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Jason B. Fleming
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Journal Articles

Abstract 2522: Pathway and immune profile analysis of cyst-derived versus PanIN-derived pancreatic ductal adenocarcinomas

Margaret A. Park, Somashekar G. Krishna, Maria C. Genilo-Delgado, Kristyn Gumpper-Fedus, Darwin L. Conwell, Phil A. Hart, Mary E. Dillhoff, Maria F. Gomez, Toni L. Basinski, Aamir N. Dam, Jason B. Klapman, Jason B. Fleming, Mokenge Malafa, Amir Mohammadi, Barbara A. Centeno, Kun Jiang, Daniel Jeong, Dung-Tsa Chen, Mengyu Xie, Aik Choon Tan, Brooke L. Fridley, Jamie K. Teer, Zobeida Cruz-Monserrate, Jennifer B. Permuth
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2522.
https://doi.org/10.1158/1538-7445.AM2022-2522
Published: 15 June 2022
View article titled, Abstract 2522: Pathway and immune profile analysis of cyst-derived versus PanIN-derived pancreatic ductal adenocarcinomas
Journal Articles

Predictive Signatures Inform the Effective Repurposing of Decitabine to Treat KRAS–Dependent Pancreatic Ductal Adenocarcinoma

Carla Mottini, Hideo Tomihara, Diego Carrella, Alessia Lamolinara, Manuela Iezzi, Justin K. Huang, Carla A. Amoreo, Simonetta Buglioni, Isabella Manni, Frederick S. Robinson, Rosalba Minelli, Ya'an Kang, Jason B. Fleming, Michael P. Kim, Christopher A. Bristow, Daniela Trisciuoglio, Antonella Iuliano, Donatella Del Bufalo, Diego Di Bernardo, Davide Melisi, Giulio F. Draetta, Gennaro Ciliberto, Alessandro Carugo, Luca Cardone
Journal: Cancer Research
Series: Author Choice
Cancer Res (2019) 79 (21): 5612–5625.
https://doi.org/10.1158/0008-5472.CAN-19-0187
Published: 01 November 2019
View article titled, Predictive Signatures Inform the Effective Repurposing of Decitabine to Treat KRAS–Dependent Pancreatic Ductal Adenocarcinoma
Open the PDF for Predictive Signatures Inform the Effective Repurposing of Decitabine to Treat KRAS–Dependent Pancreatic Ductal Adenocarcinoma in another window
Includes: Supplementary data
Journal Articles

Abstract 3088: Farnesyl/geranylgeranyl transferase dual inhibitor thwarts mutant KRas-driven patient-derived pancreatic tumors

Aslamuzzaman Kazi, Shengyan Xiang, Hua Yang, Liwei Chen, Perry Kennedy, Muhammad Ayaz, Steven Fletcher, Christopher Cummings, Harshani Lawrence, Francisca Beato, Ya'an Yang, Michael P. Kim, Andrea Delitto, Patrick Underwood, Jason B. Fleming, Jose Trevino, Andrew D. Hamilton, Said M. Sebti
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3088.
https://doi.org/10.1158/1538-7445.AM2019-3088
Published: 01 July 2019
View article titled, Abstract 3088: Farnesyl/geranylgeranyl transferase dual inhibitor thwarts mutant KRas-driven patient-derived pancreatic tumors
Journal Articles

Abstract 4732: CDK4/6 inhibition with lerociclib (G1T38) enhances response to PI3K or ERK inhibitors in high-throughput, ex vivo pancreatic PDX screens

Bingbing Dai, Daniel M. Freed, Jessica A. Sorrentino, Jithesh Jose Augustine, Tara G. Hughes, Ya'an Kang, Patrick J. Roberts, Jason B. Fleming, Michael P. Kim
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4732.
https://doi.org/10.1158/1538-7445.AM2019-4732
Published: 01 July 2019
View article titled, Abstract 4732: CDK4/6 inhibition with lerociclib (G1T38) enhances response to PI3K or ERK inhibitors in high-throughput, ex vivo pancreatic PDX screens
Journal Articles

Abstract 116: IGFBP2 promotes tumor progression by inducing alternative polarization of macrophages in pancreatic ductal adenocarcinoma

Longhao Sun, Liang Liu, Weijun Tian, Zhixiang Zhang, Ya'an Kang, Huamin Wang, Jason B. Fleming, Boris C. Pasche, Wei Zhang
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 116.
https://doi.org/10.1158/1538-7445.AM2018-116
Published: 01 July 2018
View article titled, Abstract 116: IGFBP2 promotes tumor progression by inducing alternative polarization of macrophages in pancreatic ductal adenocarcinoma
Journal Articles

Oncogenic Functions of Gli1 in Pancreatic Adenocarcinoma Are Supported by Its PRMT1-Mediated Methylation

Yan Wang, Jung-Mao Hsu, Ya'an Kang, Yongkun Wei, Pei-Chih Lee, Shing-Jyh Chang, Yi-Hsin Hsu, Jennifer L. Hsu, Hung-Ling Wang, Wei-Chao Chang, Chia-Wei Li, Hsin-Wei Liao, Shih-Shin Chang, Weiya Xia, How-Wen Ko, Chao-Kai Chou, Jason B. Fleming, Huamin Wang, Rosa F. Hwang, Yue Chen, Jun Qin, Mien-Chie Hung
Journal: Cancer Research
Cancer Res (2016) 76 (23): 7049–7058.
https://doi.org/10.1158/0008-5472.CAN-16-0715
Published: 30 November 2016
View article titled, Oncogenic Functions of Gli1 in Pancreatic Adenocarcinoma Are Supported by Its PRMT1-Mediated Methylation
Open the PDF for Oncogenic Functions of Gli1 in Pancreatic Adenocarcinoma Are Supported by Its PRMT1-Mediated Methylation in another window
Includes: Supplementary data
Journal Articles

IGFBP2 Activates the NF-κB Pathway to Drive Epithelial–Mesenchymal Transition and Invasive Character in Pancreatic Ductal Adenocarcinoma

Song Gao, Yan Sun, Xuebin Zhang, Limei Hu, Yuexin Liu, Corrine Yingxuan Chua, Lynette M. Phillips, He Ren, Jason B. Fleming, Huamin Wang, Paul J. Chiao, Jihui Hao, Wei Zhang
Journal: Cancer Research
Cancer Res (2016) 76 (22): 6543–6554.
https://doi.org/10.1158/0008-5472.CAN-16-0438
Published: 14 November 2016
View article titled, IGFBP2 Activates the NF-κB Pathway to Drive Epithelial–Mesenchymal Transition and Invasive Character in Pancreatic Ductal Adenocarcinoma
Open the PDF for IGFBP2 Activates the NF-κB Pathway to Drive Epithelial–Mesenchymal Transition and Invasive Character in Pancreatic Ductal Adenocarcinoma in another window
Includes: Supplementary data
Journal Articles

Abstract 4215: Hyperpolarized magnetic resonance metabolic imaging and NMR metabolomics to assess the progression and aggressiveness of patient-derived pancreatic cancer xenografts

Prasanta Dutta, Mayrim Rios Perez, Travis Cole Salzillo, Michael Pratt, Yaan Kang, Niki Zacharias, Anirban Maitra, Jason B. Fleming, Pratip Bhattacharya
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 4215.
https://doi.org/10.1158/1538-7445.AM2016-4215
Published: 15 July 2016
View article titled, Abstract 4215: Hyperpolarized magnetic resonance metabolic imaging and NMR metabolomics to assess the progression and aggressiveness of patient-derived pancreatic cancer xenografts
Journal Articles

Abstract 1701: Identification of epigenetic modifiers able to suppress growth of pancreatic ductal adenocarcinoma: A patient-oriented in vivo functional platform

Alessandro Carugo, Giannicola Genovese, Sahil Seth, Luigi Nezi, Johnathon L. Rose, Andrea Viale, Piergiorgio F. Pettazzoni, Angelo Cicalese, Daniela Bossi, Wantong Yao, Jason B. Fleming, Luisa Lanfrancone, Timothy P. Heffernan, Giulio F. Draetta
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 1701.
https://doi.org/10.1158/1538-7445.AM2015-1701
Published: 01 August 2015
View article titled, Abstract 1701: Identification of epigenetic modifiers able to suppress growth of pancreatic ductal adenocarcinoma: A patient-oriented <em>in vivo</em> functional platform
Journal Articles

Abstract LB-121: Identification of Carboxylesterase-2 as a determinant of response to irinotecan and neoadjuvant FOLFIRINOX therapy in pancreatic ductal adenocarcinoma

Michela Capello, Minhee Lee, Hong Wang, Ingrid Babel, Matthew H. Katz, Jason B. Fleming, Anirban Maitra, Huamin Wang, Weihua Tian, Ayumu Taguchi, Samir M. Hanash
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): LB-121.
https://doi.org/10.1158/1538-7445.AM2015-LB-121
Published: 01 August 2015
View article titled, Abstract LB-121: Identification of Carboxylesterase-2 as a determinant of response to irinotecan and neoadjuvant FOLFIRINOX therapy in pancreatic ductal adenocarcinoma
Journal Articles

Abstract 219: Fluorescence-guided surgery with an anti-CA 19-9-conjugated fluorophore in combination with neoadjuvant chemotherapy inhibits metastatic recurrence in a pancreatic cancer patient derived orthotopic xenograft (PDOX) nude mouse model

Yukihiko Hiroshima, Ali Maawy, Yong Zhang, Takashi Murakami, Masashi Momiyama, Ryutaro Mori, Ryusei Matsuyama, Matthew H. Katz, Jason B. Fleming, Takashi Chishima, Kuniya Tanaka, Yasushi ichikawa, Itaru Endo, Robert M. Hoffman, Michael Bouvet
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 219.
https://doi.org/10.1158/1538-7445.AM2015-219
Published: 01 August 2015
View article titled, Abstract 219: Fluorescence-guided surgery with an anti-CA 19-9-conjugated fluorophore in combination with neoadjuvant chemotherapy inhibits metastatic recurrence in a pancreatic cancer patient derived orthotopic xenograft (PDOX) nude mouse model
Journal Articles

Genetic Events That Limit the Efficacy of MEK and RTK Inhibitor Therapies in a Mouse Model of KRAS-Driven Pancreatic Cancer

Piergiorgio Pettazzoni, Andrea Viale, Parantu Shah, Alessandro Carugo, Haoqiang Ying, Huamin Wang, Giannicola Genovese, Sahil Seth, Rosalba Minelli, Tessa Green, Emmet Huang-Hobbs, Denise Corti, Nora Sanchez, Luigi Nezi, Matteo Marchesini, Avnish Kapoor, Wantong Yao, Maria E. Di Francesco, Alessia Petrocchi, Angela K. Deem, Kenneth Scott, Simona Colla, Gordon B. Mills, Jason B. Fleming, Timothy P. Heffernan, Philip Jones, Carlo Toniatti, Ronald A. DePinho, Giulio F. Draetta
Journal: Cancer Research
Series: Author Choice
Cancer Res (2015) 75 (6): 1091–1101.
https://doi.org/10.1158/0008-5472.CAN-14-1854
Published: 12 March 2015
View article titled, Genetic Events That Limit the Efficacy of MEK and RTK Inhibitor Therapies in a Mouse Model of KRAS-Driven Pancreatic Cancer
Open the PDF for Genetic Events That Limit the Efficacy of MEK and RTK Inhibitor Therapies in a Mouse Model of KRAS-Driven Pancreatic Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 1218: Telomerase-specific GFP-expressing adenovirus enables fluorescence-guided surgery (FGS) for patient-derived orthotopic xenograft (PDOX) in nude mice

Shuya Yano, Yukihiko Hiroshima, Ali Maawy, Matthew H.G. Katz, Jason B. Fleming, Hiroyuki Kishimoto, Atsushi Suetsugu, Fuminari Uehara, Shinji Miwa, Hiroshi Tazawa, Michael Bouvet, Toshiyoshi Fujiwara, Robert M. Hoffman
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 1218.
https://doi.org/10.1158/1538-7445.AM2014-1218
Published: 01 October 2014
View article titled, Abstract 1218: Telomerase-specific GFP-expressing adenovirus enables fluorescence-guided surgery (FGS) for patient-derived orthotopic xenograft (PDOX) in nude mice
Journal Articles

Abstract 1230: Efficacy of Salmonella typhimurium A1-R and anti-VEGF therapy on a patient-derived orthotopic xenograft (PDOX) pancreatic cancer model

Yukihiko Hiroshima, Ming Zhao, Matthew H.G. Katz, Jason B. Fleming, Sho Sato, Takashi Murakami, Mako Yamamoto, Fuminari Uehara, Shinji Miwa, Shuya Yano, Masashi Momiyama, Yong Zhang, Ali Maawy, Takashi Chishima, Kuniya Tanaka, Michael Bouvet, Itaru Endo, Robert M. Hoffman
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 1230.
https://doi.org/10.1158/1538-7445.AM2014-1230
Published: 01 October 2014
View article titled, Abstract 1230: Efficacy of Salmonella typhimurium A1-R and anti-VEGF therapy on a patient-derived orthotopic xenograft (PDOX) pancreatic cancer model
Journal Articles

Abstract 3130: Zoledronic acid inhibits proliferation and metastasis of human pancreatic cancer in the patient-derived orthotopic xenograft (PDOX) model by targeting tumor-educated macrophages

Yukihiko Hiroshima, Mohamed K. Hassenein, Rhiana Menen, Matthew H.g. Katz, Jason B. Fleming, Sho Sato, Takashi Murakami, Mako Yamamoto, Fuminari Uehara, Shinji Miwa, Shuya Yano, Masashi Momiyama, Ali Maawy, Takashi Chishima, Kuniya Tanaka, Michael Bouvet, Itaru Endo, Robert M. Hoffman
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 3130.
https://doi.org/10.1158/1538-7445.AM2014-3130
Published: 01 October 2014
View article titled, Abstract 3130: Zoledronic acid inhibits proliferation and metastasis of human pancreatic cancer in the patient-derived orthotopic xenograft (PDOX) model by targeting tumor-educated macrophages
Journal Articles

Abstract A28: Phase I trial of radiotherapy with concurrent bevacizumab, erlotinib, and capecitabine for locally advanced pancreatic cancer (LAPC).

Heath D. Skinner, Christopher H. Crane, Sunil Krishnan, Milind M. Javle, Robert A. Wolff, Jason B. Fleming, Marilyn V. Clemons, Mark F. Munsell, Marc E. Delclos, Prajnan Das
Journal: Cancer Research
Cancer Res (2012) 72 (14_Supplement): A28.
https://doi.org/10.1158/1538-7445.PANCA2012-A28
Published: 03 April 2014
View article titled, Abstract A28: Phase I trial of radiotherapy with concurrent bevacizumab, erlotinib, and capecitabine for locally advanced pancreatic cancer (LAPC).
Journal Articles

Abstract 3317: Efficacy of Salmonella typhimurium A1-R treatment on human patient pancreatic tumorgrafts.

Ming Zhao, Matthew H.G. Katz, Jason B. Fleming, Atsushi Suetsugu, Yong Zhang, Ali Maawy, Takashi Chishima, Kuniya Tanaka, Michael Bouvet, Yukihiko Hiroshima, Itaru Endo, Robert M. Hoffman
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 3317.
https://doi.org/10.1158/1538-7445.AM2013-3317
Published: 15 April 2013
View article titled, Abstract 3317: Efficacy of <em>Salmonella typhimurium</em> A1-R treatment on human patient pancreatic tumorgrafts.
Journal Articles

Abstract 2681: Multicolor imageable orthotopic tumorgraft models of human patient pancreatic cancer

Atsushi Suetsugu, Matthew H.G. Katz, Jason B. Fleming, Mohamed K. Hassanein, Hisataka Moriwaki, Michael Bouvet, Shigetoyo Saji, Robert M. Hoffman
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 2681.
https://doi.org/10.1158/1538-7445.AM2012-2681
Published: 15 April 2012
View article titled, Abstract 2681: Multicolor imageable orthotopic tumorgraft models of human patient pancreatic cancer
Journal Articles

Abstract 5527: Overexpression of protein phosphatase 4 is associated with poor prognosis in patients with pancreatic ductal adenocarcinoma

Shaofan Weng, Weihong Chen, Hamilton R. Stanley, Deyali Chatterjee, Matthew H. Katz, Jeffrey E. Lee, Peter W. Pisters, Henry F. Gomez, James L. Abbruzzese, Jason B. Fleming, Huamin Wang, Hua Wang
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 5527.
https://doi.org/10.1158/1538-7445.AM2012-5527
Published: 15 April 2012
View article titled, Abstract 5527: Overexpression of protein phosphatase 4 is associated with poor prognosis in patients with pancreatic ductal adenocarcinoma
Journal Articles

TrkBT1 Induces Liver Metastasis of Pancreatic Cancer Cells by Sequestering Rho GDP Dissociation Inhibitor and Promoting RhoA Activation

Zhongkui Li, Zhe Chang, Lucia J. Chiao, Ya'an Kang, Qianghua Xia, Cihui Zhu, Jason B. Fleming, Douglas B. Evans, Paul J. Chiao
Journal: Cancer Research
Cancer Res (2009) 69 (19): 7851–7859.
https://doi.org/10.1158/0008-5472.CAN-08-4002
Published: 01 October 2009
View article titled, TrkBT1 Induces Liver Metastasis of Pancreatic Cancer Cells by Sequestering Rho GDP Dissociation Inhibitor and Promoting RhoA Activation
Open the PDF for TrkBT1 Induces Liver Metastasis of Pancreatic Cancer Cells by Sequestering Rho GDP Dissociation Inhibitor and Promoting RhoA Activation in another window
Includes: Supplementary data