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Journal Articles

Abstract 4001: Evaluation of novel therapeutics using the Mayo Clinic GBM Patient-Derived Xenograft (PDX) collection

Danielle M. Burgenske, Ann C. Mladek, Shulan Tian, Mark A. Schroeder, Zeng Hu, Brett L. Carlson, Paul A. Decker, Jeanette E. Eckel-Passow, Rachael Vaubel, Jann N. Sarkaria
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 4001.
DOI: https://doi.org/10.1158/1538-7445.AM2022-4001
Published: 15 June 2022
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Abstract 4014: Pathway based analysis of glioblastoma by multi-omics with applications in targeted therapy, prognosis and probabilistic classification

Simona Migliozzi, Young Taek Oh, Luciano Garofano, Hasanain Mohammad, Fulvio D'Angelo, Ryan D. Najac, Franck Bielle, Karima Mokhtari, Jann N. Sarkaria, Michele Ceccarelli, Marc Sanson, Anna Lasorella, Antonio Iavarone
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 4014.
DOI: https://doi.org/10.1158/1538-7445.AM2022-4014
Published: 15 June 2022
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Abstract 2598: AZD1390 radio-sensitizes p53-mutant GBM via disrupting homology directed DNA repair

Shiv K. Gupta, Jiajia Chen, Daniel J. Laverty, Surabhi Talele, Brett L. Carlson, Ann C. Mladek Tuma, Danielle Burgenske, Gaspar J. Kitange, Petra Hamerlik, Zachary D. Nagel, Stephen T. Durant, William F. Elmquist, Jann N. Sarkaria
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2598.
DOI: https://doi.org/10.1158/1538-7445.AM2022-2598
Published: 15 June 2022
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Abstract 334: Convection enhanced delivery of EGFR-targeting antibody drug conjugates ABBV-321 and Depatux-M

Kendra A. Porath, Ann Mladek, Rachael A. Vaubel, Michael S. Regan, Sonia Jain, Danielle Burgenske, Katrina Bakken, Brett Carlson, Margaret Connors, Zeng Hu, Lihong He, Paul A. Decker, Gaspar Kitange, Shiv Gupta, Nathalie Y. Agar, Thomas M. Feldsien, Didier R. Lefebvre, Jann N. Sarkaria
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 334.
DOI: https://doi.org/10.1158/1538-7445.AM2022-334
Published: 15 June 2022
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Journal Articles

Abstract 3305: WSD-0628, a novel brain penetrant ATM inhibitor, radiosensitizes GBM and melanoma patient derived xenografts

Ann Mladek Tuma, Wei Zhong, Lily Liu, Danielle M. Burgenske, Brett L. Carlson, Katrina K. Bakken, Zeng Hu, Margaret A. Connors, Jann N. Sarkaria
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3305.
DOI: https://doi.org/10.1158/1538-7445.AM2022-3305
Published: 15 June 2022
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Journal Articles

Quantitative Analysis of Tyrosine Phosphorylation from FFPE Tissues Reveals Patient-Specific Signaling Networks

Ishwar N. Kohale, Danielle M. Burgenske, Ann C. Mladek, Katrina K. Bakken, Jenevieve Kuang, Judy C. Boughey, Liewei Wang, Jodi M. Carter, Eric B. Haura, Matthew P. Goetz, Jann N. Sarkaria, Forest M. White
Journal: Cancer Research
Cancer Res (2021) 81 (14): 3930–3941.
DOI: https://doi.org/10.1158/0008-5472.CAN-21-0214
Published: 15 July 2021
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Includes: Supplementary data
Journal Articles

Inhibition of ATM Induces Hypersensitivity to Proton Irradiation by Upregulating Toxic End Joining

Qin Zhou, Michelle E. Howard, Xinyi Tu, Qian Zhu, Janet M. Denbeigh, Nicholas B. Remmes, Michael G. Herman, Chris J. Beltran, Jian Yuan, Patricia T. Greipp, Judy C. Boughey, Liewei Wang, Neil Johnson, Matthew P. Goetz, Jann N. Sarkaria, Zhenkun Lou, Robert W. Mutter
Journal: Cancer Research
Cancer Res (2021) 81 (12): 3333–3346.
DOI: https://doi.org/10.1158/0008-5472.CAN-20-2960
Published: 15 June 2021
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Includes: Supplementary data
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Abstract PO035: Engineered glioblastoma tumor models reveal extracellular matrix signals influence the efficacy of targeted inhibitors

Sara Pedron, Jann N. Sarkaria, Brendan A.C. Harley
Journal: Cancer Research
Cancer Res (2021) 81 (5_Supplement): PO035.
DOI: https://doi.org/10.1158/1538-7445.TME21-PO035
Published: 01 March 2021
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Abstract 1113: Evaluation of novel therapeutics using models from the Mayo Clinic GBM patient-derived xenograft (PDX) collection

Danielle Burgenske, Ann C. Mladek, Rachael A. Vaubel, Shulan Tian, Mark A. Schroeder, Zeng Hu, Brett L. Carlson, Paul A. Decker, Jeanette E. Eckel-Passow, Jann N. Sarkaria
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 1113.
DOI: https://doi.org/10.1158/1538-7445.AM2020-1113
Published: 15 August 2020
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Journal Articles

Abstract 6276: Brain penetrant MDM2 inhibitor RG7388 extends survival benefit of radiation treatment in select glioblastoma patient-derived xenograft models

Shiv K. Gupta, Ann C. Mladek, Surabhi Telele, Afroz S. Mohammad, Lihong He, Zeng Hu, Katrina K. Bakken, Danielle M. Burgenske, Brett L. Carlson, William F. Elmquist, Jann N. Sarkaria
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 6276.
DOI: https://doi.org/10.1158/1538-7445.AM2020-6276
Published: 15 August 2020
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Journal Articles

Abstract 1381: Inhibition of DNA-PKcs by M3814 potentiates efficacy of ionizing radiation in patient derived xenografts of melanoma brain metastases

Jianxiong Ji, Emily J. Smith, Paige Sarkaria, Ann C. Mladek, Surabhi Talele, Katelyn Swanson, Afroz S. Mohammad, Lihong He, Zeng Hu, Katrina K. Bakken, Shiv K. Gupta, Danielle M. Burgenske, Gaspar J. Kitange, William F. Elmquist, Jann N. Sarkaria
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 1381.
DOI: https://doi.org/10.1158/1538-7445.AM2020-1381
Published: 15 August 2020
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Abstract 4190: A promising blood-brain-barrier penetrant MDM2-p53 antagonist, BI-MDM2, increases survival in orthotopic, glioblastoma patient-derived xenograft models

Ann C. Mladek Tuma, Shiv Gupta, Surabhi Talele, Afroz Shareef Mohammad, Katrina K. Bakken, Helen He, Zeng Hu, Margaret A. Connors, Danielle M. Burgenske, Brett L. Carlson, William F. Elmquist, Ulrike Weyer-Czernilofsky, Jann N. Sarkaria
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 4190.
DOI: https://doi.org/10.1158/1538-7445.AM2020-4190
Published: 15 August 2020
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Journal Articles

Abstract 6506: Targeting ATM with AZD1390 for radio-sensitization of glioblastoma patient derived xenografts

Jiajia Chen, Shiv K. Gupta, Gaspar J. Kitange, Ann C. Mladek, Brett L. Carlson, Lihong He, Zeng Hu, Katrina K. Bakken, Danielle M. Burgenske, Margaret A. Connors, Jann N. Sarkaria
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 6506.
DOI: https://doi.org/10.1158/1538-7445.AM2020-6506
Published: 15 August 2020
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Journal Articles

Localized Metabolomic Gradients in Patient-Derived Xenograft Models of Glioblastoma

Elizabeth C. Randall, Begoña G.C. Lopez, Sen Peng, Michael S. Regan, Walid M. Abdelmoula, Sankha S. Basu, Sandro Santagata, Haejin Yoon, Marcia C. Haigis, Jeffrey N. Agar, Nhan L. Tran, William F. Elmquist, Forest M. White, Jann N. Sarkaria, Nathalie Y.R. Agar
Journal: Cancer Research
Cancer Res (2020) 80 (6): 1258–1267.
DOI: https://doi.org/10.1158/0008-5472.CAN-19-0638
Published: 13 March 2020
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Includes: Supplementary data
Journal Articles

Temozolomide Sensitizes MGMT-Deficient Tumor Cells to ATR Inhibitors

Christopher B. Jackson, Seth I. Noorbakhsh, Ranjini K. Sundaram, Aravind N. Kalathil, Sachita Ganesa, Lanqi Jia, Hank Breslin, Danielle M. Burgenske, Oren Gilad, Jann N. Sarkaria, Ranjit S. Bindra
Journal: Cancer Research
Cancer Res (2019) 79 (17): 4331–4338.
DOI: https://doi.org/10.1158/0008-5472.CAN-18-3394
Published: 03 September 2019
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Includes: Supplementary data
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Abstract 3870: The addition of CB-839 to temozolomide significantly reduces glioma aspartate and glutamate in an IDH mutated patient derived glioma xenograft model

Sani Haider Kizilbash, Danielle M. Burgenske, Samuel McBrayer, Sandhya Devarajan, Shiv K. Gupta, Taro Hitosugi, Lihong He, Mark A. Schroeder, Brett L. Carlson, Marina Gelman, Charles A. Kunos, Joel M. Reid, Alex A. Adjei, Jann N. Sarkaria
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3870.
DOI: https://doi.org/10.1158/1538-7445.AM2019-3870
Published: 01 July 2019
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Abstract 3930: Oligosaccharyltransferase inhibition reduces glioma cell invasion and migration

Marta Baro, Jann N. Sarkaria, Joseph N. Contessa
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3930.
DOI: https://doi.org/10.1158/1538-7445.AM2019-3930
Published: 01 July 2019
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Journal Articles

Abstract 4858: CNS delivery of VX-970: A selective ATR inhibitor for radiosensitization in GBM

Surabhi Talele, Afroz Mohammad, Minjee Kim, Danielle Burgenske, Ann C. Mladek Tuma, Jann N. Sarkaria, William F. Elmquist
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4858.
DOI: https://doi.org/10.1158/1538-7445.AM2019-4858
Published: 01 July 2019
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Abstract 991: Development and characterization of patient derived xenografts from central nervous system metastasis reveal minor clone expansion linked with aggressive tumor behavior

Ben Yi Tew, Christophe Legendre, Tim Triche, Gerald C. Gooden, Kyle N. Johnson, Rae Anne Martinez, Emanuel F. Petricoin, Mariaelena Pierobon, Joyce O'Shaughnessy, Cindy Osborne, Mark A. Schroeder, Daniel J. Ma, Mark Bernstein, Jann N. Sarkaria, Steven A. Toms, Bodour Salhia
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 991.
DOI: https://doi.org/10.1158/1538-7445.AM2018-991
Published: 01 July 2018
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Abstract 840: ATR inhibition is a promising radiosensitizing strategy for chemotherapy-resistant triple negative breast cancer (TNBC)

Robert W. Mutter, Mohamed M. Kahila, Xinyi Tu, Qin Zhou, Jia Yu, Krishna R. Kalari, Liewei Wang, Judy C. Boughey, Matthew P. Goetz, Jann N. Sarkaria, Zhenkun Lou
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 840.
DOI: https://doi.org/10.1158/1538-7445.AM2018-840
Published: 01 July 2018
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