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Jason W. Locasale
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Journal Articles

Lactate Utilization Enables Metabolic Escape to Confer Resistance to BET Inhibition in Acute Myeloid Leukemia

Andrew J. Monteith, Haley E. Ramsey, Alexander J. Silver, Donovan Brown, Dalton Greenwood, Brianna N. Smith, Ashley D. Wise, Juan Liu, Sarah D. Olmstead, Jackson Watke, Maria P. Arrate, Agnieszka E. Gorska, Londa Fuller, Jason W. Locasale, Matthew C. Stubbs, Jeffrey C. Rathmell, Michael R. Savona
Journal: Cancer Research
Cancer Res (2024) 84 (7): 1101–1114.
https://doi.org/10.1158/0008-5472.CAN-23-0291
Published: 01 April 2024
View article titled, Lactate Utilization Enables Metabolic Escape to Confer Resistance to BET Inhibition in Acute Myeloid Leukemia
Open the PDF for Lactate Utilization Enables Metabolic Escape to Confer Resistance to BET Inhibition in Acute Myeloid Leukemia in another window
Includes: Supplementary data
Journal Articles

Delineating a Role for Methionine Metabolism in Colorectal Cancer

Shiyu Liu, Jason W. Locasale
Journal: Cancer Research
Cancer Res (2023) 83 (23): 3833–3834.
https://doi.org/10.1158/0008-5472.CAN-23-3169
Published: 01 December 2023
View article titled, Delineating a Role for Methionine Metabolism in Colorectal Cancer
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Journal Articles

Abstract P5-05-01: Metabolite profiling and RNA-seq identifies novel metabolomic-genomic biomarker and therapeutic options for rapidly proliferating breast cancers

Cherise R Glodowski, Chengheng Liao, Cheng Fan, Juan Liu, Kevin R Mott, Akash Kaushik, Hieu Vu, Jason W Locasale, Samuel K McBrayer, Ralph J DeBerardinis, Charles M Perou, Qing Zhang
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P5-05-01.
https://doi.org/10.1158/1538-7445.SABCS21-P5-05-01
Published: 15 February 2022
View article titled, Abstract P5-05-01: Metabolite profiling and RNA-seq identifies novel metabolomic-genomic biomarker and therapeutic options for rapidly proliferating breast cancers
Journal Articles

Integrated Metabolic Profiling and Transcriptional Analysis Reveals Therapeutic Modalities for Targeting Rapidly Proliferating Breast Cancers

Chengheng Liao, Cherise Ryan Glodowski, Cheng Fan, Juan Liu, Kevin R. Mott, Akash Kaushik, Hieu Vu, Jason W. Locasale, Samuel K. McBrayer, Ralph J. DeBerardinis, Charles M. Perou, Qing Zhang
Journal: Cancer Research
Cancer Res (2022) 82 (4): 665–680.
https://doi.org/10.1158/0008-5472.CAN-21-2745
Published: 15 February 2022
View article titled, Integrated Metabolic Profiling and Transcriptional Analysis Reveals Therapeutic Modalities for Targeting Rapidly Proliferating Breast Cancers
Open the PDF for Integrated Metabolic Profiling and Transcriptional Analysis Reveals Therapeutic Modalities for Targeting Rapidly Proliferating Breast Cancers in another window
Includes: Supplementary data
Journal Articles

Abstract PD15-10: Identification of BBOX1 as a therapeutic target in triple-negative breast cancer

Chengheng Liao, Yang Zhang, Cheng Fan, Laura E. Herring, Juan Liu, Jason W. Locasale, Mamoru Takada, Jin Zhou, Giada Zurlo, Lianxin Hu, Jeremy M. Simon, Travis S. Ptacek, Victor G. Andrianov, Einars Loza, Yan Peng, Huanghe Yang, Charles M. Perou, Qing Zhang
Journal: Cancer Research
Cancer Res (2021) 81 (4_Supplement): PD15-10.
https://doi.org/10.1158/1538-7445.SABCS20-PD15-10
Published: 15 February 2021
View article titled, Abstract PD15-10: Identification of BBOX1 as a therapeutic target in triple-negative breast cancer
Journal Articles

Abstract 5709: Disruption of mitochondrial metabolism underlies the efficacy of devimistat in acute myeloid leukemia

Michael A. Reid, Shree Bose, Zhengtao Xiao, Peter G. Mikhael, Juan Liu, Jason W. Locasale, Timothy S. Pardee
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 5709.
https://doi.org/10.1158/1538-7445.AM2020-5709
Published: 15 August 2020
View article titled, Abstract 5709: Disruption of mitochondrial metabolism underlies the efficacy of devimistat in acute myeloid leukemia
Journal Articles

Abstract 792: Acetate production from glucose and coupling to mitochondrial metabolism in mammals

Xiaojing Liu, Daniel E. Cooper, Ahmad A. Cluntun, Marc O. Warmoes, Steven Zhao, Michael A. Reid, Juan Liu, Peder J. Lund, Mariana Lopes, Benjamin A. Garcia, Kathryn E. Wellen, David G. Kirsch, Jason W. Locasale
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 792.
https://doi.org/10.1158/1538-7445.AM2019-792
Published: 01 July 2019
View article titled, Abstract 792: Acetate production from glucose and coupling to mitochondrial metabolism in mammals
Journal Articles

Abstract 388: p16/MTAP status as a model for investigating gene-environment interactions in metabolism

Sydney M. Sanderson, Peter Mikhael, Ziwei Dai, Jason W. Locasale
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 388.
https://doi.org/10.1158/1538-7445.AM2018-388
Published: 01 July 2018
View article titled, Abstract 388: p16/MTAP status as a model for investigating gene-environment interactions in metabolism
Journal Articles

Abstract 5496: A predictive model for selective targeting of the Warburg effect through GAPDH inhibition with a natural product

Maria V. Liberti, Ziwei Dai, Suzanne E. Wardell, Joshua A. Baccile, Xiaojing Liu, Xia Gao, Robert Baldi, Mahya Mehrmohamadi, Marc O. Johnson, Neel S. Madhukar, Alexander Shestov, Iok I. C. Chio, Olivier Elemento, Jeffrey C. Rathmell, Frank C. Schroeder, Donald P. McDonnell, Jason W. Locasale
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5496.
https://doi.org/10.1158/1538-7445.AM2018-5496
Published: 01 July 2018
View article titled, Abstract 5496: A predictive model for selective targeting of the Warburg effect through GAPDH inhibition with a natural product
Journal Articles

Gain of Glucose-Independent Growth upon Metastasis of Breast Cancer Cells to the Brain

Jinyu Chen, Ho-Jeong Lee, Xuefeng Wu, Lei Huo, Sun-Jin Kim, Lei Xu, Yan Wang, Junqing He, Lakshmi R. Bollu, Guang Gao, Fei Su, James Briggs, Xiaojing Liu, Tamar Melman, John M. Asara, Isaiah J. Fidler, Lewis C. Cantley, Jason W. Locasale, Zhang Weihua
Journal: Cancer Research
Cancer Res (2015) 75 (3): 554–565.
https://doi.org/10.1158/0008-5472.CAN-14-2268
Published: 01 February 2015
View article titled, Gain of Glucose-Independent Growth upon Metastasis of Breast Cancer Cells to the Brain
Open the PDF for Gain of Glucose-Independent Growth upon Metastasis of Breast Cancer Cells to the Brain in another window
Includes: Supplementary data
Journal Articles

Abstract A101: Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism.

Haoqiang Ying, Hailei Zhang, Jonathan L. Coloff, Haiyan Yan, Wei Wang, Shujuan Chen, Andrea Viale, Hongwu Zheng, Ji-hye Paik, Carol Lim, Alexander R. Guimaraes, Alec C. Kimmelman, Eric S. Martin, Jeffery Chang, Aram Hezel, Samuel R. Perry, Jian Hu, Boyi Gan, Yonghong Xiao, John M. Asara, Ralph Weissleder, Y. Alan Wang, Costas A. Lyssiotis, Lynda Chin, Lewis C. Cantley, Ronald A. DePinho, Sujun Hua, Gerald C. Chu, Eliot Fletcher-Sananikone, Jason W. Locasale, Jaekyoung Son
Journal: Cancer Research
Cancer Res (2012) 72 (14_Supplement): A101.
https://doi.org/10.1158/1538-7445.PANCA2012-A101
Published: 03 April 2014
View article titled, Abstract A101: Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism.
Journal Articles

Abstract 5428: Rewiring of glucose metabolism in cancer.

Jason W. Locasale
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 5428.
https://doi.org/10.1158/1538-7445.AM2013-5428
Published: 15 April 2013
View article titled, Abstract 5428: Rewiring of glucose metabolism in cancer.