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Jason Roszik
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Journal Articles

Abstract CT012: Personalized neoantigen vaccine with or without pembrolizumab in patients with microsatellite-stable metastatic colorectal cancer

Free
Saurav Daniel Haldar, Gayathri Anandappa, Arjun Katailiha, Amjad Talukder, Sarah Shin, Jae Lee, Erin Coyne, Alens Valentin, Sapna Parshottam, Chantale Bernatchez, Jane Thomas, Jason Roszik, Anirban Maitra, Scott Kopetz, Elizabeth Jaffee, Won Jin Ho, Gregory Lizee, Michael Overman
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_2): CT012.
https://doi.org/10.1158/1538-7445.AM2025-CT012
Published: 25 April 2025
View articletitled, Abstract CT012: Personalized neoantigen vaccine with or without pembrolizumab in patients with microsatellite-stable metastatic colorectal cancer
Journal Articles

Abstract 7499: Driver mutations propel subclonal evolution and spatial patterns of tumor growth in intrahepatic cholangiocarcinoma

Free
Evit John, Pooja Shukla, Anish Jain, Alexandria Lau, Tom Lesluyes, Huw Ogilvie, Maxime Tarabichi, Jason Roszik, Yinyin Yuan, Peter Van Loo, Lawrence Kwong, Yun Shin Chun
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 7499.
https://doi.org/10.1158/1538-7445.AM2025-7499
Published: 21 April 2025
View articletitled, Abstract 7499: Driver mutations propel subclonal evolution and spatial patterns of tumor growth in intrahepatic cholangiocarcinoma
Journal Articles

Abstract 4994: Crizotinib enhances the efficacy of BX-795 identified by high-throughput screening of pan-active drugs in colorectal cancer cells

Free
Susmita Ghosh, Fan Fan, Jason Roszik, Reid Powell, Yong Park, Clifford Stephan, Lee M. Ellis, Rajat Bhattacharya
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4994.
https://doi.org/10.1158/1538-7445.AM2023-4994
Published: 04 April 2023
View articletitled, Abstract 4994: Crizotinib enhances the efficacy of BX-795 identified by high-throughput screening of pan-active drugs in colorectal cancer cells
Journal Articles

Abstract 4261: Genomic landscape of 2128 thyroid cancers from the aacr genie database: Implications for targeted therapies

Free
Blessie Elizabeth Nelson, Mohammed Gouda, Jason Roszik, Mimi L. Hu, Maria Cabanillas, Vivek Subbiah
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4261.
https://doi.org/10.1158/1538-7445.AM2023-4261
Published: 04 April 2023
View articletitled, Abstract 4261: Genomic landscape of 2128 thyroid cancers from the aacr genie database: Implications for targeted therapies
Journal Articles

Abstract 2184: Landscape of genomic alterations of ultra-rare sarcomas (URS) from 1,079 patients in the AACR GENIE real world database: Clinical implications

Free
Justin Tyler Moyers, Danielle Brazel, Priyanka Kumar, Hung Doan, Jason Roszik, Jennifer B. Valerin, Roberto Carmagnani Pestana, Warren A. Chow, Vivek K. Subbiah
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2184.
https://doi.org/10.1158/1538-7445.AM2022-2184
Published: 15 June 2022
View articletitled, Abstract 2184: Landscape of genomic alterations of ultra-rare sarcomas (URS) from 1,079 patients in the AACR GENIE real world database: Clinical implications
Journal Articles

Abstract 1056: Determining efficacy of combining the MEK inhibitor trametinib with vincristine identified by unbiased high throughput screening in RAS-mutated colorectal cancer cells

Free
Susmita Ghosh, Fan Fan, Jason Roszik, Reid Powell, Yong Park, Clifford Stephan, Lee M. Ellis, Rajat Bhattacharya
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1056.
https://doi.org/10.1158/1538-7445.AM2022-1056
Published: 15 June 2022
View articletitled, Abstract 1056: Determining efficacy of combining the MEK inhibitor trametinib with vincristine identified by unbiased high throughput screening in RAS-mutated colorectal cancer cells
Journal Articles

Abstract 5237: B-Raf V600E harboring non-melanoma cancers treated with Vemurafenib monotherapy and in combination with Everolimus/Sorafenib/Crizotinib/Paclitaxel+ Carboplatin: A pooled analysis of five phase 1/2 studies

Free
Blessie Elizabeth Nelson, Jason Roszik, Filip Janku, David Hong, Shumei Kato, Aung Naing, Sarina Piha-Paul, Siqing Fu, Apostolia Tsimberidou, Maria Cabanillas, Naifa Busaidy, Milind Javle, Lauren Byers, John Heymach, Funda Meric-Bernstam, Vivek Subbiah
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5237.
https://doi.org/10.1158/1538-7445.AM2022-5237
Published: 15 June 2022
View articletitled, Abstract 5237: B-Raf V600E harboring non-melanoma cancers treated with Vemurafenib monotherapy and in combination with Everolimus/Sorafenib/Crizotinib/Paclitaxel+ Carboplatin: A pooled analysis of five phase 1/2 studies
Journal Articles

Abstract 1221: The landscape of 2,706 RET alterations from 89,754 adult patients with cancer: Clinical implications

Free
Jacob J. Adashek, Alexander Andreev-Drakhlin, Jason Roszik, Aakash P. Desai, Vivek Subbiah
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1221.
https://doi.org/10.1158/1538-7445.AM2021-1221
Published: 01 July 2021
View articletitled, Abstract 1221: The landscape of 2,706 RET alterations from 89,754 adult patients with cancer: Clinical implications
Journal Articles

Abstract 1479: Pan-cancer efficacy of BRAF and/or MEK inhibitors in BRAF V600-mutant multiple non-melanoma cancers: A clinico-genomic study

Free
Jacob J. Adashek, Aakash P. Desai, Arjun K. Menta, Jason Roszik, Vivek Subbiah
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1479.
https://doi.org/10.1158/1538-7445.AM2021-1479
Published: 01 July 2021
View articletitled, Abstract 1479: Pan-cancer efficacy of BRAF and/or MEK inhibitors in BRAF V600-mutant multiple non-melanoma cancers: A clinico-genomic study
Journal Articles

Abstract B18: The expression of CD74-regulated inflammatory markers in stage IV melanoma: Risk of CNS metastasis and patient survival

Free
Dai Ogata, Sun-Hee Kim, Jason Roszik, Roland L Bassett, Jr, Elizabeth A Grimm, Suhendan Ekmekcioglu
Journal: Cancer Research
Cancer Res (2020) 80 (19_Supplement): B18.
https://doi.org/10.1158/1538-7445.MEL2019-B18
Published: 02 October 2020
View articletitled, Abstract B18: The expression of CD74-regulated inflammatory markers in stage IV melanoma: Risk of CNS metastasis and patient survival
Journal Articles

Abstract PR15: CD74 regulated inflammatory pattern is associated with TIL growth and favorable response to adoptive immunotherapy

Free
Dai-Ogata, Caitlin A. Creasy, Sun-Hee Kim, Jason Roszik, Patrick Hwu, Elizabeth A. Grimm, Chantale Bernatchez, Suhendan Ekmekcioglu
Journal: Cancer Research
Cancer Res (2020) 80 (19_Supplement): PR15.
https://doi.org/10.1158/1538-7445.MEL2019-PR15
Published: 02 October 2020
View articletitled, Abstract PR15: CD74 regulated inflammatory pattern is associated with TIL growth and favorable response to adoptive immunotherapy
Journal Articles

Abstract IA08: Elevated endogenous SDHA drives pathologic metabolism in highly metastatic uveal melanoma

Free
Chandrani Chattopadhyay, Junna Oba, Jason Roszik, Scott E. Woodman, Elizabeth A. Grimm
Journal: Cancer Research
Cancer Res (2020) 80 (19_Supplement): IA08.
https://doi.org/10.1158/1538-7445.MEL2019-IA08
Published: 02 October 2020
View articletitled, Abstract IA08: Elevated endogenous SDHA drives pathologic metabolism in highly metastatic uveal melanoma
Journal Articles

Abstract B09: Nitric oxide stimulates PI3K-AKT pathway activation by S-nitrosylation of PTEN in human melanoma cells

Free
Zhen Ding, Dai Ogata, Jason Roszik, Yong Qin, Sun-Hee Kim, Suhendan Ekmekcioglu, Elizabeth A. Grimm
Journal: Cancer Research
Cancer Res (2020) 80 (19_Supplement): B09.
https://doi.org/10.1158/1538-7445.MEL2019-B09
Published: 02 October 2020
View articletitled, Abstract B09: Nitric oxide stimulates PI3K-AKT pathway activation by S-nitrosylation of PTEN in human melanoma cells
Journal Articles

Abstract B13: Intrinsic microsomal PGE2 synthase-1 associates with poor patient survival and T-cell infiltration, and regulates immunosuppression in human and mouse melanoma models

Free
Sun-Hee Kim, Jason Roszik, Sungnam Cho, Dai Ogata, Suhendan Ekmekcioglu, Elizabeth A Grimm
Journal: Cancer Research
Cancer Res (2020) 80 (19_Supplement): B13.
https://doi.org/10.1158/1538-7445.MEL2019-B13
Published: 02 October 2020
View articletitled, Abstract B13: Intrinsic microsomal PGE2 synthase-1 associates with poor patient survival and T-cell infiltration, and regulates immunosuppression in human and mouse melanoma models
Journal Articles

Abstract A12: Presence of circulating tumor cells is an adverse risk factor for early-stage uveal melanoma

Free
Jason Roszik, Dan Gombos, Joshua Upshaw, Vanessa Sarli, Salyna Meas, Anthony Lucci, Carolyn Hall, Sapna Patel, Kartik Anand
Journal: Cancer Research
Cancer Res (2020) 80 (19_Supplement): A12.
https://doi.org/10.1158/1538-7445.MEL2019-A12
Published: 02 October 2020
View articletitled, Abstract A12: Presence of circulating tumor cells is an adverse risk factor for early-stage uveal melanoma
Journal Articles

Abstract 1516: Deep profiling of T-cell repertoire and tumor heterogeneity in chronic lymphocytic leukemia patients following allogeneic T-cell therapy

Free
Celine Kerros, John P. Miller, Xizeng Mao, Haven R. Garber, Hannah C. Beird, Jianhua Zhang, Jason Roszik, Paul Leonard, Li Zhao, Sahil Seth, Pei Lin, Huandong Sun, William G. Wierda, Issa F. Khouri, Karen Clise-Dwyer, Andrew Futreal, Shoudan Liang, Koppikar Priya, Jeffrey Molldrem
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 1516.
https://doi.org/10.1158/1538-7445.AM2020-1516
Published: 15 August 2020
View articletitled, Abstract 1516: Deep profiling of T-cell repertoire and tumor heterogeneity in chronic lymphocytic leukemia patients following allogeneic T-cell therapy
Journal Articles

Abstract 2547: USP18 promotes lipolysis, fatty acid oxidation and lung cancer growth

Free
Xi Liu, Yun Lu, Zibo Chen, Xiuxia Liu, Weiguo Hu, Lin Zheng, Yulong Chen, Mi Shi, Lisa Mustachio, Jason Roszik, Masanori Kawakami, Sarah Freemantle, Ethan Dmitrovsky
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 2547.
https://doi.org/10.1158/1538-7445.AM2020-2547
Published: 15 August 2020
View articletitled, Abstract 2547: USP18 promotes lipolysis, fatty acid oxidation and lung cancer growth
Journal Articles

Abstract 550: Determining efficacy of drug combinations identified by unbiased high throughput screening for RAS-mutated colorectal cancer

Free
Fan Fan, Reid Powell, Jason Roszik, Rui Wang, Xiangcang Ye, Clifford Stephan, Lee Ellis, Rajat Bhattacharya
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 550.
https://doi.org/10.1158/1538-7445.AM2020-550
Published: 15 August 2020
View articletitled, Abstract 550: Determining efficacy of drug combinations identified by unbiased high throughput screening for RAS-mutated colorectal cancer
Journal Articles

Targeting the SAGA and ATAC Transcriptional Coactivator Complexes in MYC-Driven Cancers

Available to Purchase
Lisa Maria Mustachio, Jason Roszik, Aimee Farria, Sharon Y.R. Dent
Journal: Cancer Research
Cancer Res (2020) 80 (10): 1905–1911.
https://doi.org/10.1158/0008-5472.CAN-19-3652
Published: 15 May 2020
View articletitled, Targeting the SAGA and ATAC Transcriptional Coactivator Complexes in MYC-Driven Cancers
Open the PDF for Targeting the SAGA and ATAC Transcriptional Coactivator Complexes in MYC-Driven Cancers in another window
Journal Articles

Abstract 3279: All-trans-retinoic acid (ATRA) markedly augments anti-tumor immunity

Free
Lu Huang, Zibo Chen, Leila Williams, Yulong Chen, Yunfei Wang, Masanori Kawakami, Jason Roszik, Patrick Hwu, Ethan Dmitrovsky, Weiyi Peng, Xi Liu
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3279.
https://doi.org/10.1158/1538-7445.AM2019-3279
Published: 01 July 2019
View articletitled, Abstract 3279: All-trans-retinoic acid (ATRA) markedly augments anti-tumor immunity