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Jan J. Molenaar
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Journal Articles

Abstract B021: Enhancing clinical decision-making: The role of ex vivo drug sensitivity profiling in pediatric precision medicine

Marlinde C. Schoonbeek, Lindy Vernooij, Sarah E.M. Swaak, Vicky J.E. Amo-Addae, Jan Koster, Sander Van Hooff, Selma Eising, Marlinde T.L. Van den Boogaard, Jan J. Molenaar
Journal: Cancer Research
Cancer Res (2024) 84 (17_Supplement): B021.
https://doi.org/10.1158/1538-7445.PEDIATRIC24-B021
Published: 05 September 2024
View article titled, Abstract B021: Enhancing clinical decision-making: The role of ex vivo drug sensitivity profiling in pediatric precision medicine
Journal Articles

Abstract PR004: Next generation pediatric precision oncology: Functional profiling of patient-derived viable tumor material to link genotype and phenotype

Eleonora J. Looze, Jie Mao, Heike Peterziel, Arjan Boltjes, Bianca Koopmans, Jan Koster, Marcel Kool, Max M. Van Noesel, Olaf Witt, Jan J. Molenaar, Ina Oehme, M. Emmy M. Dolman, Karin P.S. Langenberg
Journal: Cancer Research
Cancer Res (2024) 84 (17_Supplement): PR004.
https://doi.org/10.1158/1538-7445.PEDIATRIC24-PR004
Published: 05 September 2024
View article titled, Abstract PR004: Next generation pediatric precision oncology: Functional profiling of patient-derived viable tumor material to link genotype and phenotype
Journal Articles

Abstract 5469: ITCC-P4, a preclinical proof-of-concept drug testing platform as a tool for pharmacological screening in pediatric tumor models

Emilie Indersie, Sophie Branchereau, Brice Fresneau, Christophe Chardot, Didier Surdez, Alexandra Saint-Charles, Maria Eugénia Marques da Costa, Ángel M. Carcaboso, Katia Scotlandi, Massimo Moro, Heinrich Kovar, Jan-Henning Klusmann, Klaus-Michael Debatin, Simon Bomken, Louis Chesler, Chris Jones, Beat Schäfer, Marco Wachtel, Johannes Gojo, Walter Berger, Christina Guttke, Maureen Hattersley, Frédéric Colland, Ashley Strougo, Dennis Gürgen, Jens Hoffmann, Julia Schueler, Pablo M. Aviles, María José Guillén, Aniello Federico, Apurva Gopisetty, Justyna Anna Wierzbinska, Andreas Schlicker, Sara Colombetti, Olaf Heidenreich, Fatima Iradier, Nicole Huebener, Natalie Jäger, Jan Koster, Marcel Kool, Gudrun Schleiermacher, Jan J. Molenaar, Birgit Geoerger, David J. Shields, Hubert N. Caron, Louis F. Stancato, Stefan M. Pfister, Gilles Vassal, Eva-Maria Rief, Olivier Déas
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 5469.
https://doi.org/10.1158/1538-7445.AM2024-5469
Published: 22 March 2024
View article titled, Abstract 5469: ITCC-P4, a preclinical proof-of-concept drug testing platform as a tool for pharmacological screening in pediatric tumor models
Journal Articles

Abstract 234: ITCC-P4: Genomic profiling and analyses of pediatric patient tumor and patient-derived xenograft (PDX) models for high throughput in vivo testing

Apurva Gopisetty, Aniello Federico, Didier Surdez, Yasmine Iddir, Sakina Zaidi, Alexandra Saint-Charles, Joshua Waterfall, Elnaz Saberi-Ansari, Justyna Wierzbinska, Andreas Schlicker, Norman Mack, Benjamin Schwalm, Christopher Previti, Lena Weiser, Ivo Buchhalter, Anna-Lisa Böttcher, Martin Sill, Robert Autry, Frank Estermann, David Jones, Richard Volckmann, Danny Zwijnenburg, Angelika Eggert, Olaf Heidenreich, Fatima Iradier, Irmela Jeremias, Heinrich Kovar, Jan-Henning Klusmann, Klaus-Michael Debatin, Simon Bomken, Petra Hamerlik, Maureen Hattersley, Olaf Witt, Louis Chesler, Alan Mackay, Johannes Gojo, Stefano Cairo, Julia Schueler, Johannes Schulte, Birgit Geoerger, Jan J. Molenaar, David J. Shields, Hubert N. Caron, Gilles Vassal, Louis F. Stancato, Stefan M. Pfister, Natalie Jaeger, Jan Koster, Marcel Kool, Gudrun Schleiermacher
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 234.
https://doi.org/10.1158/1538-7445.AM2023-234
Published: 04 April 2023
View article titled, Abstract 234: ITCC-P4: Genomic profiling and analyses of pediatric patient tumor and patient-derived xenograft (PDX) models for high throughput <em>in vivo</em> testing
Journal Articles

Abstract 3571: The ITCC-P4 sustainable platform of fully characterized PDXs supports the preclinical proof-of-concept drug testing of high-risk pediatric tumor models

Aniello Federico, Apurva Gopisetty, Didier Surdez, Yasmine Iddir, Alexandra Saint-Charles, Justyna Wierzbinska, Andreas Schlicker, Richard Volckmann, Danny Zwijnenburg, Sara Colombetti, Olaf Heidenreich, Fatima Iradier, Heinrich Kovar, Jan-Henning Klusmann, Klaus-Michael Debatin, Simon Bomken, Christina Guttke, Maureen M. Hattersley, Frédéric Colland, Ashley Strougo, María José Guillén, Louis Chesler, Chris Jones, Maria Eugénia Marques da Costa, Katia Scotlandi, Massimo Moro, Beat Schäfer, Marco Wachtel, Johannes Gojo, Walter Berger, Ángel Montero Carcaboso, Dennis Gürgen, Jens Hoffmann, Emilie Indersie, Stefano Cairo, Julia Schueler, Nicole Huebener, Johannes H. Schulte, Jan J. Molenaar, Birgit Geoerger, David J. Shields, Hubert N. Caron, Gilles Vassal, Lou F. Stancato, Lou F. Stancato, Stefan M. Pfister, Natalie Jäger, Jan Koster, Marcel Kool, Gudrun Schleiermacher
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3571.
https://doi.org/10.1158/1538-7445.AM2023-3571
Published: 04 April 2023
View article titled, Abstract 3571: The ITCC-P4 sustainable platform of fully characterized PDXs supports the preclinical proof-of-concept drug testing of high-risk pediatric tumor models
Journal Articles

RAS–MAPK Pathway-Driven Tumor Progression Is Associated with Loss of CIC and Other Genomic Aberrations in Neuroblastoma

Thomas F. Eleveld, Linda Schild, Jan Koster, Danny A. Zwijnenburg, Lindy K. Alles, Marli E. Ebus, Richard Volckmann, Godelieve A. Tijtgat, Peter van Sluis, Rogier Versteeg, Jan J. Molenaar
Journal: Cancer Research
Cancer Res (2018) 78 (21): 6297–6307.
https://doi.org/10.1158/0008-5472.CAN-18-1045
Published: 01 November 2018
View article titled, RAS–MAPK Pathway-Driven Tumor Progression Is Associated with Loss of CIC and Other Genomic Aberrations in Neuroblastoma
Open the PDF for RAS–MAPK Pathway-Driven Tumor Progression Is Associated with Loss of CIC and Other Genomic Aberrations in Neuroblastoma in another window
Includes: Supplementary data
Journal Articles

Abstract 2630: Preclinical identification of Venetoclax combination strategies with Idasanutlin, CUDC-907, Prexasertib or Talazoparib for neuroblastoma treatment

M. Emmy M. Dolman, Laurel T. Bate-Eya, Lindy Vernooij, Bianca Koopmans, Lindy K. Alles, Anke H. Essing, Daphne Lelieveld, David A. Egan, Mark Kerstjens, Ronald W. Stam, Huib N. Caron, Jan J. Molenaar
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 2630.
https://doi.org/10.1158/1538-7445.AM2018-2630
Published: 01 July 2018
View article titled, Abstract 2630: Preclinical identification of Venetoclax combination strategies with Idasanutlin, CUDC-907, Prexasertib or Talazoparib for neuroblastoma treatment
Journal Articles

Abstract 5815: The HBP1 tumor suppressor is a negative epigenetic regulator of MYCN driven neuroblastoma through interaction with the PRC2 complex

Geertrui Denecker, Shana Claeys, Irina Lambertz, Els Janssens, Suzanne Vanhauwaert, Bieke Decaesteker, Tom Van Maerken, Bram De Wilde, Genevieve Laureys, Kristina Althoff, Johannes Schulte, Jean-Baptiste Demoulin, Stephen S. Roberts, Laurel Bate-Eya, Jan J. Molenaar, Frank Westermann, Katleen De Preter, Frank Speleman
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 5815.
https://doi.org/10.1158/1538-7445.AM2017-5815
Published: 01 July 2017
View article titled, Abstract 5815: The HBP1 tumor suppressor is a negative epigenetic regulator of MYCN driven neuroblastoma through interaction with the PRC2 complex
Journal Articles

Abstract 3876: Active enhancers delineate intra-tumor heterogeneity of developmental states in neuroblastoma

Johan van Nes, Tim van Groningen, Linda J. Valentijn, Danny Zwijnenburg, Jan J. Molenaar, Bart A. Westerman, Ellen M. Westerhout, Mohamed Hamdi, Godelieve A. Tytgat, Jan Koster, Rogier Versteeg
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 3876.
https://doi.org/10.1158/1538-7445.AM2017-3876
Published: 01 July 2017
View article titled, Abstract 3876: Active enhancers delineate intra-tumor heterogeneity of developmental states in neuroblastoma
Journal Articles

Abstract 2453: Neuroblastoma is bi-phasic and includes classical neuro-epithelial cells and chemo-resistant mesenchymal cells

Rogier Versteeg, Tim van Groningen, Linda J. Valentijn, Bart A. Westerman, Jan J. Molenaar, Ellen M. Westerhout, Mohamed Hamdi, Godelieve A. Tytgat, Jan Koster, Johan van Nes.
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2453.
https://doi.org/10.1158/1538-7445.AM2016-2453
Published: 15 July 2016
View article titled, Abstract 2453: Neuroblastoma is bi-phasic and includes classical neuro-epithelial cells and chemo-resistant mesenchymal cells
Journal Articles

Abstract PR06: TERT rearrangements are frequent in neuroblastoma and identify aggressive tumors

Jan Koster, Linda J. Valentijn, Danny A. Zwijnenburg, Nancy E. Hasselt, Peter G. van Sluis, Max M. van Noesel, Rani E. George, Godelieve A. Tytgat, Jan J. Molenaar, Rogier Versteeg
Journal: Cancer Research
Cancer Res (2016) 76 (5_Supplement): PR06.
https://doi.org/10.1158/1538-7445.PEDCA15-PR06
Published: 04 April 2016
View article titled, Abstract PR06: TERT rearrangements are frequent in neuroblastoma and identify aggressive tumors
Journal Articles

Abstract B09: MCL-1 inhibition improves ABT199 efficacy for BCL-2-dependent neuroblastoma

Laurel T. Bate-Eya, Ilona J.M. den Hartog, Ida van der Ploeg, Linda Schild, Jan Koster, Rogier Versteeg, Huib N. Caron, Jan J. Molenaar, M. Emmy M. Dolman
Journal: Cancer Research
Cancer Res (2016) 76 (5_Supplement): B09.
https://doi.org/10.1158/1538-7445.PEDCA15-B09
Published: 04 April 2016
View article titled, Abstract B09: MCL-1 inhibition improves ABT199 efficacy for BCL-2-dependent neuroblastoma
Journal Articles

Abstract PR08: Neuroblastoma is biphasic and includes classical neuroepithelial cells and chemoresistant mesenchymal cells

Rogier Versteeg, Tim van Groningen, Bart A. Westerman, Jan J. Molenaar, Ellen M. Westerhout, Mohamed Hamdi, Godelieve A. Tytgat, Jan Koster, Johan van Nes
Journal: Cancer Research
Cancer Res (2016) 76 (5_Supplement): PR08.
https://doi.org/10.1158/1538-7445.PEDCA15-PR08
Published: 04 April 2016
View article titled, Abstract PR08: Neuroblastoma is biphasic and includes classical neuroepithelial cells and chemoresistant mesenchymal cells
Journal Articles

Abstract A2-45: R2: Accessible web-based genomics analysis and visualization platform for biomedical researchers

Jan Koster, Jan J. Molenaar, Rogier Versteeg
Journal: Cancer Research
Cancer Res (2015) 75 (22_Supplement_1): A2-45.
https://doi.org/10.1158/1538-7445.TRANSCAGEN-A2-45
Published: 15 November 2015
View article titled, Abstract A2-45: R2: Accessible web-based genomics analysis and visualization platform for biomedical researchers
Journal Articles

Abstract B1-05: R2: Accessible web-based genomics analysis and visualization platform for biomedical researchers

Jan Koster, Jan J. Molenaar, Rogier Versteeg
Journal: Cancer Research
Cancer Res (2015) 75 (22_Supplement_2): B1-05.
https://doi.org/10.1158/1538-7445.COMPSYSBIO-B1-05
Published: 15 November 2015
View article titled, Abstract B1-05: R2: Accessible web-based genomics analysis and visualization platform for biomedical researchers
Journal Articles

Abstract 2980: Relapsed neuroblastomas show frequent RAS-MAPK pathway mutations

Derek A. Oldridge, Thomas F. Eleveld, Virginie Bernard, Jan Koster, Leo C. Daage, Sharon J. Diskin, Linda Schild, Nadia B. Bentahar, Angela Bellini, Mathieu Chicard, Eve Lapouble, Valérie Combaret, Patricia Legoix-Né, Jean Michon, Trevor J. Pugh, Lori S. Hart, JulieAnn Rader, Edward F. Attiyeh, Jun S. Wei, Shile Zhang, Arlene Naranjo, Julie M. Gastier-Foster, Michael D. Hogarty, Malcolm A. Smith, Jaime G. Auvil, Thomas B. K. Watkins, Danny A. Zwijnenburg, Marli E. Ebus, Peter van Sluis, Anne Hakkert, Esther van Wezel, C. Ellen van der Schoot, Ellen M. Westerhout, Johannes H. Schulte, Godelieve A. Tytgat, M. Emmy M. Dolman, Isabelle Janoueix-Lerosey, Daniela S. Gerhard, Huib N. Caron, Olivier Delattre, Javed Khan, Rogier Versteeg, Gudrun Schleiermacher, John M. Maris, Jan J. Molenaar
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 2980.
https://doi.org/10.1158/1538-7445.AM2015-2980
Published: 01 August 2015
View article titled, Abstract 2980: Relapsed neuroblastomas show frequent RAS-MAPK pathway mutations
Journal Articles

Abstract LB-209: Neuroblastoma is biphasic with classical neuro-epithelial cells and chemoresistant mesenchymal cells controlled by PRRX1-NOTCH signaling

Tim van Groningen, Natalia E. Nowakowska, Nurdan Akogul, Marloes Broekmans, Johannes Bras, Jan Booij, Marli E. Ebus, Jan J. Molenaar, Ellen M. Westerhout, Mohamed Hamdi, Peter van Sluis, Jan Koster, Bart A. Westerman, Godelieve A. Tytgat, Rogier Versteeg, Johan van Nes
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): LB-209.
https://doi.org/10.1158/1538-7445.AM2015-LB-209
Published: 01 August 2015
View article titled, Abstract LB-209: Neuroblastoma is biphasic with classical neuro-epithelial cells and chemoresistant mesenchymal cells controlled by PRRX1-NOTCH signaling
Journal Articles

Abstract B41: Whole genome sequencing identifies tumor evolution events in relapse neuroblastoma

Thomas F. Eleveld, Linda Schild, Jan Koster, Danny Zwijnenburg, Marli E. Ebus, Peter Sluis van, Johannes H. Schulte, Huib N. Caron, Rogier Versteeg, Jan J. Molenaar
Journal: Cancer Research
Cancer Res (2014) 74 (20_Supplement): B41.
https://doi.org/10.1158/1538-7445.PEDCAN-B41
Published: 09 October 2014
View article titled, Abstract B41: Whole genome sequencing identifies tumor evolution events in relapse neuroblastoma
Journal Articles

Abstract 3804: Rare DNA variants are enriched at the BARD1 locus and likely influence neuroblastoma susceptibility.

Andrew C. Wood, Trevor J. Pugh, Olena Morozova, Jan Koster, Jan J. Molenaar, Vanessa Pineros, Kristopher R. Bosse, Juan C. Perin, Sharon Diskin, Maura A. Diamond, Marco Marra, Matthew Meyerson, Rogier Versteeg, John M. Maris
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 3804.
https://doi.org/10.1158/1538-7445.AM2013-3804
Published: 15 April 2013
View article titled, Abstract 3804: Rare DNA variants are enriched at the BARD1 locus and likely influence neuroblastoma susceptibility.
Journal Articles

Cyclin D1 and CDK4 Activity Contribute to the Undifferentiated Phenotype in Neuroblastoma

Jan J. Molenaar, Marli E. Ebus, Jan Koster, Peter van Sluis, Carel J.M. van Noesel, Rogier Versteeg, Huib N. Caron
Journal: Cancer Research
Cancer Res (2008) 68 (8): 2599–2609.
https://doi.org/10.1158/0008-5472.CAN-07-5032
Published: 15 April 2008
View article titled, Cyclin D1 and CDK4 Activity Contribute to the Undifferentiated Phenotype in Neuroblastoma
Open the PDF for Cyclin D1 and CDK4 Activity Contribute to the Undifferentiated Phenotype in Neuroblastoma in another window