 March 2024
View article titled, Abstract 6148: Multiple new Ewing sarcoma susceptibility loci expand knowledge of germline genetic etiology and nominate mechanisms of risk
Journal Articles

Abstract 1089: Endogenous HiBiT-tagging of PAX3-FOXO1 reveals downregulation of the fusion oncogene by CDK inhibitors and has synergy with vincristine

Yong Yean Kim, Katrina Jia, Mehal Churiwal, Teresa Hawley, Silvia Pomella, Christine Evans, Raj Chari, David Milewski, Ranuka Sinniah, Young Song, Hsien-Chao Chou, Xinyu Wen, Craig Thomas, Michele Ceribelli, Jun Wei, Robert Hawley, Javed Khan
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1089.
https://doi.org/10.1158/1538-7445.AM2024-1089
Published: 22 March 2024
View article titled, Abstract 1089: Endogenous HiBiT-tagging of PAX3-FOXO1 reveals downregulation of the fusion oncogene by CDK inhibitors and has synergy with vincristine
Journal Articles

Abstract 4739: Targeting resistance to BET inhibitors in Fusion-Positive Rhabdomyosarcoma

Matteo Cassandri, Erika Ferraro, Lucrezia D'Archivio, Francesca Aiello, Hsien-Chao Chou, Young K. Song, Berkley E. Gryder, Jun S. Wei, Simone Sidoli, Robert G. Hawley, Rossella Rota, Franco Locatelli, Javed Khan, Silvia Pomella
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 4739.
https://doi.org/10.1158/1538-7445.AM2024-4739
Published: 22 March 2024
View article titled, Abstract 4739: Targeting resistance to BET inhibitors in Fusion-Positive Rhabdomyosarcoma
Journal Articles

Abstract 1099: Combined MEK and RET inhibition overcomes resistance to single agent RET inhibition in medullary thyroid cancer

Arwa Fallatah, Abdelrahman Rahmy, Sophia Khan, Hsien-chao Chou, Kerstin Heselmeyer-Haddad, Darawalee Wangsa, David Milewski, Yong Kim, Robert Hawley, Young Song, Xiaohu Zhang, Craig Thomas, Jun S. Wei, Jong-In Park, John Glod, Javed Khan
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1099.
https://doi.org/10.1158/1538-7445.AM2024-1099
Published: 22 March 2024
View article titled, Abstract 1099: Combined MEK and RET inhibition overcomes resistance to single agent RET inhibition in medullary thyroid cancer
Journal Articles

Abstract LB315: Inhibition of FGFR4 with futibatinib combined with inhibition of IGF1R, Src family kinases, or AKT is synergistic against rhabdomyosarcoma

Jerry Wu, Adam Cheuk, Jun S. Wei, Yong Kim, David Milewski, Xiaohu Zhang, Michele Ceribelli, Erin Beck, Paul Shinn, Carleen Klump-Thomas, Kelli M. Wilson, Crystal McKnight, Zina Itkin, Elizabeth Calleja, Volker Wacheck, Hiroshi Sotome, Hiroshi Hirai, Craig Thomas, Javed Khan
Journal: Cancer Research
Cancer Res (2023) 83 (8_Supplement): LB315.
https://doi.org/10.1158/1538-7445.AM2023-LB315
Published: 14 April 2023
View article titled, Abstract LB315: Inhibition of FGFR4 with futibatinib combined with inhibition of IGF1R, Src family kinases, or AKT is synergistic against rhabdomyosarcoma
Journal Articles

Abstract 6736: Suppression of antigen presentation is a hallmark of pediatric rhabdomyosarcoma

David Milewski, Meijie Tian, Yong Kim, Jun Wei, Javed Khan
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 6736.
https://doi.org/10.1158/1538-7445.AM2023-6736
Published: 04 April 2023
View article titled, Abstract 6736: Suppression of antigen presentation is a hallmark of pediatric rhabdomyosarcoma
Journal Articles

Abstract 3538: Endogenous HiBiT-tagging of PAX3-FOXO1 identifies potent suppressors of PAX3-FOXO1 protein levels by high-throughput screening

Yong Yean Kim, Robert G. Hawley, Mehal Churiwal, Teresa S. Hawley, Christine N. Evans, Raj Chari, David Milewski, Ranuka Sinniah, Young K. Song, Hsien-Chao Chou, Xinyu Wen, Ying Pang, Jing Wu, Craig J. Thomas, Jun S. Wei, Michele Ceribelli, Javed Khan
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3538.
https://doi.org/10.1158/1538-7445.AM2023-3538
Published: 04 April 2023
View article titled, Abstract 3538: Endogenous HiBiT-tagging of PAX3-FOXO1 identifies potent suppressors of PAX3-FOXO1 protein levels by high-throughput screening
Journal Articles

Abstract 1199: Discovery of subtype-specific and therapy associated effects on the tumor immune microenvironment in pediatric neuroblastoma

Katherine E. Masih, Zahin Islam, Paul Aiyetan, Ben J. Somerville, Igor B. Kuznetsov, William Bocik, Daniel R. Catchpoole, Jun S. Wei, Javed Khan
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1199.
https://doi.org/10.1158/1538-7445.AM2023-1199
Published: 04 April 2023
View article titled, Abstract 1199: Discovery of subtype-specific and therapy associated effects on the tumor immune microenvironment in pediatric neuroblastoma
Journal Articles

Abstract 1784: FGFR4 and CD276 dual targeting CAR T cells demonstrate synergistic antitumor activity in childhood rhabdomyosarcoma

Meijie Tian, Jun S. Wei, Adam Cheuk, David Milewski, Zhongmei Zhang, Yong Yuan Kim, Can Liu, Sherif Badr, Michael C. Kelly, Jerry T. Wu, Abdelrahman Rahmy, Hsien-Chao Chou, Xinyu Wen, Javed Khan
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1784.
https://doi.org/10.1158/1538-7445.AM2023-1784
Published: 04 April 2023
View article titled, Abstract 1784: FGFR4 and CD276 dual targeting CAR T cells demonstrate synergistic antitumor activity in childhood rhabdomyosarcoma
Journal Articles

Abstract LB062: Profiling of pediatric neuroblastoma reveals a dynamic and clinically significant tumor immune microenvironment

Katherine E. Masih, Zahin Islam, Paul Aiyetan, Igor B. Kuznetsov, Stephen M. Hewitt, Daniel Catchpoole, Jun S. Wei, William Bocik, Javed Khan
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): LB062.
https://doi.org/10.1158/1538-7445.AM2022-LB062
Published: 15 June 2022
View article titled, Abstract LB062: Profiling of pediatric neuroblastoma reveals a dynamic and clinically significant tumor immune microenvironment
Journal Articles

Abstract 683: Identification of common germline variants associated with pediatric rhabdomyosarcoma survival: A report from the Children's Oncology Group (COG)

Bailey A. Martin-Giacalone, Michael E. Scheurer, Javed Khan, Stephen J. Chanock, Shengchao Alfred Li, Meredith Yeager, Deborah A. Marquez-Do, Donald A. Barkauskas, David Hall, Matthew T. McEvoy, Melissa A. Richard, Pagna Sok, Austin L. Brown, Aniko Sabo, Stephen X. Skapek, Douglas S. Hawkins, Rajkumar Venkatramani, Lisa Mirabello, Philip J. Lupo
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 683.
https://doi.org/10.1158/1538-7445.AM2022-683
Published: 15 June 2022
View article titled, Abstract 683: Identification of common germline variants associated with pediatric rhabdomyosarcoma survival: A report from the Children's Oncology Group (COG)
Journal Articles

Abstract LB213: Potent antitumor activity of a FGFR4 CAR-T in rhabdomyosarcoma

Adam Tai Chi Cheuk, Meijie Tian, Nityashree Shivaprasad, Steven Highfill, David Milewski, G Tom Brown, Peter Azorsa, Dina Schneider, Berkley Gryder, Jun S Wei, Young Kwok Song, Hsien-Chao Chou, Jerry Wu, Joon-Yong Chung, Brian Belyea, Corinne Linardic, Stephen M Hewitt, Boro Dropulic, Rimas Orentas, Javed Khan
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): LB213.
https://doi.org/10.1158/1538-7445.AM2022-LB213
Published: 15 June 2022
View article titled, Abstract LB213: Potent antitumor activity of a FGFR4 CAR-T in rhabdomyosarcoma
Journal Articles

Abstract 703: Novel histone lysine demethylase inhibitors disrupt PAX3-FOXO1-driven transcriptional output in fusion-positive rhabdomyosarcoma

Yong Yean Kim, Girma Woldemichael, Berkley Gryder, Silvia Pomella, Ranuka Sinniah, Josh Kowalczyk, Young Song, Mehal Churiwal, Joseph Barchi, John Schneekloth, Xinyu Wen, Hsein-Chao Chou, Barry Okeefe, John Shern, Robert Hawley, Javed Khan
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 703.
https://doi.org/10.1158/1538-7445.AM2022-703
Published: 15 June 2022
View article titled, Abstract 703: Novel histone lysine demethylase inhibitors disrupt PAX3-FOXO1-driven transcriptional output in fusion-positive rhabdomyosarcoma
Journal Articles

Abstract 3581: Multi-omic analysis identifies mechanisms of resistance to CD19 CAR T-cell therapy in children with acute lymphoblastic leukemia

Katherine E. Masih, Rebecca Gardner, Hsien-Chao Chou, Abdalla Abdelmaksoud, Young K. Song, Luca Mariani, Vineela Gangalapudi, Berkley E. Gryder, Ashley Wilson, Serifat O. Adebola, Benjamin Z. Stanton, Chaoyu Wang, Xinyu Wen, Gregoire Altan-Bonnet, Michael C. Kelly, Jun S. Wei, Martha L. Bulyk, Michael C. Jensen, Rimas J. Orentas, Javed Khan
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3581.
https://doi.org/10.1158/1538-7445.AM2022-3581
Published: 15 June 2022
View article titled, Abstract 3581: Multi-omic analysis identifies mechanisms of resistance to CD19 CAR T-cell therapy in children with acute lymphoblastic leukemia
Journal Articles

Abstract 466: Predicting survival of rhabdomyosarcoma patients based on deep learning of H&E images

David Milewski, Hyun Jung, G. Thomas Brown, Yanling Liu, Jack Collins, Marc Ladanyi, Erin Rudzinski, Javed Khan
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 466.
https://doi.org/10.1158/1538-7445.AM2022-466
Published: 15 June 2022
View article titled, Abstract 466: Predicting survival of rhabdomyosarcoma patients based on deep learning of H&E images
Journal Articles

Abstract 579: Anti-myeloid poly-pharmacy allows FGFR4-targeted chimeric antigen receptors to effectively treat an orthotopic model of rhabdomyosarcoma

Peter M. Sullivan, Rajesh Kumar, Wei Li, Lingyang Wang, Yue Zhang, Sophie Jamet, Adam Cheuk, Javed Khan, Dimiter S. Dimitrov, Rimas J. Orentas
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 579.
https://doi.org/10.1158/1538-7445.AM2022-579
Published: 15 June 2022
View article titled, Abstract 579: Anti-myeloid poly-pharmacy allows FGFR4-targeted chimeric antigen receptors to effectively treat an orthotopic model of rhabdomyosarcoma