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Jan Koster
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Journal Articles

Abstract B021: Enhancing clinical decision-making: The role of ex vivo drug sensitivity profiling in pediatric precision medicine

Marlinde C. Schoonbeek, Lindy Vernooij, Sarah E.M. Swaak, Vicky J.E. Amo-Addae, Jan Koster, Sander Van Hooff, Selma Eising, Marlinde T.L. Van den Boogaard, Jan J. Molenaar
Journal: Cancer Research
Cancer Res (2024) 84 (17_Supplement): B021.
https://doi.org/10.1158/1538-7445.PEDIATRIC24-B021
Published: 05 September 2024
View article titled, Abstract B021: Enhancing clinical decision-making: The role of ex vivo drug sensitivity profiling in pediatric precision medicine
Journal Articles

Abstract PR004: Next generation pediatric precision oncology: Functional profiling of patient-derived viable tumor material to link genotype and phenotype

Eleonora J. Looze, Jie Mao, Heike Peterziel, Arjan Boltjes, Bianca Koopmans, Jan Koster, Marcel Kool, Max M. Van Noesel, Olaf Witt, Jan J. Molenaar, Ina Oehme, M. Emmy M. Dolman, Karin P.S. Langenberg
Journal: Cancer Research
Cancer Res (2024) 84 (17_Supplement): PR004.
https://doi.org/10.1158/1538-7445.PEDIATRIC24-PR004
Published: 05 September 2024
View article titled, Abstract PR004: Next generation pediatric precision oncology: Functional profiling of patient-derived viable tumor material to link genotype and phenotype
Journal Articles

Abstract 5469: ITCC-P4, a preclinical proof-of-concept drug testing platform as a tool for pharmacological screening in pediatric tumor models

Emilie Indersie, Sophie Branchereau, Brice Fresneau, Christophe Chardot, Didier Surdez, Alexandra Saint-Charles, Maria Eugénia Marques da Costa, Ángel M. Carcaboso, Katia Scotlandi, Massimo Moro, Heinrich Kovar, Jan-Henning Klusmann, Klaus-Michael Debatin, Simon Bomken, Louis Chesler, Chris Jones, Beat Schäfer, Marco Wachtel, Johannes Gojo, Walter Berger, Christina Guttke, Maureen Hattersley, Frédéric Colland, Ashley Strougo, Dennis Gürgen, Jens Hoffmann, Julia Schueler, Pablo M. Aviles, María José Guillén, Aniello Federico, Apurva Gopisetty, Justyna Anna Wierzbinska, Andreas Schlicker, Sara Colombetti, Olaf Heidenreich, Fatima Iradier, Nicole Huebener, Natalie Jäger, Jan Koster, Marcel Kool, Gudrun Schleiermacher, Jan J. Molenaar, Birgit Geoerger, David J. Shields, Hubert N. Caron, Louis F. Stancato, Stefan M. Pfister, Gilles Vassal, Eva-Maria Rief, Olivier Déas
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 5469.
https://doi.org/10.1158/1538-7445.AM2024-5469
Published: 22 March 2024
View article titled, Abstract 5469: ITCC-P4, a preclinical proof-of-concept drug testing platform as a tool for pharmacological screening in pediatric tumor models
Journal Articles

Abstract 3571: The ITCC-P4 sustainable platform of fully characterized PDXs supports the preclinical proof-of-concept drug testing of high-risk pediatric tumor models

Aniello Federico, Apurva Gopisetty, Didier Surdez, Yasmine Iddir, Alexandra Saint-Charles, Justyna Wierzbinska, Andreas Schlicker, Richard Volckmann, Danny Zwijnenburg, Sara Colombetti, Olaf Heidenreich, Fatima Iradier, Heinrich Kovar, Jan-Henning Klusmann, Klaus-Michael Debatin, Simon Bomken, Christina Guttke, Maureen M. Hattersley, Frédéric Colland, Ashley Strougo, María José Guillén, Louis Chesler, Chris Jones, Maria Eugénia Marques da Costa, Katia Scotlandi, Massimo Moro, Beat Schäfer, Marco Wachtel, Johannes Gojo, Walter Berger, Ángel Montero Carcaboso, Dennis Gürgen, Jens Hoffmann, Emilie Indersie, Stefano Cairo, Julia Schueler, Nicole Huebener, Johannes H. Schulte, Jan J. Molenaar, Birgit Geoerger, David J. Shields, Hubert N. Caron, Gilles Vassal, Lou F. Stancato, Lou F. Stancato, Stefan M. Pfister, Natalie Jäger, Jan Koster, Marcel Kool, Gudrun Schleiermacher
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3571.
https://doi.org/10.1158/1538-7445.AM2023-3571
Published: 04 April 2023
View article titled, Abstract 3571: The ITCC-P4 sustainable platform of fully characterized PDXs supports the preclinical proof-of-concept drug testing of high-risk pediatric tumor models
Journal Articles

Abstract 234: ITCC-P4: Genomic profiling and analyses of pediatric patient tumor and patient-derived xenograft (PDX) models for high throughput in vivo testing

Apurva Gopisetty, Aniello Federico, Didier Surdez, Yasmine Iddir, Sakina Zaidi, Alexandra Saint-Charles, Joshua Waterfall, Elnaz Saberi-Ansari, Justyna Wierzbinska, Andreas Schlicker, Norman Mack, Benjamin Schwalm, Christopher Previti, Lena Weiser, Ivo Buchhalter, Anna-Lisa Böttcher, Martin Sill, Robert Autry, Frank Estermann, David Jones, Richard Volckmann, Danny Zwijnenburg, Angelika Eggert, Olaf Heidenreich, Fatima Iradier, Irmela Jeremias, Heinrich Kovar, Jan-Henning Klusmann, Klaus-Michael Debatin, Simon Bomken, Petra Hamerlik, Maureen Hattersley, Olaf Witt, Louis Chesler, Alan Mackay, Johannes Gojo, Stefano Cairo, Julia Schueler, Johannes Schulte, Birgit Geoerger, Jan J. Molenaar, David J. Shields, Hubert N. Caron, Gilles Vassal, Louis F. Stancato, Stefan M. Pfister, Natalie Jaeger, Jan Koster, Marcel Kool, Gudrun Schleiermacher
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 234.
https://doi.org/10.1158/1538-7445.AM2023-234
Published: 04 April 2023
View article titled, Abstract 234: ITCC-P4: Genomic profiling and analyses of pediatric patient tumor and patient-derived xenograft (PDX) models for high throughput <em>in vivo</em> testing
Journal Articles

Correction: Mesenchymal-Type Neuroblastoma Cells Escape ALK Inhibitors

Ellen M. Westerhout, Mohamed Hamdi, Peter Stroeken, Natalia E. Nowakowska, Arjan Lakeman, Jennemiek van Arkel, Nancy E. Hasselt, Boris Blejlevens, Nurdan Akogul, Franciska Haneveld, Alvin Chan, Peter van Sluis, Danny Zwijnenburg, Richard Volckmann, Carel JM van Noesel, Igor Adameyko, Tim van Gronigen, Jan Koster, Linda J. Valentijn, Johan van Nes, Rogier Versteeg
Journal: Cancer Research
Cancer Res (2022) 82 (14): 2657.
https://doi.org/10.1158/0008-5472.CAN-22-1915
Published: 18 July 2022
View article titled, Correction: Mesenchymal-Type Neuroblastoma Cells Escape ALK Inhibitors
Open the PDF for Correction: Mesenchymal-Type Neuroblastoma Cells Escape ALK Inhibitors in another window
Journal Articles

Abstract 2616: Stemness factors nanog and oct4 contribute to epithelial-to-mesenchymal transition and are predictive for outcome in esophageal adenocarcinoma

Amber Perenna van der Zalm, Mark P. Dings, Reimer Janssen, Peter Bailey, Jan Koster, Danny Zwijnenburg, Richard Volckmann, Cynthia Waasdorp, Jeroen Blokhuis, César Oyarce, Gerrit Hooijer, Sybren L. Meijer, Jan Paul Medema, Hanneke W. van Laarhoven, Maarten F. Bijlsma
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2616.
https://doi.org/10.1158/1538-7445.AM2022-2616
Published: 15 June 2022
View article titled, Abstract 2616: Stemness factors nanog and oct4 contribute to epithelial-to-mesenchymal transition and are predictive for outcome in esophageal adenocarcinoma
Journal Articles

Mesenchymal-Type Neuroblastoma Cells Escape ALK Inhibitors

Ellen M. Westerhout, Mohamed Hamdi, Peter Stroeken, Natalia E. Nowakowska, Arjan Lakeman, Jennemiek van Arkel, Nancy E. Hasselt, Boris Bleijlevens, Nurdan Akogul, Franciska Haneveld, Alvin Chan, Peter van Sluis, Danny Zwijnenburg, Richard Volckmann, Carel J.M. van Noesel, Igor Adameyko, Tim van Groningen, Jan Koster, Linda J. Valentijn, Johan van Nes, Rogier Versteeg
Journal: Cancer Research
Cancer Res (2022) 82 (3): 484–496.
https://doi.org/10.1158/0008-5472.CAN-21-1621
Published: 02 February 2022
View article titled, Mesenchymal-Type Neuroblastoma Cells Escape ALK Inhibitors
Open the PDF for Mesenchymal-Type Neuroblastoma Cells Escape ALK Inhibitors in another window
Includes: Supplementary data
Journal Articles

Abstract 3662: Plasticity of transcriptional and epigenetic cellular states in neuroblastoma is driven by core lineage transcription factors

Johan van Nes, Tim van Groningen, Linda Valentijn, Danny Zwijnenburg, Ellen M. Westerhout, Mohamed Hamdi, Jan Koster, Rogier Versteeg
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3662.
https://doi.org/10.1158/1538-7445.AM2019-3662
Published: 01 July 2019
View article titled, Abstract 3662: Plasticity of transcriptional and epigenetic cellular states in neuroblastoma is driven by core lineage transcription factors
Journal Articles

Abstract 2490: R2: Genomics analysis and visualization platform

Jan Koster, Richard Volckmann, Danny Zwijnenburg, Piet Molenaar, Rogier Versteeg
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2490.
https://doi.org/10.1158/1538-7445.AM2019-2490
Published: 01 July 2019
View article titled, Abstract 2490: R2: Genomics analysis and visualization platform
Journal Articles

Abstract SY24-02: Neuroblastoma: A developmental twist

Rogier Versteeg, Linda Valentijn, Jan Koster, Tim van Groningen, Mohamed Hamdi, Ellen Westerhout, Johan van Nes
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): SY24-02.
https://doi.org/10.1158/1538-7445.AM2019-SY24-02
Published: 01 July 2019
View article titled, Abstract SY24-02: Neuroblastoma: A developmental twist
Journal Articles

Abstract 3152: A tumor suppressor-regulated cell cycle derived gene signature is prognostic of recurrence risk in prostate cancer

Joshua M. Corbin, Constantin Georgescu, Sandra Thibivilliers, Zachary Webb, Yan Zhao, Jan Koster, Kar-Ming Fung, Adam Asch, Jonathan Wren, Maria Ruiz-Echevarria
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3152.
https://doi.org/10.1158/1538-7445.AM2019-3152
Published: 01 July 2019
View article titled, Abstract 3152: A tumor suppressor-regulated cell cycle derived gene signature is prognostic of recurrence risk in prostate cancer
Journal Articles

RAS–MAPK Pathway-Driven Tumor Progression Is Associated with Loss of CIC and Other Genomic Aberrations in Neuroblastoma

Thomas F. Eleveld, Linda Schild, Jan Koster, Danny A. Zwijnenburg, Lindy K. Alles, Marli E. Ebus, Richard Volckmann, Godelieve A. Tijtgat, Peter van Sluis, Rogier Versteeg, Jan J. Molenaar
Journal: Cancer Research
Cancer Res (2018) 78 (21): 6297–6307.
https://doi.org/10.1158/0008-5472.CAN-18-1045
Published: 01 November 2018
View article titled, RAS–MAPK Pathway-Driven Tumor Progression Is Associated with Loss of CIC and Other Genomic Aberrations in Neuroblastoma
Open the PDF for RAS–MAPK Pathway-Driven Tumor Progression Is Associated with Loss of CIC and Other Genomic Aberrations in Neuroblastoma in another window
Includes: Supplementary data
Journal Articles

Patient-Derived Xenograft Models Reveal Intratumor Heterogeneity and Temporal Stability in Neuroblastoma

Noémie Braekeveldt, Kristoffer von Stedingk, Susanne Fransson, Angela Martinez-Monleon, David Lindgren, Håkan Axelson, Fredrik Levander, Jakob Willforss, Karin Hansson, Ingrid Øra, Torbjörn Backman, Anna Börjesson, Siv Beckman, Javanshir Esfandyari, Ana P. Berbegall, Rosa Noguera, Jenny Karlsson, Jan Koster, Tommy Martinsson, David Gisselsson, Sven Påhlman, Daniel Bexell
Journal: Cancer Research
Series: Author Choice
Cancer Res (2018) 78 (20): 5958–5969.
https://doi.org/10.1158/0008-5472.CAN-18-0527
Published: 15 October 2018
View article titled, Patient-Derived Xenograft Models Reveal Intratumor Heterogeneity and Temporal Stability in Neuroblastoma
Open the PDF for Patient-Derived Xenograft Models Reveal Intratumor Heterogeneity and Temporal Stability in Neuroblastoma in another window
Includes: Supplementary data
Journal Articles

Abstract IA10: Neuroblastoma is a biphasic tumor

Rogier Versteeg, Tim van Groningen, Jan Koster, Linda J. Valentijn, Johan van Nes
Journal: Cancer Research
Cancer Res (2018) 78 (19_Supplement): IA10.
https://doi.org/10.1158/1538-7445.PEDCA17-IA10
Published: 01 October 2018
View article titled, Abstract IA10: Neuroblastoma is a biphasic tumor
Journal Articles

Abstract 4131: Plasticity of transcriptional and epigenetic cellular states in neuroblastoma is driven by core lineage transcription factors

Johan V. Nes, Tim V. Groningen, Jan Koster, Linda Valentijn, Danny Zwijnenburg, Ellen M. Westerhout, Mohamed Hamdi, Rogier Versteeg
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 4131.
https://doi.org/10.1158/1538-7445.AM2018-4131
Published: 01 July 2018
View article titled, Abstract 4131: Plasticity of transcriptional and epigenetic cellular states in neuroblastoma is driven by core lineage transcription factors
Journal Articles

Abstract 576: A cancer drug atlas enables prediction of parallel drug vulnerabilities

Ravi Narayan, Piet Molenaar, Jian Teng, Bakhos Tannous, Tom Wurdinger, Jan Koster, Bart Westerman
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 576.
https://doi.org/10.1158/1538-7445.AM2018-576
Published: 01 July 2018
View article titled, Abstract 576: A cancer drug atlas enables prediction of parallel drug vulnerabilities
Journal Articles

Tumorigenic and Antiproliferative Properties of the TALE-Transcription Factors MEIS2D and MEIS2A in Neuroblastoma

Anja Groß, Catrine Schulz, Jasmine Kolb, Jan Koster, Sibylle Wehner, Sebastian Czaplinski, Abdulghani Khilan, Hermann Rohrer, Patrick N. Harter, Thomas Klingebiel, Julian D. Langer, Dirk Geerts, Dorothea Schulte
Journal: Cancer Research
Cancer Res (2018) 78 (8): 1935–1947.
https://doi.org/10.1158/0008-5472.CAN-17-1860
Published: 12 April 2018
View article titled, Tumorigenic and Antiproliferative Properties of the TALE-Transcription Factors MEIS2D and MEIS2A in Neuroblastoma
Open the PDF for Tumorigenic and Antiproliferative Properties of the TALE-Transcription Factors MEIS2D and MEIS2A in Neuroblastoma in another window
Includes: Supplementary data
Journal Articles

Abstract 3876: Active enhancers delineate intra-tumor heterogeneity of developmental states in neuroblastoma

Johan van Nes, Tim van Groningen, Linda J. Valentijn, Danny Zwijnenburg, Jan J. Molenaar, Bart A. Westerman, Ellen M. Westerhout, Mohamed Hamdi, Godelieve A. Tytgat, Jan Koster, Rogier Versteeg
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 3876.
https://doi.org/10.1158/1538-7445.AM2017-3876
Published: 01 July 2017
View article titled, Abstract 3876: Active enhancers delineate intra-tumor heterogeneity of developmental states in neuroblastoma
Journal Articles

Abstract 5506: SOX11 acts as part of the MYCN-WEE1 regulatory protein complex implicated in neuroblastoma

Bieke Decaesteker, Sara De Brouwer, Fanny De Vloed, Geertrui Denecker, Suzanne Vanhauwaert, Jolien De Wyn, Geneviève Laureys, Bjorn Menten, Pauline Depuydt, Patrick Reynolds, Jo Vandorpe, Kris Gevaert, Jan Koster, Sara Ek, Frank Speleman, Katleen De Preter
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 5506.
https://doi.org/10.1158/1538-7445.AM2017-5506
Published: 01 July 2017
View article titled, Abstract 5506: SOX11 acts as part of the MYCN-WEE1 regulatory protein complex implicated in neuroblastoma