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Jann N. Sarkaria
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Journal Articles

Abstract 2531: Novel staining method for visualization, isolation and processing of intracranial brain tumors

Sonia Jain, Anders Herfindahl-Quint, Caroline D. Doherty, Wenjuan Zhang, Danielle M. Burgenske, Jann N. Sarkaria
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 2531.
https://doi.org/10.1158/1538-7445.AM2025-2531
Published: 21 April 2025
View articletitled, Abstract 2531: Novel staining method for visualization, isolation and processing of intracranial brain tumors
Journal Articles

Abstract 4684: An in vivo comparison of 137Cs and orthovoltage irradiation for murine bone marrow transplantation

Danielle M. Burgenske, Brett L. Carlson, Matthew J. Rajcula, Michael J. Shapiro, Virginia M. Shapiro, Jann N. Sarkaria
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 4684.
https://doi.org/10.1158/1538-7445.AM2025-4684
Published: 21 April 2025
View articletitled, Abstract 4684: An in vivo comparison of 137Cs and orthovoltage irradiation for murine bone marrow transplantation
Journal Articles

Abstract 2910: Pamiparib-induced replication stress augments the efficacy of temozolomide in GBM PDX models

Shiv K. Gupta, Ann C. Mladek, Sonia Jain, Katrina K. Bakken, Zeng HU, Brett L. Carlson, Danielle M. Burgenske, Jann N. Sarkaria
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 2910.
https://doi.org/10.1158/1538-7445.AM2025-2910
Published: 21 April 2025
View articletitled, Abstract 2910: Pamiparib-induced replication stress augments the efficacy of temozolomide in GBM PDX models
Journal Articles

Abstract A011: ATM inhibitors exploit checkpoint defects and ATM-dependent double strand break repair to induce mitotic cell death in TP53-mutant glioblastoma

Daniel J Laverty, Shiv Gupta, Gary Bradshaw, Jiajia Chen, Brett L Carlson, Nery Matias Calmo, Shulan Tian, Jann N Sarkaria, Zachary D Nagel
Journal: Cancer Research
Cancer Res (2025) 85 (5_Supplement): A011.
https://doi.org/10.1158/1538-7445.GENFUNC25-A011
Published: 11 March 2025
View articletitled, Abstract A011: ATM inhibitors exploit checkpoint defects and ATM-dependent double strand break repair to induce mitotic cell death in TP53-mutant glioblastoma
Journal Articles

Abstract 2130: Glioblastoma-derived extracellular vesicle cargo as a reporter of drug delivery and effect

Valerie DeLuca, Nanyun Tang, Nathaniel Hansen, Anjali Raju, Charles Shaffer, Yue Hao, Terry C. Burns, Jann N. Sarkaria, Ian Parney, Patrick Pirrotte, Kendall Van Keuren-Jensen, Michael E. Berens
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 2130.
https://doi.org/10.1158/1538-7445.AM2024-2130
Published: 22 March 2024
View articletitled, Abstract 2130: Glioblastoma-derived extracellular vesicle cargo as a reporter of drug delivery and effect
Journal Articles

Abstract 6897: Defining critical features for successful preclinical use of glioblastoma patient-derived xenografts (PDX) models for therapeutic assessment and clinical trial development

Danielle M. Burgenske, Ann C. Mladek, Katrina K. Bakken, Zeng Hu, Brett L. Carlson, Paul A. Decker, Jeanette E. Eckel-Passow, Jann N. Sarkaria
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6897.
https://doi.org/10.1158/1538-7445.AM2024-6897
Published: 22 March 2024
View articletitled, Abstract 6897: Defining critical features for successful preclinical use of glioblastoma patient-derived xenografts (PDX) models for therapeutic assessment and clinical trial development
Journal Articles

Abstract 701: Preclinical data of a novel DNA-PK inhibitor in combination with radiation therapy shows promise in the treatment of established GBM and lung carcinoma cell lines

Ann C. Mladek, Danielle L. Burgenske, William F. Elmquist, Wei Zhong, Jann N. Sarkaria
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 701.
https://doi.org/10.1158/1538-7445.AM2024-701
Published: 22 March 2024
View articletitled, Abstract 701: Preclinical data of a novel DNA-PK inhibitor in combination with radiation therapy shows promise in the treatment of established GBM and lung carcinoma cell lines
Journal Articles

Abstract B023: CNS and systemic pharmacokinetics of antibody-drug conjugate payloads through convection-enhanced delivery

Jessica I. Griffith, Jiayan Le, Kendra A. Porath, Sonia Jain, Katrina K. Bakken, Jann N. Sarkaria, William F. Elmquist
Journal: Cancer Research
Cancer Res (2024) 84 (5_Supplement_1): B023.
https://doi.org/10.1158/1538-7445.BRAIN23-B023
Published: 04 March 2024
View articletitled, Abstract B023: CNS and systemic pharmacokinetics of antibody-drug conjugate payloads through convection-enhanced delivery
Journal Articles

Abstract A004: GTP signaling links metabolism, DNA repair, and responses to genotoxic stress

Weihua Zhou, Zitong Zhao, Angelica Lin, John Yang, Jie Xu, Kari Wilder-Romans, Annabel Yang, Andrew J. Scott, Jing Li, Sumeet Solanki, Jennifer Speth, Natalie Walker, Ayesha U. Kothari, Yangyang Yao, Erik R. Peterson, Navyateja Korimerla, Christian K. Werner, Jessica Liang, Janna Jacobson, Sravya Palavalasa, Alexandra M Obrien, Ameer L Elaimy, Sean P. Ferris, Shuang G. Zhao, Jann N. Sarkaria, Balázs Győrffy, Shuqun Zhang, Wajd N. Al-Holou, Yoshie Umemura, Meredith A Morgan, Theodore S. Lawrence, Costas A. Lyssiotis, Marc Peters-Golden, Yatrik M. Shah, Daniel R. Wahl
Journal: Cancer Research
Cancer Res (2024) 84 (5_Supplement_1): A004.
https://doi.org/10.1158/1538-7445.BRAIN23-A004
Published: 04 March 2024
View articletitled, Abstract A004: GTP signaling links metabolism, DNA repair, and responses to genotoxic stress
Journal Articles

Abstract 556: Bystander effects of EGFR-targeting 40H3 antibody-drug conjugates in glioblastoma with heterogeneous EGFR expression

Sonia Jain, Eric Chun Ho, Kendra A. Porath, Antonella Antignani, David J. FitzGerald, Jann N. Sarkaria
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 556.
https://doi.org/10.1158/1538-7445.AM2023-556
Published: 04 April 2023
View articletitled, Abstract 556: Bystander effects of EGFR-targeting 40H3 antibody-drug conjugates in glioblastoma with heterogeneous EGFR expression
Journal Articles

Abstract 3498: GTP-dependent signaling links metabolism, non-homologous end joining and treatment responses in cancer and normal tissues

Weihua Zhou, Angelica Lin, Zitong Zhao, John Yang, Kari Wilder-Romans, Jie Xu, Sumeet Solanki, Jing Li, Annabel Yang, Andrew Scott, Ayesha Kothari, Erik Peterson, Navyateja Korimerla, Jessica Liang, Janna Jacobson, Sravya Palavalasa, Alexandra Obrien, Sean Ferris, Shuang Zhao, Jann N. Sarkaria, Meredith Morgan, Theodore S. Lawrence, Costas A. Lyssiotis, Yatrik Shah, Daniel R. Wahl
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3498.
https://doi.org/10.1158/1538-7445.AM2023-3498
Published: 04 April 2023
View articletitled, Abstract 3498: GTP-dependent signaling links metabolism, non-homologous end joining and treatment responses in cancer and normal tissues
Journal Articles

Abstract 3305: WSD-0628, a novel brain penetrant ATM inhibitor, radiosensitizes GBM and melanoma patient derived xenografts

Ann Mladek Tuma, Wei Zhong, Lily Liu, Danielle M. Burgenske, Brett L. Carlson, Katrina K. Bakken, Zeng Hu, Margaret A. Connors, Jann N. Sarkaria
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3305.
https://doi.org/10.1158/1538-7445.AM2022-3305
Published: 15 June 2022
View articletitled, Abstract 3305: WSD-0628, a novel brain penetrant ATM inhibitor, radiosensitizes GBM and melanoma patient derived xenografts
Journal Articles

Abstract 2598: AZD1390 radio-sensitizes p53-mutant GBM via disrupting homology directed DNA repair

Shiv K. Gupta, Jiajia Chen, Daniel J. Laverty, Surabhi Talele, Brett L. Carlson, Ann C. Mladek Tuma, Danielle Burgenske, Gaspar J. Kitange, Petra Hamerlik, Zachary D. Nagel, Stephen T. Durant, William F. Elmquist, Jann N. Sarkaria
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2598.
https://doi.org/10.1158/1538-7445.AM2022-2598
Published: 15 June 2022
View articletitled, Abstract 2598: AZD1390 radio-sensitizes p53-mutant GBM via disrupting homology directed DNA repair
Journal Articles

Abstract 334: Convection enhanced delivery of EGFR-targeting antibody drug conjugates ABBV-321 and Depatux-M

Kendra A. Porath, Ann Mladek, Rachael A. Vaubel, Michael S. Regan, Sonia Jain, Danielle Burgenske, Katrina Bakken, Brett Carlson, Margaret Connors, Zeng Hu, Lihong He, Paul A. Decker, Gaspar Kitange, Shiv Gupta, Nathalie Y. Agar, Thomas M. Feldsien, Didier R. Lefebvre, Jann N. Sarkaria
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 334.
https://doi.org/10.1158/1538-7445.AM2022-334
Published: 15 June 2022
View articletitled, Abstract 334: Convection enhanced delivery of EGFR-targeting antibody drug conjugates ABBV-321 and Depatux-M
Journal Articles

Abstract 4001: Evaluation of novel therapeutics using the Mayo Clinic GBM Patient-Derived Xenograft (PDX) collection

Danielle M. Burgenske, Ann C. Mladek, Shulan Tian, Mark A. Schroeder, Zeng Hu, Brett L. Carlson, Paul A. Decker, Jeanette E. Eckel-Passow, Rachael Vaubel, Jann N. Sarkaria
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 4001.
https://doi.org/10.1158/1538-7445.AM2022-4001
Published: 15 June 2022
View articletitled, Abstract 4001: Evaluation of novel therapeutics using the Mayo Clinic GBM Patient-Derived Xenograft (PDX) collection
Journal Articles

Abstract 4014: Pathway based analysis of glioblastoma by multi-omics with applications in targeted therapy, prognosis and probabilistic classification

Simona Migliozzi, Young Taek Oh, Luciano Garofano, Hasanain Mohammad, Fulvio D'Angelo, Ryan D. Najac, Franck Bielle, Karima Mokhtari, Jann N. Sarkaria, Michele Ceccarelli, Marc Sanson, Anna Lasorella, Antonio Iavarone
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 4014.
https://doi.org/10.1158/1538-7445.AM2022-4014
Published: 15 June 2022
View articletitled, Abstract 4014: Pathway based analysis of glioblastoma by multi-omics with applications in targeted therapy, prognosis and probabilistic classification
Journal Articles

Quantitative Analysis of Tyrosine Phosphorylation from FFPE Tissues Reveals Patient-Specific Signaling Networks

Ishwar N. Kohale, Danielle M. Burgenske, Ann C. Mladek, Katrina K. Bakken, Jenevieve Kuang, Judy C. Boughey, Liewei Wang, Jodi M. Carter, Eric B. Haura, Matthew P. Goetz, Jann N. Sarkaria, Forest M. White
Journal: Cancer Research
Cancer Res (2021) 81 (14): 3930–3941.
https://doi.org/10.1158/0008-5472.CAN-21-0214
Published: 15 July 2021
View articletitled, Quantitative Analysis of Tyrosine Phosphorylation from FFPE Tissues Reveals Patient-Specific Signaling Networks
Open the PDF for Quantitative Analysis of Tyrosine Phosphorylation from FFPE Tissues Reveals Patient-Specific Signaling Networks in another window
Includes: Supplementary data
Journal Articles

Inhibition of ATM Induces Hypersensitivity to Proton Irradiation by Upregulating Toxic End Joining

Qin Zhou, Michelle E. Howard, Xinyi Tu, Qian Zhu, Janet M. Denbeigh, Nicholas B. Remmes, Michael G. Herman, Chris J. Beltran, Jian Yuan, Patricia T. Greipp, Judy C. Boughey, Liewei Wang, Neil Johnson, Matthew P. Goetz, Jann N. Sarkaria, Zhenkun Lou, Robert W. Mutter
Journal: Cancer Research
Cancer Res (2021) 81 (12): 3333–3346.
https://doi.org/10.1158/0008-5472.CAN-20-2960
Published: 15 June 2021
View articletitled, Inhibition of ATM Induces Hypersensitivity to Proton Irradiation by Upregulating Toxic End Joining
Open the PDF for Inhibition of ATM Induces Hypersensitivity to Proton Irradiation by Upregulating Toxic End Joining in another window
Includes: Supplementary data
Journal Articles

Abstract PO035: Engineered glioblastoma tumor models reveal extracellular matrix signals influence the efficacy of targeted inhibitors

Sara Pedron, Jann N. Sarkaria, Brendan A.C. Harley
Journal: Cancer Research
Cancer Res (2021) 81 (5_Supplement): PO035.
https://doi.org/10.1158/1538-7445.TME21-PO035
Published: 01 March 2021
View articletitled, Abstract PO035: Engineered glioblastoma tumor models reveal extracellular matrix signals influence the efficacy of targeted inhibitors
Journal Articles

Abstract 6506: Targeting ATM with AZD1390 for radio-sensitization of glioblastoma patient derived xenografts

Jiajia Chen, Shiv K. Gupta, Gaspar J. Kitange, Ann C. Mladek, Brett L. Carlson, Lihong He, Zeng Hu, Katrina K. Bakken, Danielle M. Burgenske, Margaret A. Connors, Jann N. Sarkaria
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 6506.
https://doi.org/10.1158/1538-7445.AM2020-6506
Published: 15 August 2020
View articletitled, Abstract 6506: Targeting ATM with AZD1390 for radio-sensitization of glioblastoma patient derived xenografts