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Jason E. Toombs
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Journal Articles

SMAD4 Deficiency Promotes Pancreatic Cancer Progression and Confers Susceptibility to TGFβ Inhibition

Open Access
Gilbert Z. Murimwa, Natalie E. Williams, Dina Alzhanova, Amir Mohammadi, Jill M. Westcott, Francisca Beato, Ruifan Dai, Luis Nivelo, Francesca Rossi, Henry K. Fleming, Alexandra F. Tassielli, Zeynep Yazgan, Jason E. Toombs, Jason B. Fleming, Aatur D. Singhi, Cecilia G. Ethun, Huocong Huang, Rolf A. Brekken
Journal: Cancer Research
Cancer Res (2025)
https://doi.org/10.1158/0008-5472.CAN-24-1970
Published: 29 May 2025
View articletitled, SMAD4 Deficiency Promotes Pancreatic Cancer Progression and Confers Susceptibility to TGFβ Inhibition
Open the PDF for SMAD4 Deficiency Promotes Pancreatic Cancer Progression and Confers Susceptibility to TGFβ Inhibition in another window
Includes: Supplementary data
Journal Articles

Small-Molecule Inhibition of Axl Targets Tumor Immune Suppression and Enhances Chemotherapy in Pancreatic Cancer

Free
Kathleen F. Ludwig, Wenting Du, Noah B. Sorrelle, Katarzyna Wnuk-Lipinska, Mary Topalovski, Jason E. Toombs, Victoria H. Cruz, Shinichi Yabuuchi, N.V. Rajeshkumar, Anirban Maitra, James B. Lorens, Rolf A. Brekken
Journal: Cancer Research
Series: Author Choice
Cancer Res (2018) 78 (1): 246–255.
https://doi.org/10.1158/0008-5472.CAN-17-1973
Published: 02 January 2018
View articletitled, Small-Molecule Inhibition of Axl Targets Tumor Immune Suppression and Enhances Chemotherapy in Pancreatic Cancer
Open the PDF for Small-Molecule Inhibition of Axl Targets Tumor Immune Suppression and Enhances Chemotherapy in Pancreatic Cancer in another window
Includes: Supplementary data
Journal Articles

Fibulin-5 Blocks Microenvironmental ROS in Pancreatic Cancer

Free
Miao Wang, Mary Topalovski, Jason E. Toombs, Christopher M. Wright, Zachary R. Moore, David A. Boothman, Hiromi Yanagisawa, Huamin Wang, Agnieszka Witkiewicz, Diego H. Castrillon, Rolf A. Brekken
Journal: Cancer Research
Cancer Res (2015) 75 (23): 5058–5069.
https://doi.org/10.1158/0008-5472.CAN-15-0744
Published: 30 November 2015
View articletitled, Fibulin-5 Blocks Microenvironmental ROS in Pancreatic Cancer
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Includes: Supplementary data
Journal Articles

Warfarin Blocks Gas6-Mediated Axl Activation Required for Pancreatic Cancer Epithelial Plasticity and Metastasis

Free
Amanda Kirane, Kathleen F. Ludwig, Noah Sorrelle, Gry Haaland, Tone Sandal, Renate Ranaweera, Jason E. Toombs, Miao Wang, Sean P. Dineen, David Micklem, Michael T. Dellinger, James B. Lorens, Rolf A. Brekken
Journal: Cancer Research
Cancer Res (2015) 75 (18): 3699–3705.
https://doi.org/10.1158/0008-5472.CAN-14-2887-T
Published: 14 September 2015
View articletitled, Warfarin Blocks Gas6-Mediated Axl Activation Required for Pancreatic Cancer Epithelial Plasticity and Metastasis
Open the PDF for Warfarin Blocks Gas6-Mediated Axl Activation Required for Pancreatic Cancer Epithelial Plasticity and Metastasis in another window
Includes: Supplementary data
Journal Articles

Abstract B78: Warfarin blocks Gas6-mediated Axl activation required for pancreatic tumor plasticity and metastasis

Free
Amanda Kirane, Kathleen W. Ludwig, Gry Haaland, Tone Sandal, Renata Ranaweera, Jason E. Toombs, Laura A. Sullivan, Miao Wang, Noah Sorrelle, Sean P. Dineen, Michael T. Dellinger, James B. Lorens, Rolf A. Brekken
Journal: Cancer Research
Cancer Res (2015) 75 (13_Supplement): B78.
https://doi.org/10.1158/1538-7445.PANCA2014-B78
Published: 30 June 2015
View articletitled, Abstract B78: Warfarin blocks Gas6-mediated Axl activation required for pancreatic tumor plasticity and metastasis
Journal Articles

Abstract A24: Strategies to combat hypoxia-driven PDAC invasion after antiangiogenic therapy.

Free
Lee B. Rivera, Juliet G. Carbon, Kristina Aguilera, Jason E. Toombs, Amanda Kirane, Michael T. Dellinger, Gaurab Chakrabarti, Jordan Braunfeld, Rolf A. Brekken
Journal: Cancer Research
Cancer Res (2012) 72 (14_Supplement): A24.
https://doi.org/10.1158/1538-7445.PANCA2012-A24
Published: 03 April 2014
View articletitled, Abstract A24: Strategies to combat hypoxia-driven PDAC invasion after antiangiogenic therapy.
Journal Articles

Collagen Signaling Enhances Tumor Progression after Anti-VEGF Therapy in a Murine Model of Pancreatic Ductal Adenocarcinoma

Free
Kristina Y. Aguilera, Lee B. Rivera, Hoon Hur, Juliet G. Carbon, Jason E. Toombs, Courtney D. Goldstein, Michael T. Dellinger, Diego H. Castrillon, Rolf A. Brekken
Journal: Cancer Research
Cancer Res (2014) 74 (4): 1032–1044.
https://doi.org/10.1158/0008-5472.CAN-13-2800
Published: 16 February 2014
View articletitled, Collagen Signaling Enhances Tumor Progression after Anti-VEGF Therapy in a Murine Model of Pancreatic Ductal Adenocarcinoma
Open the PDF for Collagen Signaling Enhances Tumor Progression after Anti-VEGF Therapy in a Murine Model of Pancreatic Ductal Adenocarcinoma in another window
Includes: Supplementary data
Journal Articles

Abstract 3819: COX-2 inhibition with apricoxib drives mesenchymal to epithelial transition and synergizes with anti-VEGF therapy

Free
Amanda R. Kirane, Michael T. Dellinger, Jason E. Toombs, Francis J. Burrows, Rolf A. Brekken
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 3819.
https://doi.org/10.1158/1538-7445.AM2012-3819
Published: 15 April 2012
View articletitled, Abstract 3819: COX-2 inhibition with apricoxib drives mesenchymal to epithelial transition and synergizes with anti-VEGF therapy
Journal Articles

Smac Mimetic Increases Chemotherapy Response and Improves Survival in Mice with Pancreatic Cancer

Free
Sean P. Dineen, Christina L. Roland, Rachel Greer, Juliet G. Carbon, Jason E. Toombs, Puja Gupta, Nabeel Bardeesy, Haizhou Sun, Noelle Williams, John D. Minna, Rolf A. Brekken
Journal: Cancer Research
Cancer Res (2010) 70 (7): 2852–2861.
https://doi.org/10.1158/0008-5472.CAN-09-3892
Published: 31 March 2010
View articletitled, Smac Mimetic Increases Chemotherapy Response and Improves Survival in Mice with Pancreatic Cancer
Open the PDF for Smac Mimetic Increases Chemotherapy Response and Improves Survival in Mice with Pancreatic Cancer in another window
Includes: Supplementary data